UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                   ------------------------------------------



                                 SCHEDULE 13G/A
                   Under the Securities Exchange Act of 1934
                               (Amendment No. 2)*
                   ------------------------------------------



                         Atlantic Pharmaceuticals, Inc.
                   -----------------------------------------
                                 Name of Issuer


                    Common Stock, par value $.001 per share
                   ------------------------------------------
                         (Title of Class of Securities)


                                   048785109
                                  -----------
                                  CUSIP Number


        *The  remainder  of this cover page shall be filled out for a  reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.

        The  information  required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise  subject to the  liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however,  see
the Notes to Schedule 13G).






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                                  SCHEDULE 13G

CUSIP No.  048785109
- --------------------------------------------------------------------------------
1)      NAME OF REPORTING PERSON
        S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
        Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)      CHECK THE APPROPRIATE BOX IF MEMBER OF A GROUP   (a)  |_|      (b)   |_|
- --------------------------------------------------------------------------------
3)      SEC USE ONLY
- --------------------------------------------------------------------------------
4)      CITIZENSHIP OR PLACE OF ORGANIZATION
        United States
- --------------------------------------------------------------------------------
                      5)     SOLE VOTING POWER
                             499,298 /1/
        NUMBER        ----------------------------------------------------------
        OF            6)     SHARED VOTING POWER
        SHARES
        BENEFICIALLY  ----------------------------------------------------------
        OWNED BY      7)     SOLE DISPOSITIVE POWER
        EACH                 499,298 /1/
        REPORTING     ----------------------------------------------------------
        PERSON        8)     SHARED DISPOSITIVE POWER
        WITH
- --------------------------------------------------------------------------------
9)      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
        499,298 /1/
- --------------------------------------------------------------------------------
10)     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES                                                               [X]
- --------------------------------------------------------------------------------
11)     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
        10.8%
- --------------------------------------------------------------------------------
12)     TYPE OF REPORTING PERSON
        IN
- --------------------------------------------------------------------------------

Item 1.
- -------------------------
        1 Includes  344,508  shares of common  stock of the  Issuer and  154,410
shares of common stock  issuable upon  conversion of Series A Convertible  Stock
(the "Preferred Stock")  underlying  47,202.  Also includes 190 shares of common
stock held by June  Street  Corporation  and 190 shares of common  stock held by
Huntington Street  Corporation.  Dr. Rosenwald is the sole proprietor of each of
June Street Corporation and Huntington Street Corporation.



                                        2



        (a)           Name of Issuer:

                      Atlantic Pharmaceuticals, Inc. (the "Company")

        (b)           Address of Issuer's Principal Executive Offices:

                      1017 Main Campus Drive, Suite 3900
                      Raleigh, North Carolina, 27606

Item 2.

        (a)           Name of Person Filing:

                      Lindsay A. Rosenwald, M.D. ("Dr. Rosenwald")

        (b)           Address of Principal Business Office or, if None, 
                      Residence:

                      787 Seventh Avenue, 48th Floor
                      New York, N.Y.  10019

        (c)           Citizen:

                      Dr. Rosenwald is a citizen of the United States.

        (d)           Title of Class of Securities:

                      Common Stock, $0.001 par value ("shares").

        (e)           CUSIP#:

                      048785109

Item 3.

                      Not applicable.

Item 4.               Ownership:

                      For  information  concerning the ownership of Common Stock
                      of the Company by Dr. Rosenwald, see Items 5 through 9 and
                      11 of the cover page to this  schedule  13G and  footnotes
                      thereto.

Item 5.               Ownership of Five Percent or Less of a Class:



                                        3



                      Not applicable.

Item 6.               Ownership of More than Five Percent on Behalf of Another 
                      Person:

                      Not applicable.

Item 7.               Identification  and Classification of the Subsidiary Which
                      Acquired  the  Security  Being  Reported  On By the Parent
                      Holding Company:

                      Not applicable.

Item 8.               Identification and Classification of Members of the Group:

                      Not applicable.

Item 9.               Notice of Dissolution of Group:

                      Not applicable.

Item 10.              Certification:

                      Not applicable.



                                    SIGNATURE

        After  reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


Dated:  February 12, 1999
         New York, New York                      /s/ Lindsay A. Rosenwald, M.D. 
                                                --------------------------------
                                                Lindsay A. Rosenwald, M.D.



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