As filed with the Securities and Exchange Commission on November 8, 1996
                                                 Registration No. 333-
===============================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      Under
                           The Securities Act of 1933

                               ------------------

                         ATLANTIC PHARMACEUTICALS, INC.
             (Exact name of registrant as specified in its charter)

          Delaware                                        36-389269
(State or other jurisdiction                  (IRS Employer Identification No.)
of incorporation or organization)

                             142 Cypress Point Road
                         Half Moon Bay, California 94019
               (Address of principal executive offices) (Zip Code)

                               ------------------

                             1995 STOCK OPTION PLAN
                            (Full title of the Plan)

                               ------------------

                                 Jon D. Lindjord
                       President & Chief Executive Officer
             142 Cypress Point Road, Half Moon Bay, California 94019
           (Name and address, including zip code of agent for service)
                                 (415) 726-1327
          (Telephone number, including area code, of agent for service)

                               ------------------

                         CALCULATION OF REGISTRATION FEE

================================================================================================================

Proposed Proposed Title of Maximum Maximum Securities Amount Offering Aggregate Amount of to be to be Price Offering Registration Registered Registered(1) per Share(2) Price(2) Fee ---------- ------------- ------------ -------- --- 1995 Stock Option Plan: Options to Purchase Common Stock, $0.001 par value 950,000 N/A N/A N/A Common Stock, $0.001 par value 950,000 shares $7.50 $7,125,000 $2,457 ================================================================================================================ (1) This Registration Statement shall also cover any additional shares of Common Stock which become issuable under the Atlantic Pharmaceuticals, Inc. 1995 Stock Option Plan, by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration which results in an increase in the number of the outstanding shares of Common Stock of Atlantic Pharmaceuticals, Inc. (2) Calculated solely for purposes of this offering under Rule 457(h) of the Securities Act of 1933, as amended (the "1933 Act"), on the basis of the fair market value per share of Common Stock of Atlantic Pharmaceuticals, Inc. on November 4, 1996, as reported on the Nasdaq Small Cap Market.
PART II Information Required in the Registration Statement Item 3. Incorporation of Documents by Reference Atlantic Pharmaceuticals, Inc. (the "Registrant") hereby incorporates by reference into this Registration Statement the following documents previously filed with the Securities and Exchange Commission ("SEC"): (a) The Registrant's annual report on Form 10-KSB for the fiscal year ended December 31, 1995, filed with the SEC on March 29, 1996; (b) The Registrant's quarterly reports on Form 10-QSB for the quarters ended March 31, 1996, June 30, 1996 and September 30, 1996 filed with the SEC on May 3, 1996, August 8, 1996 and November 6, 1996 respectively; (c) The Registrant's report on Form 8-K filed with the SEC on August 30, 1996; and (d) The Registrant's Registration Statement No. 00-27282 on Form 8-A filed with the SEC on November 28, 1995, pursuant to Section 12(b) of the Securities Exchange Act of 1934, as amended (the "1934 Act"), in which there is described the terms, rights and provisions applicable to the Registrant's outstanding Common Stock. All reports and definitive proxy or information statements filed pursuant to Section 13(a), 13(c), 14 or 15(d) of the 1934 Act after the date of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document which also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement. Item 4. Description of Securities Not Applicable. Item 5. Interests of Named Experts and Counsel Not Applicable. Item 6. Indemnification of Directors and Officers Section 145 of the Delaware General Corporation Law ("Section 145") authorizes a court to award or a corporation's Board of Directors to grant indemnification to directors and officers in terms sufficiently broad to permit such indemnification under certain circumstances for liabilities (including reimbursement for expenses incurred) arising under the 1933 Act. Article Ten of the Registrant's Restated Certificate of Incorporation provides for mandatory indemnification by the Registrant of all persons the Registrant may indemnify under Section 145 to the maximum extent permitted by the Delaware General Corporation Law. Article Nine of the Registrant's Restated Certificate of Incorporation provides that the personal liability of its directors to the Registrant is eliminated to the fullest extent permitted by the Delaware General Corporation Law. These provisions in the Restated Certificate of Incorporation do not eliminate the directors' fiduciary duty, and in appropriate circumstances equitable remedies such as injunctive or other forms of non-monetary relief will remain available under Delaware law. In addition, each director will continue to be subject to liability for breach of the director's duty of loyalty to the Company for acts or omissions not in good faith or involving intentional misconduct, for knowing violations of law, for actions leading to improper personal benefit to the director, and for payment of dividends or approval of stock repurchases or redemptions that are unlawful under Delaware law. The provision also does not affect a director's responsibilities under any other law, such as the federal securities laws or state or federal environmental laws. Item 7. Exemption from Registration Claimed Not Applicable. Item 8. Exhibits Exhibit Number Exhibit - -------------- ------- 4 Instruments Defining Rights of Stockholders. Reference is made to Registrant's Registration No. 00-27282 on Form 8-A which is incorporated herein by reference pursuant to Item 3(b) of this Registration Statement. 5 Opinion and consent of Brobeck, Phleger & Harrison LLP. 23.1 Consent of KPMG Peat Marwick LLP - Independent Accountants. 23.2 Consent of Brobeck, Phleger & Harrison LLP is contained in Exhibit 5. 24 Power of Attorney. Reference is made to page II-4 of this Registration Statement. 99.1 1995 Stock Option Plan. 99.2 Form of Notice of Grant of Stock Option. 99.3 Form of Stock Option Agreement. 99.4 Form of Addendum to Stock Option Agreement (Special Tax Elections). 99.5 Form of Addendum to Stock Option Agreement (Involuntary Termination Following Change in Control). 99.6 Form of Addendum to Stock Option Agreement (Limited Stock Appreciation Rights). 99.7 Form of Notice of Grant of Automatic Stock Option (Initial Grant). 99.8 Form of Notice of Grant of Automatic Stock Option (Annual Grant). 99.9 Form of Automatic Stock Option Agreement. Item 9. Undertakings A. The undersigned Registrant hereby undertakes: (1) to file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement (i) to include any prospectus required by Section 10(a)(3) of the 1933 Act, (ii) to reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement and (iii) to include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement or any material change to such information in this Registration Statement; provided, however, that clauses (1)(i) and (1)(ii) shall not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed by the Registrant pursuant to Section 13 or Section 15(d) of the 1934 Act that are incorporated by reference into this Registration Statement; (2) that for the purpose of determining any liability under the 1933 Act each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof and (3) to remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the Registrant's 1995 Stock Option Plan. B. The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the 1933 Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the 1934 Act that is incorporated by reference into this Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. II-2 C. Insofar as indemnification for liabilities arising under the 1933 Act may be permitted to directors, officers or controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that, in the opinion of the SEC, such indemnification is against public policy as expressed in the 1933 Act, and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the 1933 Act and will be governed by the final adjudication of such issue. II-3 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8, and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Half Moon Bay, State of California, on this 6th day of September, 1996. ATLANTIC PHARMACEUTICALS, INC. By: /s/ Jon D. Lindjord -------------------------------------- Jon D. Lindjord Chief Executive Officer, President and Director POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS: That the undersigned officers and directors of Atlantic Pharmaceuticals, Inc., a Delaware corporation, do hereby constitute and appoint Jon D. Lindjord the lawful attorney-in-fact and agent with full power and authority to do any and all acts and things and to execute any and all instruments which said attorney and agent, determine may be necessary or advisable or required to enable said corporation to comply with the Securities Act of 1933, as amended, and any rules or regulations or requirements of the Securities and Exchange Commission in connection with this Registration Statement. Without limiting the generality of the foregoing power and authority, the powers granted include the power and authority to sign the names of the undersigned officers and directors in the capacities indicated below to this Registration Statement, to any and all amendments, both pre-effective and post-effective, and supplements to this Registration Statement, and to any and all instruments or documents filed as part of or in conjunction with this Registration Statement or amendments or supplements thereof, and each of the undersigned hereby ratifies and confirms that said attorney and agent, shall do or cause to be done by virtue hereof. This Power of Attorney may be signed in several counterparts. IN WITNESS WHEREOF, each of the undersigned has executed this Power of Attorney as of the date indicated. Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed below by the following persons in the capacities and on the dates indicated. Signature Title Date - --------- ----- ---- /s/ Jon d. Lindjord Chief Executive Officer, September 6, 1996 - --------------------------- President and Director Jon D. Lindjord (Principal Executive Officer) /s/ Shimshon Mizrachi Controller September 6, 1996 - --------------------------- (Principal Financial Officer) Shimshon Mizrachi II-4 Signature Title Date - --------- ----- ---- /s/ Steve H. Kanzer Director September 6, 1996 - ------------------------------ Steve H. Kanzer /s/ Lindsay A. Rosenwald, M.D. Director September 6, 1996 - ------------------------------ Lindsay A. Rosenwald, M.D. /s/ John K.A. Prendergast Director September 6, 1996 - ------------------------------ John K. A. Prendergast, Ph.D. /s/ Yiuchi Iwaki Director September 6 , 1996 - ------------------------------ Yiuchi Iwaki, M.D. II-5 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. EXHIBITS TO FORM S-8 UNDER SECURITIES ACT OF 1933 ATLANTIC PHARMACEUTICALS, INC. EXHIBIT INDEX Exhibit Number Exhibit - -------------- -------- 4 Instruments Defining Rights of Stockholders. Reference is made to Registrant's Registration No. 00-27282 on Form 8-A which is incorporated herein by reference pursuant to Item 3(b) of this Registration Statement. 5 Opinion and consent of Brobeck, Phleger & Harrison LLP. 23.1 Consent of KPMG Peat Marwick LLP - Independent Accountants. 23.2 Consent of Brobeck, Phleger & Harrison LLP is contained in Exhibit 5. 24 Power of Attorney. Reference is made to page II-4 of this Registration Statement. 99.1 1995 Stock Option Plan. 99.2 Form of Notice of Grant of Stock Option. 99.3 Form of Stock Option Agreement. 99.4 Form of Addendum to Stock Option Agreement (Special Tax Elections). 99.5 Form of Addendum to Stock Option Agreement (Involuntary Termination Following Change in Control). 99.6 Form of Addendum to Stock Option Agreement (Limited Stock Appreciation Rights). 99.7 Form of Notice of Grant of Automatic Stock Option (Initial Grant). 99.8 Form of Notice of Grant of Automatic Stock Option (Annual Grant). 99.9 Form of Automatic Stock Option Agreement.


                                October 23, 1996


Atlantic Pharmaceuticals, Inc.
142 Cypress Point Road
Half Moon Bay, California 94019


                          Re:  Atlantic Pharmaceuticals, Inc. (the "Company")
                               Registration Statement on Form S-8
                               registering 950,000 shares of Common Stock
                               -------------------------------------------


Ladies and Gentlemen:

We refer to your registration on Form S-8 (the  "Registration  Statement") under
the  Securities  Act of 1933, as amended,  of the 950,000 shares of Common Stock
available for issuance under the Company's 1995 Stock Option Plan. We advise you
that, in our opinion, when such shares have been issued and sold pursuant to the
applicable  provisions of the Company's 1995 Stock Option Plan and in accordance
with the Registration Statement,  such shares will be validly issued, fully paid
and nonassessable shares of the Company's Common Stock.

We  hereby  consent  to  the  filing  of  this  opinion  as an  exhibit  to  the
Registration Statement.

                                       Very truly yours,

                                       /s/ Brobeck, Phleger & Harrison LLP

                                       BROBECK, PHLEGER & HARRISON LLP



                                                                    EXHIBIT 23.1

                         INDEPENDENT AUDITORS' CONSENT


The Board of Directors
Atlantic Pharmaceuticals, Inc.

We  consent  to the use of our  report  dated  March  6,  1996  relating  to the
consolidated balance sheets of Atlantic  Pharmaceuticals,  Inc. and subsidiaries
(a  development  stage company) as of December 31, 1995 and 1994 and the related
consolidated statements of operations,  stockholders' deficit and cash flows for
each of the two years ended December 31, 1995 and 1994, for the period from July
13, 1993 (inception) to December 31, 1993, and for the period from July 13, 1993
(inception)  to December 31,  1995,  incorporated  herein by reference  from the
Company's  annual  report on Form 10-KSB for the fiscal year ended  December 31,
1995.

Our report dated March 6, 1996  contains an  explanatory  paragraph  that states
that the Company has suffered  recurring  losses from operations and has limited
capital resources,  which raises substantial doubt about its ability to continue
as a going concern.  The  consolidated  financial  statements do not include any
adjustments that might result from the outcome of that uncertainty.



                                        /s/ KPMG Peat Marwick LLP


Chicago, Illinois
November 5, 1996



                         ATLANTIC PHARMACEUTICALS, INC.
                             1995 STOCK OPTION PLAN
                      as amended and restated June 9, 1996


                                   ARTICLE ONE

                               GENERAL PROVISIONS


        I.        PURPOSE OF THE PLAN

                  This  1995  Stock  Option  Plan is  intended  to  promote  the
interests  of  Atlantic  Pharmaceuticals,   Inc.,  a  Delaware  corporation,  by
providing  eligible  persons  with the  opportunity  to  acquire  a  proprietary
interest,  or otherwise increase their proprietary  interest, in the Corporation
as an incentive for them to remain in the service of the Corporation.

                  Capitalized  terms  shall have the  meanings  assigned to such
terms in the attached Appendix.

       II.        STRUCTURE OF THE PLAN

                  A.  The  Plan  shall  be  divided  into  two  separate  equity
programs:

                                  (i) the  Discretionary  Option  Grant  Program
         under  which  eligible  persons  may,  at the  discretion  of the  Plan
         Administrator,  be granted  options to purchase shares of Common Stock,
         and

                                  (ii) the Automatic  Option Grant Program under
         which Eligible Directors shall  automatically  receive option grants at
         periodic intervals to purchase shares of Common Stock.

                  B. The  provisions of Articles One and Four shall apply to all
equity programs under the Plan and shall accordingly govern the interests of all
persons under the Plan.

      III.        ADMINISTRATION OF THE PLAN

                  A.  The  Primary  Committee  shall  have  sole  and  exclusive
authority to administer the  Discretionary  Option Grant Program with respect to
Section 16 Insiders.  No non-employee Board member shall be eligible to serve on
the Primary  Committee  if such  individual  has,  during the twelve  (12)-month
period immediately preceding the date of his or her appointment to the Committee
or (if shorter) the period commencing with the




Section  12(g)  Registration  Date  and  ending  with  the  date  of  his or her
appointment to the Primary  Committee,  received an option grant or direct stock
issuance  under the Plan or any other stock option,  stock  appreciation,  stock
bonus or other  stock plan of the  Corporation  (or any  Parent or  Subsidiary),
other than pursuant to the Automatic Option Grant Program.

                  B.  Administration of the  Discretionary  Option Grant Program
with respect to all other persons  eligible to  participate in that program may,
at the Board's  discretion,  be vested in the Primary  Committee  or a Secondary
Committee,  or the Board may retain the power to administer  those programs with
respect to all such persons. The members of the Secondary Committee may be Board
members who are  Employees  eligible to receive  discretionary  option grants or
direct  stock  issuances  under  the  Plan  or any  other  stock  option,  stock
appreciation,  stock bonus or other stock plan of the Corporation (or any Parent
or Subsidiary).

                  C. Members of the Primary Committee or any Secondary Committee
shall  serve  for such  period of time as the  Board  may  determine  and may be
removed by the Board at any time.  The Board may also at any time  terminate the
functions of any  Secondary  Committee  and  reassume  all powers and  authority
previously delegated to such committee.

                  D.  Each Plan  Administrator  shall,  within  the scope of its
administrative  functions  under the  Plan,  have full  power and  authority  to
establish  such  rules and  regulations  as it may deem  appropriate  for proper
administration  of the  Discretionary  Option  Grant  Program  and to make  such
determinations  under, and issue such interpretations of, the provisions of such
program and any  outstanding  options  thereunder  as it may deem  necessary  or
advisable.  Decisions  of  the  Plan  Administrator  within  the  scope  of  its
administrative  functions  under  the Plan  shall be final  and  binding  on all
parties who have an interest in the Discretionary Option Grant Program under its
jurisdiction or any option thereunder.

                  E. Service on the Primary Committee or the Secondary Committee
shall constitute  service as a Board member,  and members of each such committee
shall accordingly be entitled to full indemnification and reimbursement as Board
members for their service on such committee.  No member of the Primary Committee
or the Secondary  Committee shall be liable for any act or omission made in good
faith with respect to the Plan or any option grants under the Plan.

                  F.  Administration of the Automatic Option Grant Program shall
be self-  executing in accordance  with the terms of that  program,  and no Plan
Administrator shall exercise any discretionary  functions with respect to option
grants made thereunder.


                                       2.



      IV.         ELIGIBILITY

                  A. The persons  eligible to participate  in the  Discretionary
Option Grant Program are as follows:

                                  (i) Employees,

                                  (ii) non-employee  members of the Board (other
         than those serving as members of the Primary Committee) or the board of
         directors of any Parent or Subsidiary, and

                                  (iii)   consultants   and  other   independent
         advisors  who  provide  services to the  Corporation  (or any Parent or
         Subsidiary).

                  B.  Each Plan  Administrator  shall,  within  the scope of its
administrative  jurisdiction under the Plan, have full authority (subject to the
provisions  of the Plan) to  determine,  with respect to the option grants under
the  Discretionary  Option Grant Program,  which eligible persons are to receive
option  grants,  the time or times when such option  grants are to be made,  the
number of shares to be covered  by each such  grant,  the status of the  granted
option as either an  Incentive  Option or a  Non-Statutory  Option,  the time or
times at which each option is to become exercisable and the vesting schedule (if
any)  applicable  to the option shares and the maximum term for which the option
is to remain outstanding.

                  C. The  individuals  eligible to  participate in the Automatic
Option  Grant  Program  shall  be  (i)  those   individuals   who  first  become
non-employee  Board members after the Automatic  Option Grant Program  Effective
Date, whether through  appointment by the Board or election by the Corporation's
stockholders,  and (ii) those  individuals who continue to serve as non-employee
Board  members  after one or more Annual  Stockholders  Meetings  held after the
Automatic  Option Grant Program  Effective  Date,  including  those  individuals
serving as  non-employee  Board  members on the  Automatic  Option Grant Program
Effective  Date.  A  non-employee  Board member who has  previously  been in the
employ of the Corporation (or any Parent or Subsidiary) shall not be eligible to
receive an initial option grant under the Automatic  Option Grant Program at the
time he or she first becomes a non-employee  Board member,  but such  individual
shall be eligible to receive  periodic option grants under the Automatic  Option
Grant Program upon his or her continued  service as a non-employee  Board member
following one or more Annual Stockholders Meetings. However, in no event shall a
non-employee  Board  member be  eligible  to  receive  option  grants  under the
Automatic  Option Grant Program if such  individual is a 5%  Stockholder or is a
representative of, or affiliated with, a 5% Stockholder.


                                       3.



        V.        STOCK SUBJECT TO THE PLAN

                  A. The  stock  issuable  under  the Plan  shall be  shares  of
authorized but unissued or reacquired Common Stock, including shares repurchased
by the  Corporation  on the open market.  The maximum number of shares of Common
Stock which may be issued over the term of the Plan shall  initially  not exceed
950,000 shares.

                  B. The number of shares of Common Stock available for issuance
under the Plan shall  automatically  increase  on the first  trading day of each
calendar  year  during the term of the Plan,  beginning  with the 1997  calendar
year,  by an amount  equal to one  percent  (1%) of the  shares of Common  Stock
outstanding  on December  31 of the  immediately  preceding  calendar  year.  No
Incentive Options may be granted on the basis of the additional shares of Common
Stock resulting from such annual increases.

                  C. No one person participating in the Plan may receive options
and  separately  exercisable  stock  appreciation  rights for more than  100,000
shares of Common Stock in the aggregate per calendar  year,  beginning  with the
1995 calendar year; provided,  however, that for the calendar year in which such
person first commences Service, the limit shall be increased to 200,000 shares.

                  D. Shares of Common Stock subject to outstanding options shall
be  available  for  subsequent  issuance  under the Plan to the  extent  (i) the
options expire or terminate for any reason prior to exercise in full or (ii) the
options are cancelled in accordance with the cancellation-regrant  provisions of
Article Two. All shares  issued under the Plan,  whether or not those shares are
subsequently  repurchased by the Corporation  pursuant to its repurchase  rights
under the Plan, shall reduce on a share-for-share  basis the number of shares of
Common Stock  available  for  subsequent  issuance  under the Plan. In addition,
should the  exercise  price of an option  under the Plan be paid with  shares of
Common Stock or should shares of Common Stock otherwise  issuable under the Plan
be withheld by the Corporation in satisfaction of the withholding taxes incurred
in connection  with the exercise of an option under the Plan, then the number of
shares of Common Stock available for issuance under the Plan shall be reduced by
the gross number of shares for which the option is exercised, and not by the net
number of shares of Common Stock issued to the holder of such option.

                  E. Should any change be made to the Common  Stock by reason of
any stock  split,  stock  dividend,  recapitalization,  combination  of  shares,
exchange of shares or other change  affecting the outstanding  Common Stock as a
class  without  the   Corporation's   receipt  of   consideration,   appropriate
adjustments  shall be made to (i) the maximum  number and/or class of securities
issuable under the Plan,  (ii) the maximum number and/or class of securities for
which the share reserve is to increase automatically each year, (iii) the number
and/or class of securities  for which any one person may be granted  options and
separately  exercisable  stock  appreciation  rights per calendar year, (iv) the
number and/or class of securities  for which  automatic  option grants are to be
made subsequently per

                                       4.



Eligible  Director  under the Automatic  Option Grant Program and (v) the number
and/or class of securities and the exercise price per share in effect under each
outstanding  option in order to prevent the dilution or  enlargement of benefits
thereunder. The adjustments determined by the Plan Administrator shall be final,
binding and conclusive, absent manifest error.

                                       5.



                                   ARTICLE TWO

                       DISCRETIONARY OPTION GRANT PROGRAM


I.       OPTION TERMS

                  Each option shall be evidenced by one or more documents in the
form  approved  by the Plan  Administrator;  provided,  however,  that each such
document shall comply with the terms specified below.  Each document  evidencing
an Incentive Option shall, in addition, be subject to the provisions of the Plan
applicable to such options.

                  A.       Exercise Price.

                           1. The exercise price per share shall be fixed by the
Plan  Administrator  and may be less  than,  equal to or  greater  than the Fair
Market Value per share of Common Stock on the option grant date.

                           2. The exercise  price shall become  immediately  due
upon exercise of the option and shall, subject to the provisions of Section I of
Article  Four and the  documents  evidencing  the option,  be payable in cash or
check made  payable to the  Corporation.  After the Section  12(g)  Registration
Date, the exercise price may also be paid as follows:

                                  (i) in  shares of  Common  Stock  held for the
         requisite  period  necessary  to  avoid a charge  to the  Corporation's
         earnings  for  financial  reporting  purposes and valued at Fair Market
         Value on the Exercise Date, or

                                  (ii) to the extent the option is exercised for
         vested shares, through a special sale and remittance procedure pursuant
         to which the Optionee shall concurrently  provide  irrevocable  written
         instructions to (a) a  Corporation-designated  brokerage firm to effect
         the  immediate   sale  of  the  purchased   shares  and  remit  to  the
         Corporation, out of the sale proceeds available on the settlement date,
         sufficient funds to cover the aggregate  exercise price payable for the
         purchased  shares plus all applicable  Federal,  state and local income
         and  employment  taxes  required to be withheld by the  Corporation  by
         reason  of such  exercise  and  (b)  the  Corporation  to  deliver  the
         certificates  for the purchased  shares directly to such brokerage firm
         in order to complete the sale.

                  Except to the extent  such sale and  remittance  procedure  is
utilized, payment of the exercise price for the purchased shares must be made on
the Exercise Date.


                                       6.



                  B.  Exercise  and  Term  of  Options.  Each  option  shall  be
exercisable  at such time or times,  during  such  period and for such number of
shares as shall be  determined  by the Plan  Administrator  and set forth in the
documents evidencing the option.  However, no option shall have a term in excess
of ten (10) years measured from the option grant date.

                  C.       Effect of Termination of Service.

                           1. The following provisions shall govern the exercise
of any  options  held by the  Optionee  at the time of  cessation  of Service or
death:

                                  (i) Any option  outstanding at the time of the
         Optionee's cessation of Service for any reason shall remain exercisable
         for such period of time  thereafter  as shall be determined by the Plan
         Administrator and set forth in the documents evidencing the option, but
         no such option shall be exercisable  after the expiration of the option
         term.

                                  (ii)  Any  option  exercisable  in whole or in
         part by the Optionee at the time of death may be exercised subsequently
         by the  personal  representative  of the  Optionee's  estate  or by the
         person or  persons to whom the option is  transferred  pursuant  to the
         Optionee's  will  or  in  accordance  with  the  laws  of  descent  and
         distribution.

                                  (iii)  During  the   applicable   post-Service
         exercise  period,  the option may not be exercised in the aggregate for
         more  than the  number  of  vested  shares  for  which  the  option  is
         exercisable  on the date of the Optionee's  cessation of Service.  Upon
         the expiration of the applicable  exercise  period or (if earlier) upon
         the expiration of the option term, the option shall terminate and cease
         to be  outstanding  for any vested  shares for which the option has not
         been  exercised.  However,  the  option  shall,  immediately  upon  the
         Optionee's cessation of Service,  terminate and cease to be outstanding
         to the extent the option is not otherwise at that time  exercisable for
         vested shares.

                                  (iv)   Should   the   Optionee's   Service  be
         terminated for  Misconduct,  then all  outstanding  options held by the
         Optionee shall terminate immediately and cease to be outstanding.

                                  (v) In the event of an Involuntary Termination
         following a Corporate Transaction,the provisions of Section III of this
         Article Two shall govern the period for which the  outstanding  options
         are to remain exercisable following the Optionee's cessation of Service
         and shall supersede any provisions to the contrary in this section.

                                       7.



                           2. The Plan Administrator  shall have the discretion,
exercisable  either at the time an option is  granted  or at any time  while the
option remains outstanding, to:

                                  (i)  extend  the  period of time for which the
         option is to remain exercisable  following the Optionee's  cessation of
         Service  from the period  otherwise  in effect for that  option to such
         greater   period  of  time  as  the  Plan   Administrator   shall  deem
         appropriate,  but in no event beyond the expiration of the option term,
         and/or

                                  (ii) permit the option to be exercised, during
         the applicable  post-Service  exercise period, not only with respect to
         the number of vested  shares of Common  Stock for which such  option is
         exercisable at the time of the Optionee's cessation of Service but also
         with  respect  to one or more  additional  installments  in  which  the
         Optionee would have vested under the option had the Optionee  continued
         in Service.

                  D. Stockholder  Rights.  The holder of an option shall have no
stockholder  rights with respect to the shares  subject to the option until such
person shall have  exercised  the option,  paid the exercise  price and become a
holder of record of the purchased shares.

                  E. Repurchase Rights.  The Plan  Administrator  shall have the
discretion to grant options which are  exercisable for unvested shares of Common
Stock. Should the Optionee cease Service while holding such unvested shares, the
Corporation  shall have the right to repurchase,  at the exercise price paid per
share, any or all of those unvested shares. The terms upon which such repurchase
right shall be exercisable  (including the period and procedure for exercise and
the appropriate  vesting schedule for the purchased shares) shall be established
by the  Plan  Administrator  and  set  forth  in the  document  evidencing  such
repurchase right.

                  F. First Refusal Rights.  Until the Section 12(g) Registration
Date, the Corporation  shall have the right of first refusal with respect to any
proposed sale or other disposition by the Optionee (or any successor in interest
by reason of  purchase,  gift or other  transfer)  of any shares of Common Stock
issued  under the Plan.  Such right of first  refusal  shall be  exercisable  in
accordance with the terms and conditions  established by the Plan  Administrator
and set forth in the agreement evidencing such right.

                  G. Limited  Transferability of Options. During the lifetime of
the Optionee, the option shall be exercisable only by the Optionee and shall not
be assignable or  transferable  other than by will or by the laws of descent and
distribution following the Optionee's death. However, a Non-Statutory Option may
be  assigned in whole or in part during the  Optionee's  lifetime in  accordance
with the terms of a Qualified Domestic Relations Order. The assigned portion may
only be exercised by the person or persons who acquire a proprietary interest in
the option pursuant to such Qualified Domestic Relations

                                       8.



Order.  The terms  applicable to the assigned portion shall be the same as those
in effect for the option  immediately  prior to such assignment and shall be set
forth in such  documents  issued to the assignee as the Plan  Administrator  may
deem appropriate.

       II.        INCENTIVE OPTIONS

                  The terms specified below shall be applicable to all Incentive
Options.  Except as  modified  by the  provisions  of this  Section  II, all the
provisions  of  Articles  One,  Two and Five shall be  applicable  to  Incentive
Options. Options which are specifically designated as Non-Statutory Options when
issued under the Plan shall not be subject to the terms of this Section II.

                  A.  Eligibility.  Incentive  Options  may only be  granted  to
Employees.

                  B. Exercise  Price.  The exercise price per share shall not be
less  than one  hundred  percent  (100%) of the Fair  Market  Value per share of
Common Stock on the option grant date.

                  C. Dollar  Limitation.  The aggregate Fair Market Value of the
shares of Common Stock  (determined as of the respective date or dates of grant)
for which one or more  options  granted to any  Employee  under the Plan (or any
other option plan of the  Corporation or any Parent or  Subsidiary)  may for the
first time become  exercisable as Incentive  Options during any one (1) calendar
year shall not exceed the sum of One Hundred Thousand Dollars ($100,000). To the
extent the Employee holds two (2) or more such options which become  exercisable
for the first time in the same calendar  year,  the foregoing  limitation on the
exercisability  of such  options as  Incentive  Options  shall be applied on the
basis of the order in which such options are granted.

                  D.  10%  Stockholder.  If any  Employee  to whom an  Incentive
Option is granted is a 10% Stockholder,  then the exercise price per share shall
not be less than one  hundred ten  percent  (110%) of the Fair Market  Value per
share of Common  Stock on the option  grant date,  and the option term shall not
exceed five (5) years measured from the option grant date.

      III.        CORPORATE TRANSACTION/CHANGE IN CONTROL

                  A. In the event of any Corporate Transaction, each outstanding
option  shall   automatically   accelerate  so  that  each  such  option  shall,
immediately  prior to the effective  date of the Corporate  Transaction,  become
fully  exercisable  for all of the shares of Common Stock at the time subject to
such option and may be exercised for any or all of those shares as  fully-vested
shares of Common Stock.  However,  an outstanding option shall not so accelerate
if and to the  extent:  (i) such  option is, in  connection  with the  Corporate
Transaction,  either to be  assumed  by the  successor  corporation  (or  parent
thereof) or to be replaced  with a comparable  option to purchase  shares of the
capital stock of the successor

                                       9.



corporation (or parent thereof),  (ii) such option is to be replaced with a cash
incentive  program  of the  successor  corporation  which  preserves  the spread
existing on the unvested option shares at the time of the Corporate  Transaction
and provides for subsequent  payout in accordance with the same vesting schedule
applicable to such option or (iii) the acceleration of such option is subject to
other  limitations  imposed by the Plan  Administrator at the time of the option
grant. The determination of option comparability under clause (i) above shall be
made by the Plan Administrator,  and its determination  shall be final,  binding
and conclusive, absent manifest error.

                  B. All  outstanding  repurchase  rights  shall also  terminate
automatically, and the shares of Common Stock subject to those terminated rights
shall  immediately  vest in full,  in the  event of any  Corporate  Transaction,
except to the  extent:  (i) those  repurchase  rights are to be  assigned to the
successor  corporation  (or parent  thereof) in connection  with such  Corporate
Transaction or (ii) such accelerated  vesting is precluded by other  limitations
imposed by the Plan Administrator at the time the repurchase right is issued.

                  C.  Immediately  following the  consummation  of the Corporate
Transaction,   all   outstanding   options  shall  terminate  and  cease  to  be
outstanding,  except to the extent  assumed  by the  successor  corporation  (or
parent thereof).

                  D. Each option which is assumed in connection with a Corporate
Transaction  shall be appropriately  adjusted,  immediately after such Corporate
Transaction,  to apply to the number and class of  securities  which  would have
been issuable to the Optionee in consummation of such Corporate  Transaction had
the option  been  exercised  immediately  prior to such  Corporate  Transaction.
Appropriate  adjustments  shall  also be made to (i) the  number  and  class  of
securities  available for issuance under the Plan following the  consummation of
such Corporate Transaction, (ii) the exercise price payable per share under each
outstanding  option,  provided the  aggregate  exercise  price  payable for such
securities  shall  remain the same and (iii) the  maximum  number of  securities
and/or class of securities  for which any one person may be granted  options and
separately  exercisable  stock  appreciation  rights under the Plan per calendar
year.

                  E. Any options  which are assumed or replaced in the Corporate
Transaction and do not otherwise  accelerate at that time,  shall  automatically
accelerate (and any of the Corporation's  outstanding repurchase rights which do
not  otherwise  terminate  at  the  time  of  the  Corporate  Transaction  shall
automatically  terminate  and the  shares  of  Common  Stock  subject  to  those
terminated  rights shall  immediately  vest in full) in the event the Optionee's
Service should  subsequently  terminate by reason of an Involuntary  Termination
within  eighteen  (18) months  following the  effective  date of such  Corporate
Transaction.   Any  options  so  accelerated   shall  remain   exercisable   for
fully-vested  shares until the earlier of (i) the  expiration of the option term
or (ii) the  expiration of the one (1)- year period  measured from the effective
date of the Involuntary Termination.


                                       10.



                  F. The Plan  Administrator  shall have the discretion to grant
options  with  terms  different  from those  described  in this  Section  III in
connection with a Corporate Transaction.

                  G.  The  Plan   Administrator   shall  have  the   discretion,
exercisable  either at the time the  option is  granted or at any time while the
option remains outstanding, to (i) provide for the automatic acceleration of one
or more  outstanding  options  (and  the  automatic  termination  of one or more
outstanding repurchase rights with the immediate vesting of the shares of Common
Stock  subject to those  rights) upon the  occurrence  of a Change in Control or
(ii)  condition  any  such  option  acceleration  (and  the  termination  of any
outstanding  repurchase rights) upon the subsequent  Involuntary  Termination of
the Optionee's Service within a specified period following the effective date of
such Change in Control.  Any options  accelerated in connection with a Change in
Control  shall  remain  fully   exercisable   until  the  expiration  or  sooner
termination of the option term.

                  H.  The  portion  of  any  Incentive  Option   accelerated  in
connection  with a  Corporate  Transaction  or Change in  Control  shall  remain
exercisable as an Incentive Option only to the extent the applicable One Hundred
Thousand Dollar ($100,000) limitation is not exceeded. To the extent such dollar
limitation  is  exceeded,  the  accelerated  portion  of such  option  shall  be
exercisable as a Non-Statutory Option under the Federal tax laws.

                  I. The grant of options under the  Discretionary  Option Grant
Program  shall  in no way  affect  the  right  of  the  Corporation  to  adjust,
reclassify,  reorganize or otherwise change its capital or business structure or
to merge, consolidate,  dissolve,  liquidate or sell or transfer all or any part
of its business or assets.

       IV.        CANCELLATION AND REGRANT OF OPTIONS

                  The Plan Administrator  shall have the authority to effect, at
any time and from time to time, with the consent of the affected option holders,
the  cancellation  of any or all  outstanding  options  under the  Discretionary
Option Grant Program and to grant in substitution  new options covering the same
or  different  number of shares of Common  Stock but with an exercise  price per
share based on the Fair Market Value per share of Common Stock on the new option
grant date.

        V.        STOCK APPRECIATION RIGHTS

                  A. The Plan Administrator  shall have full power and authority
to grant to selected Optionees tandem stock  appreciation  rights and/or limited
stock appreciation rights.

                  B. The following  terms shall govern the grant and exercise of
tandem stock appreciation rights:


                                       11.



                                  (i) One or more  Optionees  may be granted the
         right,  exercisable  upon  such  terms  as the Plan  Administrator  may
         establish,  to elect between the exercise of the underlying  option for
         shares of Common Stock and the surrender of that option in exchange for
         a distribution from the Corporation in an amount equal to the excess of
         (a) the Fair Market Value (on the option  surrender date) of the number
         of  shares  in which  the  Optionee  is at the time  vested  under  the
         surrendered  option  (or  surrendered  portion  thereof)  over  (b) the
         aggregate exercise price payable for such shares.

                                  (ii)  No  such  option   surrender   shall  be
         effective  unless  it is  approved  by the Plan  Administrator.  If the
         surrender is so approved,  then the  distribution to which the Optionee
         shall be entitled  may be made in shares of Common Stock valued at Fair
         Market Value on the option surrender date, in cash, or partly in shares
         and  partly  in  cash,  as the  Plan  Administrator  shall  in its sole
         discretion deem appropriate.

                                  (iii)  If  the   surrender  of  an  option  is
         rejected by the Plan  Administrator,  then the  Optionee  shall  retain
         whatever  rights  the  Optionee  had under the  surrendered  option (or
         surrendered  portion  thereof)  on the  option  surrender  date and may
         exercise  such  rights  at any time  prior to the later of (a) five (5)
         business days after the receipt of the rejection notice or (b) the last
         day on which the option is otherwise exercisable in accordance with the
         terms of the documents evidencing such option, but in no event may such
         rights be  exercised  more than ten (10) years  after the option  grant
         date.

                  C. The following  terms shall govern the grant and exercise of
limited stock appreciation rights:

                                  (i) One or more  Section  16  Insiders  may be
         granted  limited  stock  appreciation  rights  with  respect  to  their
         outstanding options.

                                  (ii)   Upon  the   occurrence   of  a  Hostile
         Take-Over, each such individual holding one or more options with such a
         limited stock  appreciation right in effect for at least six (6) months
         shall have the unconditional  right  (exercisable for a thirty (30)-day
         period following such Hostile  Take-Over) to surrender each such option
         to the Corporation, to the extent the option is at the time exercisable
         for  vested  shares of Common  Stock.  In  return  for the  surrendered
         option,  the  Optionee  shall  receive  a cash  distribution  from  the
         Corporation in an amount equal to the excess of (a) the Take-Over Price
         of the shares of Common  Stock which are at the time vested  under each
         surrendered  option  (or  surrendered  portion  thereof)  over  (b) the
         aggregate   exercise   price   payable  for  such  shares.   Such  cash
         distribution  shall be paid within five (5) days  following  the option
         surrender date.

                                       12.



                                  (iii)   Neither  the   approval  of  the  Plan
         Administrator  nor the  consent  of the  Board  shall  be  required  in
         connection with such option surrender and cash distribution.

                                  (iv) The  balance of the option (if any) shall
         continue  in full force and  effect in  accordance  with the  documents
         evidencing such option.


                                       13.



                                  ARTICLE THREE

                         AUTOMATIC OPTION GRANT PROGRAM


        I.        OPTION TERMS

                  A.  Grant  Dates.  Option  grants  shall be made on the  dates
specified below:

                           1. Each  Eligible  Director  who is first  elected or
appointed  as a  non-employee  Board  member  after the  Automatic  Option Grant
Program  Effective  Date shall  automatically  be  granted,  on the date of such
initial election or appointment (as the case may be), a Non-Statutory  Option to
purchase 10,000 shares of Common Stock.

                           2. On the date of each  Annual  Stockholders  Meeting
held after the Automatic  Option Grant Program  Effective  Date, each individual
who is to continue to serve as an Eligible  Director  after such meeting,  shall
automatically  be  granted,  whether  or not such  individual  is  standing  for
re-election as a Board member at that Annual Meeting, a Non-Statutory  Option to
purchase an additional  2,000 shares of Common Stock,  provided such  individual
has served as a  non-employee  Board  member for at least six (6) months.  There
shall  be no limit on the  number  of such  2,000-share  option  grants  any one
Eligible Director may receive over his or her period of Board service.

                  B.       Exercise Price.

                           1. The exercise price per share shall be equal to one
hundred percent (100%) of the Fair Market Value per share of Common Stock on the
option grant date.

                           2. The exercise price shall be payable in one or more
of the  alternative  forms  authorized  under  the  Discretionary  Option  Grant
Program.  Except  to the  extent  the sale and  remittance  procedure  specified
thereunder is utilized,  payment of the exercise price for the purchased  shares
must be made on the Exercise Date.

                  C.  Option  Term.  Each  option  shall have a term of ten (10)
years measured from the option grant date.

                  D.  Exercise  and  Vesting of Options.  Each  option  shall be
immediately exercisable for any or all of the option shares. However, any shares
purchased under the option shall be subject to repurchase by the Corporation, at
the  exercise  price  paid per share,  upon the  Optionee's  cessation  of Board
service prior to vesting in those shares. Each initial grant shall vest, and the
Corporation's repurchase right shall lapse, in a series of three

                                       14.



(3)  successive  and equal annual  installments  over the  Optionee's  period of
continued  service as a Board member,  with the first such  installment  to vest
upon the  Optionee's  completion of one (1) year of Board service  measured from
the option  grant date.  Each annual  grant  shall vest,  and the  Corporation's
repurchase right shall lapse, upon the Optionee's  completion of one (1) year of
Board service measured from the option grant date.

                  E.  Effect of  Termination  of Board  Service.  The  following
provisions  shall govern the exercise of any options held by the Optionee at the
time the Optionee ceases to serve as a Board member:

                                  (i)  The   Optionee   (or,  in  the  event  of
         Optionee's death, the personal  representative of the Optionee's estate
         or the person or persons to whom the option is transferred  pursuant to
         the  Optionee's  will or in  accordance  with the laws of  descent  and
         distribution) shall have a twelve (12)- month period following the date
         of such  cessation  of Board  service  in which to  exercise  each such
         option.

                                  (ii)  During  the twelve  (12)-month  exercise
         period,  the option may not be exercised in the aggregate for more than
         the  number of vested  shares of Common  Stock for which the  option is
         exercisable at the time of the Optionee's cessation of Board service.

                                  (iii) Should the Optionee  cease to serve as a
         Board  member  by  reason of death or  Permanent  Disability,  then all
         shares at the time subject to the option shall immediately vest so that
         such option may, during the twelve (12)-month exercise period following
         such cessation of Board service, be exercised for all or any portion of
         those shares as fully-vested shares of Common Stock.

                           (iv) In no event shall the option remain  exercisable
         after the  expiration  of the option term.  Upon the  expiration of the
         twelve  (12)-month  exercise period or (if earlier) upon the expiration
         of the  option  term,  the  option  shall  terminate  and  cease  to be
         outstanding  for any  vested  shares  for which the option has not been
         exercised.  However, the option shall,  immediately upon the Optionee's
         cessation of Board service for any reason other than death or Permanent
         Disability,  terminate  and cease to be  outstanding  to the extent the
         option is not otherwise at that time exercisable for vested shares.


                                       15.



       II.        CORPORATE TRANSACTION/CHANGE IN CONTROL/HOSTILE TAKE-
                  OVER

                  A. In the event of any  Corporate  Transaction,  the shares of
Common Stock at the time subject to each  outstanding  option but not  otherwise
vested  shall  automatically  vest  in  full so that  each  such  option  shall,
immediately  prior to the effective  date of the Corporate  Transaction,  become
fully  exercisable  for all of the shares of Common Stock at the time subject to
such  option and may be  exercised  for all or any  portion  of those  shares as
fully-vested shares of Common Stock.  Immediately  following the consummation of
the Corporate Transaction, each automatic option grant shall terminate and cease
to be outstanding, except to the extent assumed by the successor corporation (or
parent thereof).

                  B. In  connection  with any Change in  Control,  the shares of
Common Stock at the time subject to each  outstanding  option but not  otherwise
vested  shall  automatically  vest  in  full so that  each  such  option  shall,
immediately  prior to the effective date of the Change in Control,  become fully
exercisable  for all of the shares of Common  Stock at the time  subject to such
option  and  may  be  exercised  for  all or  any  portion  of  such  shares  as
fully-vested  shares of Common Stock. Each such option shall remain  exercisable
for such fully-vested  option shares until the expiration or sooner  termination
of the option term or the surrender of the option in  connection  with a Hostile
Take-Over.

                  C. Upon the  occurrence of a Hostile  Take-Over,  the Optionee
shall have a thirty  (30)-day  period in which to surrender  to the  Corporation
each  automatic  option  held by him or her for a  period  of at  least  six (6)
months. The Optionee shall in return be entitled to a cash distribution from the
Corporation  in an amount equal to the excess of (i) the Take-Over  Price of the
shares of Common Stock at the time subject to the surrendered option (whether or
not the Optionee is otherwise at the time vested in those  shares) over (ii) the
aggregate  exercise price payable for such shares.  Such cash distribution shall
be paid  within  five (5) days  following  the  surrender  of the  option to the
Corporation. No approval or consent of the Board or any Plan Administrator shall
be required in connection with such option surrender and cash distribution.

                  D. Each option which is assumed in connection with a Corporate
Transaction  shall be appropriately  adjusted,  immediately after such Corporate
Transaction,  to apply to the number and class of  securities  which  would have
been issuable to the Optionee in consummation of such Corporate  Transaction had
the option  been  exercised  immediately  prior to such  Corporate  Transaction.
Appropriate  adjustments  shall also be made to the exercise  price  payable per
share under each  outstanding  option,  provided the  aggregate  exercise  price
payable for such securities shall remain the same.

                  E. The grant of  options  under  the  Automatic  Option  Grant
Program  shall  in no way  affect  the  right  of  the  Corporation  to  adjust,
reclassify,  reorganize or otherwise change its capital or business structure or
to merge, consolidate,  dissolve,  liquidate or sell or transfer all or any part
of its business or assets.

                                       16.



      III.        AMENDMENT OF THE AUTOMATIC OPTION GRANT PROGRAM

                  The  provisions  of  this  Automatic   Option  Grant  Program,
together with the option grants  outstanding  thereunder,  may not be amended at
intervals  more  frequently  than once every six (6)  months,  other than to the
extent  necessary  to  comply  with  applicable  Federal  income  tax  laws  and
regulations.

       IV.        REMAINING TERMS

                  The remaining terms of each option granted under the Automatic
Option Grant  Program shall be the same as the terms in effect for option grants
made under the Discretionary Option Grant Program.


                                       17.



                                  ARTICLE FOUR

                                  MISCELLANEOUS


        I.        FINANCING

                  A. The Plan  Administrator  may permit any Optionee to pay the
option exercise price under the Discretionary Option Grant Program by delivering
a  promissory  note payable in one or more  installments.  The terms of any such
promissory note  (including the interest rate and the terms of repayment)  shall
be  established by the Plan  Administrator  in its sole  discretion.  Promissory
notes may be authorized with or without  security or collateral.  In all events,
the maximum  credit  available to the Optionee may not exceed the sum of (i) the
aggregate  option exercise price payable for the purchased  shares plus (ii) any
Federal,  state and local income and  employment  tax liability  incurred by the
Optionee in connection with the option exercise.

                  B. The Plan  Administrator  may, in its discretion,  determine
that one or more such  promissory  notes shall be subject to  forgiveness by the
Corporation  in whole or in part upon such terms as the Plan  Administrator  may
deem appropriate.

       II.        TAX WITHHOLDING

                  A. The  Corporation's  obligation to deliver  shares of Common
Stock upon the exercise of options or stock  appreciation  rights under the Plan
shall be subject to the satisfaction of all applicable Federal,  state and local
income and employment tax withholding requirements.

                  B. The Plan Administrator may, in its discretion,  provide any
or all holders of  Non-Statutory  Options under the Plan (other than the options
granted under the Automatic  Option Grant  Program) with the right to use shares
of Common  Stock in  satisfaction  of all or part of the Taxes  incurred by such
holders in  connection  with the  exercise of their  options.  Such right may be
provided to any such holder in either or both of the following formats:

                                  (i) Stock  Withholding:  The  election to have
         the  Corporation  withhold,  from the shares of Common Stock  otherwise
         issuable upon the exercise of such  Non-Statutory  Option, a portion of
         those  shares  with  an  aggregate  Fair  Market  Value  equal  to  the
         percentage  of the Taxes (not to exceed  one  hundred  percent  (100%))
         designated by the holder.

                                  (ii) Stock  Delivery:  The election to deliver
         to the Corporation,  at the time the Non-Statutory Option is exercised,
         one or more

                                       18.



         shares of Common Stock  previously  acquired by such holder (other than
         in connection  with the option  exercise  triggering the Taxes) with an
         aggregate  Fair Market Value equal to the  percentage of the Taxes (not
         to exceed one hundred percent (100%)) designated by the holder.

      III.        EFFECTIVE DATE AND TERM OF THE PLAN

                  A.  The  Discretionary   Option  Grant  Program  shall  became
effective  on the Plan  Effective  Date and  options  may be  granted  under the
Discretionary  Option Grant Program at any time after the Plan  Effective  Date.
The Automatic  Option Grant  Program  became  effective on the Automatic  Option
Grant Program  Effective Date and option grants under the Automatic Option Grant
Program  may be made to the  Eligible  Directors  after such date.  However,  no
options  granted  under the Plan may be exercised  until the Plan is approved by
the  Corporation's  stockholders.  If such stockholder  approval is not obtained
within  twelve  (12)  months  after the Plan  Effective  Date,  then all options
previously  granted under this Plan shall terminate and cease to be outstanding,
and no further  options shall be granted and no shares shall be issued under the
Plan.

                  B. The Plan was  amended on June 9, 1995 to (i)  increase  the
total  number of shares of Common  Stock  available  for  issuance  from 650,000
shares to  950,000  shares and (ii) to  increase  the number of shares of Common
Stock subject to the options  granted  under the Automatic  Option Grant Program
upon the initial  election or  appointment  of an Eligible  Director  from 5,000
shares to 10,000 and to increase the number of shares of Common Stock subject to
the  annual  option  grants  thereunder  to be made on the  date of each  Annual
Stockholders  Meeting to  continuing  non-employee  Board  members from 1,000 to
2,000 shares.

                  C. The Plan shall  terminate upon the earliest of (i) June 30,
2005,  (ii) the date on which all shares  available for issuance  under the Plan
shall have been issued pursuant to the exercise of the options under the Plan or
(iii) the termination of all outstanding  options in connection with a Corporate
Transaction.  Upon such Plan termination, all outstanding options shall continue
to have force and effect in  accordance  with the  provisions  of the  documents
evidencing such options.

       IV.        AMENDMENT OF THE PLAN

                  A. The Board  shall  have  complete  and  exclusive  power and
authority to amend or modify the Plan in any or all  respects.  However,  (i) no
such amendment or modification shall adversely affect any rights and obligations
with  respect to options or stock  appreciation  rights at the time  outstanding
under the Plan unless the Optionee  consents to such amendment or  modification,
and (ii) any  amendment  made to the  Automatic  Option  Grant  Program  (or any
options  outstanding  thereunder) shall be in compliance with the limitations of
that  program.  In  addition,  the Board shall not,  without the approval of the
Corporation's stockholders, (i) materially increase the maximum number of shares
issuable

                                       19.



under the Plan,  the number of shares for which options may be granted under the
Automatic Option Grant Program or the maximum number of shares for which any one
person  may be granted  options or  separately  exercisable  stock  appreciation
rights in the aggregate per calendar year, except for permissible adjustments in
the  event  of  certain  changes  in  the  Corporation's  capitalization,   (ii)
materially modify the eligibility  requirements for Plan  participation or (iii)
materially increase the benefits accruing to Plan participants.

                  B.  Options to purchase  shares of Common Stock may be granted
under the Discretionary Option Grant Program that are in excess of the number of
shares then  available for issuance  under the Plan,  provided any excess shares
actually  issued under those programs are held in escrow until there is obtained
stockholder  approval  of an  amendment  sufficiently  increasing  the number of
shares  of  Common  Stock  available  for  issuance  under  the  Plan.  If  such
stockholder  approval is not obtained  within  twelve (12) months after the date
the first such excess grants are made, then (i) any unexercised  options granted
on the basis of such excess shares shall  terminate and cease to be  outstanding
and (ii) the  Corporation  shall  promptly  refund to the Optionees the exercise
price  paid for any  excess  shares  issued  under the Plan and held in  escrow,
together  with  interest (at the  applicable  Short Term  Federal  Rate) for the
period the shares  were held in  escrow,  and such  shares  shall  thereupon  be
automatically cancelled and cease to be outstanding.

        V.        USE OF PROCEEDS

                  Any cash proceeds received by the Corporation from the sale of
shares  of  Common  Stock  under the Plan  shall be used for  general  corporate
purposes.

       VI.        REGULATORY APPROVALS

                  A. The  implementation of the Plan, the granting of any option
or stock  appreciation  right  under the Plan and the  issuance of any shares of
Common Stock upon the exercise of any option or stock  appreciation  right shall
be  subject  to the  Corporation's  procurement  of all  approvals  and  permits
required  by  regulatory  authorities  having  jurisdiction  over the Plan,  the
options and stock appreciation  rights granted under it and the shares of Common
Stock issued pursuant to it.

                  B. No shares of Common  Stock or other  assets shall be issued
or  delivered  under the Plan unless and until there shall have been  compliance
with all applicable  requirements  of Federal and state  securities laws and all
applicable  listing  requirements  of any stock exchange (or the Nasdaq National
Market, if applicable) on which Common Stock is then listed for trading.

      VII.        NO EMPLOYMENT/SERVICE RIGHTS

                  Nothing in the Plan shall  confer upon the  Optionee any right
to continue in Service for any period of specific  duration or interfere with or
otherwise restrict in any way

                                       20.



the  rights  of the  Corporation  (or any  Parent  or  Subsidiary  employing  or
retaining  such person) or of the  Optionee,  which rights are hereby  expressly
reserved by each, to terminate such person's Service at any time for any reason,
with or without cause.

                                       21.



                                    APPENDIX


            The following definitions shall be in effect under the Plan:

         A. Automatic Option Grant Program shall mean the automatic option grant
program in effect under the Plan.

         B. Automatic Option Grant Program Effective Date shall mean the date on
which the  Underwriting  Agreement is executed and the initial  public  offering
price of the Common Stock is established.

         C. Board shall mean the Corporation's Board of Directors.

         D. Change in Control shall mean a change in ownership or control of the
Corporation effected through either of the following transactions:

                         (i) the  acquisition,  directly or  indirectly,  by any
         person or related  group of persons  (other than the  Corporation  or a
         person that directly or indirectly  controls,  is controlled  by, or is
         under common control with, the  Corporation),  of beneficial  ownership
         (within  the  meaning  of Rule  13d-3  of the 1934  Act) of  securities
         possessing  more than fifty percent (50%) of the total combined  voting
         power of the Corporation's  outstanding securities pursuant to a tender
         or exchange offer made directly to the Corporation's stockholders which
         the Board does not recommend such stockholders to accept, or

                        (ii) a change in the  composition  of the  Board  over a
         period  of  thirty-six  (36)  consecutive  months  or less  such that a
         majority  of the  Board  members  ceases,  by  reason  of  one or  more
         contested   elections  for  Board   membership,   to  be  comprised  of
         individuals who either (A) have been Board members  continuously  since
         the  beginning of such period or (B) have been elected or nominated for
         election as Board members  during such period by at least a majority of
         the Board  members  described in clause (A) who were still in office at
         the time the Board approved such election or nomination.

         E. Code shall mean the Internal Revenue Code of 1986, as amended.

         F. Common Stock shall mean the Corporation's common stock.

         G.   Corporate   Transaction   shall  mean  either  of  the   following
stockholder-approved transactions to which the Corporation is a party:


                                      A-1.



                        (i)  a  merger  or  consolidation  in  which  securities
         possessing  more than fifty percent (50%) of the total combined  voting
         power of the Corporation's  outstanding securities are transferred to a
         person or persons  different from the persons holding those  securities
         immediately prior to such transaction; or

                        (ii) the sale,  transfer or other  disposition of all or
         substantially all of the Corporation's  assets in complete  liquidation
         or dissolution of the Corporation.

         H. Corporation  shall mean Atlantic  Pharmaceuticals,  Inc., a Delaware
corporation,  and any  corporate  successor to all or  substantially  all of the
assets  or  voting  stock  of  Atlantic  Pharmaceuticals,  Inc.  which  shall by
appropriate action adopt the Plan.

         I.  Discretionary  Option Grant  Program  shall mean the  discretionary
option grant program in effect under the Plan.

         J. Domestic  Relations  Order shall mean any judgment,  decree or order
(including  approval  of a property  settlement  agreement)  which  provides  or
otherwise  conveys,   pursuant  to  applicable  State  domestic  relations  laws
(including  community  property laws),  marital property rights to any spouse or
former spouse of the Optionee.

         K. Eligible Director shall mean a non-employee Board member eligible to
participate  in the  Automatic  Option  Grant  Program  in  accordance  with the
eligibility provisions of Article One.

         L.  Employee  shall  mean an  individual  who is in the  employ  of the
Corporation (or any Parent or Subsidiary),  subject to the control and direction
of the employer  entity as to both the work to be  performed  and the manner and
method of performance.

         M.  Exercise  Date shall mean the date on which the  Corporation  shall
have received written notice of the option exercise.

         N. Fair Market  Value per share of Common  Stock on any  relevant  date
shall be determined in accordance with the following provisions:

                         (i) If the  Common  Stock is at the time  traded on the
         Nasdaq National Market, then the Fair Market Value shall be the closing
         selling  price per share of Common  Stock on the date in  question,  as
         such  price is  reported  by the  National  Association  of  Securities
         Dealers on the Nasdaq National Market or any successor system. If there
         is no  closing  selling  price  for the  Common  Stock  on the  date in
         question, then the Fair Market Value shall be the closing selling price
         on the last preceding date for which such quotation exists.

                                      A-2.



                        (ii) If the  Common  Stock is at the time  traded on the
         Nasdaq SmallCap Market or the  over-the-counter  market,  then the Fair
         Market  Value shall be the average of the highest bid and lowest  asked
         prices per share of Common  Stock on the date in question on the Nasdaq
         SmallCap  Market or the  over-the-counter  market,  as such  prices are
         reported by the National  Association of Securities Dealers through its
         Nasdaq system or any successor system. If there are no reported bid and
         asked  prices for the Common  Stock on the date in  question,  then the
         Fair  Market  Value  shall be the average of the highest bid and lowest
         asked  prices  on the last  preceding  date for which  such  quotations
         exist.

                       (iii) If the  Common  Stock is at the time  listed on any
         Stock Exchange, then the Fair Market Value shall be the closing selling
         price per share of Common  Stock on the date in  question  on the Stock
         Exchange  determined by the Plan Administrator to be the primary market
         for the  Common  Stock,  as such  price  is  officially  quoted  in the
         composite tape of transactions on such exchange. If there is no closing
         selling  price for the Common Stock on the date in  question,  then the
         Fair  Market  Value  shall  be the  closing  selling  price on the last
         preceding date for which such quotation exists.

                        (iv) For purposes of any option  grants made on the date
         the Underwriting  Agreement is executed and the initial public offering
         price of the Common Stock is  established,  the Fair Market Value shall
         be deemed to be equal to the  established  initial  offering  price per
         share.  For purposes of option grants made prior to such date, the Fair
         Market Value shall be determined by the Plan Administrator after taking
         into  account  such  factors  as  the  Plan  Administrator  shall  deem
         appropriate.

         O. 5% Stockholder  shall mean the owner of stock (as  determined  under
Code  Section  424(d))  possessing  more  than  five  percent  (5%) of the total
combined  voting power of all classes of stock of the Corporation (or any Parent
or Subsidiary).

         P.  Hostile   Take-Over  shall  mean  a  change  in  ownership  of  the
Corporation effected through the following transaction:

                         (i) the  acquisition,  directly or  indirectly,  by any
         person or related  group of persons  (other than the  Corporation  or a
         person that directly or indirectly  controls,  is controlled  by, or is
         under common control with,  the  Corporation)  of beneficial  ownership
         (within  the  meaning  of Rule  13d-3  of the 1934  Act) of  securities
         possessing  more than fifty percent (50%) of the total combined  voting
         power of the Corporation's  outstanding securities pursuant to a tender
         or exchange offer made directly to the Corporation's

                                      A-3.



         stockholders  which the Board does not recommend such  stockholders  to
         accept, and

                        (ii) more than fifty percent (50%) of the  securities so
         acquired are accepted from persons other than Section 16 Insiders.

         Q.  Incentive   Option  shall  mean  an  option  which   satisfies  the
requirements of Code Section 422.

         R. Involuntary Termination shall mean the termination of the Service of
any individual which occurs by reason of:

                        (i) such individual's involuntary dismissal or discharge
         by the Corporation for reasons other than Misconduct, or

                        (ii) such individual's  voluntary  resignation following
         (A) a  change  in  his or  her  position  with  the  Corporation  which
         materially reduces his or her level of responsibility,  (B) a reduction
         in his or her level of  compensation  (including  base  salary,  fringe
         benefits  and  participation  in  corporate-performance  based bonus or
         incentive  programs)  by  more  than  fifteen  percent  (15%)  or (C) a
         relocation of such individual's  place of employment by more than fifty
         (50) miles,  provided and only if such change,  reduction or relocation
         is effected by the Corporation without the individual's consent.

         S.  Misconduct   shall  mean  the  commission  of  any  act  of  fraud,
embezzlement or dishonesty by the Optionee,  any  unauthorized use or disclosure
by such person of  confidential  information or trade secrets of the Corporation
(or any  Parent or  Subsidiary),  or any other  intentional  misconduct  by such
person  adversely  affecting the business or affairs of the  Corporation (or any
Parent or Subsidiary) in a material manner.  The foregoing  definition shall not
be deemed to be inclusive of all the acts or omissions which the Corporation (or
any Parent or Subsidiary) may consider as grounds for the dismissal or discharge
of any Optionee or other person in the Service of the Corporation (or any Parent
or Subsidiary).

         T. 1934 Act shall mean the Securities Exchange Act of 1934, as amended.

         U.  Non-Statutory  Option  shall mean an option not intended to satisfy
the requirements of Code Section 422.

         V.  Optionee  shall mean any person to whom an option is granted  under
the Discretionary Option Grant or Automatic Option Grant Program.


                                      A-4.



         W. Parent shall mean any corporation (other than the Corporation) in an
unbroken  chain of  corporations  ending  with the  Corporation,  provided  each
corporation in the unbroken chain (other than the Corporation) owns, at the time
of the determination,  stock possessing fifty percent (50%) or more of the total
combined  voting power of all classes of stock in one of the other  corporations
in such  chain.  For  purposes of the grant of  Non-Statutory  Options and stock
appreciation  rights  under the  Discretionary  Option Grant  Program,  the term
Parent shall also include any corporation,  partnership,  joint venture or other
business  entity which,  directly or  indirectly,  controls the  management  and
policies of the Corporation, whether through the ownership of voting securities,
by contract or otherwise.

         X.  Permanent   Disability  or  Permanently  Disabled  shall  mean  the
inability  of the  Optionee  to engage in any  substantial  gainful  activity by
reason of any medically  determinable  physical or mental impairment expected to
result in death or to be of  continuous  duration of twelve (12) months or more.
However,  solely  for  the  purposes  of the  Automatic  Option  Grant  Program,
Permanent  Disability or  Permanently  Disabled  shall mean the inability of the
non-employee  Board  member to perform his or her usual duties as a Board member
by reason of any medically  determinable  physical or mental impairment expected
to result in death or to be of  continuous  duration  of twelve  (12)  months or
more.

         Y. Plan shall mean the  Corporation's  1995 Stock Option  Plan,  as set
forth in this document.

         Z. Plan  Administrator  shall mean the particular  entity,  whether the
Board, the Primary Committee or the Secondary Committee,  which is authorized to
administer  the  Discretionary  Option Grant Program with respect to one or more
classes of eligible  persons,  to the extent  such  entity is  carrying  out its
administrative  functions under those programs with respect to the persons under
its jurisdiction.

         AA.  Plan  Effective  Date  shall  mean the  date on which  the Plan is
adopted by the Board.

         AB. Primary  Committee shall mean the committee of two (2) or more non-
employee Board members  appointed by the Board to administer  the  Discretionary
Option Grant Program with respect to Section 16 Insiders.

         AC. Qualified  Domestic Relations Order shall mean a Domestic Relations
Order which substantially complies with the requirements of Code Section 414(p).
The Plan  Administrator  shall have the sole  discretion to determine  whether a
Domestic Relations Order is a Qualified Domestic Relations Order.

         AD. Secondary Committee shall mean a committee of two (2) or more Board
members  appointed by the Board to  administer  the  Discretionary  Option Grant
Program with respect to eligible persons other than Section 16 Insiders.

                                      A-5.



         AE.  Section 16  Insider  shall  mean an  officer  or  director  of the
Corporation  subject to the short-swing  profit liabilities of Section 16 of the
1934 Act.

         AF. Section 12(g)  Registration Date shall mean the first date on which
the Common Stock is registered under Section 12(g) of the 1934 Act.

         AG. Service shall mean the provision of services to the Corporation (or
any  Parent  or  Subsidiary)  by a person  in the  capacity  of an  Employee,  a
non-employee  member of the board of directors or a  consultant  or  independent
advisor,  except to the extent otherwise  specifically provided in the documents
evidencing the option grant.

         AH. Stock Exchange shall mean either the American Stock Exchange or the
New York Stock Exchange.

         AI. Subsidiary shall mean any corporation  (other than the Corporation)
in an unbroken chain of corporations  beginning with the  Corporation,  provided
each corporation  (other than the last  corporation) in the unbroken chain owns,
at the time of the  determination,  stock possessing fifty percent (50%) or more
of the total  combined  voting power of all classes of stock in one of the other
corporations in such chain. For purposes of the grant of  Non-Statutory  Options
and stock appreciation rights under the Discretionary  Option Grant Program, the
term Subsidiary shall also include any corporation,  partnership,  joint venture
or other  business  entity in which the  Corporation,  directly  or  indirectly,
controls the  management and policies,  whether  through the ownership of voting
securities, by contract or otherwise.

         AJ. Take-Over Price shall mean the greater of (i) the Fair Market Value
per  share  of  Common  Stock  on the  date the  option  is  surrendered  to the
Corporation in connection with a Hostile  Take-Over or (ii) the highest reported
price per share of Common  Stock paid by the tender  offeror in  effecting  such
Hostile  Take-Over.  However,  if the surrendered option is an Incentive Option,
the Take-Over Price shall not exceed the clause (i) price per share.

         AK. Taxes shall mean the Federal, state and local income and employment
tax  liabilities  incurred  by the holder of  Non-Statutory  Options or unvested
shares of Common Stock in  connection  with the exercise of those options or the
vesting of those shares.

         AL. 10% Stockholder  shall mean the owner of stock (as determined under
Code  Section  424(d))  possessing  more  than ten  percent  (10%) of the  total
combined  voting power of all classes of stock of the Corporation (or any Parent
or Subsidiary).

         AM.  Underwriting  Agreement  shall  mean  the  agreement  between  the
Corporation  and the  underwriter  or  underwriters  managing the initial public
offering of the Common Stock.

                                      A-6.


                         ATLANTIC PHARMACEUTICALS, INC.
                         NOTICE OF GRANT OF STOCK OPTION

                  Notice is hereby  given of the  following  option  grant  (the
"Option") to purchase  shares of the Common  Stock of Atlantic  Pharmaceuticals,
Inc. (the "Corporation"):

                  Optionee:_____________________________________________________

                  Grant Date:___________________________________________________

                  Vesting Commencement Date:____________________________________

                  Exercise Price:  $_____________________  per share

                  Number of Option Shares: ________________________ shares

                  Expiration Date:______________________________________________

                  Type of Option:    ___________ Incentive Stock Option

                                     ___________ Non-Statutory Stock Option

                  Exercise Schedule:  The Option shall become exercisable of one
                  (1) year of Service  measured  from the  Vesting  Commencement
                  Date in four (4)  successive  equal annual  installments  upon
                  Optionee's  completion  of each year of Service  measured from
                  the Vesting  Commencement  Date.  In no event shall the Option
                  become  exercisable  for any  additional  Option  Shares after
                  Optionee's cessation of Service.

                  Optionee  understands  and  agrees  that the Option is granted
subject to and in  accordance  with the terms of the  Atlantic  Pharmaceuticals,
Inc. 1995 Stock Option Plan (the "Plan"). Optionee further agrees to be bound by
the  terms of the Plan and the  terms of the  Option  as set  forth in the Stock
Option Agreement attached hereto as Exhibit A.

                  Optionee hereby acknowledges receipt of a copy of the official
prospectus for the Plan in the form attached  hereto as Exhibit B. A copy of the
Plan  is  available  upon  request  made  to  the  Corporate  Secretary  at  the
Corporation's principal offices.




                  No Employment or Service  Contract.  Nothing in this Notice or
in the attached  Stock Option  Agreement or Plan shall confer upon  Optionee any
right to continue in Service  for any period of specific  duration or  interfere
with or  otherwise  restrict  in any way the rights of the  Corporation  (or any
Parent or  Subsidiary  employing  or retaining  Optionee) or of Optionee,  which
rights are hereby expressly reserved by each, to terminate Optionee's Service at
any time for any reason, with or without cause.

                  Definitions.  All capitalized  terms in this Notice shall have
the  meaning  assigned to them in this Notice or in the  attached  Stock  Option
Agreement.

________________________, 199__
          Date


                                           ATLANTIC PHARMACEUTICALS, INC.


                                           By:    ______________________________

                                           Title: ______________________________


                                           _____________________________________
                                           OPTIONEE

                                           Address: ____________________________

                                           _____________________________________

ATTACHMENTS
Exhibit A - Stock Option Agreement
Exhibit B - Plan Summary and Prospectus


                                       2.




                                    EXHIBIT A

                             STOCK OPTION AGREEMENT







                                    EXHIBIT B

                           PLAN SUMMARY AND PROSPECTUS



                         ATLANTIC PHARMACEUTICALS, INC.
                             STOCK OPTION AGREEMENT



RECITALS

         A. The Board has  adopted  the Plan for the  purpose of  retaining  the
services of selected Employees,  non-employee  members of the Board or the board
of directors of any Parent or Subsidiary and consultants  and other  independent
advisors who provide services to the Corporation (or any Parent or Subsidiary).

         B. Optionee is to render  valuable  services to the  Corporation  (or a
Parent or  Subsidiary),  and this  Agreement  is  executed  pursuant  to, and is
intended  to  carry  out the  purposes  of,  the  Plan in  connection  with  the
Corporation's grant of an option to Optionee.

         C. All  capitalized  terms in this  Agreement  shall  have the  meaning
assigned to them in the attached Appendix.

                  NOW, THEREFORE, it is hereby agreed as follows:

                  1. Grant of Option. The Corporation hereby grants to Optionee,
as of the Grant Date,  an option to  purchase up to the number of Option  Shares
specified in the Grant Notice.  The Option Shares shall be purchasable from time
to time during the option term specified in Paragraph 2 at the Exercise Price.

                  2.  Option  Term.  This  option  shall have a term of ten (10)
years measured from the Grant Date and shall accordingly  expire at the close of
business on the Expiration  Date,  unless sooner  terminated in accordance  with
Paragraph 5 or 6.

                  3.  Limited  Transferability.  This  option  shall be  neither
transferable  nor  assignable  by Optionee  other than by will or by the laws of
descent and distribution following Optionee's death and may be exercised, during
Optionee's lifetime,  only by Optionee.  However, if this option is designated a
Non-Statutory  Option in the Grant Notice, then this option may also be assigned
in whole or in part during Optionee's lifetime in accordance with the terms of a
Qualified  Domestic  Relations  Order. The assigned portion shall be exercisable
only by the person or persons who acquire a  proprietary  interest in the option
pursuant to such Qualified Domestic Relations Order. The terms applicable to the
assigned  portion  shall  be the  same  as  those  in  effect  for  this  option
immediately  prior to such  assignment  and shall be set forth in such documents
issued to the assignee as the Plan Administrator may deem appropriate.




                  4. Dates of Exercise. This option shall become exercisable for
the Option Shares in one or more  installments as specified in the Grant Notice.
As the option becomes  exercisable  for such  installments,  those  installments
shall  accumulate and the option shall remain  exercisable  for the  accumulated
installments  until the Expiration Date or sooner termination of the option term
under Paragraph 5 or 6.

                  5.  Cessation  of  Service.   The  option  term  specified  in
Paragraph  2 shall  terminate  (and this option  shall cease to be  outstanding)
prior to the  Expiration  Date  should any of the  following  provisions  become
applicable:

                                  (i) Should Optionee cease to remain in Service
         for any reason (other than death,  Permanent  Disability or Misconduct)
         while this option is outstanding,  then Optionee shall have a period of
         three  (3)  months  (commencing  with  the  date of such  cessation  of
         Service)  during which to exercise  this option,  but in no event shall
         this option be exercisable at any time after the Expiration Date.

                                  (ii) Should  Optionee die while this option is
         outstanding,  then the personal  representative of Optionee's estate or
         the person or persons to whom the  option is  transferred  pursuant  to
         Optionee's  will  or  in  accordance  with  the  laws  of  descent  and
         distribution  shall have the right to exercise this option.  Such right
         shall lapse and this  option  shall  cease to be  outstanding  upon the
         earlier of (A) the expiration of the twelve (12)- month period measured
         from the date of Optionee's death or (B) the Expiration Date.

                                  (iii) Should  Optionee cease Service by reason
         of Permanent Disability while this option is outstanding, then Optionee
         shall have a period of twelve (12) months  (commencing with the date of
         such cessation of Service) during which to exercise this option.  In no
         event shall this option be exercisable at any time after the Expiration
         Date.

                                  (iv) Should  Optionee's  Service be terminated
         for Misconduct,  then this option shall terminate immediately and cease
         to remain outstanding.

                                  (v) During the limited period of  post-Service
         exercisability,  this option may not be exercised in the  aggregate for
         more than the  number of vested  Option  Shares for which the option is
         exercisable  at the time of Optionee's  cessation of Service.  Upon the
         expiration  of such limited  exercise  period or (if earlier)  upon the
         Expiration   Date,   this  option  shall  terminate  and  cease  to  be
         outstanding  for any vested  Option Shares for which the option has not
         been  exercised.  To the  extent  Optionee  is not vested in the Option
         Shares at the time of Optionee's cessation of Service, this option

                                       2.



         shall immediately terminate and cease to be outstanding with respect to
         those shares.

                                  (vi) In the event of a Corporate  Transaction,
         the  provisions  of  Paragraph 6 shall govern the period for which this
         option is to  remain  exercisable  following  Optionee's  cessation  of
         Service and shall  supersede  any  provisions  to the  contrary in this
         paragraph.

                  6.       Special Acceleration of Option.

                           (a) In the  event  of a  Corporate  Transaction,  the
exercisability  of this option,  to the extent  outstanding at such time but not
otherwise fully exercisable,  shall automatically accelerate so that this option
shall,  immediately  prior to the effective  date of the Corporate  Transaction,
become  exercisable  for any or all of the Option  Shares at the time subject to
this option as fully-vested shares of Common Stock. No such acceleration of this
option,  however,  shall  occur if and to the  extent:  (i) this  option  is, in
connection with the Corporate Transaction, either to be assumed by the successor
corporation  (or parent  thereof) or to be replaced with a comparable  option to
purchase  shares of the capital  stock of the successor  corporation  (or parent
thereof) or (ii) this option is to be replaced with a cash incentive  program of
the successor  corporation  which  preserves  the spread  existing on the Option
Shares for which this  option is not  exercisable  at the time of the  Corporate
Transaction  (the excess of the Fair Market Value of such Option Shares over the
aggregate  Exercise  Price payable for such shares) and provides for  subsequent
pay-out in accordance  with the same exercise  schedule in effect for the option
pursuant to the option  exercise  schedule  set forth in the Grant  Notice.  The
determination of option comparability under clause (i) shall be made by the Plan
Administrator, and such determination shall be final, binding and conclusive.

                           (b) Immediately following the Corporate  Transaction,
this option, to the extent not previously  exercised,  shall terminate and cease
to be outstanding, except to the extent assumed by the successor corporation (or
parent thereof) in connection with the Corporate Transaction.

                           (c) If this  option is assumed in  connection  with a
Corporate  Transaction,  then  this  option  shall  be  appropriately  adjusted,
immediately after such Corporate  Transaction,  to apply to the number and class
of securities which would have been issuable to Optionee in consummation of such
Corporate  Transaction had the option been exercised  immediately  prior to such
Corporate  Transaction,  and appropriate  adjustments  shall also be made to the
Exercise Price, provided the aggregate Exercise Price shall remain the same.

                           (d) Upon an  Involuntary  Termination  of  Optionee's
Service within eighteen (18) months  following a Corporate  Transaction in which
this option is assumed or replaced,  the  exercisability  of this option, to the
extent outstanding at such time but not

                                       3.



otherwise fully exercisable,  shall automatically accelerate so that this option
shall immediately become fully exercisable for all the Option Shares at the time
subject  to this  option  as  fully-vested  shares  of  Common  Stock and may be
exercised for any or all of those shares at any time prior to the earlier of (i)
the Expiration  Date or (ii) the expiration of the one (1)-year  period measured
from the effective date of the Involuntary Termination.

                           (e) This  Agreement  shall not in any way  affect the
right of the Corporation to adjust,  reclassify,  reorganize or otherwise change
its capital or business structure or to merge, consolidate,  dissolve, liquidate
or sell or transfer all or any part of its business or assets.

                  7.  Adjustment in Option Shares.  Should any change be made to
the Common Stock by reason of any stock split, stock dividend, recapitalization,
combination  of  shares,  exchange  of  shares  or other  change  affecting  the
outstanding  Common  Stock  as a class  without  the  Corporation's  receipt  of
consideration,  appropriate  adjustments  shall be made to (i) the total  number
and/or class of securities subject to this option and (ii) the Exercise Price in
order to reflect such change and thereby  preclude a dilution or  enlargement of
benefits hereunder.

                  8.  Stockholder  Rights.  The holder of this option  shall not
have any stockholder  rights with respect to the Option Shares until such person
shall have exercised the option,  paid the Exercise Price and become a holder of
record of the purchased shares.

                  9. Manner of Exercising Option.

                           (a) In order to exercise  this option with respect to
all or any part of the  Option  Shares  for  which  this  option  is at the time
exercisable,  Optionee  (or any other person or persons  exercising  the option)
must take the following actions:

                                  (i) Execute and deliver to the  Corporation  a
         Notice of  Exercise  for the  Option  Shares  for  which the  option is
         exercised.

                                  (ii) Pay the aggregate  Exercise Price for the
         purchased shares in one or more of the following forms:

                                            (A) cash or check  made  payable  to
                  the Corporation;

                                            (B) a promissory note payable to the
                  Corporation,  but only to the  extent  authorized  by the Plan
                  Administrator in accordance with Paragraph 13;

                                            (C)  shares of Common  Stock held by
                  Optionee  (or any  other  person  or  persons  exercising  the
                  option) for the requisite

                                       4.



                  period  necessary  to  avoid  a  charge  to the  Corporation's
                  earnings for financial  reporting  purposes and valued at Fair
                  Market Value on the Exercise Date; or

                                            (D)  through  a  special   sale  and
                  remittance  procedure pursuant to which Optionee (or any other
                  person or persons  exercising  the option) shall  concurrently
                  provide   irrevocable   written    instructions   (I)   to   a
                  Corporation-designated  brokerage firm to effect the immediate
                  sale of the purchased shares and remit to the Corporation, out
                  of  the  sale  proceeds  available  on  the  settlement  date,
                  sufficient funds to cover the aggregate Exercise Price payable
                  for the purchased  shares plus all applicable  Federal,  state
                  and local income and employment  taxes required to be withheld
                  by the  Corporation by reason of such exercise and (II) to the
                  Corporation  to deliver  the  certificates  for the  purchased
                  shares  directly to such  brokerage  firm in order to complete
                  the sale.

                           Except  to  the  extent   the  sale  and   remittance
                  procedure is utilized in connection with the option  exercise,
                  payment of the  Exercise  Price must  accompany  the Notice of
                  Exercise  delivered to the  Corporation in connection with the
                  option exercise.

                                  (iii) Furnish to the  Corporation  appropriate
         documentation  that the  person or  persons  exercising  the option (if
         other than Optionee) have the right to exercise this option.

                                  (iv) Make  appropriate  arrangements  with the
         Corporation (or Parent or Subsidiary  employing or retaining  Optionee)
         for the  satisfaction  of all  Federal,  state  and  local  income  and
         employment  tax  withholding  requirements  applicable  to  the  option
         exercise.

                           (b) As soon as practical after the Exercise Date, the
Corporation  shall  issue to or on behalf of  Optionee  (or any other  person or
persons  exercising this option) a certificate for the purchased  Option Shares,
with the appropriate legends affixed thereto.

                           (c) In no event may this option be exercised  for any
fractional shares.

                  10.      Compliance with Laws and Regulations.

                           (a) The  exercise of this option and the  issuance of
the Option  Shares  upon such  exercise  shall be subject to  compliance  by the
Corporation  and  Optionee  with all  applicable  requirements  of law  relating
thereto and with all applicable regulations

                                       5.



of any stock exchange (or the Nasdaq  National  Market,  if applicable) on which
the Common  Stock may be listed for  trading  at the time of such  exercise  and
issuance.

                           (b)  The  inability  of  the  Corporation  to  obtain
approval from any regulatory body having  authority deemed by the Corporation to
be  necessary to the lawful  issuance  and sale of any Common Stock  pursuant to
this option shall relieve the  Corporation  of any liability with respect to the
non-issuance  or sale of the Common  Stock as to which such  approval  shall not
have been  obtained.  The  Corporation,  however,  shall use its best efforts to
obtain all such approvals.

                  11.  Successors  and Assigns.  Except to the extent  otherwise
provided in Paragraphs 3 and 6, the provisions of this Agreement  shall inure to
the benefit of, and be binding upon,  the  Corporation  and its  successors  and
assigns and Optionee,  Optionee's assigns and the legal  representatives,  heirs
and legatees of Optionee's estate.

                  12.  Notices.  Any notice required to be given or delivered to
the  Corporation  under  the terms of this  Agreement  shall be in  writing  and
addressed to the  Corporation  at its principal  corporate  offices.  Any notice
required to be given or delivered to Optionee  shall be in writing and addressed
to Optionee at the address  indicated  below  Optionee's  signature  line on the
Grant Notice.  All notices shall be deemed  effective upon personal  delivery or
upon deposit in the U.S.  mail,  postage  prepaid and properly  addressed to the
party to be notified.

                  13.  Financing.  The Plan  Administrator  may, in its absolute
discretion  and  without any  obligation  to do so,  permit  Optionee to pay the
Exercise Price for the purchased  Option Shares by delivering a promissory note.
The  terms of any  such  promissory  note  (including  the  interest  rate,  the
requirements  for collateral and the terms of repayment) shall be established by
the Plan Administrator in its sole discretion.1/

                  14.  Construction.  This  Agreement  and the option  evidenced
hereby are made and granted pursuant to the Plan and are in all respects limited
by and subject to the terms of the Plan. All decisions of the Plan Administrator
with respect to any question or issue arising  under the Plan or this  Agreement
shall be  conclusive  and  binding on all  persons  having an  interest  in this
option.

                  15.  Governing  Law.  The   interpretation,   performance  and
enforcement  of this  Agreement  shall be  governed  by the laws of the State of
California without resort to that State's conflict-of-laws rules.

- --------
1/   Authorization  of payment of the Exercise  Price by a promissory  note may,
under currently proposed Treasury  Regulations,  result in the loss of incentive
stock option treatment under the Federal tax laws.

                                       6.



                  16.  Excess  Shares.  If the  Option  Shares  covered  by this
Agreement  exceed,  as of the Grant Date,  the number of shares of Common  Stock
which may  without  stockholder  approval  be issued  under the Plan,  then this
option  shall be void with  respect to such excess  shares,  unless  stockholder
approval of an amendment sufficiently  increasing the number of shares of Common
Stock issuable  under the Plan is obtained in accordance  with the provisions of
the Plan.

                  17. Additional Terms Applicable to an Incentive Option. In the
event this option is  designated an Incentive  Option in the Grant  Notice,  the
following terms and conditions shall also apply to the grant:

                                  (i) This  option  shall  cease to qualify  for
         favorable tax  treatment as an Incentive  Option if (and to the extent)
         this option is exercised for one or more Option  Shares:  (A) more than
         three (3) months after the date  Optionee  ceases to be an Employee for
         any reason  other than death or Permanent  Disability  or (B) more than
         twelve (12) months after the date Optionee  ceases to be an Employee by
         reason of Permanent Disability.

                                  (ii) No  installment  under this option  shall
         qualify for favorable  tax treatment as an Incentive  Option if (and to
         the extent) the aggregate  Fair Market Value  (determined  at the Grant
         Date) of the Common  Stock for which  such  installment  first  becomes
         exercisable   hereunder  would,  when  added  to  the  aggregate  value
         (determined as of the respective date or dates of grant) of any earlier
         installments  of the Common  Stock and any other  securities  for which
         this option or any other Incentive Options granted to Optionee prior to
         the Grant Date (whether  under the Plan or any other option plan of the
         Corporation  or any  Parent or  Subsidiary)  first  become  exercisable
         during the same  calendar  year,  exceed One Hundred  Thousand  Dollars
         ($100,000) in the aggregate.  Should such One Hundred  Thousand  Dollar
         ($100,000)  limitation  be exceeded in any calendar  year,  this option
         shall  nevertheless  become  exercisable  for the excess shares in such
         calendar year as a Non-Statutory Option.

                                  (iii) Should the exercisability of this option
         be  accelerated  upon a Corporate  Transaction,  then this option shall
         qualify for favorable tax treatment as an Incentive  Option only to the
         extent the aggregate  Fair Market Value  (determined at the Grant Date)
         of the Common Stock for which this option first becomes  exercisable in
         the calendar year in which the Corporate  Transaction  occurs does not,
         when added to the aggregate value (determined as of the respective date
         or dates of grant) of the Common  Stock or other  securities  for which
         this option or one or more other Incentive  Options granted to Optionee
         prior to the Grant  Date  (whether  under the Plan or any other  option
         plan of the  Corporation  or any  Parent or  Subsidiary)  first  become
         exercisable during the same calendar year, exceed

                                       7.



         One Hundred  Thousand Dollars  ($100,000) in the aggregate.  Should the
         applicable  One  Hundred  Thousand  Dollar  ($100,000)   limitation  be
         exceeded in the calendar year of such Corporate Transaction, the option
         may  nevertheless  be exercised  for the excess shares in such calendar
         year as a Non-Statutory Option.

                                  (iv) Should Optionee hold, in addition to this
         option, one or more other options to purchase Common Stock which become
         exercisable  for the  first  time  in the  same  calendar  year as this
         option,  then the foregoing  limitations on the  exercisability of such
         options as Incentive Options shall be applied on the basis of the order
         in which such options are granted.

                                       8.



                                    EXHIBIT I

                               NOTICE OF EXERCISE


                  I  hereby   notify   Atlantic   Pharmaceuticals,   Inc.   (the
"Corporation")  that I elect to purchase  __________ shares of the Corporation's
Common  Stock  (the  "Purchased   Shares")  at  the  option  exercise  price  of
$____________  per share (the "Exercise  Price") pursuant to that certain option
(the "Option") granted to me under the  Corporation's  1995 Stock Option Plan on
______________, 199___.

                  Concurrently  with the delivery of this Exercise Notice to the
Corporation,  I shall hereby pay to the  Corporation  the Exercise Price for the
Purchased  Shares in accordance  with the  provisions  of my agreement  with the
Corporation  (or other  documents)  evidencing  the  Option  and  shall  deliver
whatever  additional  documents may be required by such agreement as a condition
for exercise.  Alternatively,  I may utilize the special  broker-dealer sale and
remittance procedure specified in my agreement to effect payment of the Exercise
Price.


____________________________________, 199___
Date


                                    ____________________________________________
                                    Optionee

                                    Address: ___________________________________


                                    ____________________________________________


Print name in exact manner
it is to appear on the
stock certificate:                  ____________________________________________


Address to which certificate
is to be sent, if different
from address above:                 ____________________________________________


                                    ____________________________________________


Social Security Number:             ____________________________________________


Employee Number:                    ____________________________________________





                                    APPENDIX


                  The  following  definitions  shall  be  in  effect  under  the
Agreement:

         A. Agreement shall mean this Stock Option Agreement.

         B. Board shall mean the Corporation's Board of Directors.

         C. Code shall mean the Internal Revenue Code of 1986, as amended.

         D. Common Stock shall mean the Corporation's common stock.

         E.   Corporate   Transaction   shall  mean  either  of  the   following
stockholder-approved transactions to which the Corporation is a party:

                (i) a merger or  consolidation  in which  securities  possessing
         more than fifty percent (50%) of the total combined voting power of the
         Corporation's  outstanding  securities  are  transferred to a person or
         persons different from the persons holding those securities immediately
         prior to such transaction, or

                (ii)  the  sale,   transfer  or  other  disposition  of  all  or
         substantially all of the Corporation's  assets in complete  liquidation
         or dissolution of the Corporation.

         F. Corporation  shall mean Atlantic  Pharmaceuticals,  Inc., a Delaware
corporation.

         G. Domestic  Relations  Order shall mean any judgment,  decree or order
(including  approval  of a property  settlement  agreement)  which  provides  or
otherwise  conveys,   pursuant  to  applicable  State  domestic  relations  laws
(including  community  property laws),  marital property rights to any spouse or
former spouse of the Optionee.

         H.  Employee  shall  mean an  individual  who is in the  employ  of the
Corporation (or any Parent or Subsidiary),  subject to the control and direction
of the employer  entity as to both the work to be  performed  and the manner and
method of performance.

         I.  Exercise  Date shall  mean the date on which the option  shall have
been exercised in accordance with Paragraph 9 of the Agreement.

         J. Exercise  Price shall mean the exercise price per share as specified
in the Grant Notice.


                                      A-1.



         K.  Expiration  Date shall mean the date on which the option expires as
specified in the Grant Notice.

         L. Fair Market  Value per share of Common  Stock on any  relevant  date
shall be determined in accordance with the following provisions:

                (i) If the  Common  Stock is at the time  traded  on the  Nasdaq
         National  Market,  then  the Fair  Market  Value  shall be the  closing
         selling price per share of Common Stock on the date in question, as the
         price is reported by the National  Association of Securities Dealers on
         the Nasdaq  National  Market or any  successor  system.  If there is no
         closing  selling  price for the Common  Stock on the date in  question,
         then the Fair Market  Value shall be the closing  selling  price on the
         last preceding date for which such quotation exists.

               (ii) If the  Common  Stock is at the  time  listed  on any  Stock
         Exchange, then the Fair Market Value shall be the closing selling price
         per share of Common Stock on the date in question on the Stock Exchange
         determined by the Plan  Administrator  to be the primary market for the
         Common Stock, as such price is officially  quoted in the composite tape
         of transactions on such exchange.  If there is no closing selling price
         for the  Common  Stock on the date in  question,  then the Fair  Market
         Value shall be the closing selling price on the last preceding date for
         which such quotation exists.

         M. Grant  Date shall mean the date of grant of the option as  specified
in the Grant Notice.

         N.  Grant  Notice  shall  mean the  Notice  of  Grant  of Stock  Option
accompanying the Agreement,  pursuant to which Optionee has been informed of the
basic terms of the option evidenced hereby.

         O.  Incentive   Option  shall  mean  an  option  which   satisfies  the
requirements of Code Section 422.

         P.  Involuntary  Termination  shall mean the  termination of Optionee's
Service which occurs by reason of:

                (i)  Optionee's  dismissal or discharge by the  Corporation  for
         reasons other than Misconduct, or

                (ii) Optionee's voluntary  resignation following (A) a change in
         Optionee's  position  with the  Corporation  (or  Parent or  Subsidiary
         employing  Optionee)  which  materially  reduces  Optionee's  level  of
         responsibility, (B) a

                                      A-2.



         reduction in Optionee's  level of compensation  (including base salary,
         fringe benefits and participation in corporate-performance  based bonus
         or  incentive  programs) by more than  fifteen  percent  (15%) or (C) a
         relocation  of  Optionee's  place of employment by more than fifty (50)
         miles,  provided and only if such change,  reduction or  relocation  is
         effected by the Corporation without Optionee's consent.

         Q.  Misconduct   shall  mean  the  commission  of  any  act  of  fraud,
embezzlement or dishonesty by Optionee,  any  unauthorized  use or disclosure by
Optionee of confidential information or trade secrets of the Corporation (or any
Parent or Subsidiary), or any other intentional misconduct by Optionee adversely
affecting  the  business  or  affairs  of the  Corporation  (or  any  Parent  or
Subsidiary) in a material manner.  The foregoing  definition shall not be deemed
to be  inclusive  of all the acts or  omissions  which the  Corporation  (or any
Parent or Subsidiary)  may consider as grounds for the dismissal or discharge of
Optionee  or any other  individual  in the  Service of the  Corporation  (or any
Parent or Subsidiary).

         R.  Non-Statutory  Option  shall mean an option not intended to satisfy
the requirements of Code Section 422.

         S.  Notice of  Exercise  shall mean the notice of  exercise in the form
attached hereto as Exhibit I.

         T.  Option  Shares  shall  mean the  number of  shares of Common  Stock
subject to the option as specified in the Grant Notice.

         U.  Optionee  shall  mean the  person to whom the  option is granted as
specified in the Grant Notice.

         V. Parent shall mean any corporation (other than the Corporation) in an
unbroken  chain of  corporations  ending  with the  Corporation,  provided  each
corporation in the unbroken chain (other than the Corporation) owns, at the time
of the determination,  stock possessing fifty percent (50%) or more of the total
combined  voting power of all classes of stock in one of the other  corporations
in such chain.

         W. Permanent  Disability shall mean the inability of Optionee to engage
in any  substantial  gainful  activity by reason of any  medically  determinable
physical or mental impairment which is expected to result in death or has lasted
or can be  expected  to last for a  continuous  period of twelve  (12) months or
more.

         X. Plan shall mean the Corporation's 1995 Stock Option Plan.


                                      A-3.



         Y. Plan  Administrator  shall mean either the Board or a  committee  of
Board members,  to the extent the committee is at the time  responsible  for the
administration of the Plan.

         Z. Qualified  Domestic  Relations Order shall mean a Domestic Relations
Order which substantially complies with the requirements of Code Section 414(p).
The Plan  Administrator  shall have the sole  discretion to determine  whether a
Domestic Relations Order is a Qualified Domestic Relations Order.

         AA. Service shall mean the  Optionee's  performance of services for the
Corporation  (or any Parent or  Subsidiary)  in the capacity of an  Employee,  a
non-employee  member of the board of directors or a  consultant  or  independent
advisor.

         AB. Stock  Exchange  shall mean the American  Stock Exchange or the New
York Stock Exchange.

         AC. Subsidiary shall mean any corporation  (other than the Corporation)
in an unbroken chain of corporations  beginning with the  Corporation,  provided
each corporation  (other than the last  corporation) in the unbroken chain owns,
at the time of the  determination,  stock possessing fifty percent (50%) or more
of the total  combined  voting power of all classes of stock in one of the other
corporations in such chain.

                                      A-4.


                                    ADDENDUM
                                       TO
                             STOCK OPTION AGREEMENT


                  The following provisions are hereby incorporated into, and are
hereby  made  a  part  of,   that   certain   Stock   Option   Agreement   dated
_________________   (the   "Option   Agreement")   by   and   between   Atlantic
Pharmaceuticals,  Inc. (the "Corporation") and  __________________  ("Optionee")
evidencing the non-statutory stock option granted on such date to Optionee under
the terms of the Corporation's 1995 Stock Option Plan, and such provisions shall
be effective immediately.  Capitalized terms in this Addendum, to the extent not
otherwise defined herein,  shall have the meanings assigned to such terms in the
Option Agreement.

                              SPECIAL TAX ELECTIONS

                  1. Stock Withholding.  Optionee is hereby granted the election
to have the Corporation withhold, at the time the option is exercised, a portion
of the purchased Option Shares with an aggregate Fair Market Value not to exceed
one hundred percent (100%) of the applicable Federal, state and local income and
employment tax withholding liability (the "Taxes") Optionee incurs in connection
with the option exercise.

                           Any such exercise of the election must be effected in
accordance with the following terms and conditions:

                           (i) The  election  must be made on or before the date
         the  liability  for the Taxes is  determined  (the  "Tax  Determination
         Date").

                           (ii) The election shall be irrevocable.

                           (iii) The  election  shall be subject to the approval
         of the Plan  Administrator,  and  none of the  Option  Shares  shall be
         withheld  in  satisfaction  of the  Taxes,  except  to the  extent  the
         election is approved by the Plan Administrator.

                           (iv)  The  Option  Shares  withheld  pursuant  to the
         election shall be valued at Fair Market Value on the Tax  Determination
         Date.

                           (v) In no event  may the  number  of shares of Common
         Stock  requested to be withheld  exceed in Fair Market Value the dollar
         amount of the Taxes.

                           If the stock withholding election is made by Optionee
at a time when Optionee is an officer or director of the Corporation  subject to
the short-swing profit




restrictions  of  Section  16(b) of the  Securities  Exchange  Act of  1934,  as
amended,  then  the  following   limitations,   in  addition  to  the  preceding
provisions, shall also be applicable:

                           (i) The  election  shall not become  effective at any
         time prior to the expiration of the six (6)-month  period measured from
         the Effective  Date of this  Addendum  indicated  below,  and no Option
         Shares shall be withheld in connection with any Tax Determination  Date
         which occurs before the expiration of such six (6)-month period.

                           (ii) The stock  withholding  election must be made in
         accordance with the following limitations:

                                  (A) Such  election  must be made at least  six
         (6) months before the Tax Determination Date, or

                                  (B) Both the exercise of such election and the
         exercise  of the option  must  occur  concurrently  within a  quarterly
         "window"  period.  Quarterly  window  periods  shall begin on the third
         (3rd)  business  day  following  the  date of  public  release  of each
         quarterly or annual statement of the  Corporation's  sales and earnings
         and end on the earlier of the twelfth  (12th)  business  day  following
         such release date or the Tax Determination Date.

                  2. Stock Delivery.  Optionee is hereby granted the election to
deliver, at the time the option is exercised, one or more shares of Common Stock
previously  acquired by Optionee  (other than in connection with the acquisition
triggering  the Taxes) with an  aggregate  Fair  Market  Value not to exceed one
hundred percent (100%) of the Taxes.

                           Any such exercise of the election must be effected in
accordance with the following terms and conditions:

                           (i) The  election  must be made on or before  the Tax
         Determination Date for the Taxes.

                           (ii) The election shall be irrevocable.

                           (iii) The  election  shall be subject to the approval
         of the Plan  Administrator,  and none of the delivered shares of Common
         Stock  shall be accepted in  satisfaction  of the Taxes,  except to the
         extent the election is approved by the Plan Administrator.

                           (iv)  The  shares  of  Common   Stock   delivered  in
         satisfaction  of the Taxes shall be valued at Fair Market  Value on the
         Tax Determination Date.

                                       2.



                           (v) In no event may the  number of  delivered  shares
         exceed in Fair Market Value the dollar amount of the Taxes.


                  IN WITNESS WHEREOF, Atlantic Pharmaceuticals,  Inc. has caused
this Addendum to be executed by its  duly-authorized  officer,  and Optionee has
executed this Addendum, all as of the Effective Date specified below.


                                       ATLANTIC PHARMACEUTICALS, INC.

                                       By:    __________________________________

                                       Title: __________________________________


                                       _________________________________________
                                       OPTIONEE



EFFECTIVE DATE:________________, 199__


                                       3.


                                    ADDENDUM
                                       TO
                             STOCK OPTION AGREEMENT

                  The following provisions are hereby incorporated into, and are
hereby  made  a  part  of,   that   certain   Stock   Option   Agreement   dated
__________________   (the   "Option   Agreement")   by  and   between   Atlantic
Pharmaceuticals,  Inc. (the "Corporation") and  __________________  ("Optionee")
evidencing  the stock option granted on such date to Optionee under the terms of
the Corporation's 1995 Stock Option Plan, and such provisions shall be effective
immediately. All capitalized terms in this Addendum, to the extent not otherwise
defined  herein,  shall  have  the  meanings  assigned  to  them  in the  Option
Agreement.

                        INVOLUNTARY TERMINATION FOLLOWING
                                CHANGE IN CONTROL

                  1. The  exercisability of the option shall not accelerate upon
the  occurrence of a Change in Control,  and the option shall,  over  Optionee's
continued  period of Service  after the Change in  Control,  continue  to become
exercisable  for the Option  Shares in  accordance  with the  provisions  of the
Option  Agreement.  However,  immediately  upon an  Involuntary  Termination  of
Optionee's  Service within eighteen (18) months following the Change in Control,
the  exercisability  of this  option,  to the  extent  the option is at the time
outstanding but not otherwise fully exercisable,  shall automatically accelerate
so that the option shall immediately become fully exercisable for all the Option
Shares at the time subject to the option and may be exercised  for any or all of
those  shares as fully  vested  shares of Common  Stock at any time prior to the
earlier of (i) the  Expiration  Date or (ii) the  expiration of the one (1)-year
period measured from the date of the Involuntary Termination.

                  2. For purposes of this Addendum, a Change in Control shall be
deemed  to  occur in the  event  of a change  in  ownership  or  control  of the
Corporation effected through either of the following transactions:

                         (i) the  acquisition,  directly or  indirectly,  by any
         person or related  group of persons  (other than the  Corporation  or a
         person that directly or indirectly  controls,  is controlled  by, or is
         under common control with,  the  Corporation)  of beneficial  ownership
         (within the  meaning of Rule 13d-3 of the  Securities  Exchange  Act of
         1934,  as amended) of  securities  possessing  more than fifty  percent
         (50%)  of  the  total  combined  voting  power  of  the   Corporation's
         outstanding  securities  pursuant  to a tender or  exchange  offer made
         directly  to the  Corporation's  stockholders  which the Board does not
         recommend such stockholders to accept, or




                        (ii) a change in the  composition  of the  Board  over a
         period  of  thirty-six  (36)  consecutive  months  or less  such that a
         majority of the Board members ceases by reason of one or more contested
         elections  for Board  membership,  to be comprised of  individuals  who
         either (A) have been Board members  continuously since the beginning of
         such period or (B) have been elected or nominated for election as Board
         members  during such period by at least a majority of the Board members
         described  in  clause  (A) who were  still in  office  at the time such
         election or nomination was approved by the Board.

                  3. The provisions of Paragraph 1 of this Addendum shall govern
the  period  for  which  the  option  is to  remain  exercisable  following  the
Involuntary  Termination of Optionee's Service within eighteen (18) months after
the Change in Control and shall  supersede any provisions to the contrary in the
Option Agreement.

                  IN WITNESS WHEREOF, Atlantic Pharmaceuticals,  Inc. has caused
this Addendum to be executed by its  duly-authorized  officer,  and Optionee has
executed this Addendum, all as of the Effective Date specified below.

                                     ATLANTIC PHARMACEUTICALS, INC.

                                     By:    ____________________________________

                                     Title: ____________________________________


                                     ___________________________________________
                                     OPTIONEE


EFFECTIVE DATE: ____________, 199___

                                       2.



                                    ADDENDUM
                                       TO
                             STOCK OPTION AGREEMENT

                  The following provisions are hereby incorporated into, and are
hereby made a part of, that certain Stock Option Agreement dated 2~ (the "Option
Agreement") by and between Atlantic  Pharmaceuticals,  Inc. (the  "Corporation")
and 1~ ("Optionee") evidencing the stock option granted on such date to Optionee
under the terms of the Corporation's 1995 Stock Option Plan, and such provisions
shall be effective  immediately.  All capitalized terms in this Addendum, to the
extent not otherwise defined herein, shall have the meanings assigned to them in
the Option Agreement.

                        LIMITED STOCK APPRECIATION RIGHT

                  1.  Optionee is hereby  granted a limited  stock  appreciation
right in tandem with the option, exercisable upon the terms set forth below:

                         (i) Should a Hostile  Take-Over occur at any time after
         the option has been outstanding for a period of at least six (6) months
         measured from the Effective Date of this Addendum indicated below, then
         Optionee shall have the  unconditional  right  (exercisable  during the
         thirty (30)-day period  following such Hostile  Take-Over) to surrender
         the option to the Corporation,  to the extent the option is at the time
         exercisable  for  vested  shares of  Common  Stock.  In return  for the
         surrendered option, Optionee shall receive a cash distribution from the
         Corporation in an amount equal to the excess of (A) the Take-Over Price
         of the shares of Common  Stock which are at the time  vested  under the
         surrendered  option (or  surrendered  portion)  over (B) the  aggregate
         Exercise Price payable for such shares.

                        (ii) To exercise this limited stock appreciation  right,
         Optionee must,  during the applicable  thirty (30)-day exercise period,
         provide the Corporation  with written notice of the option surrender in
         which there is  specified  the number of Option  Shares as to which the
         option is being  surrendered.  Such notice must be  accompanied  by the
         return of Optionee's  copy of the Option  Agreement,  together with any
         written  amendments to such Agreement.  The cash distribution  shall be
         paid to Optionee within five (5) days following such delivery date, and
         neither the approval of the Plan  Administrator  nor the consent of the
         Board shall be required in  connection  with such option  surrender and
         cash distribution.  Upon receipt of such cash distribution,  the option
         shall be  cancelled  with  respect to the  Option  Shares for which the
         option  has been  surrendered,  and  Optionee  shall  cease to have any
         further   right  to  acquire  those  Option  Shares  under  the  Option
         Agreement.   The  option  shall,   however,   remain   outstanding  and
         exercisable for the balance of the Option Shares (if any) in accordance
         with the terms of the Option




         Agreement, and the Corporation shall issue a new stock option agreement
         (substantially  in the same form of the surrendered  Option  Agreement)
         for those remaining Option Shares.

                       (iii) In no event  may this  limited  stock  appreciation
         right be exercised when there is not a positive spread between the Fair
         Market  Value of the Option  Shares and the  aggregate  Exercise  Price
         payable for such shares. This limited stock appreciation right shall in
         all events  terminate upon the expiration or sooner  termination of the
         option term and may not be assigned or transferred by Optionee.

                  2. For purposes of this  Addendum,  the following  definitions
shall be in effect:

                         (i) A Hostile Take-Over shall be deemed to occur in the
         event (A) any  person  or  related  group of  persons  (other  than the
         Corporation  or a person  that  directly  or  indirectly  controls,  is
         controlled  by,  or is under  common  control  with,  the  Corporation)
         directly  or  indirectly  acquires  beneficial  ownership  (within  the
         meaning  of Rule  13d-3 of the  Securities  Exchange  Act of  1934,  as
         amended) of securities  possessing more than fifty percent (50%) of the
         total combined voting power of the Corporation's outstanding securities
         pursuant  to  a  tender  or  exchange   offer  made   directly  to  the
         Corporation's  stockholders  which the Board  does not  recommend  such
         stockholders  to accept,  and (B) more than fifty  percent (50%) of the
         securities  so acquired in such tender or exchange  offer are  accepted
         from holders other than the officers and  directors of the  Corporation
         subject to the  short-swing  profit  restrictions  of Section 16 of the
         Securities Exchange Act of 1934, as amended.

                        (ii) The Take-Over Price per share shall be deemed to be
         equal to the greater of (A) the Fair Market  Value per Option  Share on
         the option  surrender date or (B) the highest  reported price per share
         of Common  Stock paid by the tender  offeror in  effecting  the Hostile
         Take-Over.  However,  if the  surrendered  option is  designated  as an
         Incentive  Option in the Grant Notice,  then the Take-Over  Price shall
         not exceed the clause (A) price per share.


                                       2.



                  IN WITNESS WHEREOF, Atlantic Pharmaceuticals,  Inc. has caused
this Addendum to be executed by its  duly-authorized  officer,  and Optionee has
executed this Addendum, all as of the Effective Date specified below.


                                       ATLANTIC PHARMACEUTICALS, INC.

                                       By:    __________________________________

                                       Title: __________________________________


                                       _________________________________________
                                       1~, OPTIONEE



EFFECTIVE DATE: _______________, 199___


                                       3.


                                                                   INITIAL GRANT


                         ATLANTIC PHARMACEUTICALS, INC.
                    NOTICE OF GRANT OF NON-EMPLOYEE DIRECTOR
                             AUTOMATIC STOCK OPTION

                  Notice is hereby  given of the  following  option  grant  (the
"Option") to purchase  shares of the Common  Stock of Atlantic  Pharmaceuticals,
Inc. (the "Corporation"):

                  Optionee:_____________________________________________________

                  Grant Date:___________________________________________________

                  Exercise Price:  $ __________________________ per share

                  Number of Option Shares: 10,000 shares

                  Expiration Date:______________________________________________

                  Type of Option:   Non-Statutory Stock Option

                  Date Exercisable:  Immediately Exercisable

                  Vesting  Schedule:  The Option  Shares  shall be unvested  and
                  subject to repurchase by the Corporation at the Exercise Price
                  paid per share.  Optionee shall acquire a vested  interest in,
                  and the Corporation's  repurchase right will accordingly lapse
                  with  respect  to  the  Option   Shares  in  three  (3)  equal
                  successive annual  installments upon Optionee's  completion of
                  each year of service as a member of the Corporation's Board of
                  Directors  (the  "Board")  measured from the Grant Date. In no
                  event shall any additional Option Shares vest after Optionee's
                  cessation of Board service.

                  Optionee  understands  and  agrees  that the Option is granted
subject  to and in  accordance  with the  terms of the  automatic  option  grant
program  under the Atlantic  Pharmaceuticals,  Inc.  1995 Stock Option Plan (the
"Plan").  Optionee  further  agrees to be bound by the terms of the Plan and the
terms  of the  Option  as set  forth in the  Automatic  Stock  Option  Agreement
attached hereto as Exhibit A.

                  Optionee hereby acknowledges receipt of a copy of the official
prospectus for the Plan in the form attached  hereto as Exhibit B. A copy of the
Plan  is  available  upon  request  made  to  the  Corporate  Secretary  at  the
Corporation's principal offices.




                  REPURCHASE  RIGHT.  OPTIONEE  HEREBY  AGREES  THAT ALL  OPTION
SHARES ACQUIRED UPON THE EXERCISE OF THE OPTION SHALL BE SUBJECT TO A REPURCHASE
RIGHT  EXERCISABLE BY THE CORPORATION  AND ITS ASSIGNS.  THE TERMS OF SUCH RIGHT
SHALL  BE  SPECIFIED  IN A  STOCK  PURCHASE  AGREEMENT,  IN FORM  AND  SUBSTANCE
SATISFACTORY TO THE CORPORATION,  EXECUTED BY OPTIONEE AT THE TIME OF THE OPTION
EXERCISE.

                  No  Impairment  of  Rights.  Nothing  in  this  Notice  or the
attached Automatic Stock Option Agreement or in the Plan shall interfere with or
otherwise   restrict  in  any  way  the  rights  of  the   Corporation  and  the
Corporation's  stockholders  to  remove  Optionee  from the Board at any time in
accordance with the provisions of applicable law.

                  Definitions.  All capitalized  terms in this Notice shall have
the meaning  assigned to them in this Notice or in the attached  Automatic Stock
Option Agreement.

____________________________, 199___
         Date


                                       ATLANTIC PHARMACEUTICALS, INC.


                                       By:    __________________________________

                                       Title: __________________________________



                                       _________________________________________
                                       OPTIONEE

                                       Address:_________________________________


ATTACHMENTS
Exhibit A - Automatic Stock Option Agreement
Exhibit B - Plan Summary and Prospectus

                                       2.





                                    EXHIBIT A

                        AUTOMATIC STOCK OPTION AGREEMENT







                                    EXHIBIT B

                           PLAN SUMMARY AND PROSPECTUS




                                                                    ANNUAL GRANT


                         ATLANTIC PHARMACEUTICALS, INC.
                    NOTICE OF GRANT OF NON-EMPLOYEE DIRECTOR
                             AUTOMATIC STOCK OPTION

                  Notice is hereby  given of the  following  option  grant  (the
"Option") to purchase  shares of the Common  Stock of Atlantic  Pharmaceuticals,
Inc. (the "Corporation"):

                  Optionee:_____________________________________________________

                  Grant Date:___________________________________________________

                  Exercise Price:  $______________________________per share

                  Number of Option Shares: 2,000 shares

                  Expiration Date:______________________________________________

                  Type of Option:   Non-Statutory Stock Option

                  Date Exercisable: Immediately Exercisable

                  Vesting  Schedule:  The Option  Shares  shall be unvested  and
                  subject to repurchase by the Corporation at the Exercise Price
                  paid per share.  Optionee shall acquire a vested  interest in,
                  and the Corporation's  repurchase right will accordingly lapse
                  with respect to the Option Shares upon  Optionee's  completion
                  of one (1) year of  service  as a member of the  Corporation's
                  Board of Directors (the "Board") measured from the Grant Date.
                  In no event  shall any  additional  Option  Shares  vest after
                  Optionee's cessation of Board service.

                  Optionee  understands  and  agrees  that the Option is granted
subject  to and in  accordance  with the  terms of the  automatic  option  grant
program  under the Atlantic  Pharmaceuticals,  Inc.  1995 Stock Option Plan (the
"Plan").  Optionee  further  agrees to be bound by the terms of the Plan and the
terms  of the  Option  as set  forth in the  Automatic  Stock  Option  Agreement
attached hereto as Exhibit A.

                  Optionee hereby acknowledges receipt of a copy of the official
prospectus for the Plan in the form attached  hereto as Exhibit B. A copy of the
Plan  is  available  upon  request  made  to  the  Corporate  Secretary  at  the
Corporation's principal offices.




                  REPURCHASE  RIGHT.  OPTIONEE  HEREBY  AGREES  THAT ALL  OPTION
SHARES ACQUIRED UPON THE EXERCISE OF THE OPTION SHALL BE SUBJECT TO A REPURCHASE
RIGHT  EXERCISABLE BY THE CORPORATION  AND ITS ASSIGNS.  THE TERMS OF SUCH RIGHT
SHALL  BE  SPECIFIED  IN A  STOCK  PURCHASE  AGREEMENT,  IN FORM  AND  SUBSTANCE
SATISFACTORY TO THE CORPORATION,  EXECUTED BY OPTIONEE AT THE TIME OF THE OPTION
EXERCISE.

                  No  Impairment  of  Rights.  Nothing  in  this  Notice  or the
attached Automatic Stock Option Agreement or in the Plan shall interfere with or
otherwise   restrict  in  any  way  the  rights  of  the   Corporation  and  the
Corporation's  stockholders  to  remove  Optionee  from the Board at any time in
accordance with the provisions of applicable law.

                  Definitions.  All capitalized  terms in this Notice shall have
the meaning  assigned to them in this Notice or in the attached  Automatic Stock
Option Agreement.

________________________, 199___
         Date


                                       ATLANTIC PHARMACEUTICALS, INC.


                                       By:    __________________________________

                                       Title: __________________________________



                                        ________________________________________
                                        OPTIONEE

                                        Address:________________________________

                                        ________________________________________


ATTACHMENTS
Exhibit A - Automatic Stock Option Agreement
Exhibit B - Plan Summary and Prospectus

                                       2.



                                    EXHIBIT A

                        AUTOMATIC STOCK OPTION AGREEMENT







                                    EXHIBIT B

                           PLAN SUMMARY AND PROSPECTUS




                         ATLANTIC PHARMACEUTICALS, INC.
                        AUTOMATIC STOCK OPTION AGREEMENT



RECITALS

         A. The Corporation  has  implemented an automatic  option grant program
under the Plan pursuant to which eligible non-employee members of the Board will
automatically  receive  special  option grants at periodic  intervals over their
period of Board service in order to provide such  individuals  with a meaningful
incentive to continue to serve as members of the Board.

         B.  Optionee  is  an  eligible  non-employee  Board  member,  and  this
Agreement is executed pursuant to, and is intended to carry out the purposes of,
the Plan in connection  with the automatic grant of an option to purchase shares
of Common Stock under the Plan.

         C. All  capitalized  terms in this  Agreement  shall  have the  meaning
assigned to them in the attached Appendix.

                  NOW, THEREFORE, it is hereby agreed as follows:

                  1. Grant of Option. The Corporation hereby grants to Optionee,
as of the Grant  Date,  a  Non-Statutory  Option to purchase up to the number of
Option  Shares  specified  in the  Grant  Notice.  The  Option  Shares  shall be
purchasable from time to time during the option term specified in Paragraph 2 at
the Exercise Price.

                  2.  Option  Term.  This  option  shall have a term of ten (10)
years measured from the Grant Date and shall accordingly  expire at the close of
business on the Expiration  Date,  unless sooner  terminated in accordance  with
Paragraph 5, 6 or 7.

                  3. Limited  Transferability.  This option,  together  with the
special stock appreciation right provided under Paragraph 7(b), shall be neither
transferable  nor  assignable  by Optionee  other than by will or by the laws of
descent and distribution following Optionee's death and may be exercised, during
Optionee's lifetime, only by Optionee. However, this option may also be assigned
in whole or in part during Optionee's lifetime in accordance with the terms of a
Qualified  Domestic  Relations  Order. The assigned portion shall be exercisable
only by the person or persons who acquire a  proprietary  interest in the option
pursuant to such Qualified Domestic Relations Order. The terms applicable to the
assigned  portion  shall  be the  same  as  those  in  effect  for  this  option
immediately  prior to such  assignment  and shall be set forth in such documents
issued to the assignee as the Board may deem appropriate.





                  4.       Exercisability/Vesting.

                           (a) This option shall be immediately  exercisable for
any or all of the Option Shares,  whether or not the Option Shares are vested in
accordance with the Vesting  Schedule and shall remain so exercisable  until the
Expiration Date or sooner termination of the option term under Paragraph 5, 6 or
7.

                           (b) Optionee  shall,  in accordance  with the Vesting
Schedule,  vest in the Option Shares in one or more installments over his or her
period  of Board  service.  Vesting  in the  Option  Shares  may be  accelerated
pursuant to the provisions of Paragraph 5, 6 or 7. In no event,  however,  shall
any additional Option Shares vest following Optionee's cessation of service as a
Board member.

                  5. Cessation of Board Service.  Should Optionee's service as a
Board member cease while this option remains  outstanding,  then the option term
specified  in  Paragraph 2 shall  terminate  (and this option  shall cease to be
outstanding)  prior to the  Expiration  Date in  accordance  with the  following
provisions:

                           (a) Should  Optionee cease to serve as a Board member
for any reason  (other than death or Permanent  Disability)  while  holding this
option,  then the period for exercising this option shall be reduced to a twelve
(12)-month period (commencing with the date of such cessation of Board service),
but in no  event  shall  this  option  be  exercisable  at any  time  after  the
Expiration Date. During such limited period of  exercisability,  this option may
not be exercised in the  aggregate for more than the number of Option Shares (if
any) in which Optionee is vested on the date Optionee  ceases service as a Board
member.  Upon the earlier of (i) the expiration of such twelve (12)-month period
or (ii) the specified  Expiration  Date, the option shall terminate and cease to
be exercisable with respect to any vested Option Shares for which the option has
not been exercised.

                           (b) Should Optionee die during the twelve  (12)-month
period  following  his or her  cessation  of Board  service,  then the  personal
representative  of Optionee's estate or the person or persons to whom the option
is  transferred  pursuant to Optionee's  will or in accordance  with the laws of
descent and distribution shall have the right to exercise this option for any or
all of the Option  Shares in which  Optionee is vested at the time of Optionee's
cessation of Board service (less any Option Shares  purchased by Optionee  after
such  cessation  of Board  service  but prior to death).  Such right of exercise
shall terminate,  and this option shall  accordingly cease to be exercisable for
such vested Option Shares,  upon the earlier of (i) the expiration of the twelve
(12)-month  period  measured  from the  date of  Optionee's  cessation  of Board
service or (ii) the specified Expiration Date.

                           (c) Should  Optionee  cease service as a Board member
by reason of death or Permanent  Disability,  then all Option Shares at the time
subject  to this  option  but not  otherwise  vested  shall vest in full so that
Optionee (or the personal representative

                                       2.



of Optionee's  estate or the person or persons to whom the option is transferred
upon  Optionee's  death) shall have the right to exercise this option for any or
all of the  Option  Shares as  fully-vested  shares of Common  Stock at any time
prior to the  earlier  of (i) the  expiration  of the twelve  (12)-month  period
measured  from the date of  Optionee's  cessation  of Board  service or (ii) the
specified Expiration Date.

                           (d) Upon  Optionee's  cessation of Board  service for
any  reason  other  than  death  or  Permanent  Disability,  this  option  shall
immediately  terminate and cease to be  outstanding  with respect to any and all
Option  Shares  in which  Optionee  is not  otherwise  at that  time  vested  in
accordance with the normal Vesting Schedule or the special vesting  acceleration
provisions of Paragraph 6 or 7 below.

                           (e) In the event of a Corporate Transaction or Change
in Control, the provisions of Paragraph 6 or 7 shall govern the period for which
this option is to remain  exercisable  following  Optionee's  cessation of Board
service and shall supersede any provisions to the contrary in this paragraph.

                  6.       Corporate Transaction.

                           (a) In the  event  of a  Corporate  Transaction,  all
Option Shares at the time subject to this option but not otherwise  vested shall
automatically vest so that this option shall, immediately prior to the effective
date of such Corporate  Transaction,  become  exercisable  for any or all of the
Option Shares as fully-vested shares of Common Stock.  Immediately following the
Corporate  Transaction,  this option shall terminate and cease to be exercisable
except to the extent assumed by the successor corporation (or parent thereof) in
connection with such Corporate Transaction.

                           (b) If this  option is assumed in  connection  with a
Corporate  Transaction,  then  this  option  shall  be  appropriately  adjusted,
immediately after such Corporate  Transaction,  to apply to the number and class
of securities which would have been issuable to Optionee in consummation of such
Corporate  Transaction had the option been exercised  immediately  prior to such
Corporate  Transaction,  and appropriate  adjustments  shall also be made to the
Exercise Price, provided the aggregate Exercise Price shall remain the same.

                           (c) This  Agreement  shall not in any way  affect the
right of the Corporation to adjust,  reclassify,  reorganize or otherwise change
its capital or business structure or to merge, consolidate,  dissolve, liquidate
or sell or transfer all or any part of its business or assets.

                  7.       Change in Control/Hostile Take-Over.

                           (a) All Option  Shares  subject to this option at the
time of a Change in Control but not otherwise vested shall automatically vest so
that this option shall,

                                       3.



immediately prior to the effective date of such Change in Control,  become fully
exercisable  for all of the Option Shares at the time subject to this option and
may be exercised for all or any portion of such shares as fully-vested shares of
Common Stock. This option shall remain exercisable for such fully-vested  Option
Shares until the earliest to occur of (i) the Expiration  Date,  (ii) the sooner
termination  of this  option in  accordance  with  Paragraph 5 or 6 or (iii) the
surrender of the option in connection with a Hostile Take-Over.

                           (b) Provided this option has been  outstanding for at
least six (6) months prior to the  occurrence of a Hostile  Take-Over,  Optionee
shall have the  unconditional  right  (exercisable  during  the thirty  (30)-day
period  immediately  following the  consummation  of such Hostile  Take-Over) to
surrender  this option to the  Corporation  in exchange for a cash  distribution
from the Corporation in an amount equal to the excess of (i) the Take-Over Price
of the Option Shares at the time subject to the  surrendered  option (whether or
not  those  Option  Shares  are  otherwise  at the time  vested)  over  (ii) the
aggregate  Exercise  Price payable for such shares.  This Paragraph 7(b) limited
stock  appreciation  right shall in all events  terminate upon the expiration or
sooner  termination of the option term and may not be assigned or transferred by
Optionee.

                           (c) To exercise  the  Paragraph  7(b)  limited  stock
appreciation  right,  Optionee  must,  during  the  applicable  thirty  (30)-day
exercise  period,  provide the  Corporation  with  written  notice of the option
surrender  in which there is specified  the number of Option  Shares as to which
the Option is being  surrendered.  Such notice must be accompanied by the return
of Optionee's  copy of this Agreement,  together with any written  amendments to
such Agreement.  The cash distribution shall be paid to Optionee within five (5)
days following such delivery date, and no approval or consent of the Board shall
be required in connection with such option surrender and cash distribution. Upon
receipt of such cash  distribution,  this option shall be cancelled with respect
to the Option  Shares  subject  to the  surrendered  option (or the  surrendered
portion) and  Optionee  shall cease to have any further  right to acquire  those
Option  Shares  under  this  Agreement.   The  option  shall,  however,   remain
outstanding for the balance of the Option Shares (if any) in accordance with the
terms of this  Agreement,  and the  Corporation  shall issue a new stock  option
agreement (substantially in the same form as this Agreement) for those remaining
Option Shares.

                  8.  Adjustment in Option Shares.  Should any change be made to
the Common Stock by reason of any stock split, stock dividend, recapitalization,
combination  of  shares,  exchange  of  shares  or other  change  affecting  the
outstanding  Common  Stock  as a class  without  the  Corporation's  receipt  of
consideration,  appropriate  adjustments  shall be made to (i) the total  number
and/or class of securities subject to this option and (ii) the Exercise Price in
order to reflect such change and thereby  preclude a dilution or  enlargement of
benefits hereunder.


                                       4.



                  9.  Stockholder  Rights.  The holder of this option  shall not
have any stockholder  rights with respect to the Option Shares until such person
shall have exercised the option,  paid the Exercise Price and become a holder of
record of the purchased shares.

                  10.      Manner of Exercising Option.

                           (a) In order to exercise  this option with respect to
all or any part of the  Option  Shares  for  which  this  option  is at the time
exercisable,  Optionee  (or any other person or persons  exercising  the option)
must take the following actions:

                                  (i) To the extent the option is exercised  for
         vested Option Shares,  execute and deliver to the  Corporation a Notice
         of Exercise for the Option Shares for which the option is exercised. To
         the extent this option is exercised for unvested Option Shares, execute
         and deliver to the Corporation a Purchase Agreement.

                                  (ii) Pay the aggregate  Exercise Price for the
         purchased shares in one or more of the following forms:

                                            (A) cash or check  made  payable  to
                  the Corporation,

                                            (B)  shares of Common  Stock held by
                  Optionee  (or any  other  person  or  persons  exercising  the
                  option) for the requisite  period  necessary to avoid a charge
                  to the Corporation's earnings for financial reporting purposes
                  and valued at Fair Market Value on the Exercise Date, or

                                            (C)  to the  extent  the  option  is
                  exercised for vested Option Shares, through a special sale and
                  remittance  procedure pursuant to which Optionee (or any other
                  person or persons  exercising  the option) shall  concurrently
                  provide   irrevocable   written    instructions   (I)   to   a
                  Corporation-designated  brokerage firm to effect the immediate
                  sale of the purchased shares and remit to the Corporation, out
                  of  the  sale  proceeds  available  on  the  settlement  date,
                  sufficient funds to cover the aggregate Exercise Price payable
                  for the purchased  shares plus all applicable  Federal,  state
                  and local income and employment  taxes required to be withheld
                  by the  Corporation by reason of such exercise and (II) to the
                  Corporation  to deliver  the  certificates  for the  purchased
                  shares  directly to such  brokerage  firm in order to complete
                  the sale.

                           Except  to  the  extent   the  sale  and   remittance
                  procedure is utilized in connection with the option  exercise,
                  payment of the  Exercise  Price must  accompany  the Notice of
                  Exercise (or the Purchase

                                       5.



                  Agreement) delivered to the Corporation in connection with the
                  option exercise.

                                  (iii) Furnish to the  Corporation  appropriate
         documentation  that the  person or  persons  exercising  the option (if
         other than Optionee) have the right to exercise this option.

                           (b) As soon after the Exercise Date as practical, the
Corporation  shall  issue to or on behalf of  Optionee  (or any other  person or
persons  exercising this option) a certificate for the purchased  Option Shares,
with the  appropriate  legends  affixed  thereto.  To the extent any such Option
Shares are unvested,  the certificates for those Option Shares shall be endorsed
with an appropriate  legend evidencing the  Corporation's  repurchase rights and
may be held in escrow with the Corporation until such shares vest.

                           (c) In no event may this option be exercised  for any
fractional shares.

                  11.      Compliance with Laws and Regulations.

                           (a) The  exercise of this option and the  issuance of
the Option  Shares  upon such  exercise  shall be subject to  compliance  by the
Corporation  and  Optionee  with all  applicable  requirements  of law  relating
thereto and with all applicable regulations of any stock exchange (or the Nasdaq
National  Market if  applicable)  on which the  Common  Stock may be listed  for
trading at the time of such exercise and issuance.

                           (b)  The  inability  of  the  Corporation  to  obtain
approval from any regulatory body having  authority deemed by the Corporation to
be  necessary to the lawful  issuance  and sale of any Common Stock  pursuant to
this option shall relieve the  Corporation  of any liability with respect to the
non-issuance  or sale of the Common  Stock as to which such  approval  shall not
have been  obtained.  The  Corporation,  however,  shall use its best efforts to
obtain all such approvals.

                  12.  Successors  and Assigns.  Except to the extent  otherwise
provided in Paragraph 3 or 6, the  provisions of this  Agreement  shall inure to
the benefit of, and be binding upon,  the  Corporation  and its  successors  and
assigns and Optionee,  Optionee's assigns and the legal  representatives,  heirs
and legatees of Optionee's estate.

                  13.  Notices.  Any notice required to be given or delivered to
the  Corporation  under  the terms of this  Agreement  shall be in  writing  and
addressed to the  Corporation  at its principal  corporate  offices.  Any notice
required to be given or delivered to Optionee  shall be in writing and addressed
to Optionee at the address  indicated  below  Optionee's  signature  line on the
Grant Notice.  All notices shall be deemed  effective upon personal  delivery or
upon deposit in the U.S.  mail,  postage  prepaid and properly  addressed to the
party to be notified.

                                       6.



                  14.  Construction.  This  Agreement  and the option  evidenced
hereby are made and granted pursuant to the Plan and are in all respects limited
by and subject to the terms of the Plan.

                  15.  Governing  Law.  The   interpretation,   performance  and
enforcement  of this  Agreement  shall be  governed  by the laws of the State of
California without resort to that State's conflict-of-laws rules.


                                       7.



                                    EXHIBIT I

                               NOTICE OF EXERCISE


                  I  hereby   notify   Atlantic   Pharmaceuticals,   Inc.   (the
"Corporation")  that  I  elect  to  purchase   _______________   shares  of  the
Corporation's Common Stock (the "Purchased Shares") at the option exercise price
of  $______________  per share (the "Exercise  Price")  pursuant to that certain
option (the "Option")  granted to me under the  Corporation's  1995 Stock Option
Plan on _______________, 199_____.

                  Concurrently  with the delivery of this Exercise Notice to the
Corporation,  I shall hereby pay to the  Corporation  the Exercise Price for the
Purchased  Shares in accordance  with the  provisions  of my agreement  with the
Corporation  (or other  documents)  evidencing  the  Option  and  shall  deliver
whatever  additional  documents may be required by such agreement as a condition
for exercise.  Alternatively,  I may utilize the special  broker-dealer sale and
remittance procedure specified in my agreement to effect payment of the Exercise
Price for any  Purchased  Shares in which I am vested at the time of exercise of
the Option.


_______________________________, 199___
Date


                                        ________________________________________
                                        Optionee

                                        Address:________________________________


                                        ________________________________________

Print name in exact manner
it is to appear on the
stock certificate:                      ________________________________________


Address to which certificate
is to be sent, if different
from address above:                     ________________________________________


                                        ________________________________________


Social Security Number:                 ________________________________________






                                    APPENDIX


         The following definitions shall be in effect under the Agreement:

         A. Agreement shall mean this Automatic Stock Option Agreement.

         B. Board shall mean the Corporation's Board of Directors.

         C. Change in Control shall mean a change in ownership or control of the
Corporation effected through either of the following transactions:

                (i) the  acquisition,  directly or indirectly,  by any person or
         related group of persons  (other than the  Corporation or a person that
         directly or indirectly  controls,  is controlled by, or is under common
         control with,  the  Corporation)  of beneficial  ownership  (within the
         meaning of Rule 13d-3 of the 1934 Act) of  securities  possessing  more
         than fifty  percent  (50%) of the total  combined  voting  power of the
         Corporation's  outstanding  securities pursuant to a tender or exchange
         offer made directly to the Corporation's  stockholders  which the Board
         does not recommend such stockholders to accept, or

               (ii) a change in the  composition  of the Board  over a period of
         thirty-six (36) consecutive  months or less such that a majority of the
         Board members ceases, by reason of one or more contested  elections for
         Board  membership,  to be comprised of individuals  who either (A) have
         been Board members  continuously  since the beginning of such period or
         (B) have been elected or nominated for election as Board members during
         such period by at least a majority of the Board  members  described  in
         clause (A) who were still in office at the time the Board approved such
         election or nomination.

         D. Code shall mean the Internal Revenue Code of 1986, as amended.

         E. Common Stock shall mean the Corporation's common stock.

         F.   Corporate   Transaction   shall  mean  either  of  the   following
stockholder-approved transactions to which the Corporation is a party:

                (i) a merger or  consolidation  in which  securities  possessing
         more than fifty percent (50%) of the total combined voting power of the
         Corporation's  outstanding  securities  are  transferred to a person or
         persons different from the persons holding those securities immediately
         prior to such transaction, or


                                      A-1.



               (ii)  the  sale,   transfer  or  other   disposition  of  all  or
         substantially all of the Corporation's  assets in complete  liquidation
         or dissolution of the Corporation.

         G. Corporation shall mean Atlantic Pharmaceuticals, Inc., a Delaware
corporation.

         H. Domestic  Relations  Order shall mean any judgment,  decree or order
(including  approval  of a property  settlement  agreement)  which  provides  or
otherwise  conveys,   pursuant  to  applicable  State  domestic  relations  laws
(including  community  property laws),  marital property rights to any spouse or
former spouse of Optionee.

         I.  Exercise  Date shall  mean the date on which the option  shall have
been exercised in accordance with Paragraph 10 of the Agreement.

         J. Exercise  Price shall mean the exercise price per share as specified
in the Grant Notice.

         K.  Expiration  Date shall mean the date on which the option expires as
specified in the Grant Notice.

         L. Fair Market  Value per share of Common  Stock on any  relevant  date
shall be determined in accordance with the following provisions:

                (i) If the  Common  Stock is at the time  traded  on the  Nasdaq
         National  Market,  then  the Fair  Market  Value  shall be the  closing
         selling price per share of Common Stock on the date in question, as the
         price is reported by the National  Association of Securities Dealers on
         the Nasdaq  National  Market or any  successor  system.  If there is no
         closing  selling  price for the Common  Stock on the date in  question,
         then the Fair Market  Value shall be the closing  selling  price on the
         last preceding date for which such quotation exists.

               (ii) If the  Common  Stock is at the time  traded  on the  Nasdaq
         SmallCap Market or the  over-the-counter  market,  then the Fair Market
         Value shall be the average of the highest bid and lowest  asked  prices
         per  share  of  Common  Stock  on the date in  question  on the  Nasdaq
         SmallCap  Market or the  over-the-counter  market,  as such  prices are
         reported by the National  Association of Securities Dealers through its
         Nasdaq system or any successor system. If there are no reported bid and
         asked  prices for the Common  Stock on the date in  question,  then the
         Fair  Market  Value  shall be the average of the highest bid and lowest
         asked  prices  on the last  preceding  date for which  such  quotations
         exist.


                                      A-2.



              (iii)  If the  Common  Stock is at the time  listed  on any  Stock
         Exchange, then the Fair Market Value shall be the closing selling price
         per share of Common Stock on the date in question on the Stock Exchange
         which serves as the primary market for the Common Stock,  as such price
         is officially  quoted in the  composite  tape of  transactions  on such
         exchange.  If there is no closing selling price for the Common Stock on
         the date in  question,  then the Fair Market Value shall be the closing
         selling  price on the last  preceding  date for  which  such  quotation
         exists.

         M. Grant  Date shall mean the date of grant of the option as  specified
in the Grant Notice.

         N.  Grant  Notice  shall mean the  Notice of Grant of  Automatic  Stock
Option accompanying the Agreement,  pursuant to which Optionee has been informed
of the basic terms of the option evidenced hereby.

         O.  Hostile   Take-Over  shall  mean  a  change  in  ownership  of  the
Corporation effected through the following transaction:

                  (i) the acquisition,  directly or indirectly, by any person or
         related group of persons  (other than the  Corporation or a person that
         directly or indirectly  controls,  is controlled by, or is under common
         control with,  the  Corporation)  of beneficial  ownership  (within the
         meaning of Rule 13d-3 of the 1934 Act) of  securities  possessing  more
         than fifty  percent  (50%) of the total  combined  voting  power of the
         Corporation's  outstanding  securities pursuant to a tender or exchange
         offer made directly to the Corporation's  stockholders  which the Board
         does not recommend such stockholders to accept, and

                  (ii) more than fifty percent (50%) of the acquired  securities
         are accepted  from persons other than the officers and directors of the
         Corporation  subject to the short-swing profit  restrictions of Section
         16 of the 1934 Act.

         P. 1934 Act shall mean the Securities Exchange Act of 1934, as amended.

         Q.  Non-Statutory  Option  shall mean an option not intended to satisfy
the requirements of Code Section 422.

         R. Notice of Exercise  shall mean the notice of exercise in the form of
Exhibit I.

         S.  Option  Shares  shall  mean the  number of  shares of Common  Stock
subject to the option.


                                      A-3.



         T.  Optionee  shall  mean the  person to whom the  option is granted as
specified in the Grant Notice.

         U. Permanent Disability shall mean the inability of Optionee to perform
his or her usual  duties  as a member  of the  Board by reason of any  medically
determinable  physical or mental impairment which is expected to result in death
or has lasted or can be expected to last for a continuous  period of twelve (12)
months or more.

         V. Plan shall mean the Corporation's 1995 Stock Option Plan.

         W. Purchase  Agreement shall mean the stock purchase agreement (in form
and substance  satisfactory to the Corporation) which grants the Corporation the
right to repurchase,  at the Exercise Price,  any and all unvested Option Shares
held by Optionee at the time of Optionee's  cessation of Board service and which
precludes the sale, transfer or other disposition of any purchased Option Shares
while subject to such repurchase right.

         X. Qualified  Domestic  Relations Order shall mean a Domestic Relations
Order which substantially complies with the requirements of Code Section 414(p).
The Corporation  shall have the sole discretion to determine  whether a Domestic
Relations Order is a Qualified Domestic Relations Order.

         Y. Stock  Exchange  shall mean the American  Stock  Exchange or the New
York Stock Exchange.

         Z. Take-Over  Price shall mean the greater of (i) the Fair Market Value
per  share  of  Common  Stock  on the  date the  option  is  surrendered  to the
Corporation in connection with a Hostile  Take-Over or (ii) the highest reported
price per share of Common  Stock paid by the tender  offeror  in  effecting  the
Hostile Take-Over.

         AA. Vesting Schedule shall mean the vesting  schedule  specified in the
Grant Notice.


                                      A-4.