SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549


                             -----------------------


                                   FORM 8-KSB

                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934




Date of Report (Date of earliest event reported):   August 16, 1996


                         ATLANTIC PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
               (Exact name of registrant as specified in charter)


         Delaware                        0-27282                  36-3898269
- --------------------------------------------------------------------------------
(State or Other Jurisdiction            (Commission             (IRS Employer
   of Incorporation)                    File Number)         Identification No.)


 142 Cypress Point Road, Half Moon Bay, California                      94019
- --------------------------------------------------------------------------------
(Address of Principal Executive Offices)                              (Zip Code)


Registrant's telephone number, including area code:   (415) 726-1327



- --------------------------------------------------------------------------------
         (Former Name or Former Address, if Changed Since Last Report.)






                                  Page 1 of __

                             Exhibit Index on Page 4




Item 1.    Changes in Control of Registrant

           Pursuant  to the  terms of a Common  Stock  Purchase  Agreement  (the
"Agreement"),  dated August 16, 1996, among Atlantic Pharmaceuticals,  Inc. (the
"Company"),  Dreyfus Growth and Value Funds,  Inc., a Maryland  corporation,  --
Dreyfus  Aggressive  Growth Fund  ("Aggressive  Growth")  and Premier  Strategic
Growth Fund, a Massachusetts  business trust ("Strategic  Growth"),  the Company
issued in a private  placement  140,000  shares of its Common  Stock,  par value
$.001 per share (the "Common Stock"), to Aggressive Growth and 110,000 shares of
its Common Stock to Strategic  Growth in consideration of $856,100 and $672,650,
respectively.  The Dreyfus Corporation serves as the investment advisor for each
of Aggressive  Growth and  Strategic  Growth.  Based on 2,663,880  shares of the
Company's Common Stock  outstanding on August 16, 1996 prior to the consummation
of this  transaction,  Aggressive Growth and Strategic Growth purchased 4.8% and
3.8% respectively,  of the outstanding Common Stock of the Company.  Pursuant to
the terms of an  Investors'  Rights  Agreement  executed  concurrently  with the
Agreement,  the Company granted certain registration rights to Aggressive Growth
and Strategic Growth.

           A copy of the Press  Release  issued in  connection  with the private
placement is attached hereto as Exhibit 1.

Item 7.    Financial Statements, Pro Forma Financial Information and Exhibits.

           (a)    Financial Statements.

           The  registrant  has  determined  that no  financial  statements  are
required to be filed pursuant to this item.

           (b)    Pro Forma Financial Information.

           The registrant has determined that no pro forma financial information
is required to be filed pursuant to this item.

           (c)    Exhibits.

     Exhibit No.                     Description
     -----------                     -----------
         1.       Press Release, dated August 19, 1996.

         2.       Common Stock Purchase Agreement, dated August 16, 1996.

         3.       Investors' Rights Agreement, dated August 16, 1996.


                                       2.





                                   SIGNATURES



                  Pursuant to the requirements of the Securities Exchange Act of
1934,  the  registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized.

Date:  August 28, 1996                   ATLANTIC PHARMACEUTICALS, INC.
                                                           (Registrant)


                                         By:      //s//
                                             -----------------------------------
                                         Name:    Jon D. Lindjord
                                         Title:   President and Chief Executive
                                                  Officer



                                       3.




                         Atlantic Pharmaceuticals, Inc.
                                  Exhibit Index
                                  to Form 8-KSB



                                                                    Sequentially
                                                                      Numbered
Exhibit No.                      Description                            Page
- -----------                      -----------                            ----
    1         Press Release, dated August 19, 1996.

    2         Common Stock Purchase Agreement, dated August 16, 1996

    3         Investors' Rights Agreement, dated August 16, 1996



                                       4.




LOGO OMITTED


Atlantic Pharmaceuticals, Inc.


            ATLANTIC PHARMACEUTICALS SELLS QUARTER-MILLION SHARES OF
                     TREASURY STOCK TO INSTITUTIONAL FUNDS

       --Mutual Funds Managed by the Dreyfus Corporation to Own 8 Percent
                              of Atlantic Stock--

Half Moon Bay, CA,  August 19, 1996 -- Atlantic  Pharmaceuticals,  Inc.  (Nasdaq
Small Cap;  ATLC)  today  announced  that  mutual  funds  managed by the Dreyfus
Corporation have purchased  250,000 shares of Atlantic's  Treasury Stock at a 15
percent discount to market. As a result of these purchases,  these funds now own
approximately 8 percent of Atlantic's Common Stock.

"We are pleased to receive this vote of confidence  from one of the world's most
respected funds," said J.D.  Lindjord,  President and Chief Executive Officer of
Atlantic.  This capital infusion will help us build on recent promising research
data we have observed for our various technologies."

Atlantic  completed its initial public offering (IPO) of 1.5 million units at $4
per unit in December 1995. Following this transacdtion, Atlantic has 2.9 million
shares of Common Stock outstanding.

Atlantic   Pharmaceuticals,   based  in  Half   Moon  Bay,   California,   is  a
biopharmaceutical  company developing pharmaceutical and biomedical producst for
a  variety  of  therapeutic  areas.  Currently,  Atlantic  is  developing  novel
technologies  in  the  areas  of  cataract  removal,   antisense  gene  therapy,
prevention   of   restenosis   following   coronary   angioplasty,    and   anti
inflammatory/analgesic drugs.

As with any company  developing  novel  therapeutics,  Atlantic may make certain
forward-looking  statements that relate to future events or future  business and
financial  performance.  Such  statements can only be predictions and the actual
events or results may differ from those  discussed due,  among other things,  to
those risks described in the company's reports on Forms 10-QSB and 10-KSB.

                                      ####

Editor's    Notes:    This   release   is   available   on   the   internet   at
http://www.atlan.com and http://www.noonanrusso.com.

A fact sheet on Atlantic  is  available  via fax through  September 2 by calling
(212) 696-4455 ext. 329 and requesting document number 900.


                142 Cypress Point Road, Half Moon Bay, CA 94019
            Tel. 415-728-1327 Fax 415-726-3647 Email; mail@atlan.com



                  --------------------------------------------

                         ATLANTIC PHARMACEUTICALS, INC.

                        COMMON STOCK PURCHASE AGREEMENT

                                AUGUST 16, 1996

                  ---------------------------------------------


                                TABLE OF CONTENTS

                                                                            Page


Section  1     Authorization and Sale of Shares of Common Stock.............  1
         1.1   Authorization................................................  1
         1.2   Sale of Shares of Common Stock...............................  1

Section  2     Closing Date; Delivery.......................................  1
         2.1   Closing Date.................................................  1
         2.2   Delivery.....................................................  1
         2.3   Subsequent Sales.............................................  1

Section  3     Representations and Warranties of the Company................  2
         3.1   Organization and Standing....................................  2
         3.2   Corporate Power; Authorization...............................  2
         3.3   Issuance and Delivery of the Shares of Common Stock..........  2
         3.4   SEC Documents; Financial Statement...........................  2
         3.5   Governmental Consents........................................  3
         3.6   No Material Adverse Change...................................  3
         3.7   Authorized Capital Stock.....................................  3
         3.8   No Liens, Encumbrances.......................................  3
         3.9   Registration Rights..........................................  3

Section  4     Representations, Warranties and Covenants of the Purchasers..  4
         4.1   Authorization................................................  4
         4.2   Due Organization.............................................  4
         4.3   Investment Experience........................................  4
         4.4   Investment Intent............................................  4
         4.5   Registration or Exemption Requirements.......................  4
         4.6   No Conflicting Agreements....................................  5
         4.7   No Legal, Tax or Investment Advice...........................  5

Section  5     Conditions to Closing of Purchasers..........................  5
         5.1   Representations and Warranties...............................  5
         5.2   Performance..................................................  5
         5.3   Compliance Certificate.......................................  5
         5.4   Qualifications...............................................  5
         5.5   Investors' Rights Agreement..................................  5

Section  6     Conditions to Closing of Company.............................  5
         6.1   Representations and Warranties...............................  5
         6.2   Covenants....................................................  6
         6.3   Blue Sky.....................................................  6

Section  7     Affirmative Covenants of the Company.........................  6
         7.1   Financial Information........................................  6





Section  8     Miscellaneous................................................  6
         8.1   Waivers and Amendments.......................................  6
         8.2   Broker's Fee.................................................  6
         8.3   Governing Law................................................  6
         8.4   Successors and Assigns.......................................  6
         8.5   Entire Agreement.............................................  6
         8.6   Notices, etc.................................................  6
         8.7   Severability of this Agreement...............................  7
         8.8   Counterparts.................................................  7
         8.9   Further Assurances...........................................  7
         8.10  Termination..................................................  7
         8.11  Expenses.....................................................  7
         8.12  Currency.....................................................  7
         8.13  Effectiveness of Agreement...................................  7
         8.14  Multiple Parties.............................................  7

Schedule I -- Schedule of Purchasers
Exhibit A -- Form of Investors' Rights Agreement







                                       ii.



                         ATLANTIC PHARMACEUTICALS, INC.

                         COMMON STOCK PURCHASE AGREEMENT


                  This Common Stock Purchase Agreement (the "Agreement") is made
as of August 16, 1996, by and among Atlantic  Pharmaceuticals,  Inc., a Delaware
corporation  (the  "Company"),  with its  principal  office at 142 Cypress Point
Road, Half Moon Bay, California 94019, and the persons listed on the Schedule of
Purchasers attached hereto as Schedule I (the "Purchasers").

                                    Section 1

                Authorization and Sale of Shares of Common Stock

                  1.1  Authorization.  The Company has  authorized  the sale and
issuance pursuant to this Agreement of 500,000 shares of common stock, par value
$.001 (the "Common Stock").

                  1.2 Sale of Shares of Common  Stock.  Subject to the terms and
conditions  of this  Agreement,  the  Company  agrees  to issue and sell to each
Purchaser and each Purchaser  severally  agrees to purchase from the Company the
number of shares of Common Stock set forth  opposite  each  Purchaser's  name on
Schedule I for a price per share of Common  Stock equal to 85% of the average of
the bid and asked closing price of the Company's Common Stock as reported by the
Nasdaq Small Capitalization  Market on the ten trading days immediately prior to
the date of this Agreement.

                                    Section 2

                             Closing Date; Delivery

                  2.1 Closing Date.  The closing of the purchase and sale of the
shares of Common Stock hereunder (the "Closing") shall be held at the offices of
Brobeck,  Phleger & Harrison LLP, 1301 Avenue of the Americas,  30th floor,  New
York, New York, at 12:00 noon New York Time, on August 16, 1996 or at such other
time and place upon which the Company and the Purchasers purchasing the majority
of the  shares  of  Common  Stock  shall  agree.  The  date  of the  Closing  is
hereinafter referred to as the "Closing Date."

                  2.2 Delivery. At the Closing, the Company will deliver to each
Purchaser certificates,  registered in the Purchaser's name as shown on Schedule
I,  representing  the number of shares of Common  Stock to be  purchased  by the
Purchaser. Such delivery shall be against payment of the purchase price therefor
by wire  transfer  to the  Company's  bank  account  in the  amount set forth on
Schedule I.

                  2.3  Subsequent  Sales.  At any time on or before the 60th day
following the Closing,  the Company may sell up to the balance of the authorized
shares  of  Common  Stock  not sold at the  Closing  to such  persons  as may be
approved by the  President of the  Company.  All such sales shall be made on the
terms and  conditions set forth in this  Agreement.  Any shares sold pursuant to
this Section 2.3 shall be deemed to be Common  Stock sold under this  Agreement,
and any purchasers  thereof shall be deemed to be "Purchasers"  for all purposes
under this  Agreement.  Should any such sales be made, the Company shall prepare
and  distribute  to the  Purchasers  a  revised  Schedule  I to  this  Agreement
reflecting such.


                                       1.



                                    Section 3

                  Representations and Warranties of the Company

                  The Company  represents  and warrants to the  Purchasers as of
the Closing Date as follows:

                  3.1  Organization  and Standing.  The Company is a corporation
duly  organized and validly  existing  under,  and by virtue of, the laws of the
State of Delaware and is in good  standing as a domestic  corporation  under the
laws of said state with all  requisite  corporate  power and  authority  to own,
operate  and  lease  its  properties  and  conduct  its  business  as  presently
conducted.  The Company is qualified to do business as a foreign corporation and
is in good  standing in the State of  California  and in each other state of the
United States where its failure to do so would have a material adverse effect on
its business as presently conducted. The Company holds all licenses, franchises,
permits and authorizations necessary for the lawful conduct of its business.

                  3.2  Corporate  Power;  Authorization.  The  Company  has  all
requisite legal and corporate power and has taken all requisite corporate action
to execute and deliver this Agreement and the Investors'  Rights  Agreement;  to
sell and issue the shares of Common  Stock;  and to carry out and perform all of
its obligations under this Agreement and the Investors'  Rights Agreement.  This
Agreement and the Investors'  Rights Agreement  constitute the legal,  valid and
binding  obligations  of the  Company,  enforceable  in  accordance  with  their
respective terms,  except (i) as limited by applicable  bankruptcy,  insolvency,
reorganization  or similar laws  relating to or  affecting  the  enforcement  of
creditors'  rights  generally  and  (ii)  as  limited  by  equitable  principles
generally.  The  execution  and delivery of this  Agreement  and the  Investors'
Rights  Agreement  do  not,  and  the  performance  of  this  Agreement  and the
Investors'  Rights  Agreement and the compliance with the provisions  hereof and
thereof,  and the  issuance,  sale and delivery of the shares of Common Stock by
the Company will not materially conflict with, or result in a material breach or
violation of the terms,  conditions or  provisions  of, or constitute a material
default  under,  or result in the creation or  imposition  of any material  lien
pursuant  to the terms of, the  Certificate  of  Incorporation  or Bylaws of the
Company or any statute,  law, rule or regulation or any state or federal  order,
judgment or decree or any indenture, mortgage, lease or other material agreement
or  instrument  which the  Company is required to file as an Exhibit to its Form
10-KSB.

                  3.3 Issuance and Delivery of the Shares of Common  Stock.  The
shares of Common Stock,  when issued in compliance  with the  provisions of this
Agreement,  will be validly issued,  fully paid and nonassessable.  The issuance
and delivery of the shares of Common Stock is not subject to  preemptive  or any
other  similar  rights  of the  stockholders  of the  Company  or any  liens  or
encumbrances.

                  3.4 SEC Documents;  Financial Statement. The Company has filed
in a timely manner all documents  that the Company was required to file with the
Securities  and Exchange  Commission  (the "SEC")  under  Sections 13, 14(a) and
15(d) of the Securities  Exchange Act of 1934, as amended (the "Exchange  Act"),
during the twelve (12) months  preceding the date of this Agreement,  and all of
such documents  complied in all material  respects with the  requirements of the
Exchange Act and the rules and  regulations  thereunder  as of their  respective
filing dates. As of their  respective  filing dates,  all documents filed by the
Company with the SEC (the "SEC  Documents")  complied in all  material  respects
with the requirements of the Securities Act of 1933, as amended (the "Securities
Act") and the rules and regulations thereunder.  None of the SEC Documents as of
their  respective  dates  contained  any untrue  statement  of material  fact or
omitted to state a material fact  required to be stated  therein or necessary to
make the statements made therein, in light of the circumstances under which they
were made, not misleading.  The financial  statements of the Company included in
the SEC Documents (the "Financial Statements") comply as to form in all material
respects with applicable  accounting  requirements  and with the published rules
and regulations of the SEC with respect thereto.  The Financial  Statements have
been  prepared in  accordance  with  generally  accepted  accounting  principles
consistently  applied and fairly present the consolidated  financial position of
the Company and any subsidiaries at the dates thereof and the consolidated

                                       2.



results of their  operations  and  consolidated  cash flows for the periods then
ended  (subject,  in the case of  unaudited  statements,  to  normal,  recurring
adjustments that are not in the aggregate material).

                  3.5  Governmental  Consents.  No consent,  approval,  order or
authorization of, or registration,  qualification,  designation,  declaration or
filing with, any federal,  state, or local governmental authority on the part of
the Company is required in connection with the  consummation of the transactions
contemplated by this Agreement except for (a) compliance with the securities and
blue sky laws in the states in which shares of Common  Stock are offered  and/or
sold,  which  compliance  will be effected in accordance with such laws, (b) the
filing of the Nasdaq National Market  Notification Form with the Nasdaq National
Market, and (c) the filing of Form 10-C with the SEC.

                  3.6  No Material Adverse Change. Except as otherwise disclosed
herein, since June 30, 1996, there have not been:

                       (a) Any changes in the financial  condition or results of
operations of the Company from that reflected in the Financial Statements except
changes  in the  ordinary  course  of  business  which  have  not  been,  either
individually or in the aggregate, materially adverse;

                       (b) Any material  increase in  indebtedness  for borrowed
money,  current  liabilities or total liabilities  (whether  absolute,  accrued,
contingent  or  otherwise)  incurred  by the  Company,  except for  liabilities,
commitments and obligations incurred in the ordinary course of business;

                       (c) Any sale,  assignment,  transfer or other disposition
of any  material  tangible or  intangible  asset of the  Company,  except in the
ordinary course of business;

                       (d) Any extraordinary transaction; and

                       (e) Any  material  agreement  that the  Company  would be
required to file with the SEC.

                  3.7 Authorized  Capital Stock. The authorized capital stock of
the Company consists of (i) 80,000,000 shares of Common Stock,  $.001 par value,
of which,  as of July 1,  1996,  2,663,880  shares  were  outstanding,  and (ii)
50,000,000  shares of  Preferred  Stock,  $.001 par  value,  none of which  were
outstanding  immediately prior to the Closing.  As of July 1, 1996, an aggregate
of 950,000  shares of Common Stock were  reserved  for issuance  pursuant to the
Company's 1995 Stock Option Plan and an aggregate of 3,702,750  shares of Common
Stock were  reserved for issuance  upon  exercise of the  Company's  outstanding
warrants.

                  3.8  No  Liens,  Encumbrances.  Except  as  reflected  in  the
Financial  Statements,  all tangible  and  intangible  personal  property of the
Company is free and clear of all  material  liens,  pledges,  charges,  security
interests, prior assignments and encumbrances.

                  3.9 Registration  Rights.  Except for the registration  rights
granted to Lindsay A. Rosenwald,  M.D. and  VentureTek,  L.P. in connection with
the conversion of loans made by them to the Company into shares of the Company's
Common  Stock,  the Company  has not agreed to  register  the sale of any of its
securities under the Securities Act of 1933, as amended.


                                    Section 4

           Representations, Warranties and Covenants of the Purchasers

                  Each Purchaser hereby severally represents and warrants to the
Company, effective as of the Closing Date, as follows:


                                       3.




                  4.1  Authorization.  Purchaser  represents and warrants to the
Company that: (i) Purchaser has all requisite legal and corporate or other power
and  capacity and has taken all  requisite  corporate or other action to execute
and deliver this Agreement and the Investors' Rights Agreement;  to purchase the
shares of Common  Stock to be  purchased by it; and to carry out and perform all
of its obligations under this Agreement and the Investors' Rights Agreement; and
(ii) this Agreement  constitutes the legal,  valid and binding obligation of the
Purchaser,  enforceable in accordance  with its terms,  except (a) as limited by
applicable bankruptcy,  insolvency,  reorganization, or similar laws relating to
or affecting the enforcement of creditors'  rights  generally and (b) as limited
by equitable principles generally.

                  4.2  Due  Organization.  The  Purchaser  is a  corporation  or
business trust duly organized,  validly  existing and in good standing under the
laws of the jurisdiction under which it was formed, with all requisite power and
authority to own its properties and conduct its business as now being conducted.

                  4.3  Investment   Experience.   Purchaser  is  an  "accredited
investor" as defined in Rule 501(a) under the Securities Act. Purchaser is aware
of the Company's business affairs and financial  condition and has had access to
and has acquired  sufficient  information about the Company to reach an informed
and knowledgeable  decision to acquire the shares of Common Stock. Purchaser has
such business and financial experience as is required to give it the capacity to
protect  its own  interests  in  connection  with the  purchase of the shares of
Common Stock.  Purchaser is an "investment company" as defined in the Investment
Company Act of 1940, as amended.

                  4.4 Investment  Intent.  Purchaser is purchasing the shares of
Common Stock for its own account as principal, for investment purposes only, and
not with a present view to, or for,  resale,  distribution or  fractionalization
thereof,  in  whole  or in part,  within  the  meaning  of the  Securities  Act.
Purchaser understands that its acquisition of the shares of Common Stock has not
been  registered  under the Securities Act or registered or qualified  under any
state  securities  law in  reliance  on  specific  exemptions  therefrom,  which
exemptions  may  depend  upon,  among  other  things,  the bona  fide  nature of
Purchaser's investment intent as expressed herein.  Purchaser has, in connection
with its  decision to purchase the number of shares of Common Stock set forth in
Schedule  I  hereto,  relied  solely  upon the SEC and the  representations  and
warranties of the Company  contained  herein.  Purchaser  will not,  directly or
indirectly,  offer, sell,  pledge,  transfer or otherwise dispose of (or solicit
any offers to buy, purchase or otherwise acquire or take a pledge of) any of the
shares of Common Stock except in  compliance  with the  Securities  Act, and the
rules and regulations promulgated thereunder.

                  4.5 Registration or Exemption Requirements.  Purchaser further
acknowledges  and understands  that the shares of Common Stock may not be resold
or otherwise transferred except in a transaction registered under the Securities
Act or unless  an  exemption  from such  registration  is  available.  Purchaser
understands that the  certificate(s)  evidencing the shares of Common Stock will
be  imprinted  with (i) a legend that  prohibits  the  transfer of the shares of
Common  Stock  unless  (a)  they  are  registered  or such  registration  is not
required,  and (b) if the transfer is pursuant to an exemption from registration
other  than Rule 144 under  the  Securities  Act and,  if the  Company  shall so
request in writing, an opinion of counsel reasonably satisfactory to the Company
is  obtained to the effect that the  transaction  is so exempt,  (ii) any legend
required by state blue sky laws, and (iii) a legend  reflecting  that the shares
of Common Stock are subject to a lock-up  provision set forth in the  Investors'
Rights  Agreement.  Purchaser is not a party to any agreement or instrument,  or
subject to any charter or other corporate restriction or, to its knowledge,  any
judgment,  order,  decree,  law,  ordinance,   regulation  or  other  government
restriction  which would  prevent or impede,  or be breached or violated by, the
transaction contemplated in this Agreement.

                  4.6 No Conflicting Agreements. Purchaser is not a party to any
agreement  or  instrument,   or  subject  to  any  charter  or  other  corporate
restriction or, to its knowledge,  any judgment,  order, decree, law, ordinance,
regulation or other government  restriction which would prevent or impede, or be
breached or violated by, the transaction contemplated in this Agreement.


                                       4.



                  4.7 No Legal, Tax or Investment Advice.  Purchaser understands
that nothing in this Agreement and the Investors'  Rights Agreement  constitutes
legal,  tax or investment  advice.  Purchaser has consulted such legal,  tax and
investment  advisors  as it, in its sole  discretion,  has deemed  necessary  or
appropriate in connection with its purchase of the shares of Common Stock.

                                    Section 5

                       Conditions to Closing of Purchasers

                  Each  Purchaser's  obligation to purchase the shares of Common
Stock at the  Closing  is,  at the  option  of such  Purchaser,  subject  to the
fulfillment or waiver as of the Closing Date of the following conditions:

                  5.1  Representations  and Warranties.  The representations and
warranties of the Company  contained in Section 3 shall be true on and as of the
Closing with the same effect as though such  representations  and warranties had
been made on and as of the date of such Closing.

                  5.2 Performance. The Company shall have performed and complied
with all agreements, obligations and conditions contained in this Agreement that
are required to be performed or complied with by it on or before the Closing.

                  5.3 Compliance Certificate. The President of the Company shall
deliver  to each  Purchaser  at the  Closing  a  certificate  stating  that  the
conditions specified in Sections 5.1 and 5.2 have been fulfilled.

                  5.4 Qualifications. All authorizations, approvals, or permits,
if any, of any governmental authority or regulatory body of the United States or
of any state that are required in connection  with the lawful  issuance and sale
of the shares of Common Stock pursuant to this Agreement  shall be duly obtained
and effective as of the Closing.

                  5.5  Investors'  Rights   Agreement.   The  Company  and  each
Purchaser  shall have entered into the Investors'  Rights  Agreement in the form
attached as Exhibit A.

                                    Section 6

                        Conditions to Closing of Company

                  The  Company's  obligation  to sell and  issue  the  shares of
Common  Stock at the  Closing is, at the option of the  Company,  subject to the
fulfillment or waiver of the following conditions:

                  6.1 Representations and Warranties.  The representations  made
by the  Purchasers in Section 4 hereof shall be true and correct in all material
respects  when made,  and shall be true and correct in all material  respects on
the Closing  Date with the same force and effect as if they had been made on and
as of such date.

                  6.2  Covenants.  All  covenants,   agreements  and  conditions
contained in this Agreement to be performed by the Purchasers on or prior to the
Closing  Date  shall  have  been  performed  or  complied  with in all  material
respects.

                  6.3 Blue Sky. The Company  shall have  obtained all  necessary
blue sky law  permits  and  qualifications,  or  secured  exemptions  therefrom,
required  by any state for the  offer  and sale of the  shares of Common  Stock.


                                       5.





                                   Section 7

                      Affirmative Covenants of the Company

                  The Company hereby covenants and agrees as follows:

                  7.1 Financial Information. The Company will mail the following
reports to each Purchaser until such Purchaser  transfers,  assigns or sells the
shares of Common Stock purchased by such Purchaser pursuant to this Agreement:

                           (a) Within one  hundred  twenty  (120) days after the
end of each fiscal year, a copy of its Annual Report on Form 10-KSB.

                           (b)  Within  sixty  (60)  days  after  the end of the
first, second and third quarterly  accounting periods of each fiscal year of the
Company, a copy of its Quarterly Report on Form 10-QSB.

                           (c) Within ten (10) days after the Company  files any
Current Report on Form 8- KSB with the SEC, such Current Report on Form 8-KSB.

                                    Section 8

                                  Miscellaneous

                  8.1 Waivers and Amendments. The terms of this Agreement may be
waived or amended with the written consent of the Company and each Purchaser.

                  8.2 Broker's Fee. Each Purchaser acknowledges that the Company
intends to pay a fee to Paramount  Capital,  Incorporated in respect of the sale
of the  shares of Common  Stock to the  Purchaser.  Each of the  parties  hereto
hereby  represents that, on the basis of any actions and agreements by it, there
are no other brokers or finders  entitled to compensation in connection with the
sale of the shares of Common Stock to the Purchasers.

                  8.3  Governing  Law. This  Agreement  shall be governed in all
respects by and construed in accordance with the laws of the State of California
without any regard to conflicts of laws principles.

                  8.4 Successors and Assigns.  The provisions hereof shall inure
to the  benefit  of,  and be  binding  upon,  the  successors,  assigns,  heirs,
executors and administrators of the parties to this Agreement.

                  8.5 Entire Agreement.  This Agreement constitutes the full and
entire  understanding  and  agreement  between  the  parties  with regard to the
subjects thereof.

                  8.6  Notices,   etc.  All  notices  and  other  communications
required or permitted  under this Agreement  shall be effective upon receipt and
shall be in writing  and may be  delivered  in person,  by  telecopy,  overnight
delivery service or registered or certified United States mail, addressed to the
Company or the Purchasers, as the case may be, at their respective addresses set
forth on Schedule I, or at such other  address as the Company or the  Purchasers
shall have  furnished  to the other  party in  writing.  All  notices  and other
communications  shall be effective upon the earlier of actual receipt thereof by
the  person  to whom  notice  is  directed  or (i) in the  case of  notices  and
communications  sent by personal  delivery or  telecopy,  one business day after
such  notice  or  communication   arrives  at  the  applicable  address  or  was
successfully sent to the applicable telecopy number, (ii) in the case of notices
and communications  sent by overnight delivery service,  at noon (local time) on
the second business day following the day such notice or communication was sent,
and (iii) in the case of notices and communications  sent by United States mail,
seven days after such notice or  communication  shall have been deposited in the
United States mail.

                                       6.



                  8.7  Severability of this Agreement.  If any provision of this
Agreement   shall  be   judicially   determined   to  be  invalid,   illegal  or
unenforceable,  the  validity,  legality  and  enforceability  of the  remaining
provisions shall not in any way be affected or impaired thereby.

                  8.8 Counterparts. This Agreement may be executed in any number
of counterparts,  each of which shall be an original,  but all of which together
shall constitute one instrument.

                  8.9 Further Assurances.  Each party to this Agreement shall do
and perform or cause to be done and  performed  all such further acts and things
and  shall  execute  and  deliver  all  such  other  agreements,   certificates,
instruments  and documents as the other party hereto may  reasonably  request in
order to carry out the intent and  accomplish the purposes of this Agreement and
the consummation of the transactions contemplated hereby.

                  8.10 Termination. In the event that the Closing shall not have
occurred on or before  ninety  (90) days from the date  hereof,  this  Agreement
shall terminate at the close of business on such date.

                  8.11 Expenses.  The Company and each such Purchaser shall bear
its own expenses  incurred on its behalf with respect to this  Agreement and the
Investors' Rights Agreement,  as well as the transactions  contemplated  hereby,
including fees of legal counsel.

                  8.12  Currency.  All  references  to  "dollars" or "$" in this
Agreement shall be deemed to refer to United States dollars.

                  8.13  Effectiveness of Agreement.  The Company's  agreement to
sell the shares of Common Stock to the Purchasers  pursuant to the terms of this
Agreement  will only be  effective  upon  acceptance  of this  Agreement  by the
Company as evidenced by the Company's execution of this Agreement.

                  8.14  Multiple  Parties.  For  administrative  purposes,  each
Purchaser  that is buying  shares of Common  Stock at the  Closing is a party to
this Agreement.


                                       7.




                  IN  WITNESS  WHEREOF,  the  Company  and each  Purchaser  have
executed  this  Common  Stock  Purchase  Agreement  as of the date  first  above
written.


                                  "COMPANY"

                                  ATLANTIC PHARMACEUTICALS, INC.
                                  a Delaware corporation



                                  By:      //s//
                                           -------------------------------------
                                           Jon D. Lindjord
                                           President and Chief Executive Officer
                                  Address: 142 Cypress Point Road
                                           Half Moon Bay, CA  94019



                                  "PURCHASER"

                                  DREYFUS GROWTH AND VALUE FUNDS, INC., a
                                  Maryland corporation, -- Dreyfus Aggressive
                                  Growth Fund


                                  By:      //s//
                                           -------------------------------------
                                  Name:    _____________________________________
                                  Title:   _____________________________________
                                  Address: 200 Park Avenue
                                           New York, NY  10166


                                 PREMIER STRATEGIC GROWTH FUND, a Massachusetts
                                 Business Trust


                                 By:      //s//
                                          --------------------------------------
                                 Name:    ______________________________________
                                 Title:   ______________________________________
                                 Address: 200 Park Avenue
                                          New York, NY  10166



                                       8.




                                                                      Schedule I

                             SCHEDULE OF PURCHASERS


Number of Shares           Aggregate
of Common Stock         Purchase Price                Name
- ---------------         --------------                ----
140,000                   $  856,100     Dreyfus Growth and Value Funds, Inc., a
                                         Maryland corporation, -- Dreyfus
                                         Aggressive Growth Fund

110,000                   $  672,650     Premier Strategic Growth Fund, a
                                         Massachusetts  business trust



                                       9.




                                   EXHIBIT A

     [See exhibit 3 to this Form 8-KSB, incorporated herein by reference.]






                                      10.


                           INVESTORS' RIGHTS AGREEMENT


                  THIS INVESTORS' RIGHTS AGREEMENT (this "Agreement") is made as
of the 16th day of August, 1996, by and among Atlantic Pharmaceuticals,  Inc., a
Delaware corporation (the "Company"),  and Dreyfus Growth and Value Funds, Inc.,
a Maryland  corporation,  -- Dreyfus Aggressive Growth Fund,  Premiere Strategic
Growth Fund, a Massachusetts  Business Trust,  and such persons who may purchase
shares of the Common Stock of the Company  pursuant to Section 2.3 of the Common
Stock Agreement, as hereinafter defined (collectively, the "Investors").

                                    RECITALS

                  WHEREAS,  the  Company  and the  Investors  are parties to the
Common  Stock  Purchase  Agreement  of even date  herewith  (the  "Common  Stock
Agreement"); and


                  WHEREAS,  in order to induce  the  Company  to enter  into the
Common  Stock  Agreement  and to induce  the  Investors  to invest  funds in the
Company  pursuant to the Common Stock  Agreement,  the Investors and the Company
hereby agree that this  Agreement  shall  govern the rights of the  Investors to
cause the Company to register  shares of Common Stock  issuable to the Investors
and certain other matters as set forth herein.

                  NOW, THEREFORE, THE PARTIES HEREBY AGREE AS
FOLLOWS:

                  1.       Registration Rights. The Company covenants and agrees
                           as follows:

                           1.1     Definitions.  For purposes of this Section 1:

                           (a)     The  term  "Act"  means the Securities Act of
1933, as amended.

                           (b)     The term "Holder" means any person  owning or
having the right to acquire  Registrable  Securities or any assignee  thereof in
accordance with Section 2.2 hereof.

                           (c)     The term "1934 Act" shall mean the Securities
Exchange Act of 1934, as amended.

                           (d)     The   terms   "register,"   "registered"  and
"registration"  refer to a  registration  effected  by  preparing  and  filing a
registration  statement or similar  document in compliance with the Act, and the
declaration  or  order  of  effectiveness  of  such  registration  statement  or
document.





                           (e)     The  term  "Registrable Securities" means (i)
the Common Stock  issued  pursuant to the Common  Stock  Agreement  and (ii) any
Common  Stock of the  Company  issued as (or  issuable  upon the  conversion  or
exercise of any warrant,  right or other security which is issued as) a dividend
or other  distribution  with respect to, or in exchange for or in replacement of
the shares referenced in (i) above and in this subparagraph  (ii),  excluding in
all cases any Registrable  Securities sold by a person in a transaction in which
his rights under this Section 1 are not assigned or are assigned in violation of
this Agreement.

                           (f)     The   number   of   shares   of  "Registrable
Securities  then  outstanding"  shall be  determined  by the number of shares of
Common  Stock  outstanding  which are,  and the number of shares of Common Stock
issuable  pursuant to then  exercisable  or  convertible  securities  which are,
Registrable Securities.

                           (g)     The term "SEC" shall  mean the Securities and
Exchange Commission.

                           1.2     Request for Registration.

                           (a)     If  the  Company  shall  receive  at any time
after sixty (60) days after the  Closing,  as such term is defined in the Common
Stock  Agreement,  a written  request  from the  Holders  of a  majority  of the
Registrable  Securities  then  outstanding  that the Company file a registration
statement  under the Act  covering  the  registration  of at least  seventy-five
percent  (75%)  of the  Registrable  Securities  then  outstanding  (or a lesser
percent  if the  anticipated  aggregate  offering  price,  net  of  underwriting
discounts and commissions, would exceed $4,000,000, then the Company shall:

                                   (i)     within  ten  (10) days of the receipt
thereof, give written notice of such request to all Holders; and

                                   (ii)    effect as soon as practicable, and in
any event within 60 days of the receipt of such request,  the registration under
the  Act  of  all  Registrable  Securities  which  the  Holders  request  to  be
registered,  subject to the limitations of subsection 1.2(b), within twenty (20)
days of the  mailing of such notice by the Company in  accordance  with  Section
2.6.

                           (b)     If  the  Holders  initiating the registration
request  hereunder  ("Initiating  Holders") intend to distribute the Registrable
Securities  covered by their request by means of an underwriting,  they shall so
advise the Company as a part of their request made pursuant to subsection 1.2(a)
and the Company shall include such information in the written notice referred to
in subsection  1.2(a). The underwriter will be selected by the Company and shall
be reasonably acceptable to a majority in interest of the Initiating Holders. In
such event,  the right of any Holder to include his  Registrable  Securities  in
such registration shall be conditioned upon such Holder's

                                       2.




participation   in  such   underwriting  and  the  inclusion  of  such  Holder's
Registrable  Securities in the underwriting (unless otherwise mutually agreed by
a majority in interest of the Initiating  Holders and such Holder) to the extent
provided herein.  All Holders  proposing to distribute their securities  through
such  underwriting  shall  (together  with the Company as provided in subsection
1.5(e))  enter  into an  underwriting  agreement  in  customary  form  with  the
underwriter or underwriters selected for such underwriting.  Notwithstanding any
other provision of this Section 1.2, if the  underwriter  advises the Initiating
Holders in writing that marketing  factors require a limitation of the number of
shares to be  underwritten,  then the  Initiating  Holders  shall so advise  all
Holders of Registrable Securities which would otherwise be underwritten pursuant
hereto, and the number of shares of Registrable  Securities that may be included
in the underwriting shall be allocated among all Holders thereof,  including the
Initiating  Holders,  in proportion (as nearly as  practicable) to the amount of
Registrable Securities of the Company owned by each Holder;  provided,  however,
that the  number of shares of  Registrable  Securities  to be  included  in such
underwriting shall not be reduced unless all other securities are first entirely
excluded from the underwriting.

                           (c)     Notwithstanding  the  foregoing,  the Company
shall not be obligated to effect any  registration  pursuant to this Section 1.2
if at the time of any request to  register  Registrable  Securities  pursuant to
this Section 1.2,  the Company is engaged,  or has fixed plans to engage  within
ninety (90) days of the time of the request,  in a registered public offering or
is engaged,  or has fixed plans to engage within ninety (90) days of the time of
the request,  in any other activity that, in the good faith determination of the
Board of Directors of the Company,  would be adversely affected by the requested
registration to the material  detriment of the Company,  then the Company may at
its option direct that such request be delayed for a period not in excess of one
hundred twenty (120) days from the effective date of such offering,  or the date
of commencement of such other material activity, as the case may be, such rights
to delay a request  to be  exercised  by the  Company  not more than once in any
twelve month period.

                           (d)     In  addition,  the   Company   shall  not  be
obligated to effect, or to take any action to effect, any registration  pursuant
to this Section 1.2:

                                    (i)  After  the  Company  has  effected  one
registration  pursuant  to this  Section  1.2 and  such  registration  has  been
declared or ordered effective;

                                    (ii)  Within one  hundred  and twenty  (120)
days after the  effective  date of any  registration  statement  effected by the
Company whether for its own account or for the account of others; or

                                    (iii) If the Initiating  Holders  propose to
dispose of shares of Registrable  Securities that may be immediately  registered
on Form S-3 pursuant to a request made pursuant to Section 1.3 below.


                                       3.



                           1.3 Form S-3 Registration Rights.

                           (a) If, at any time  following  the date  sixty  (60)
days after the Closing,  the Company  shall  receive a written  request from any
Holder(s)  of the  Registrable  Securities  requesting  that the Company  file a
registration  statement on Form S-3 under the Act covering the  registration  of
the Registrable  Securities,  provided that the anticipated  aggregate  offering
price, net of underwriting  discounts and commissions,  will exceed $250,000 (an
"S-3 Registration") then, in each case, provided that the Company is eligible to
file a  registration  statement  on Form  S-3  under  the  Act,  subject  to the
limitations set forth in this Agreement (including the limitations of subsection
1.3(b)), (x) within twenty (20) days of the receipt thereof, give written notice
of such request to all Holders (the  "Notice of Request for  Registration")  and
(y) as soon a  practicable,  use its best  efforts to effect  such  registration
under the Act covering all Registrable  Securities  which the Holders request to
be registered by notice to the Company within twenty (20) days of the mailing of
the Notice of Request for  Registration  by the Company in accordance  with this
subsection 1.3(a) and Section 2.6.

                           (b)  If  the  Holders   initiating  the  registration
request  hereunder  ("Initiating  Holders") intend to distribute the Registrable
Securities  covered by their request by means of an underwriting,  they shall so
advise the Company as part of their request made  pursuant to subsection  1.3(a)
and the Company shall include such information in the written notice referred to
in subsection 1.3(a). The underwriter will be selected by the Investors. In such
event,  the right of any Holder to include his  Registrable  Securities  in such
registration  shall be  conditioned  upon such  Holder's  participation  in such
underwriting  and the inclusion of such Holder's  Registrable  Securities in the
underwriting  (unless otherwise mutually agreed by a majority in interest of the
Initiating  Holders and such Holder) to the extent provided herein.  All Holders
proposing  to  distribute  their  securities  through  such  underwriting  shall
(together  with the  Company as  provided in  subsection  1.5(e))  enter into an
underwriting  agreement in customary form with the  underwriter or  underwriters
selected  for such  underwriting.  Notwithstanding  any other  provision of this
Section 1.3 to the contrary,  if the underwriter  advises the Initiating Holders
in writing that marketing  factors  require a limitation of the number of shares
to be underwritten,  then the Initiating  Holders shall so advise all Holders of
Registrable  Securities  which would otherwise be underwritten  pursuant hereto,
and the number of shares of Registrable  Securities  that may be included in the
underwriting  shall be  allocated  among  all  Holders  thereof,  including  the
Initiating  Holders,  in proportion (as nearly as  practicable) to the amount of
Registrable  Securities  of the  Company  owned by each  Holder or, in the event
holders  of  other   securities  of  the  Company  request   inclusion  in  such
registration, pro rata as to all holders of securities of the Company requesting
inclusion in such registration.

                           (c) Notwithstanding the foregoing,  the Company shall
not be obligated to effect any  registration  pursuant to this Section 1.3 if at
the time of any  request to  register  Registrable  Securities  pursuant to this
Section 1.3, the Company is

                                       4.



engaged, or has fixed plans to engage within ninety (90) days of the time of the
request,  in a registered  public offering or is engaged,  or has fixed plans to
engage within ninety (90) days of the time of the request, in any other activity
that, in the good faith  determination of the Board of Directors of the Company,
would be  adversely  affected  by the  requested  registration  to the  material
detriment  of the Company,  then the Company may at its option  direct that such
request be delayed for a period not in excess of one hundred  twenty  (120) days
from the effective date of such offering,  or the date of  commencement  of such
other material  activity,  as the case may be, such rights to delay a request to
be exercised by the Company not more than once in any twelve month period.

                           (d) In addition,  the Company  shall not be obligated
to effect,  or to take any action to effect,  any registration  pursuant to this
Section 1.3:

                                    (i) in  the  case  of an  S-3  Registration,
during a calendar  year in which the Company has effected two S-3  Registrations
in such year and each registration has been declared or ordered effective;

                                    (ii)  within one  hundred  and twenty  (120)
days after the  effective  date of any  registration  statement  effected by the
Company whether for its own account or for the account of others;

                                    (iii) if Form S-3 is not  available for such
offering by the Holders; or

                                    (iv) in any particular jurisdiction in which
the Company  would be required to qualify to do business or to execute a general
consent to service of process in effecting such  registration,  qualification or
compliance,   unless  the  Company  is  already   subject  to  service  in  such
jurisdiction and except as may be required by the Act.

                           1.4 "Piggy-Back" Registration Rights. If (but without
any  obligation to do so) the Company  proposes to register  (including for this
purpose a registration  effected by the Company for stockholders  other than the
Holders) any of its stock or other  securities  under the Act in connection with
the  public  offering  of  such  securities   solely  for  cash  (other  than  a
registration  relating  solely to the sale of  securities to  participants  in a
Company  stock  plan,  a  registration  on  any  form  which  does  not  include
substantially  the same  information  as would be  required  to be included in a
registration  statement  covering the sale of the  Registrable  Securities  or a
registration  in which the only Common  Stock being  registered  is Common Stock
issuable upon  conversion of debt securities  which are also being  registered),
the Company  shall,  at such time,  promptly give each Holder  written notice of
such registration. Upon the written request of each Holder given within ten (10)
days after mailing of such notice by the Company in accordance with Section 2.6,
the  Company  shall,  subject  to the  limitations  set forth in this  Agreement
(including the  limitations of Sections  1.2(b) and 1.3(b) and the provisions of
Section 1.9), include in the Company's registration statement under the

                                       5.


Act all of the Registrable  Securities that each such Holder has requested to be
registered;  provided,  however,  that nothing in this Section 1.4 shall prevent
the  Company  from at any time  abandoning  or  delaying  any such  registration
without obligation to any Holder.

                           1.5  Obligations  of the Company.  Whenever  required
under this Section 1 to effect the registration of any Registrable Securities or
to include  Registrable  Securities  in a Company  registration  statement,  the
Company shall, as expeditiously as reasonably possible:

                           (a)  Prepare  and file  with  the SEC a  registration
statement  with respect to such  Registrable  Securities  and use its reasonable
best efforts to cause such registration statement to become effective, and, upon
the  request  of  the  Holders  of a  majority  of  the  Registrable  Securities
registered  thereunder,  keep such registration statement effective for a period
of up to one hundred twenty (120) days or until the distribution contemplated in
the Registration Statement has been completed;  provided, however, that such one
hundred  twenty (120) day period shall be extended for a period of time equal to
the period the Holder  refrains  from  selling any  securities  included in such
registration  at the  request  of an  underwriter  of  Common  Stock  (or  other
securities) of the Company,  and provided further that if applicable rules under
the Act governing the obligation to file a post-effective  amendment permits, in
lieu of filing a  post-effective  amendment  which (x) includes  any  prospectus
required  by  Section  10(a)(3)  of the  Act or (y)  reflects  facts  or  events
representing a material or fundamental  change in the  information  set forth in
the registration statement, the Company may incorporate by reference information
required to be included in (x) and (y) above to the extent such  information  is
contained in periodic  reports filed pursuant to Section 13 or 15(d) of the 1934
Act in the registration statement.

                           (b) Prepare and file with the SEC such amendments and
supplements to such registration statement and the prospectus used in connection
with  such  registration  statement  as may be  necessary  to  comply  with  the
provisions of the Act with respect to the disposition of all securities  covered
by such registration statement.

                           (c) Furnish to the Holders  such numbers of copies of
a  prospectus,  including  a  preliminary  prospectus,  in  conformity  with the
requirements of the Act, and such other documents as they may reasonably request
in order to facilitate the disposition of Registrable Securities owned by them.

                           (d) Use its  reasonable  best efforts to register and
qualify the securities  covered by such registration  statement under such other
securities  or Blue  Sky  laws of such  jurisdictions  as  shall  be  reasonably
requested by the  Holders;  provided  that the Company  shall not be required in
connection  therewith or as a condition  thereto to qualify to do business or to
file a general consent to service of process in any such states

                                       6.



or  jurisdictions,  unless the  Company  is  already  subject to service in such
jurisdiction and except as may be required by the Act.

                           (e) In the event of any underwritten public offering,
enter into and perform its obligations under an underwriting agreement, in usual
and customary form, with the managing underwriter of such offering.  Each Holder
participating  in such  underwriting  shall  also  enter  into and  perform  its
obligations under such an agreement.

                           (f)  Notify  each  Holder of  Registrable  Securities
covered by such  registration  statement at any time when a prospectus  relating
thereto is required to be delivered  under the Act of the happening of any event
as a result of which the prospectus included in such registration  statement, as
then in effect,  includes  an untrue  statement  of a material  fact or omits to
state a material  fact  required to be stated  therein or  necessary to make the
statements  therein  not  misleading  in the  light  of the  circumstances  then
existing.

                           (g) Cause all such Registrable  Securities registered
pursuant  hereunder to be listed on each  securities  exchange on which  similar
securities issued by the Company are then listed.

                           (h) Provide a transfer  agent and  registrar  for all
Registrable  Securities  registered  pursuant hereunder and CUSIP number for all
such Registrable  Securities,  in each case not later than the effective date of
such registration.

                           1.6 Furnish Information.

                           (a)  It  shall  be  a  condition   precedent  to  the
obligation  of the Company to take any action  pursuant  to this  Section 1 with
respect to the  Registrable  Securities  of any selling  Holder that such Holder
shall  furnish  to the  Company  such  information  regarding  the  Holder,  the
Registrable   Securities  held  by  the  Holder,  and  the  intended  method  of
disposition of such  securities as shall be required to effect the  registration
of such Holder's Registrable Securities.

                           (b) The Company shall have no obligation with respect
to any  registration  requested  pursuant to Sections  1.2 or 1.3 if, due to the
operation  of  subsection  1.5(a),  the  number  of  shares  or the  anticipated
aggregate  offering  price of the  Registrable  Securities to be included in the
registration  does not equal or exceed the  number of shares or the  anticipated
aggregate offering price required to originally trigger the Company's obligation
to initiate such registration as specified in subsections 1.2(a) and 1.3(a).

                           1.7 Expenses of S-3 Registrations. All expenses other
than  underwriting   discounts  and  commissions  incurred  in  connection  with
registrations,  filings or  qualifications  pursuant  to  Sections  1.2 and 1.3,
including (without limitation) all

                                       7.


registration,  filing and qualification fees,  printers' and accounting fees and
fees and disbursements of counsel for the Company shall be borne by the Company;
provided,  however, that the Company shall not bear the cost of any professional
fees or costs of accounting,  financial or legal advisors to any of the Holders;
provided,  further,  that  the  Company  shall  not be  required  to pay for any
expenses of any registration proceeding begun pursuant to Sections 1.2 or 1.3 if
the registration request is subsequently withdrawn at the request of the Holders
of a majority of the Registrable  Securities to be registered (in which case all
Holders registering  Registrable Securities on such registration statement shall
bear such expenses on a pro rata basis), unless the Holders of a majority of the
Registrable Securities agree to forfeit their right to one registration,  as the
case may be,  pursuant to Sections 1.2 or 1.3.  Notwithstanding  the  foregoing,
each Holder shall pay all registration expenses which such Holder is required to
pay under applicable law.

                           1.8  Expenses  of  "Piggy-Back"   Registration.   The
Company  shall  bear  and pay all  expenses  incurred  in  connection  with  any
registration,  filing or qualification of Registrable Securities with respect to
the  registrations  pursuant to Section 1.4 of each Holder,  including  (without
limitation)  all  registration,  filing and  qualification  fees,  printers  and
accounting fees relating or apportionable  thereto,  but excluding  underwriting
discounts and commissions relating to Registrable Securities; provided, however,
that the Company  shall not bear the cost of any  professional  fees or costs of
accounting,  financial or legal advisors to any of the Holders.  Notwithstanding
the foregoing, each Holder shall pay all registration expenses which such Holder
is required to pay under applicable law.

                           1.9 Underwriting Requirements. In connection with any
offering involving an underwriting of shares of the Company's capital stock, the
Company  shall not be required  under Section 1.4 to include any of the Holders'
securities in such underwriting unless they accept the terms of the underwriting
as agreed upon  between the Company and the  underwriters  selected by it (or by
other  persons  entitled  to  select  the  underwriters),  and then only in such
quantity  as the  underwriters  determine  in  their  sole  discretion  will not
jeopardize  the success of the offering by the  Company.  If the total amount of
securities,  including Registrable  Securities,  requested by stockholders to be
included in such offering  exceeds the amount of  securities  sold other than by
the  Company  that the  underwriters  determine  in  their  sole  discretion  is
compatible with the success of the offering,  then the Company shall be required
to  include  in the  offering  only that  number of such  securities,  including
Registrable   Securities,   which  the  underwriters  determine  in  their  sole
discretion  will not jeopardize  the success of the offering (the  securities so
included to be apportioned pro rata among the selling stockholders  according to
the total amount of  securities  entitled to be included  therein  owned by each
selling  stockholder or in such other proportions as shall mutually be agreed to
by such  selling  stockholders).  For  purposes of the  preceding  parenthetical
concerning  apportionment,  for any  selling  stockholder  that is a  holder  of
Registrable  Securities and that is a partnership or corporation,  the partners,
retired partners and

                                       8.



stockholders  of such  holder,  or the  estates  and family  members of any such
partners  and  retired  partners  and any trusts  for the  benefit of any of the
foregoing persons shall be deemed to be a single "selling  stockholder," and any
pro-rata  reduction  with respect to such "selling  stockholder"  shall be based
upon the aggregate  amount of shares carrying  registration  rights owned by all
entities and individuals  included in such "selling  stockholder," as defined in
this sentence.

                           1.10 Delay of Registration.  No Holder shall have any
right to obtain or seek an injunction restraining or otherwise delaying any such
registration as the result of any  controversy  that might arise with respect to
the interpretation or implementation of this Section 1.

                           1.11  Indemnification.  In the event any  Registrable
Securities are included in a registration statement under this Section 1:

                           (a) To the extent  permitted by law, the Company will
indemnify and hold harmless each Holder, any underwriter (as defined in the Act)
for such Holder and each person, if any, who controls such Holder or underwriter
within  the  meaning of the Act or the 1934 Act,  against  any  losses,  claims,
damages or  liabilities  to which they may become  subject under the Act, or the
1934 Act, insofar as such losses,  claims, damages or liabilities (or actions in
respect thereof) arise out of or are based upon any of the following statements,
omissions or violations  (collectively a "Violation"):  (i) any untrue statement
or alleged untrue  statement of a material fact  contained in such  registration
statement,  including any preliminary  prospectus or final prospectus  contained
therein or any amendments or supplements  thereto,  (ii) the omission or alleged
omission to state  therein a material  fact  required to be stated  therein,  or
necessary to make the statements therein not misleading,  or (iii) any violation
or alleged  violation  by the  Company of the Act,  the 1934 Act, or any rule or
regulation  promulgated under the Act, or the 1934 Act, and the Company will pay
to each such Holder,  underwriter or controlling person, as incurred,  any legal
or other expenses  reasonably  incurred by them in connection with investigating
or  defending  any such loss,  claim,  damage,  liability  or action;  provided,
however, that the indemnity agreement contained in this subsection 1.11(a) shall
not  apply to  amounts  paid in  settlement  of any such  loss,  claim,  damage,
liability or action if such  settlement  is effected  without the consent of the
Company  (which  consent  shall  not be  unreasonably  withheld),  nor shall the
Company be liable in any such case for any such loss, claim,  damage,  liability
or action to the extent that it arises out of or is based upon a Violation which
occurs in reliance upon and in  conformity  with written  information  furnished
expressly  for use in  connection  with such  registration  by any such  Holder,
underwriter or controlling person.

                           (b) To the  extent  permitted  by law,  each  selling
Holder will indemnify and hold harmless the Company, each of its directors, each
of its officers who has signed the registration statement,  each person, if any,
who controls the Company  within the meaning of the Act,  any  underwriter,  any
other Holder selling securities in

                                       9.



such registration  statement and any controlling  person of any such underwriter
or other Holder, against any losses, claims, damages or liabilities to which any
of the  foregoing  persons  may become  subject  under the Act, or the 1934 Act,
insofar as such losses,  claims,  damages or liabilities  (or actions in respect
thereto)  arise  out of or are  based  upon any  Violation,  in each case to the
extent (and only to the extent) that such Violation  occurs in reliance upon and
in conformity with written  information  furnished by such Holder  expressly for
use in  connection  with such  registration;  and each such  Holder will pay, as
incurred, any legal or other expenses reasonably incurred by any person intended
to be  indemnified  pursuant to this  subsection  1.11(b),  in  connection  with
investigating or defending any such loss,  claim,  damage,  liability or action;
provided,  however,  that the indemnity  agreement  contained in this subsection
1.11(b) shall not apply to amounts paid in  settlement of any such loss,  claim,
damage,  liability or action if such settlement is effected  without the consent
of the Holder, which consent shall not be unreasonably withheld; provided, that,
in no event shall any indemnity under this  subsection  1.11(b) exceed the gross
proceeds from the offering received by such Holder.

                           (c) Promptly  after receipt by an  indemnified  party
under this Section 1.11 of notice of the  commencement of any action  (including
any governmental  action),  such indemnified  party shall, if a claim in respect
thereof is to be made against any  indemnifying  party under this Section  1.11,
deliver to the indemnifying  party a written notice of the commencement  thereof
and the  indemnifying  party shall have the right to participate in, and, to the
extent the indemnifying  party so desires,  jointly with any other  indemnifying
party similarly notified, to assume the defense thereof with counsel selected by
the  indemnifying  party and approved by the  indemnified  party (whose approval
shall not be  unreasonably  withheld);  provided,  however,  that an indemnified
party  (together  with all other  indemnified  parties which may be  represented
without  conflict by one  counsel)  shall have the right to retain one  separate
counsel,  with the fees and expenses to be paid by the  indemnifying  party,  if
representation  of  such  indemnified  party  by  the  counsel  retained  by the
indemnifying  party would be inappropriate due to actual or potential  differing
interests between such indemnified party and any other party represented by such
counsel  in such  proceeding.  The  failure  to  deliver  written  notice to the
indemnifying  party within a  reasonable  time of the  commencement  of any such
action, if prejudicial to its ability to defend such action,  shall relieve such
indemnifying  party of any liability to the indemnified party under this Section
1.11, but the omission so to deliver  written notice to the  indemnifying  party
will not relieve it of any liability that it may have to any  indemnified  party
otherwise than under this Section 1.11.

                           (d)  If the  indemnification  provided  for  in  this
Section 1.11 is held by a court of competent  jurisdiction  to be unavailable to
an  indemnified  party with  respect to any loss,  liability,  claim,  damage or
expense  referred  to  therein,   then  the  indemnifying   party,  in  lieu  of
indemnifying  such indemnified  party hereunder,  shall contribute to the amount
paid or payable by such indemnified  party as a result of such loss,  liability,
claim, damage or expense in such proportion as is appropriate to reflect

                                       10.



the  relative  fault  of the  indemnifying  party  on the  one  hand  and of the
indemnified  party on the other in connection  with the  statements or omissions
that resulted in such loss,  liability,  claim, damage or expense as well as any
other relevant equitable considerations.  The relative fault of the indemnifying
party and of the  indemnified  party shall be  determined by reference to, among
other things,  whether the untrue or alleged untrue statement of a material fact
or the omission to state a material fact relates to information  supplied by the
indemnifying party or by the indemnified party and the parties' relative intent,
knowledge,  access to  information  and  opportunity  to correct or prevent such
statement or omission.

                           (e) Notwithstanding the foregoing, to the extent that
the provisions on indemnification and contribution contained in the underwriting
agreement  entered into in connection with the underwritten  public offering are
in conflict with the foregoing  provisions,  the provisions in the  underwriting
agreement shall control.

                           (f) The  obligations of the Company and Holders under
this Section 1.11 shall survive the  completion  of any offering of  Registrable
Securities in a registration statement under this Section 1, and otherwise.

                           1.12 Reports Under  Securities  Exchange Act of 1934.
With a view to  making  available  to the  Holders  the  benefits  of  Rule  144
promulgated  under the Act and any other rule or  regulation of the SEC that may
at any time  permit a Holder to sell  securities  of the  Company  to the public
without  registration  or pursuant to a  registration  on Form S-3,  the Company
agrees to:

                           (a) make and keep public  information  available,  as
those terms are understood and defined in SEC Rule 144;

                           (b) file with the SEC in a timely  manner all reports
and other documents required of the Company under the Act and the 1934 Act; and

                           (c) furnish to any Holder, so long as the Holder owns
any Registrable  Securities,  forthwith upon request (i) a written  statement by
the Company that it has complied with the reporting requirements of SEC Rule 144
(at any time after ninety (90) days after the effective date of the registration
statement  filed by the company in connection with an IPO), the Act and the 1934
Act (at any time after it has become  subject to such  reporting  requirements),
(ii) a copy of the most  recent  annual or  quarterly  report of the Company and
such other reports and  documents so filed by the Company,  and (iii) such other
information as may be reasonably requested in availing any Holder of any rule or
regulation of the SEC which permits the selling of any such  securities  without
registration or pursuant to such form.

                           1.13 Lock-Up Provision. In connection with the Common
Stock  Agreement,  each  Investor  hereby  agrees to be subject to a lock-up for
sixty (60) days

                                       11.



following  the  Closing or, if  applicable,  for sixty (60) days  following  the
purchase of shares of Common  Stock  pursuant to Section 2.3 of the Common Stock
Agreement.  In connection  with any subsequent  public offering of the Company's
securities,  the Investor  hereby agrees to be subject to a lock-up for 120 days
or such  longer  period  following  such  public  offering  as  required  by the
underwriter or underwriters of such public  offering.  During such periods,  the
Investor agrees not to directly or indirectly sell,  offer to sell,  contract to
sell  (including,  without  limitation,  any short  sale),  grant any  option to
purchase or otherwise  transfer or dispose of (other than to donees who agree to
be similarly  bound) any securities of the Company held by it at any time during
such period except Common Stock included in such registration  without the prior
written consent of such underwriter or underwriters.  This Section 1.13 shall be
binding upon any transferee of the Registrable  Securities and the  certificates
shall bear a legend to such effect.

                  In order to enforce the  foregoing  covenant,  the Company may
impose stock-transfer instructions with respect to the Registrable Securities of
each Investor (and the shares or securities of every other person subject to the
foreign restriction) until the end of such period.

                  Notwithstanding  the foregoing,  the  obligation  described in
this Section 1.13 shall not apply to a registration  relating solely to employee
benefit plans on Form S-1 or Form S-8 or similar forms which may be  promulgated
in the  future,  or a  registration  relating  solely to a  Commission  Rule 145
transaction on From S-4 or similar forms which may promulgated in the future.

                           1.14 Termination of Registration Rights. In addition,
the right of any Holder to request registration  pursuant to Sections 1.2 or 1.3
or inclusion in any registration  pursuant to Section 1.4 shall terminate if all
shares of Registrable  Securities held or entitled to be held upon conversion by
such Holder may immediately be sold under Rule 144 or Rule 701 during any 90-day
period;  provided,  however,  that the provisions of this Section 1.14 shall not
apply  to any  Holder  who owns  more  than two  percent  (2%) of the  Company's
outstanding  stock  until such times as such  Holder  owns less than two percent
(2%) of the outstanding stock of the Company.

                  2.       Miscellaneous.

                           2.1  Successors  and  Assigns.  Except  as  otherwise
provided in Section 2.2 below and elsewhere herein,  the terms and conditions of
this Agreement  shall inure to the benefit of and be binding upon the respective
successors  and assigns of the parties  (including  transferees of any shares of
Registrable  Securities).  Nothing in this  Agreement,  express or  implied,  is
intended  to  confer  upon any  party  other  than the  parties  hereto or their
respective  successors  and  assigns  any  rights,   remedies,   obligations  or
liabilities under or by reason of this Agreement,  except as expressly  provided
in this Agreement.


                                       12.


                           2.2      Transfer of Rights.

                           (a) The rights  granted to the Investors  pursuant to
Section 1 may not be  transferred  or  assigned,  expect  that such  rights  are
assignable to anyone who acquires at least such number of shares of Common Stock
as equals the  lesser of (i) eighty  percent  (80%) of the  aggregate  number of
shares of Common  Stock  held by such  Holder and (ii)  50,000  shares of Common
Stock;  provided,  however,  that the  Company  is given  written  notice by the
transferee  at the  time of any such  permitted  transfer  stating  the name and
address  of the  transferee  and  identifying  the  shares of Common  Stock with
respect to which such rights are being assigned.

                           (b) Notwithstanding  anything to the contrary herein,
if the Investor is a partnership,  it may transfer  rights  granted  pursuant to
Section 1 to any of its partners to whom shares of Common Stock are transferred.
In the event of such transfer, such partner shall be deemed to be Holder of such
shares of Common Stock and may,  subject to paragraph (a) above,  again transfer
such right to any other  person or entity which  acquired  such shares from such
partner.

                           2.3 Governing Law. This  Agreement  shall be governed
by and  construed  under  the  laws of the  State  of  Delaware  as  applied  to
agreements among Delaware  residents  entered into and to be performed  entirely
within Delaware without regard to principles of conflicts of law.

                           2.4  Counterparts.  This Agreement may be executed in
two or more counterparts,  each of which shall be deemed an original, but all of
which together shall constitute one and the same instrument.

                           2.5 Titles and  Subtitles.  The titles and  subtitles
used  in  this  Agreement  are  used  for  convenience  only  and  are not to be
considered in construing or interpreting this Agreement.

                           2.6 Notices.  Unless otherwise  provided,  any notice
required or permitted  under this Agreement  shall be given in writing and shall
be deemed  effectively given upon personal delivery to the party to be notified,
upon  confirmed  delivery by a recognized  courier or messenger  service or upon
deposit with the United States Post Office,  by  registered  or certified  mail,
postage  prepaid  and  addressed  to the  party to be  notified  at the  address
indicated for such party on the signature page hereof,  or at such other address
as such party may  designate  by ten (10) days'  advance  written  notice to the
other parties.

                           2.7  Expenses.  If any  action at law or in equity is
necessary to enforce or interpret the terms of this  Agreement,  the  prevailing
party shall be entitled  to  reasonable  attorneys'  fees,  costs and  necessary
disbursements  in  addition  to any  other  relief  to which  such  party may be
entitled.

                                       13.




                           2.8  Subsequent  Closing.  In the event  the  Company
issues  shares of Common  Stock  pursuant  to Section  2.3 of the  Common  Stock
Agreement the Company shall prepare and distribute to the Investors  counterpart
signature pages reflecting such.

                           2.9  Amendments   and  Waivers.   Any  term  of  this
Agreement may be amended and the observance of any term of this Agreement may be
waived (either generally or in a particular instance and either retroactively or
prospectively),  only with the written consent of the Company and the holders of
a majority of the  Registrable  Securities  then  outstanding.  Any amendment or
waiver  effected in accordance  with this  paragraph  shall be binding upon each
holder of any Registrable Securities then outstanding, each future holder of all
such Registrable Securities, and the Company.

                           2.10 Severability.  If one or more provisions of this
Agreement are held to be  unenforceable  under  applicable  law, such  provision
shall be excluded from this Agreement and the balance of the Agreement  shall be
interpreted  as if such  provision  were so excluded and shall be enforceable in
accordance with its terms. The parties hereto shall endeavor to replace any such
unenforceable  provision or provisions with a valid and enforceable provision or
provisions  which  shall  have  substantially  the same  economic  effect as the
unenforceable provision or provisions.

                           2.11  Aggregation of Stock. All shares of Registrable
Securities  held  or  acquired  by  affiliated  entities  or  persons  shall  be
aggregated  together  for the purpose of  determining  the  availability  of any
rights under this Agreement.

                           2.12  Entire  Agreement;   Amendment;   Waiver.  This
Agreement  (including  the Exhibits  hereto,  if any)  constitutes  the full and
entire  understanding  and  agreement  between  the  parties  with regard to the
subjects hereof and thereof.



                                       14.




                  IN WITNESS  WHEREOF,  the parties have executed this Agreement
as of the date first above written.

                         ATLANTIC PHARMACEUTICALS, INC.



                         By:      //s//
                                  --------------------------------------
                                  J.D. Lindjord
                                  Chief Executive Officer and President
                                  Atlantic Pharmaceuticals, Inc.
                                  142 Cypress Point Road
                                  Half Moon Bay, CA 94019


                         INVESTORS:

                                  DREYFUS  GROWTH  AND  VALUE
                                  FUNDS,   INC.,  a  Maryland
                                  corporation,   --   Dreyfus
                                  Aggressive Growth Fund


                         By:      //s//
                                  --------------------------------------
                                  Name:
                                       ---------------------------------
                                  Title:
                                        --------------------------------
                                  Address:          200 Park Avenue
                                                    New York, New York  10166

                                  PREMIERE STRATEGIC GROWTH FUND,
                                  a Massachusetts Business Trust


                         By:      //s//
                                  --------------------------------------
                                  Name:
                                       ---------------------------------
                                  Title:
                                        --------------------------------
                                  Address:          200 Park Avenue
                                                    New York, New York  10166


                                       15.