<PAGE>
                            SCHEDULE 14A INFORMATION
 
                  Proxy Statement Pursuant to Section 14(a) of
            the Securities Exchange Act of 1934 (Amendment No.    )
 
    Filed by the Registrant /X/
    Filed by a Party other than the Registrant / /
 
    Check the appropriate box:
    / /  Preliminary Proxy Statement
    / /  Confidential, for Use of the Commission Only (as permitted by Rule
         14a-6(e)(2))
    /X/  Definitive Proxy Statement
    / /  Definitive Additional Materials
    / /  Soliciting Material Pursuant to Section240.14a-11(c) or
         Section240.14a-12
 
                                ATLANTIC PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)
 
- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)
 
Payment of Filing Fee (Check the appropriate box):
 
/X/  No fee required.
/ /  Fee computed on table below per Exchange Act Rules 14a-6(i)(1)
     and 0-11.
     (1) Title of each class of securities to which transaction applies:
         -----------------------------------------------------------------------
     (2) Aggregate number of securities to which transaction applies:
         -----------------------------------------------------------------------
     (3) Per unit price or other underlying value of transaction computed
         pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
         filing fee is calculated and state how it was determined):
         -----------------------------------------------------------------------
     (4) Proposed maximum aggregate value of transaction:
         -----------------------------------------------------------------------
     (5) Total fee paid:
         -----------------------------------------------------------------------
/ /  Fee paid previously with preliminary materials.
/ /  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously. Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.
     (1) Amount Previously Paid:
         -----------------------------------------------------------------------
     (2) Form, Schedule or Registration Statement No.:
         -----------------------------------------------------------------------
     (3) Filing Party:
         -----------------------------------------------------------------------
     (4) Date Filed:
         -----------------------------------------------------------------------

<PAGE>
                         ATLANTIC PHARMACEUTICALS, INC.
 
                             1017 MAIN CAMPUS DRIVE
                                   SUITE 3900
                         RALEIGH, NORTH CAROLINA 27606
 
                            ------------------------
 
                                 APRIL 13, 1998
 
Dear Stockholder:
 
    You are cordially invited to attend the Annual Meeting of Stockholders (the
"Annual Meeting") of Atlantic Pharmaceuticals, Inc. (the "Company"), which will
be held at 10:00 A.M. Eastern Daylight Time on Monday, May 11, 1998, at the
Company's principal offices, 1017 Main Campus Drive, Suite 3900, Raleigh, North
Carolina 27606.
 
    At the Annual Meeting, you will be asked to consider and vote upon the
following proposals:
 
    (i) to elect a Board of six directors to serve for the ensuing year and
        until their successors are elected and qualified;
 
    (ii) to approve an amendment to the Company's Restated Certificate of
         Incorporation, as amended, to decrease the number of authorized shares
         of Common Stock of the Company from 80,000,000 to 50,000,000 and to
         decrease the number of authorized shares of Preferred Stock of the
         Company from 50,000,000 to 10,000,000; and
 
   (iii) to ratify the appointment of KPMG Peat Marwick LLP as the Company's
         independent auditors for the fiscal year ending December 31, 1998.
 
In addition, holders of the Company's Series A Convertible Preferred Stock will
be asked to vote on the following proposals:
 
    (iv) To approve the payment by the Company to each non-employee director of
         a $6,000 annual fee plus $1,500 per Board meeting attended in person,
         $750 per Board meeting attended by telephone and $500 per meeting of
         any committee of which such director is a member;
 
    (v) To approve a Consultancy Agreement and a Financial Services Agreement to
        be entered into by and between the Company and Yuichi Iwaki, M.D.,
        Ph.D.; and
 
    (vi) To approve a Consultancy Agreement and a Financial Services Agreement
         to be entered into by and between the Company and John K.A.
         Prendergast, Ph.D.
 
    The enclosed Proxy Statement more fully describes the details of the
business to be conducted at the Annual Meeting.
 
    After careful consideration, the Company's Board of Directors has
unanimously approved the proposals and recommends that you vote IN FAVOR OF each
such proposal.
 
    After reading the Proxy Statement, please mark, date, sign and return the
enclosed proxy card in the accompanying reply envelope no later than May 1,
1998. If you hold your shares of the Company in street name and decide to attend
the Annual Meeting and vote your shares in person, please notify your broker to
obtain a ballot so that you may vote your shares. If you are a holder of record
of shares of the Company and vote by ballot at the Annual Meeting, your proxy
vote will be revoked automatically and only your vote at the Annual Meeting will
be counted. YOUR SHARES CANNOT BE VOTED UNLESS YOU MARK, DATE, SIGN AND RETURN
THE ENCLOSED PROXY OR ATTEND THE ANNUAL MEETING AND VOTE IN PERSON.
 
    Copies of the Company's 1997 Annual Report to Stockholders and the Company's
Annual Report on Form 10-KSB are also enclosed.
 
    We look forward to seeing you at the Annual Meeting.
 
                                          Sincerely,
 
                                          Jon D. Lindjord
 
                                          PRESIDENT AND CHIEF EXECUTIVE OFFICER
 
                                    IMPORTANT
    PLEASE MARK, DATE, SIGN AND RETURN THE ENCLOSED PROXY PROMPTLY IN THE
ACCOMPANYING POSTAGE-PAID RETURN ENVELOPE SO THAT, IF YOU ARE UNABLE TO ATTEND
THE ANNUAL MEETING, YOUR SHARES MAY BE VOTED.

<PAGE>
                         ATLANTIC PHARMACEUTICALS, INC.
                                ----------------
 

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD MAY 11, 1998
                             ---------------------
 
TO THE STOCKHOLDERS OF ATLANTIC PHARMACEUTICALS, INC.:
 
    NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders (the "Annual
Meeting") of Atlantic Pharmaceuticals, Inc., a Delaware corporation (the
"Company"), will be held at 10:00 A.M. Eastern Daylight Time on Monday, May 11,
1998, at the offices of Atlantic Pharmaceuticals, Inc., 1017 Main Campus Drive,
Suite 3900, Raleigh, North Carolina 27606, for the following purposes:
 
    1.  To elect a Board of six directors to serve for the ensuing year and
       until their successors are elected and qualified. The six nominees are
       Jon D. Lindjord; Robert A. Fildes, Ph.D.; Yuichi Iwaki, M.D., Ph.D.;
       Steven H. Kanzer, Esq.; John K.A. Prendergast, Ph.D.; and Paul D. Rubin,
       M.D.;
 
    2.  To approve an amendment to the Company's Restated Certificate of
       Incorporation, as amended, to decrease the number of authorized shares of
       the Company's Common Stock from 80,000,000 shares to 50,000,000 shares
       and to decrease the number of authorized shares of the Company's
       Preferred Stock from 50,000,000 shares to 10,000,000 shares;
 
    3.  To ratify the appointment of KPMG Peat Marwick LLP as the Company's
       independent auditors for the fiscal year ending December 31, 1998; and
 
    4.  To transact such other business as may properly come before the Annual
       Meeting and any adjournment or adjournments thereof.
 
In addition, holders of the Company's Series A Convertible Preferred Stock will
be asked to vote on the following proposals:
 
    5.  To approve the payment by the Company to each non-employee director of a
       $6,000 annual fee plus $1,500 per Board meeting attended in person, $750
       per Board meeting attended by telephone and $500 per meeting of any
       committee of which such director is a member;
 
    6.  To approve a Consultancy Agreement and a Financial Services Agreement to
       be entered into by and between the Company and Yuichi Iwaki, M.D., Ph.D.;
       and
 
    7.  To approve a Consultancy Agreement and a Financial Services Agreement to
       be entered into by and between the Company and John K.A. Prendergast,
       Ph.D.
 
    The foregoing items of business are more fully described in the Proxy
Statement accompanying this Notice.
 
    The record date for determining those stockholders entitled to notice of,
and to vote at, the Annual Meeting and any adjournment thereof is March 16,
1998. The stock transfer books of the Company will remain open between the
record date and the date of the meeting. A list of the stockholders entitled to
vote at the Annual Meeting will be available for inspection at the Company's
offices, 1017 Main Campus Drive, Suite 3900, Raleigh, North Carolina 27606, for
a period of at least 10 days prior to the Annual Meeting.
 
    All stockholders are cordially invited to attend the Annual Meeting in
person. Whether or not you plan to attend, to assure your representation at the
meeting, please carefully read the accompanying Proxy Statement, which describes
the matters to be voted upon at the Annual Meeting, and mark, date, sign and
return the enclosed proxy card in the reply envelope provided. Should you
receive more than one proxy because your shares are registered in different
names and addresses or you own more than one class of stock of the Company, each
proxy should be returned to ensure that all your shares will be voted. If you
hold your shares of the Company in street name and decide to attend the Annual
Meeting and vote your shares in person, please notify your broker to obtain a
ballot so that you may vote your shares. If you are a holder of record of shares
of the Company and vote by ballot at the Annual Meeting, your proxy vote will be
revoked automatically and only your vote at the Annual Meeting will be counted.
The prompt return of your proxy card will assist us in preparing for the Annual
Meeting.
 
                                          Sincerely,
 
                                          Jon D. Lindjord
 
                                          PRESIDENT AND CHIEF EXECUTIVE OFFICER
 
Raleigh, North Carolina
 
A
pril 13, 1998
 
YOUR VOTE IS VERY IMPORTANT, REGARDLESS OF THE NUMBER OF SHARES YOU OWN. PLEASE
READ THE ATTACHED PROXY STATEMENT CAREFULLY. WHETHER OR NOT YOU EXPECT TO ATTEND
IN PERSON, PLEASE COMPLETE, SIGN, DATE AND RETURN THE ENCLOSED PROXY CARD IN THE
ACCOMPANYING ENVELOPE AS PROMPTLY AS POSSIBLE.

<PAGE>
                         ATLANTIC PHARMACEUTICALS, INC.
                       1017 MAIN CAMPUS DRIVE, SUITE 3900
                         RALEIGH, NORTH CAROLINA 27606
 
                            ------------------------
 
                                PROXY STATEMENT
 
                             ---------------------
 
                     FOR THE ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON MAY 11, 1998
 
                      GENERAL INFORMATION FOR STOCKHOLDERS
 
    THE ENCLOSED PROXY ("PROXY") IS SOLICITED ON BEHALF OF THE BOARD OF
DIRECTORS (THE "BOARD") OF ATLANTIC PHARMACEUTICALS, INC., A DELAWARE
CORPORATION (THE "COMPANY"), FOR USE AT THE 1998 ANNUAL MEETING OF STOCKHOLDERS
(THE "ANNUAL MEETING") TO BE HELD AT 10:00 A.M. EASTERN DAYLIGHT TIME ON MONDAY,
MAY 11, 1998, AT THE OFFICES OF ATLANTIC PHARMACEUTICALS, INC., 1017 MAIN CAMPUS
DRIVE, SUITE 3900, RALEIGH, NORTH CAROLINA 27606, AND AT ANY ADJOURNMENT OR
ADJOURNMENTS THEREOF.
 
    This Proxy Statement and the accompanying form of Proxy are to be first
mailed to the stockholders entitled to vote at the Annual Meeting on or about
April 15, 1998.
 
RECORD DATE AND VOTING
 
    The specific proposals to be considered and acted upon at the Annual Meeting
are summarized in the accompanying Notice and are described in more detail in
this Proxy Statement. Stockholders of record at the close of business on March
16, 1998 are entitled to notice of, and to vote at, the Annual Meeting. As of
the close of business on such date, there were 3,387,751 shares of the Company's
common stock, par value $0.001 per share (the "Common Stock"), outstanding and
entitled to vote, and held by 102 stockholders of record, and 1,062,826 shares
of the Company's Series A Convertible Preferred Stock, par value $0.001 per
share (the "Series A Preferred"), outstanding and entitled to vote, and held by
211 stockholders of record. Each holder of Common Stock is entitled to one vote
for each share of Common Stock held by such stockholder as of the record date.
Each holder of Series A Preferred is entitled to one vote for each share of
Common Stock into which such holder's Series A Preferred was convertible as of
the record date. As of the record date, each share of Series A Preferred was
convertible into 2.12 shares of Common Stock and, therefore, the class of Series
A Preferred is entitled to an aggregate of 2,253,191 votes. Stockholders may not
cumulate votes in the election of directors.
 
    If a choice as to the matters coming before the Annual Meeting has been
specified by a stockholder on the Proxy, the shares will be voted accordingly.
If no choice is specified, the shares will be voted IN FAVOR OF the election of
each of the directors proposed by the Board unless the authority to vote for the
election of any such director is withheld and, if no contrary instructions are
given, the proxy will be voted IN FAVOR OF the approval of Proposals 2, 3, 4, 5,
6 and 7 described in the Notice of Annual Meeting and in this Proxy Statement.
 
    Abstentions and broker non-votes (I.E., the submission of a Proxy by a
broker or nominee specifically indicating the lack of discretionary authority to
vote on the matter) are counted for purposes of determining the presence or
absence of a quorum for the transaction of business. Abstentions will be counted
towards the tabulation of votes cast on proposals presented to the stockholders
and will have the
 
                                       1

<PAGE>
same effect as negative votes, whereas broker non-votes will not be counted for
purposes of determining whether a proposal has been approved or not.
 
    Any stockholder or stockholder's representative who, because of a
disability, may need special assistance or accommodation to allow him or her to
participate at the Annual Meeting may request reasonable assistance or
accommodation from the Company by contacting Investor Relations in writing at
1017 Main Campus Drive, Suite 3900, Raleigh, North Carolina 27606 or by
telephone at (919) 513-7020. To provide the Company sufficient time to arrange
for reasonable assistance, please submit such requests by May 1, 1998.
 
                                   IMPORTANT
 
    PLEASE MARK, DATE, SIGN AND RETURN THE ENCLOSED PROXY IN THE ACCOMPANYING
POSTAGE-PREPAID, RETURN ENVELOPE NO LATER THAN MAY 1, 1998 SO THAT, IF YOU ARE
UNABLE TO ATTEND THE ANNUAL MEETING, YOUR SHARES MAY BE VOTED.
 
REVOCABILITY OF PROXIES
 
    Any stockholder giving a Proxy pursuant to this solicitation may revoke it
at any time prior to its exercise. Stockholders of record may revoke their Proxy
by filing with the Secretary of the Company at its principal executive offices
at 1017 Main Campus Drive, Suite 3900, Raleigh, North Carolina 27606 a duly
executed Proxy bearing a later date or by attending the Annual Meeting and
voting their shares in person. Persons who hold their shares of the Company in
street name may revoke their Proxy by contacting their broker to obtain a legal
ballot and filing such ballot bearing a later date with the Secretary of the
Company at its principal executive offices or by attending the Annual Meeting
and voting such legal ballot in person.
 
SOLICITATION
 
    The Company will bear the entire cost of solicitation, including the
preparation, assembly, printing and mailing of the Notice of Annual Meeting,
this Proxy Statement, the Proxy and any additional solicitation materials
furnished to stockholders. Copies of solicitation materials will be furnished to
brokerage houses, fiduciaries and custodians holding shares in their names that
are beneficially owned by others so that they may forward this solicitation
material to such beneficial owners. To assure that a quorum will be present in
person or by proxy at the Annual Meeting, it may be necessary for certain
officers, directors, employees or other agents of the Company to solicit Proxies
by telephone, facsimile or other means or in person. The Company will not
compensate such individuals for any such services. The Company does not
presently intend to solicit Proxies other than by mail.
 
    Whether or not you expect to attend the Annual Meeting in person, please
mark, date, sign and return the enclosed Proxy in the accompanying postage
prepaid, return envelope no later than May 1, 1998.
 
    THE COMPANY'S ANNUAL REPORT TO STOCKHOLDERS FOR THE YEAR ENDED DECEMBER 31,
1997 (THE "ANNUAL REPORT") AND ANNUAL REPORT ON FORM 10-KSB FOR THE YEAR ENDED
DECEMBER 31, 1997 (THE "FORM 10-KSB") HAVE BEEN MAILED CONCURRENTLY WITH THE
MAILING OF THE NOTICE OF ANNUAL MEETING AND PROXY STATEMENT TO ALL STOCKHOLDERS
ENTITLED TO NOTICE OF AND TO VOTE AT THE ANNUAL MEETING. NEITHER THE ANNUAL
REPORT NOR THE FORM 10-KSB IS INCORPORATED INTO THIS PROXY STATEMENT AND NEITHER
IS CONSIDERED PROXY SOLICITING MATERIAL.
 
                                       2

<PAGE>
                 MATTERS TO BE CONSIDERED AT THE ANNUAL MEETING

                      PROPOSAL ONE--ELECTION OF DIRECTORS
 
    At the Annual Meeting, a Board of six directors will be elected to serve for
one year and until their successors shall have been duly elected and qualified
or until their earlier resignation or removal. The Board has selected six
nominees, all of whom are current directors of the Company. Each person
nominated for election has agreed to serve if elected, and management has no
reason to believe that any nominee will be unavailable to serve. Unless
otherwise instructed, the Proxy holders will vote the Proxies received by them
IN FAVOR OF the nominees named below. The six candidates receiving the highest
number of affirmative votes of the shares entitled to vote at the Annual Meeting
will be elected. The holders of Common Stock and Series A Preferred vote
together as a class for the election of directors. If any nominee is unable to
or declines to serve as a director, the Proxies may be voted for a substitute
nominee designated by the current Board. As of the date of this Proxy Statement,
the Board is not aware of any nominee who is unable or will decline to serve as
a director.
 
 
   THE BOARD RECOMMENDS THAT THE STOCKHOLDERS VOTE IN FAVOR OF THE ELECTION OF
EACH OF THE FOLLOWING NOMINEES TO SERVE AS DIRECTORS OF THE COMPANY UNTIL THE
NEXT ANNUAL MEETING OF STOCKHOLDERS AND UNTIL THEIR SUCCESSORS HAVE BEEN DULY
ELECTED AND QUALIFIED OR UNTIL THEIR EARLIER RESIGNATION OR REMOVAL.
 
INFORMATION WITH RESPECT TO NOMINEES
 
    Set forth below is information regarding the nominees.
 

<TABLE>
<CAPTION>
NAME OF NOMINEE                                AGE      POSITION(S) WITH THE COMPANY   DIRECTOR SINCE
- -----------------------------------------      ---      -----------------------------  ---------------
<S>                                        <C>          <C>                            <C>
Jon D. Lindjord..........................          50   Director, President and                1995
                                                          Chief Executive Officer
 
Robert A. Fildes, Ph.D...................          59   Director                               1997
 
Yuichi Iwaki, M.D., Ph.D.................          48   Director                               1996
 
Steven H. Kanzer, C.P.A., Esq............          34   Director                               1993
 
John K.A. Prendergast, Ph.D..............          42   Director                               1994
 
Paul D. Rubin, M.D.......................          44   Director                               1998
</TABLE>

 
BUSINESS EXPERIENCE OF NOMINEES
 
    JON D. LINDJORD assumed the position of Chief Executive Officer and
President of the Company effective August 1995 and was elected a director of the
Company in December 1995. Since August 1995, Mr. Lindjord also has served as
Chief Executive Officer and President of each of the Company's subsidiaries,
Optex Ophthalmologics, Inc. ("Optex"), Gemini Technologies, Inc. ("Gemini") and
Channel Therapeutics, Inc. ("Channel"), and, since January 1997, Mr. Lindjord
also has served as a director of each of Optex, Gemini and Channel. From 1988 to
1994, Mr. Lindjord worked for G.D. Searle, a pharmaceutical company, in a
variety of positions including Vice President, Corporate Marketing Planning;
Vice President, International Marketing Operations; and, most recently, Managing
Director, Eastern Europe and Russia. During the period from 1985 to 1988, Mr.
Lindjord instituted a new department at Pfizer Pharmaceuticals with the role of
optimizing two-way communications between the marketing, licensing and business
units at the New York City headquarters and the research and development
division in Groton, Connecticut. During 1984 to 1985, Mr. Lindjord served as
Director of Business Development, Medicinal Products at Bristol-Myers
International Group. Mr. Lindjord received his B.A. from Princeton University
and his M.B.A. from the Darden School at the University of Virginia.
 
    ROBERT A. FILDES, PH.D. has served as a director of the Company since
October 1997. Since August 1997, Dr. Fildes has been an independent business
consultant in the pharmaceutical industry. Dr. Fildes served
 
                                       3

<PAGE>
as Chairman of the Board and Chief Executive Officer of Scotgen
Biopharmaceuticals Inc., a biotechnology company, from February 1993 to August
1997, during which time Scotgen filed a bankruptcy petition. From August 1990 to
January 1993, he was an independent business consultant in the pharmaceutical
industry. Dr. Fildes was President and Chief Executive Officer of Cetus
Corporation, a biopharmaceutical company, from 1982 to 1990. From 1980 to 1982,
he was President of Biogen, Inc., the United States subsidiary of Biogen, N.V.,
Geneva, Switzerland. Dr. Fildes is a director of two publicly traded
biopharmaceutical companies: Carrington Laboratories, Inc., and La Jolla
Pharmaceutical Co., and several privately held companies.
 
    YUICHI IWAKI, M.D., PH.D. has served as a director of the Company since
August 1996. He has been a Director of the Transplantation Immunology and
Immunogenetics Laboratory in the Department of Urology at the University of
Southern California and a Professor of Urology and Pathology at the University
of Southern California School of Medicine since 1992. Prior to that, Dr. Iwaki
held various academic appointments at the University of Southern California
School of Medicine, the University of Pittsburgh, the University of California
at Los Angeles, Sapporo Medical School and Nihon University School of Medicine.
Dr. Iwaki, who received his M.D. and Ph.D. from Sapporo Medical School in Japan,
also serves as a director of Avigen, Inc., a publicly traded biotechnology
company, and of a second privately held company.
 
    STEVEN H. KANZER, C.P.A., ESQ. has served as a director of the Company since
its inception in 1993. Mr. Kanzer has been since 1992 a founder and Senior
Managing Director of Paramount Capital, Inc. ("Paramount"), an investment bank
specializing in the biotechnology and biopharmaceutical industries, and Senior
Managing Director--Head of Venture Capital of Paramount Capital Investments, LLC
("Paramount Investments"), a biotechnology and biopharmaceutical venture capital
and merchant banking firm that is associated with Paramount. Mr. Kanzer is a
member of the Board of Directors of Boston Life Sciences, Inc. and Endorex Corp.
and is the Chairman of the Board of Directors of Discovery Laboratories, Inc.,
all publicly traded biotechnology companies. He is also a founder, Chairman and
Interim President of several private biotechnology companies. Prior to joining
Paramount, Mr. Kanzer was an attorney with Skadden, Arps, Slate, Meagher & Flom
LLP in New York, New York from September 1988 to October 1991. Mr. Kanzer
received his J.D. from New York University School of Law and a B.B.A. in
Accounting from Baruch College.
 
    JOHN K.A. PRENDERGAST, PH.D. is a co-founder of the Company, as well as of
two of its subsidiaries, Optex and Channel. Dr. Prendergast has served as a
director of the Company since August 1994. Since February 1998, Dr. Prendergast
has been an independent business consultant in the pharmaceutical industry. From
October 1991 to January 1998, Dr. Prendergast served as a Managing Director of
Paramount Investments. Dr. Prendergast serves as a director of the following
publicly traded biopharmaceutical companies: Avigen, Inc., Avax Technologies,
Inc., Xenometrix, Inc., and of several privately held companies. Dr. Prendergast
received his M.Sc. and Ph.D. from the University of New South Wales, Sydney,
Australia and a CSS in Administration and Management from Harvard University.
 
    PAUL D. RUBIN, M.D. has been a director of the Company since March 1998. Dr.
Rubin is currently Senior Vice President, Drug Development of Sepracor Inc., a
pharmaceutical company, where he has been employed since April 1996. He was
formerly Vice President and Worldwide Director of Clinical Pharmacology for
Glaxo-Wellcome, a pharmaceutical company, from 1993 to April 1996 and Vice
President, Immunology and Metabolic Disease for Abbott Laboratories, a
pharmaceutical company, from 1987 to 1993.
 
NUMBER OF DIRECTORS; RELATIONSHIPS
 
    The Company's Bylaws authorize the Board to fix by resolution the number of
directors serving on the Board, provided that such number is one or more. Since
March 13, 1998, the number of directors has been fixed at six. All directors
hold office until the annual meeting of stockholders following the initial
election
 
                                       4

<PAGE>
or appointment of such director and until their successors have been duly
elected and qualified, or until their earlier resignation or removal. Officers
are appointed to serve at the discretion of the Board.
 
    There are no family relationships among the executive officers or directors
of the Company.
 
BOARD MEETINGS AND COMMITTEES
 
    The Board held five meetings and acted once by unanimous written consent
during the 1997 fiscal year. Each of the directors participated in or attended
at least 75% of the aggregate number of meetings held during the period that
such director was a member of the Board, except that Mr. Kanzer attended two
meetings of the Board during the 1997 fiscal year.
 
    The Board has an Audit Committee and a Compensation Committee, but not a
standing Nominating Committee. The Audit Committee, which is composed of Mr.
Kanzer and Dr. Prendergast, reviews the professional services provided by the
Company's independent auditors and monitors the scope and results of the annual
audit; reviews proposed changes in the Company's financial and accounting
standards and principles; reviews the Company's policies and procedures with
respect to its internal accounting, auditing and financial controls; makes
recommendations to the Board on the engagement of the independent auditors and
addresses other matters that may come before it or as directed by the Board of
Directors. The Audit Committee did not hold any meetings during the 1997 fiscal
year.
 
    The Compensation Committee, which is composed of Mr. Kanzer, Dr. Fildes and
Dr. Prendergast, sets the compensation for certain of the Company's personnel
and administers the Company's 1995 Stock Option Plan, as amended and restated
(the "1995 Stock Option Plan"). The Compensation Committee acted once by
unanimous written consent during the 1997 fiscal year.
 
DIRECTOR COMPENSATION
 
    Non-employee Board members are eligible to participate in the automatic
stock option grant program pursuant to the Company's 1995 Stock Option Plan.
Non-employee directors are granted an option for 10,000 shares of the Company's
Common Stock upon their initial election or appointment to the Board and an
option for 2,000 shares of the Company's Common Stock on the date of each annual
meeting of the Company for those non-employee directors continuing to serve
after such meeting. Pursuant to the automatic stock option grant program, the
Company granted each of Drs. Iwaki and Prendergast and Mr. Kanzer an option on
July 24, 1997 for 2,000 shares of Common Stock at an exercise price of $7.00 per
share, the fair market value of the Company's Common Stock on the date of grant.
Also pursuant to the automatic stock option grant program, the Company granted
Dr. Fildes an option on October 24, 1997 for 10,000 shares of Common Stock at an
exercise price of $9.875 per share, the fair market value of the Company's
Common Stock on the date of grant, and Dr. Rubin an option on March 13, 1998 for
10,000 shares of Common Stock at an exercise price of $6.8125, the fair market
value of the Company's Common Stock on the date of grant.
 
    Subject to the approval of the holders of 66.67% of the Company's Series A
Preferred, effective October 24, 1997, each non-employee member of the Board is
to receive $6,000 per year for his services as a director, payable semi-annually
in arrears, plus $1,500 for each Board meeting attended in person, $750 for each
Board meeting attended via telephone conference call and $500 for each meeting
of a Committee of the Board attended.
 
    Board members are reimbursed for reasonable expenses incurred in connection
with attendance at meetings of the Board and of Committees of the Board.
 
    Subject to the approval of the holders of 66.67% of the Company's Series A
Preferred, on March 13, 1998 the Board (with Drs. Iwaki and Prendergast
abstaining) approved a Financial Services Agreement and a Consultancy Agreement,
each between the Company and Dr. Iwaki. Pursuant to the terms of the Financial
Services Agreement, Dr. Iwaki is to provide financial advisory services to the
Company and the
 
                                       5

<PAGE>
Company is to pay Dr. Iwaki a fee of five percent of the value of the
compensation (whether cash or securities or a combination thereof) received by
the Company in the event Dr. Iwaki is instrumental to the Company in
consummating certain financing or strategic transactions. Such Financial
Services Agreement is to supersede a financial services agreement, previously
entered into between the Company and Dr. Iwaki, under which Dr. Iwaki had not
received any compensation from the Company. Pursuant to the terms of the
Consultancy Agreement, Dr. Iwaki is to provide medical and scientific
consultation and advice to the Company and the Company is to pay Dr. Iwaki a
retainer of $5,000 per month, as well as a per diem of $1,000 per day when Dr.
Iwaki is providing services pursuant to the Consultancy Agreement or the
Financial Services Agreement, and is to grant Dr. Iwaki a fully-vested option,
exercisable for 30,000 shares of the Company's Common Stock, at an exercise
price of $6.8125 per share, the fair market value of the Company's Common Stock
on March 13, 1998. Such Consultancy Agreement is to supersede a consultancy
agreement previously entered into between the Company and Dr. Iwaki pursuant to
which the Company paid Dr. Iwaki a consulting fee of $2,500 per month.
 
    Subject to the approval of the holders of 66.67% of the Company's Series A
Preferred, on March 13, 1998 the Board (with Drs. Iwaki and Prendergast
abstaining) approved a Financial Services Agreement and a Consultancy Agreement,
each between the Company and Dr. Prendergast. Pursuant to the terms of the
Financial Services Agreement, Dr. Prendergast is to provide financial advisory
services to the Company and the Company is to pay Dr. Prendergast a fee of five
percent of the value of the compensation (whether cash or securities or a
combination thereof) received by the Company in the event Dr. Prendergast is
instrumental to the Company in consummating certain financing or strategic
transactions. Pursuant to the terms of the Consultancy Agreement, Dr.
Prendergast is to provide business development and consultation and advice to
the Company and the Company is to pay Dr. Prendergast a retainer of $5,000 per
month, as well as a per diem of $1,000 per day when Dr. Prendergast is providing
services pursuant to the Consultancy Agreement, and is to grant Dr. Prendergast
a fully-vested option, exercisable for 30,000 shares of the Company's Common
Stock, at an exercise price of $6.8125 per share, the fair market value of the
Company's Common Stock on March 13, 1998. Such Consultancy Agreement is to
supersede a consultancy agreement previously entered into between the Company
and Summercloud Bay, Inc., a corporation wholly owned by Dr. Prendergast,
pursuant to which the Company paid Summercloud Bay a consulting fee of $2,500
per month and had issued a warrant exercisable for 37,500 shares of the
Company's Common Stock at an exercise price of $5.33 per share.
 
    Each employee of the Company who is also a director of the Company does not
receive any additional compensation for his service on the Board.
 
                                       6

<PAGE>

                           PROPOSAL TWO--APPROVAL OF
                           AMENDMENT TO THE COMPANY'S

                     RESTATED CERTIFICATE OF INCORPORATION
 
INTRODUCTION
 
    On March 13, 1998, the Board of Directors adopted, subject to stockholder
approval, a proposed amendment of the Company's Restated Certificate of
Incorporation, as amended (the "Certificate"), to decrease the number of
authorized shares of the Common Stock from 80,000,000 to 50,000,000 and the
number of authorized shares of Preferred Stock, par value $0.001 per share (the
"Preferred Stock"), from 50,000,000 to 10,000,000. The Board recommends to the
stockholders the proposed amendment of the Certificate to decrease the number of
authorized shares of Common Stock and Preferred Stock because the Board believes
that (1) the reduced number of authorized shares is sufficient to meet the needs
of the Company for at least the next three to five years and (2) reducing the
number of authorized shares will result in a decrease in the Company's corporate
franchise tax liability to the State of Delaware.
 
    As of the close of business on March 16, 1998, there were 3,387,751 shares
of the Company's Common Stock outstanding and an aggregate of 7,352,011 shares
of Common Stock reserved for issuance pursuant to the 1995 Stock Option Plan,
upon the exercise of outstanding warrants, upon the conversion of the
outstanding shares of Series A Preferred and upon the exercise (and subsequent
conversion into shares of Common Stock) of outstanding warrants exercisable for
Series A Preferred. Accordingly, based on the number of fully-diluted shares of
Common Stock as of the close of business on March 16, 1998, the Company would
have remaining 39,260,238 shares of Common Stock to issue if the Certificate
were amended to decrease to 50,000,000 the number of authorized shares of Common
Stock. The Company believes that such number of shares of Common Stock is
sufficient to meet the needs of the Company for at least the next three to five
years.
 
    As of the close of business on March 16, 1998, 1,375,000 shares of the
Preferred Stock had been designated as Series A Preferred. Accordingly, based on
the number of shares of Preferred Stock designated as of the close of business
on March 16, 1998, the Company would have remaining 8,625,000 shares of
Preferred Stock to issue if the Certificate were amended to decrease to
10,000,000 the number of authorized shares of Preferred Stock. The Company
believes that such number of shares of Preferred Stock is sufficient to meet the
needs of the Company for at least the next three to five years.
 
    In addition, the proposed amendment will reduce the Company's corporate
franchise tax liability to the State of Delaware. Delaware's corporate franchise
tax is based, in part, on the number of shares of stock authorized in a
corporation's certificate of incorporation. As a result of reducing, by
approximately 50%, the number of shares authorized in the Company's Certificate,
the Company annually will save approximately 50% of the corporate franchise
taxes that it would otherwise be obligated to pay to the State of Delaware. If
the proposed amendment had been effective at the beginning of fiscal year 1997,
the Company would have saved approximately $25,000 in corporate franchise taxes
payable to the State of Delaware for fiscal year 1997.
 
    It is expected that the proposed amendment of the Certificate, if approved
by the stockholders, will be made effective on or about May 11, 1998 by the
filing and recording of an appropriate Certificate of Amendment as required
under Delaware law.
 
STOCKHOLDER APPROVAL
 
    The affirmative vote of the holders of a majority of the outstanding shares
of Common Stock and Series A Preferred, voting together as a class, present in
person or represented by Proxy at the Annual Meeting and entitled to vote on
this Proposal Two is required for approval of the amendment of the Certificate
to decrease the number of authorized shares of Common Stock and the number of
authorized shares of Preferred Stock.
 
                                       7

<PAGE>
RECOMMENDATION OF THE BOARD OF DIRECTORS
 
 
   The Board of Directors recommends that the stockholders vote FOR the
approval of the amendment of the Certificate as described in this Proposal Two.
The Board believes that approval of the amendment of the Certificate is in the
best interests of the Company because (1) the reduced number of authorized
shares should be sufficient to meet the needs of the Company for at least the
next three to five years and (2) reducing the number of authorized shares will
result in a decrease in the Company's corporate franchise tax liability to the
State of Delaware. ACCORDINGLY, THE BOARD RECOMMENDS THAT THE STOCKHOLDERS VOTE
IN FAVOR OF THE APPROVAL OF THE AMENDMENT OF THE CERTIFICATE TO REDUCE THE
NUMBER OF AUTHORIZED SHARES OF COMMON STOCK AND THE NUMBER OF AUTHORIZED SHARES
OF PREFERRED STOCK.
 
                                       8

<PAGE>

                   PROPOSAL THREE--RATIFICATION OF SELECTION
                            OF INDEPENDENT AUDITORS
 
    The Board has appointed the firm of KPMG Peat Marwick LLP, independent
auditors, to audit the financial statements of the Company for the year ending
December 31, 1998 and is asking the stockholders to ratify this appointment.
 
    In the event the stockholders fail to ratify the appointment, the Board will
reconsider its selection. Even if the selection is ratified, the Board in its
discretion may direct the appointment of a different independent auditing firm
at any time during the year if the Board feels that such a change would be in
the best interests of the Company and its stockholders. The affirmative vote of
the holders of a majority of the shares of Common Stock and shares of Series A
Preferred, voting together as a class, present or represented by Proxy at the
Annual Meeting and entitled to vote is required to ratify the selection of KPMG
Peat Marwick LLP.
 
    KPMG Peat Marwick LLP commenced its annual audit of the Company's financial
statements in December 1995. A representative of KPMG Peat Marwick LLP is
expected to be present at the Annual Meeting to respond to appropriate questions
and will be given the opportunity to make a statement if he or she so desires.
 
RECOMMENDATION OF THE BOARD OF DIRECTORS
 
 
   THE BOARD RECOMMENDS THAT THE STOCKHOLDERS VOTE IN FAVOR OF THE RATIFICATION
OF THE SELECTION OF KPMG PEAT MARWICK LLP TO SERVE AS THE COMPANY'S INDEPENDENT
AUDITORS FOR THE YEAR ENDING DECEMBER 31, 1998.
 
                                       9

<PAGE>
                           PROPOSAL FIVE--APPROVAL OF
                       NON-EMPLOYEE DIRECTOR COMPENSATION
 
    On October 24, 1997, the Board approved resolutions providing that as of
such date, in addition to any other compensation arrangements then in place,
each non-employee director of the Company shall be paid (a) $1,500 for each
regularly scheduled or special Board meeting attended in person, (b) $750 for
each regularly scheduled or special Board meeting attended by telephone and (c)
$500 for attendance at a meeting of a committee of the Board (whether attended
in person or by telephone) on which such director serves as a member. In
addition, each non-employee director is to receive an annual fee of $6,000,
payable bi-annually and pro-rated for any period of time that such director has
not served for a full six months.
 
    Pursuant to Section 6(b)(vii) of the Certificate of Designations of the
Series A Preferred as filed with the Secretary of State of the State of Delaware
on May 22, 1997, for so long as at least 50% of the shares of Series A Preferred
are outstanding, the affirmative vote of the holders of at least 66 2/3% of all
outstanding Series A Preferred voting separately as a class is necessary to
permit, effect or validate the Board's approval of any transaction between the
Company and its affiliates, including directors.
 
    Currently, Board members are reimbursed by the Company for reasonable
expenses incurred in connection with attendance of Board and committee meetings.
Directors who are also employees of the Company do not receive any additional
compensation for service on the Board. Currently, all directors are eligible to
receive payments under the proposal, except Mr. Lindjord, who is a Company
employee.
 
RECOMMENDATION OF THE BOARD OF DIRECTORS
 
    The Board recommends that the holders of Series A Preferred vote FOR the
approval of compensatory payments to non-employee directors, commencing as of
October 24, 1997, the date of Board approval. The Board believes that such
payments are in the best interest of the Company because, together with director
indemnification, they are essential for the Company to attract and retain highly
qualified individuals to contribute to the Company's financial success. Such
payments are common among the Company's competitors and competition for
qualified Board candidates is increasingly intense. CONSEQUENTLY, THE BOARD
RECOMMENDS THAT THE HOLDERS OF SERIES A PREFERRED VOTE IN FAVOR OF THE APPROVAL
OF PAYMENTS TO BE MADE BY THE COMPANY TO THE COMPANY'S NON-EMPLOYEE DIRECTORS AS
DESCRIBED ABOVE.
 
                                       10

<PAGE>
                     PROPOSAL SIX--APPROVAL OF CONSULTANCY
                AND FINANCIAL SERVICES AGREEMENTS WITH DR. IWAKI
 
    Subject to the approval of the holders of shares of the Company's Series A
Preferred, on March 13, 1998 the Board approved the Company's entering into each
of a Consultancy Agreement and a Financial Services Agreement with Yuichi Iwaki,
M.D., Ph.D. Dr. Iwaki and Dr. Prendergast abstained from such vote.
 
    Pursuant to Section 6(b)(vii) of the Certificate of Designations of the
Series A Preferred as filed with the Secretary of State of the State of Delaware
on May 22, 1997, for so long as at least 50% of the shares of Series A Preferred
are outstanding, the affirmative vote of the holders of at least 66 2/3% of all
outstanding Series A Preferred voting separately as a class is necessary to
permit, effect or validate the Board's approval of any transaction between the
Company and its affiliates, including directors.
 
    Dr. Iwaki is currently Director of the Transplantation Immunology and
Immunogenetics Laboratory in the Department of Urology at the University of
Southern California and a Professor of Urology and Pathology at the University
of Southern California School of Medicine. Under the terms of the Consultancy
Agreement, which shall have an initial term of three years, Dr. Iwaki will
commit to advise the Company, among other things, with respect to the direction
of its research and product development and business development activities. The
Company will pay to Dr. Iwaki $5,000 per month for such services, plus $1,000
per day spent traveling and/or performing services for the Company.
Additionally, the Company will issue to Dr. Iwaki a fully-vested option to
purchase up to 30,000 shares of Common Stock of the Company at an exercise price
of $6.8125 per share, the fair market value of such shares on March 13, 1998,
pursuant to the Company's 1995 Stock Option Plan. Such option will terminate on
March 12, 2005. In addition to providing consulting services, Dr. Iwaki will
agree not to employ or solicit any Company employee during the term of the
agreement and for a period of one year thereafter, and will assign to the
Company ownership of any intellectual property arising from his consulting
activities. The Consultancy Agreement will be terminable by either party upon 30
days' notice, and will supersede an earlier agreement pursuant to which the
Company paid Dr. Iwaki $2,500 per month.
 
    Under the Financial Services Agreement, Dr. Iwaki will undertake for an
initial period of three years to initiate and pursue contacts in the Japanese
financial and scientific communities with respect to obtaining an equity
investment in the Company or forming a collaborative scientific or business
relationship, in each case with a specific group of potential parties approved
by the Company. If the Company enters into such a transaction within one year
following Dr. Iwaki's introduction to such investor or collaborator, then the
Company shall pay to Dr. Iwaki a fee equal to 5% of the proceeds of such
transaction or transactions. To the extent the transaction involves the issuance
of Company securities, Dr. Iwaki may elect to receive a warrant from the Company
for an amount of securities equal to 5% of those issued in the transaction, less
the amount of any cash fee paid to Dr. Iwaki by the Company. Any such warrant
shall be exercisable for a period of five years at an exercise price equal to
the par value of the underlying securities, and shall have a cashless exercise
feature. The Company will also reimburse Dr. Iwaki's reasonable costs and
expenses incurred in connection with his activities thereunder. The Financial
Services Agreement will be terminable by either party upon 30 days' notice.
 
RECOMMENDATION OF THE BOARD OF DIRECTORS
 
    The Board believes that Dr. Iwaki would continue to provide an invaluable
service to the Company as both a scientific consultant and a financial advisor.
Dr. Iwaki is eminent in his field and enjoys a particularly strong reputation
among the Japanese scientific community, towards which his efforts will be
directed in connection with the Financial Advisory Agreement. If however, Dr.
Iwaki is unsuccessful in finding an investor or collaborator, the Company will
not be committed to paying any contingent fee. CONSEQUENTLY, THE BOARD
RECOMMENDS THAT THE HOLDERS OF SHARES OF SERIES A PREFERRED VOTE IN FAVOR OF THE
PROPOSED AGREEMENTS WITH DR. IWAKI.
 
                                       11

<PAGE>
                    PROPOSAL SEVEN--APPROVAL OF CONSULTANCY
             AND FINANCIAL SERVICES AGREEMENTS WITH DR. PRENDERGAST
 
    Subject to the approval of the holders of shares of the Company's Series A
Preferred, on March 13, 1998 the Board approved the Company's entering into each
of a Consultancy Agreement and a Financial Services Agreement with John K.A.
Prendergast, Ph.D. Dr. Iwaki and Dr. Prendergast abstained from such vote.
 
    Pursuant to Section 6(b)(vii) of the Certificate of Designations of the
Series A Preferred as filed with the Secretary of State of the State of Delaware
on May 22, 1997, for so long as at least 50% of the shares of Series A Preferred
are outstanding, the affirmative vote of the holders of at least 66 2/3% of all
outstanding Series A Preferred voting separately as a class is necessary to
permit, effect or validate the Board's approval of any transaction between the
Company and its affiliates, including directors.
 
    Dr. Prendergast co-founded the Company and two of its subsidiaries, and has
recently begun work as an independent business consultant to the pharmaceutical
industry after more than six years as a Managing Director of Paramount
Investments. Under the terms of the Consultancy Agreement, which shall have an
initial term of three years, Dr. Prendergast will commit to advise the Company
regarding, among other things, its business development activities. The Company
will pay to Dr. Prendergast $5,000 per month for such services, plus $1,000 per
day spent traveling and/or performing services for the Company. Additionally,
the Company will issue to Dr. Prendergast a fully-vested option to purchase up
to 30,000 shares of Common Stock of the Company at an exercise price of $6.8125
per share, the fair market value of such shares on March 13, 1998, pursuant to
the Company's 1995 Stock Option Plan. Such option will terminate on March 12,
2005. In addition to providing consulting services, Dr. Prendergast will agree
not to employ or solicit any Company employee during the term of the agreement
and for a period of one year thereafter, and will assign to the Company
ownership to any intellectual property arising from his consulting activities.
The Consultancy Agreement will be terminable by either party upon 30 days'
notice, and will supersede an earlier agreement between the Company and
Summercloud Bay, Inc., a corporation wholly owned by Dr. Prendergast, pursuant
to which the Company paid Summercloud Bay a consulting fee of $2,500 per month
and had issued a warrant exercisable for 37,500 shares of the Company's Common
Stock at an exercise price of $5.33 per share.
 
    Under the Financial Services Agreement, Dr. Prendergast will undertake for
an initial period of three years to initiate and pursue contacts in the
financial and scientific communities with respect to obtaining an equity
investment in the Company or forming a collaborative scientific or business
relationship, in each case with a specific group of potential parties approved
by the Company. If the Company enters into such a transaction within one year
following Dr. Prendergast's introduction to such investor or collaborator, then
the Company shall pay to Dr. Prendergast a fee equal to 5% of the proceeds of
such transaction or transactions, payable in cash or warrant, at the Company's
election. To the extent the transaction involves the issuance of Company
securities, Dr. Prendergast may elect to receive a warrant from the Company for
an amount of securities equal to 5% of those issued in the transaction, less the
amount of any cash fee paid to Dr. Prendergast by the Company. Any such warrant
shall be exercisable for a period of five years at an exercise price equal to
the par value of the underlying securities, and shall have a cashless exercise
feature. The Company will also reimburse Dr. Prendergast's reasonable costs and
expenses incurred in connection with his activities thereunder. The Financial
Services Agreement may be terminated by either party upon 30 days' notice.
 
RECOMMENDATION OF THE BOARD OF DIRECTORS
 
    Because of Dr. Prendergast's years of experience in both the
biopharmaceutical and the financial and investment banking communities, the
Board believes that Dr. Prendergast would continue to provide an invaluable
service to the Company as both a scientific consultant and a financial advisor.
If however, Dr. Prendergast is unsuccessful in finding an investor or
collaborator, the Company will not be committed
 
                                       12

<PAGE>
to paying any contingent fee. CONSEQUENTLY, THE BOARD RECOMMENDS THAT THE
HOLDERS OF SHARES OF SERIES A PREFERRED VOTE IN FAVOR OF THE PROPOSED AGREEMENTS
WITH DR. PRENDERGAST.
 

                  EXECUTIVE COMPENSATION AND OTHER INFORMATION
 
EXECUTIVE OFFICERS
 
    Certain information about the Company's executive officers is set forth
below (information concerning the Company's directors is contained in Proposal
One above):
 

<TABLE>
<CAPTION>
NAME                                         AGE                         POSITION
- ---------------------------------------      ---      -----------------------------------------------
<S>                                      <C>          <C>
Stephen R. Miller, M.D.................          40   Senior Vice President, Chief Scientific and
                                                        Medical Officer
 
Margaret A. Schalk.....................          40   Vice President, Investor Relations and Project
                                                        Management
 
Shimshon Mizrachi......................          44   Chief Financial Officer, Treasurer and
                                                        Assistant Secretary
</TABLE>

 
    STEPHEN R. MILLER, M.D. assumed the position of Vice President and Chief
Medical Officer in September 1995 and was promoted to Senior Vice President,
Chief Scientific and Medical Officer in September 1996. Commencing September
1995, Dr. Miller also had served as Vice President and Chief Medical Officer of
each of the Company's subsidiaries, Optex, Gemini and Channel and, commencing
September 1996, Dr. Miller was promoted to Senior Vice President, Chief
Scientific and Medical Officer of each of Optex, Gemini and Channel. From
December 1985 through August 1995, Dr. Miller served in a variety of positions
of increasing responsibility in the research and development and the marketing
divisions of G.D. Searle, a pharmaceutical company ("G.D. Searle"), including
Senior Director, Technology Planning; Senior Director, International Marketing
Operations; Director, Cardiovascular Marketing; and Associate Director, Clinical
Research and Development. Dr. Miller is board certified in Internal Medicine and
has been an Instructor of Clinical Medicine at the Chicago Medical School since
1985. Dr. Miller received his M.D., SUMMA CUM LAUDE, from the University of
Witwatersrand Medical School, Johannesburg, South Africa.
 
    MARGARET A. SCHALK assumed the position of Senior Director, Project
Management in September 1995 and was promoted to Vice President, Investor
Relations and Project Management in September 1996. Commencing September 1995,
Ms. Schalk also had served as Senior Director, Project Management of each of the
Company's subsidiaries, Optex, Gemini and Channel and, commencing September
1996, Ms. Schalk was promoted to Vice President, Investor Relations and Project
Management of each of Optex, Gemini and Channel. From 1987 to September 1995,
Ms. Schalk held positions of increasing responsibility in the areas of project
management, drug development and marketing at G.D. Searle, including Senior
Product Manager, International Marketing Operations; Director of Project
Management, Corporate Medical and Scientific Affairs; and Associate Director,
Drug Development, Corporate Medical and Scientific Affairs. Ms. Schalk received
her B.S. and M.S. from the University of Wisconsin, Milwaukee.
 
    SHIMSHON MIZRACHI assumed the position of Controller in November 1995 and
was promoted to Chief Financial Officer, Treasurer and Assistant Secretary in
September 1997. Since November 1995, Mr. Mizrachi also has served as Controller
of each of the Company's subsidiaries, Optex, Gemini and Channel. From April
1994 to November 1995, Mr. Mizrachi served as Assistant Manager for Caldor
Corp., a regional retail company. From 1987 to April 1994, Mr. Mizrachi held
management positions of increasing responsibility for MidIsland Department
Stores, a regional retail company. Mr. Mizrachi is a Certified Public
Accountant. He received his B.A. from Tel Aviv University, his M.B.A. from
Adelphi University and his second B.A. from Queens College in New York.
 
                                       13

<PAGE>
COMPENSATION OF EXECUTIVE OFFICERS
 
    The following table sets forth the compensation earned, for services
rendered in all capacities to the Company, for the last three fiscal years, by
the Company's Chief Executive Officer and the three other highest paid executive
officers serving as such at the end of 1997 whose compensation for that fiscal
year was in excess of $100,000. The individuals named in the table will be
hereinafter referred to as the "Named Officers." No other executive officer of
the Company received compensation in excess of $100,000 during fiscal year 1997.
No executive officer who would otherwise have been included in such table on the
basis of 1997 salary and bonus resigned or terminated employment during the
year.
 
                           SUMMARY COMPENSATION TABLE
 

<TABLE>
<CAPTION>
                                                                                                        LONG-TERM
                                                                                                   COMPENSATION AWARDS
                                                                  ANNUAL COMPENSATION              --------------------
                                                      -------------------------------------------       SECURITIES
                                                                                  OTHER ANNUAL          UNDERLYING
NAME AND PRINCIPAL POSITION                  YEAR     SALARY($)(1)  BONUS($)     COMPENSATION($)     OPTIONS/SARS(#)
- -----------------------------------------  ---------  -----------  -----------  -----------------  --------------------
<S>                                        <C>        <C>          <C>          <C>                <C>
                                                1997     225,000            0           9,500               40,000
Jon D. Lindjord .........................       1996     195,833       62,500          --                   60,000
  President and Chief Executive Officer         1995      72,717(2)          0         --                  180,000
 
Stephen R. Miller, M.D. .................       1997     164,200            0           9,500               30,000
  Senior Vice President, Chief Scientific       1996     145,175       20,000          --                  100,000
  and Medical Officer                           1995      40,278(3)         ]0         --                   39,959
 
Margaret A. Schalk ......................       1997     115,000            0           6,785               25,000
  Vice President, Investor Relations and        1996     104,375       15,000          --                   90,000
  Project Management                            1995      27,777(4)          0          1,420(5)            26,639
 
Shimshon Mizrachi .......................       1997     122,000            0           5,900               20,000
  Chief Financial Officer, Treasurer and        1996      91,250       10,000          --                   50,000
  Assistant Secretary                           1995      11,250(6)          0          2,000(7)            --
</TABLE>

 
- ------------------------
 
(1) Includes amounts deferred under the Company's SAR-SEP retirement plan
    pursuant to payroll deductions but does not include matching contributions
    of the Company.
 
(2) Mr. Lindjord's annual compensation was $175,000 for the 1995 fiscal year.
    The Summary Compensation Table sets forth compensation paid to Mr. Lindjord
    by the Company commencing August 1, 1995, when he first became President and
    Chief Executive Officer of the Company.
 
(3) Dr. Miller's annual compensation was $145,000 for the 1995 fiscal year. The
    Summary Compensation Table sets forth compensation paid to Dr. Miller by the
    Company commencing September 19, 1995, when he first became employed by the
    Company.
 
(4) Ms. Schalk's annual compensation was $100,000 for the 1995 fiscal year. The
    Summary Compensation Table sets forth compensation paid to Ms. Schalk
    commencing September 19, 1995, when she first became employed by the
    Company.
 
(5) Represents the reimbursement by the Company of certain moving expenses
    incurred by Ms. Schalk in relocating to Half Moon Bay, California.
 
(6) Mr. Mizrachi's annual compensation was $90,000 for the 1995 fiscal year. The
    Summary Compensation Table sets forth compensation paid to Mr. Mizrachi
    commencing November 15, 1995, when he first became employed by the Company.
 
(7) Represents the reimbursement by the Company of certain moving expenses
    incurred by Mr. Mizrachi in relocating to Half Moon Bay, California.
 
                                       14

<PAGE>
OPTIONS AND STOCK APPRECIATION RIGHTS
 
    The following table contains information concerning the grant of stock
options under the Company's 1995 Stock Option Plan to the Named Officers during
the 1997 fiscal year. Except as described in footnote (1) below, no stock
appreciation rights were granted during the 1997 fiscal year.
 
                     OPTION/SAR GRANTS IN LAST FISCAL YEAR
 

<TABLE>
<CAPTION>
                                                                       INDIVIDUAL GRANTS
                                          ---------------------------------------------------------------------------
                                               NUMBER OF
                                              SECURITIES         % OF TOTAL OPTIONS/SARS      EXERCISE
                                          UNDERLYING OPTIONS/    GRANTED TO EMPLOYEES IN        PRICE      EXPIRATION
NAME                                      SARS GRANTED(#)(1)         FISCAL YEAR(2)         ($/SHARE)(3)      DATE
- ----------------------------------------  -------------------  ---------------------------  -------------  ----------
<S>                                       <C>                  <C>                          <C>            <C>
Jon D. Lindjord.........................          40,000                       35%            $   6.625     01/14/04
 
Stephen R. Miller, M.D..................          30,000                       26%            $   6.625     01/14/04
 
Margaret A. Schalk......................          25,000                       22%            $   6.625     01/14/04
 
Shimshon Mizrachi.......................          20,000                       17%            $   6.625     01/14/04
</TABLE>

 
- ------------------------
 
(1) Each option has a maximum term of seven years, subject to earlier
    termination in the event of the optionee's cessation of service with the
    Company. The grant date for each of the options is January 15, 1997. Each
    option becomes exercisable in four equal annual installments upon completion
    of each year of service measured from the grant date. Each option will
    become immediately exercisable in full upon an acquisition of the Company by
    merger or asset sale, unless the option is assumed by the successor entity.
    Each option includes a limited stock appreciation right pursuant to which
    the optionee may surrender the option, to the extent exercisable for vested
    shares, upon the successful completion of a hostile tender for securities
    possessing more than 50% of the combined voting power of the Company's
    outstanding voting securities. In return for the surrendered option, the
    optionee will receive a cash distribution per surrendered option share equal
    to the excess of (i) the highest price paid per share of the Company's
    Common Stock in such hostile tender offer over (ii) the exercise price
    payable per share under the cancelled option.
 
(2) Calculated based on total option grants to employees of 115,000 shares of
    Common Stock during the 1997 fiscal year.
 
(3) The exercise price may be paid in cash or in shares of Common Stock (valued
    at fair market value on the exercise date) or through a cashless exercise
    procedure involving a same-day sale of the purchased shares. The Company may
    also finance the option exercise by loaning the optionee sufficient funds to
    pay the exercise price for the purchased shares and the federal and state
    income tax liability incurred by the optionee in connection with such
    exercise. The optionee may be permitted, subject to the approval of the Plan
    Administrator, to apply a portion of the shares purchased under the option
    (or to deliver existing shares of Common Stock) in satisfaction of such tax
    liability.
 
OPTION EXERCISES AND HOLDINGS
 
    The following table provides information with respect to the Named Officers
concerning the exercisability of options during fiscal year 1997 and
unexercisable options held as of the end of fiscal year 1997. No options or
stock appreciation rights were exercised during such fiscal year, and, except
for the limited rights described in footnote (1) to the preceding table, no
stock appreciation rights were outstanding at the end of that fiscal year.
 
                                       15

<PAGE>
                AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                            AND FY-END OPTION VALUES
 

<TABLE>
<CAPTION>
                                                                                           VALUE OF UNEXERCISED
                                                                                        IN-THE-MONEY OPTIONS/SARS
                                                                NO. OF SECURITIES       AT FY-END (MARKET PRICE OF
                                                              UNDERLYING UNEXERCISED      SHARES AT FY-END LESS
                                                            OPTIONS/SARS AT FY-END(#)     EXERCISE PRICE)($)(1)
                                                            --------------------------  --------------------------
NAME                                                        EXERCISABLE  UNEXERCISABLE  EXERCISABLE  UNEXERCISABLE
- ----------------------------------------------------------  -----------  -------------  -----------  -------------
<S>                                                         <C>          <C>            <C>          <C>
Jon D. Lindjord...........................................     105,000        175,000      389,100        422,300
 
Stephen R. Miller, M.D....................................      44,980        124,979       83,440        134,187
 
Margaret A. Schalk........................................      35,820        105,819       61,110        106,532
 
Shimshon Mizrachi.........................................      12,500         57,500       11,750         37,500
</TABLE>

 
- ------------------------
 
(1) Based on the fair market value of the Company's Common Stock on December 31,
    1997 of $6.75 per share, the closing sales price per share on that date on
    the Nasdaq SmallCap Market.
 
LONG TERM INCENTIVE PLAN AWARDS
 
    No long term incentive plan awards were made to a Named Officer during the
last fiscal year.
 
EMPLOYMENT CONTRACTS AND TERMINATION OF EMPLOYMENT AND CHANGE OF CONTROL
  AGREEMENTS
 
    Effective August 1, 1995, Mr. Lindjord became Chief Executive Officer and
President of the Company and of each of the subsidiaries of the Company pursuant
to a Letter Agreement dated July 7, 1995. Pursuant to such Agreement, the
Company agreed to pay Mr. Lindjord an annual salary of $175,000 payable
semi-monthly, in addition to a $25,000 discretionary bonus payable at the end of
Mr. Lindjord's first year of employment with the Company. In the event that the
Company terminates Mr. Lindjord's employment without cause, the Company is
obligated to continue to pay his salary for one year, subject to Mr. Lindjord's
duty to mitigate damages by seeking alternative employment. Further, pursuant to
such Agreement and under the Company's 1995 Stock Option Plan, the Company
issued to Mr. Lindjord options to purchase 180,000 shares of Common Stock
exercisable at a weighted average exercise price of $2.58 per share.
Furthermore, Mr. Lindjord and his dependents will be eligible to receive paid
medical and long-term disability insurance and such other health benefits as the
Company makes available to its other senior officers and directors.
 
    Effective September 19, 1995, Dr. Miller became Vice President, Chief
Medical Officer of the Company and of each of the Company's subsidiaries
pursuant to a Letter Agreement, dated September 19, 1995. Pursuant to such
Agreement, the Company agreed to pay Dr. Miller an annual salary of $145,000. In
the event that the Company terminates Dr. Miller's employment without cause, the
Company is obligated to continue to pay his salary for nine months, subject to
Dr. Miller's duty to mitigate damages by seeking alternative employment. In
addition, the Company issued Dr. Miller under the Company's 1995 Stock Option
Plan an option to purchase 39,959 shares of the Company's Common Stock at an
exercise price of $3.75 per share. Finally, Dr. Miller and his dependents will
be eligible to receive paid medical and long-term disability insurance and such
other health benefits as the Company makes available to its other senior
officers and directors.
 
                                       16

<PAGE>
    Effective September 19, 1995, Ms. Schalk became Senior Director, Project
Management of the Company and of each of the Company's subsidiaries pursuant to
a Letter Agreement, dated September 19, 1995. Pursuant to such Agreement, the
Company agreed to pay Ms. Schalk an annual salary of $100,000 and to reimburse
Ms. Schalk for up to $8,000 of expenses incurred by her to relocate to Half Moon
Bay, California. In the event that the Company terminates Ms. Schalk's
employment without cause, the Company is obligated to continue to pay her salary
for nine months, subject to Ms. Schalk's duty to mitigate damages by seeking
alternative employment. In addition, the Company issued Ms. Schalk under the
1995 Stock Option Plan an option to purchase 26,639 shares of the Company's
Common Stock at an exercise price of $3.75 per share. Finally, Ms. Schalk and
her dependents will be eligible to receive paid medical and long-term disability
insurance and such other health benefits as the Company makes available to its
other senior officers and directors.
 
    Effective November 15, 1995, Mr. Mizrachi became Controller of the Company
and of each of the Company's subsidiaries pursuant to a Letter Agreement, dated
November 6, 1995. Pursuant to such Agreement, the Company agreed to pay Mr.
Mizrachi an annual salary of $90,000 and to reimburse Mr. Mizrachi for up to
$8,000 of expenses incurred by him to relocate to Half Moon Bay, California. In
the event that the Company terminates Mr. Mizrachi's employment without cause,
the Company is obligated to continue to pay his salary for six months, subject
to Mr. Mizrachi's duty to mitigate damages by seeking alternative employment.
Finally, Mr. Mizrachi and his dependents will be eligible to receive paid
medical and long-term disability insurance and such other health benefits as the
Company makes available to its other senior officers and directors.
 
    The Compensation Committee has the discretion under the 1995 Stock Option
Plan to accelerate options granted to the Named Officers in connection with a
change in control of the Company or upon the subsequent termination of the
officer's employment following the change of control.
 
CHANGE OF CONTROL TRANSACTIONS
 
    The Company is not aware of any transactions resulting in a change of
control during fiscal year 1997.
 
C
ERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
 
    The Company's Restated Certificate of Incorporation and Bylaws provide for
indemnification of directors, officers and other agents of the Company. At the
1997 Annual Meeting of the Stockholders of the Company, the stockholders
approved the Company entering into an indemnification agreement with each of its
directors and executive officers. Accordingly, the Company has entered into an
indemnification agreement with each of its directors and executive officers.
 
    Prior to a private financing consummated in September 1995, the Company's
operations had been financed primarily through loans provided by Lindsay A.
Rosenwald, M.D., a principal stockholder and former director of the Company, and
VentureTek, L.P. ("VentureTek"), a principal stockholder of the Company. The
principal amount of such loans that had been advanced during the period from
July 25, 1993 to June 30, 1995 together with the interest thereon through June
30, 1995, was $1,085,027 to Dr. Rosenwald and $1,357,277 to VentureTek, L.P.
(such indebtedness, including accrued interest through June 30, 1995, is
collectively referred to as the "Stockholder Loans"). On December 31, 1995,
Stockholder Loans aggregating $2,442,304 in principal and interest were
converted into an aggregate of 785,234 shares of the Company's Common Stock.
 
    In addition to the Stockholder Loans, VentureTek provided a loan to the
Company in July 1995 in an aggregate principal amount of $125,000, bearing
interest at the rate of 10% annually. This loan, together with $115,011 interest
accrued on such loan and on the Stockholder Loans (from July 1, 1995 until the
conversion thereof into shares of Common Stock), was repaid on January 15, 1996
from the proceeds of the Company's initial public offering.
 
                                       17

<PAGE>
    Joseph Stevens & Co., Inc. ("Joseph Stevens"), a principal stockholder of
the Company, was the underwriter in the Company's initial public offering. In
connection with the initial public offering, Joseph Stevens and the Company
entered into an Underwriting Agreement. In connection with a bridge financing
that occurred shortly before the initial public offering, Joseph Stevens acted
as placement agent and received fees and expenses totaling $195,000. In
addition, the Company granted Joseph Stevens, for nominal consideration, a
warrant (the "Joseph Stevens Warrant") exercisable for 165,000 units (each, a
"Unit"), the security issued by the Company in its initial public offering, each
Unit consisting of one share of Common Stock and a redeemable warrant
exercisable for one share of Common Stock. The Joseph Stevens Warrant is
exercisable until December 13, 2000 at an exercise price of $6.60 per Unit. In
addition, the Company and Joseph Stevens entered into a Financial Advisory and
Consulting Agreement and related Indemnity Agreement pursuant to which the
Company paid Joseph Stevens a monthly consulting fee of $2,000 (which obligation
terminated on December 18, 1997) and agreed to pay Joseph Stevens additional
consideration in the event Joseph Stevens assists the Company in connection with
certain financing or strategic transactions.
 
    On April 15, 1996 the Company entered into a letter agreement with
Paramount. Dr. Rosenwald is the President, Chairman and sole stockholder of
Paramount, and Paramount employs Mr. Kanzer, a director of the Company, and
Michael Weiss, Esq., the Secretary of the Company. Pursuant to such letter
agreement, Paramount agreed to render financial advisory services to the Company
and the Company agreed to compensate Paramount for such services by paying
Paramount a retainer of $5,000 per month, issuing a warrant to Paramount's
designee to purchase 25,000 shares of the Company's Common Stock at an exercise
price of $10.00 per share and paying Paramount additional consideration in the
event Paramount assisted the Company in connection with certain financing or
strategic transactions. Pursuant to the terms of the letter agreement, (1) upon
the renewal of the term of the letter agreement, the Company issued a warrant to
Paramount's designee exercisable for 25,000 shares of the Company's Common Stock
at an exercise price of $8.05 and (2) upon the consummation of a financing
transaction, the Company paid $76,438 to Paramount and issued a warrant to
Paramount's designee exercisable for 12,500 shares of the Company's Common Stock
at an exercise price of $6.73 per share. The term of the letter agreement has
expired.
 
    On June 24, 1996, the Company, Paramount and a second financial advisor
(Paramount and the second financial advisor are collectively referred to as the
"Financial Advisor") entered into a Financial Services Agreement pursuant to
which the Financial Advisor agreed to render financial advisory services.
Pursuant to the agreement, the Company paid the Financial Advisor a $30,000
retainer and agreed to pay additional consideration in the event the Financial
Advisor assisted the Company in connection with certain financing or strategic
transactions. The term of this Financial Services Agreement has expired,
although the Company may be obligated to pay fees to the Financial Advisor in
the event certain financing or strategic transactions are consummated pursuant
to the terms of the Financial Services Agreement.
 
    Effective February 26, 1997, the Company and Paramount entered into a letter
of intent whereby Paramount agreed to act as placement agent for the Company in
connection with the private placement of Series A Preferred (the "Private
Placement"). Thereafter, the Company entered into an agreement (the "Placement
Agreement") with Paramount, pursuant to which the Company agreed to pay
Paramount, for its services, compensation in the form of (i) cash commissions
equal to nine percent of the gross proceeds from the sale of the Series A
Preferred issued in the Private Placement and (ii) a non-accountable expense
allowance equal to four percent of the gross proceeds from the sale of the
Series A Preferred. In addition, upon the final closing date of the sale of the
Series A Preferred, the Company sold to Paramount and/or its designees, for
$0.001 per warrant, warrants exercisable for an aggregate of 123,720 shares of
Series A Preferred, at an exercise price of $11.00 per share of Series A
Preferred. Such warrants are exercisable for 10 years and contain certain
antidilution provisions. Under the Placement Agreement, the Company has agreed
to indemnify Paramount against certain liabilities, including liabilities under
the Securities Act.
 
                                       18

<PAGE>
    In connection with the Private Placement, the Company has committed to enter
into an advisory agreement (the "Placement Advisory Agreement") with Paramount
pursuant to which Paramount will act as the Company's non-exclusive financial
advisor. Such engagement provides that Paramount receive (i) a monthly retainer
of $4,000 commencing June 1, 1997 (with a minimum engagement of 24 months), (ii)
out-of-pocket expenses incurred in connection with services performed under the
Placement Advisory Agreement and (iii) standard success fees in the event
Paramount assists the Company in connection with certain financing and strategic
transactions. Paramount has agreed that, in the event it is entitled to
compensation under the letter agreement dated April 15, 1996 or the Financial
Services Agreement dated June 24, 1996, each described above, and the Placement
Advisory Agreement, it will seek payment under only one of the agreements.
 
    All transactions between Atlantic and its officers, directors, principal
stockholders and their affiliates are approved by a majority of the Board of
Directors, including a majority of the independent and disinterested outside
directors on the Board of Directors. The Company believes that all of the
transactions set forth above were made on terms no less favorable to the Company
than could have been obtained from unaffiliated third parties.
 
 
                       COMPLIANCE WITH SECTION 16(A) OF
                      THE SECURITIES EXCHANGE ACT OF 1934
 
    Section 16(a) of the Securities Exchange Act of 1934, as amended, requires
the Company's officers, directors and persons who are the beneficial owners of
more than 10% of the Company's Common Stock to file initial reports of ownership
and reports of changes in ownership of the Common Stock with the
Securities and Exchange Commission (the "Commission"). Officers, directors and
greater than 10% stockholders are required by Commission regulations to furnish
the Company with copies of all Section 16(a) forms they file.
 
    Based solely on its review of the copies of such forms furnished to the
Company and certain written representations that no other reports were required,
the Company believes that, during the period from January 1, 1997 to December
31, 1997, all officers, directors and beneficial owners of more than 10% of the
Company's Common Stock complied with all Section 16(a) requirements, except that
Dr. Fildes filed late the Form 3 reporting his appointment to the Company's
Board of Directors.
 
 
                     SECURITY OWNERSHIP OF MANAGEMENT AND

                           CERTAIN BENEFICIAL OWNERS
 
    The following table sets forth certain information known to the Company with
respect to the beneficial ownership of the Company's Common Stock as of March
16, 1998, by (i) all persons who are beneficial owners of five percent or more
of the Company's Common Stock, (ii) each director and nominee, (iii) the Named
Officers in the Summary Compensation Table above and (iv) all current directors
and executive officers as a group. The Company does not know of any person who
beneficially owns more than five percent of the Series A Preferred, and none of
the Company's directors or the Named Officers owns any shares of Series A
Preferred. The number of shares beneficially owned by each director or executive
officer is determined under rules of the Commission and the information is not
necessarily indicative of beneficial ownership for any other purpose. Shares of
the Company's Common Stock subject to convertible securities that are currently
exercisable or convertible or that will become exercisable or convertible within
60 days are deemed to be beneficially owned by the person holding such
convertible security for computing the percentage ownership of such person, but
are not treated as outstanding for computing the percentage of any other person.
Except as otherwise indicated, the Company believes that the beneficial owners
of the Company's Common Stock listed below, based upon such information
 
                                       19

<PAGE>
furnished by such owners, have sole investment power with respect to such
shares, subject to community property laws where applicable.
 

<TABLE>
<CAPTION>
 
                                                              NUMBER OF   PERCENT OF TOTAL SHARES
NAME AND ADDRESS                                                SHARES         OUTSTANDING(1)
- ------------------------------------------------------------  -----------  -----------------------
<S>                                                           <C>          <C>
Lindsay A. Rosenwald, M.D.(2) ..............................     445,462              13.30%
  787 7th Avenue
  New York, NY 10019
 
VentureTek, L.P.(3) ........................................     438,493              12.94%
  39 Broadway
  New York, NY 10006
 
Joseph Stevens & Co. Inc.(4) ...............................     330,000               9.74%
  33 Maiden Lane, 8th floor
  New York, NY 10038
 
Mellon Bank Corporation ....................................     280,000               8.27%
  One Mellon Bank Center
  Pittsburgh, PA 15258
 
Jon D. Lindjord(5)..........................................     130,000               3.84%
 
Stephen R. Miller, M.D.(5)..................................      77,480               2.29%
 
John K.A. Prendergast, Ph.D.(6).............................      71,656               2.12%
 
Margaret A. Schalk(5).......................................      64,570               1.91%
 
Yuichi Iwaki, M.D., Ph.D.(5)................................      42,000               1.24%
 
Shimshon Mizrachi(5)........................................      30,000              *
 
Robert A. Fildes, Ph.D.(5)..................................      10,000              *
 
Paul D. Rubin, M.D.(5)......................................      10,000              *
 
Steve H. Kanzer, Esq.(7)....................................       4,121              *
 
All current executive officers and directors as a group (9
  persons)(5-7).............................................     439,827              12.98%
</TABLE>

 
- ------------------------
 
 *  Less than 1.0%
 
(1) Percentage of beneficial ownership is calculated assuming 3,387,751 shares
    of Common Stock were outstanding on March 16, 1998. Beneficial ownership is
    determined in accordance with the rules of the Commission and includes
    voting and investment power with respect to shares of Common Stock.
 
(2) Includes 570 shares owned by Dr. Rosenwald's wife and trusts in favor of his
    minor children. Dr. Rosenwald disclaims beneficial ownership of such shares.
    Does not include 86 shares collectively owned by Dr. Rosenwald's mother and
    two brothers, of which Dr. Rosenwald disclaims beneficial ownership.
    Includes 380 shares owned by two companies of which Dr. Rosenwald is the
    sole stockholder. Includes 100,068 shares of Common Stock into which shares
    of Series A Preferred may be converted upon exercise of a warrant,
    exercisable within 60 days of March 16, 1998, for 47,202 shares of Series A
    Preferred.
 
(3) The general partner of VentureTek, L.P. is Mr. C. David Selengut. Mr.
    Selengut may be considered a beneficial owner of the shares owned by
    VentureTek, L.P. by virtue of his authority as general partner to vote
    and/or dispose of such shares. VentureTek, L.P. is a limited partnership,
    the limited partners of which include Dr. Rosenwald's wife, children,
    sisters of Dr. Rosenwald's wife and their husbands and children. Dr.
    Rosenwald disclaims beneficial ownership of such shares.
 
                                       20

<PAGE>
(4) Represents shares of Common Stock underlying a warrant, exercisable within
    60 days of March 16, 1998, for shares of Common Stock and securities
    convertible into Common Stock.
 
(5) Represents options exercisable within 60 days of March 16, 1998.
 
(6) Includes 53 shares of Common Stock held in trust for the benefit of the
    children of Dr. Prendergast. Dr. Prendergast disclaims beneficial ownership
    of such shares. Includes 34,000 shares of Common Stock underlying options
    exercisable within 60 days of March 16, 1998. Includes 37,500 shares of
    Common Stock underlying a warrant exercisable within 60 days of March 16,
    1998.
 
(7) Includes 4,000 shares underlying options exercisable within 60 days of March
    16, 1998.
 
                 DEADLINE FOR RECEIPT OF STOCKHOLDER PROPOSALS
 
    Under the present rules of the Commission, the deadline for stockholders to
submit proposals to be considered for inclusion in the Company's Proxy Statement
for the next year's Annual Meeting of Stockholders is expected to be December
12, 1998. Such proposals may be included in next year's Proxy Statement if they
comply with certain rules and regulations promulgated by the Commission.
 
                                 ANNUAL REPORT
 
    A copy of the Company's Annual Report to Stockholders for the year ended
December 31, 1997 has been mailed concurrently with this Proxy Statement to all
stockholders entitled to notice of and to vote at the Annual Meeting. The Annual
Report is not incorporated into this Proxy Statement and is not considered proxy
soliciting material.
 
                                  FORM 10-KSB
 
    The Company filed a Form 10-KSB for the year ended December 31, 1997 with
the Commission. A copy of such Form 10-KSB has been mailed concurrently with
this Proxy Statement to all stockholders entitled to notice of and to vote at
the Annual Meeting. The Form 10-KSB is not incorporated into this Proxy
Statement and is not considered proxy soliciting material. Stockholders may
obtain additional copies of this report, without charge, by writing to Investor
Relations, Atlantic Pharmaceuticals, Inc., 1017 Main Campus Drive, Suite 3900,
Raleigh, North Carolina 27606.
 
                                 OTHER MATTERS
 
    The Company knows of no other matters that will be presented for
consideration at the Annual Meeting. If any other matters properly come before
the Annual Meeting, it is the intention of the persons named in the enclosed
form of Proxy to vote the shares they represent as the Board may recommend.
Discretionary authority with respect to such other matters is granted by the
execution of the enclosed Proxy.
 
                                          THE BOARD OF DIRECTORS
 
Dated: April 13, 1998
 
                                       21

<PAGE>
                         ATLANTIC PHARMACEUTICALS, INC.
                                     PROXY
 
                  ANNUAL MEETING OF STOCKHOLDERS, MAY 11, 1998
 
               THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF
                         ATLANTIC PHARMACEUTICALS, INC.
 
    The undersigned revokes all previous proxies, acknowledges receipt of the
Notice of the Annual Meeting of Stockholders to be held May 11, 1998 and the
Proxy Statement and appoints Jon D. Lindjord and Margaret A. Schalk, and each of
them, the Proxy of the undersigned, with full power of substitution, to vote all
shares of Common Stock of Atlantic Pharmaceuticals, Inc. (the "Company") which
the undersigned is entitled to vote, either on his or her own behalf or on
behalf of any entity or entities, at the Annual Meeting of Stockholders of the
Company to be held at the Company's principal offices, 1017 Main Campus Drive,
Suite 3900, Raleigh, North Carolina 27606, on Monday, May 11, 1998 at 10:00 A.M.
Eastern Daylight Time (the "Annual Meeting"), and at any adjournment or
postponement thereof, with the same force and effect as the undersigned might or
could do if personally present thereat. The shares represented by this Proxy
shall be voted in the manner set forth on the reverse side.
 
1. To elect six directors to serve on the Board of Directors for the ensuing
year and until their respective successors are duly elected and qualified:
 

<TABLE>
<S>                           <C>        <C>
                                             WITHHOLD AUTHORITY
                                 FOR              TO VOTE
Jon D. Lindjord                  / /                / /
Robert A. Fildes, Ph.D.          / /                / /
Yuichi Iwaki, M.D., Ph.D.        / /                / /
Steve H. Kanzer                  / /                / /
John K.A. Prendergast, Ph.D.     / /                / /
Paul D. Rubin, M.D.              / /                / /
</TABLE>

 

<PAGE>
2. To approve an amendment to the Company's Restated Certificate of
   Incorporation, as amended, to decrease the number of authorized shares of
   Common Stock of the Company from 80,000,000 to 50,000,000 and to decrease the
   number of authorized shares of Preferred Stock of the Company from 50,000,000
   to 10,000,000; and
                FOR  / /        AGAINST  / /        ABSTAIN  / /
 
3. To ratify the Board of Director's selection of KPMG Peat Marwick LLP to serve
   as the Company's independent auditors for the year ending December 31, 1997;
   and
                FOR  / /        AGAINST  / /        ABSTAIN  / /
 
4. To transact such other business as may properly come before the Annual
   Meeting and any adjournment or adjournments thereof.
                FOR  / /        AGAINST  / /        ABSTAIN  / /
 
    The Board of Directors recommends a vote IN FAVOR OF each of the directors
listed above and a vote IN FAVOR OF the other proposals. This Proxy, when
properly executed, will be voted as specified above. IF NO SPECIFICATION IS
MADE, THIS PROXY WILL BE VOTED IN FAVOR OF THE ELECTION OF THE DIRECTORS LISTED
ABOVE AND IN FAVOR OF THE OTHER PROPOSALS.
 
                                                  Please print the name(s)
                                                  appearing on each share
                                                  certificate(s) over which you
                                                  have voting authority:
                                                  ______________________________
                                                  (Print name(s) on certificate)
 
                                                  Please sign your name:
                                                  ______________________________
                                                    (Authorized Signature(s))
                                                  Date: ________________________

<PAGE>
                         ATLANTIC PHARMACEUTICALS, INC.
                                     PROXY
 
                  ANNUAL MEETING OF STOCKHOLDERS, MAY 11, 1998
 
               THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF
                         ATLANTIC PHARMACEUTICALS, INC.
 
    The undersigned revokes all previous proxies, acknowledges receipt of the
Notice of the Annual Meeting of Stockholders to be held May 11, 1998 and the
Proxy Statement and appoints Jon D. Lindjord and Margaret A. Schalk, and each of
them, the Proxy of the undersigned, with full power of substitution, to vote all
shares of Preferred Stock of Atlantic Pharmaceuticals, Inc. (the "Company")
which the undersigned is entitled to vote, either on his or her own behalf or on
behalf of any entity or entities, at the Annual Meeting of Stockholders of the
Company to be held at the Company's principal offices, 1017 Main Campus Drive,
Suite 3900, Raleigh, North Carolina 27606, on Monday, May 11, 1998 at 10:00 A.M.
Eastern Daylight Time (the "Annual Meeting"), and at any adjournment or
postponement thereof, with the same force and effect as the undersigned might or
could do if personally present thereat. The shares represented by this Proxy
shall be voted in the manner set forth on the reverse side.
 
1. To elect six directors to serve on the Board of Directors for the ensuing
year and until their respective successors are duly elected and qualified:
 

<TABLE>
<S>                             <C>        <C>
                                                WITHHOLD AUTHORITY
                                   FOR               TO VOTE
Jon D. Lindjord                    / /                 / /
Robert A. Fildes, Ph.D.            / /                 / /
Yuichi Iwaki, M.D., Ph.D.          / /                 / /
Steve H. Kanzer                    / /                 / /
John K.A. Prendergast, Ph.D.       / /                 / /
Paul D. Rubin, M.D.                / /                 / /
</TABLE>

 
2. To approve an amendment to the Company's Restated Certificate of
   Incorporation, as amended, to decrease the number of authorized shares of
   Common Stock of the Company from 80,000,000 to 50,000,000 and to decrease the
   number of authorized shares of Preferred Stock of the Company from 50,000,000
   to 10,000,000; and
 
                FOR  / /        AGAINST  / /        ABSTAIN  / /

<PAGE>
3. To ratify the Board of Director's selection of KPMG Peat Marwick LLP to serve
   as the Company's independent auditors for the year ending December 31, 1997;
   and
                FOR  / /        AGAINST  / /        ABSTAIN  / /
 
4. To transact such other business as may properly come before the Annual
   Meeting and any adjournment or adjournments thereof.
                FOR  / /        AGAINST  / /        ABSTAIN  / /
 
5. To approve the payment by the Company to each non-employee director of a
   $6,000 annual fee plus $1,500 per Board meeting attended in person, $750 per
   Board meeting attended by telephone and $500 per meeting of any committee of
   which such director is a member;
                FOR  / /        AGAINST  / /        ABSTAIN  / /
 
6. To approve a Consultancy Agreement and a Financial Services Agreement to be
   entered into by and between the Company and Yuichi Iwaki, M.D., Ph.D.; and
                FOR  / /        AGAINST  / /        ABSTAIN  / /
 
7. To approve a Consultancy Agreement and a Financial Services Agreement to be
   entered into by and between the Company and John K.A. Prendergast, Ph.D.
                FOR  / /        AGAINST  / /        ABSTAIN  / /
 
    The Board of Directors recommends a vote IN FAVOR OF each of the proposals
listed above. This Proxy, when properly executed, will be voted as specified
above. IF NO SPECIFICATION IS MADE, THIS PROXY WILL BE VOTED IN FAVOR OF EACH
PROPOSAL LISTED ABOVE.
 
                                                Please print the name(s)
                                                appearing on each share
                                                certificate(s) over which you
                                                have voting authority:
                                                ________________________________
                                                 (Print name(s) on certificate)
 
                                                Please sign your name:
                                                ________________________________
                                                   (Authorized Signature(s))
                                                Date: __________________________