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Manhattan Pharmaceuticals to Webcast Annual Shareholder Meeting

May 22, 2007

NEW YORK, May 22, 2007 -- Manhattan Pharmaceuticals, Inc. (AMEX:MHA - News) today announced it will host a live webcast of its annual shareholder meeting scheduled for Thursday, May 24, 2007 at 10:30 a.m. EDT. In addition to voting on the items in the Proxy Statement the meeting will also include a presentation by Douglas Abel, president and chief executive officer. The meeting is being held at The American Stock Exchange, 86 Trinity Place in New York City.

To access the live audio webcast of this meeting please go to http://www.manhattanpharma.com approximately 15 minutes prior to the presentation in order to register and download any necessary software.

About Manhattan Pharmaceuticals, Inc.
Manhattan Pharmaceuticals, Inc. (AMEX:MHA - News) is a pharmaceutical company developing novel, high-value drug candidates primarily in the areas of endocrine/metabolic disease and dermatologic/immunologic disorders. With a pipeline consisting of five clinical-stage product candidates, Manhattan Pharmaceuticals is developing potential therapeutics for large, underserved patient populations seeking superior treatments for conditions including common obesity, morbid obesity, psoriasis, and atopic dermatitis (eczema).