UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 _________________________ SCHEDULE 13G/A UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) Manhattan Pharmaceuticals, Inc. - -------------------------------------------------------------------------------- (Name of Issuer) Common Stock, par value $.001 per share - -------------------------------------------------------------------------------- (Title of Class of Securities) 563118207 - -------------------------------------------------------------------------------- (CUSIP NUMBER) December 15, 2004 - -------------------------------------------------------------------------------- (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: / / Rule 13d-1(b) /X/ Rule 13d-1(c) / / Rule 13d-1(d) The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). Page 1 of 5 Pages
SCHEDULE 13G ========================= ========================= CUSIP No. 563118207 Page 2 of 5 Pages ========================= ========================= ________________________________________________________________________________ | 1. | NAME OF REPORTING PERSONS: J. JAY LOBELL | I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) ___|____________________________________________________________________________ | 2. | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP | | (a) [ ] | (b) [ ] ___|____________________________________________________________________________ | 3. | SEC USE ONLY ___|____________________________________________________________________________ | 4. | CITIZENSHIP or PLACE OF ORGANIZATION United States ___|____________________________________________________________________________ NUMBER OF |5. | SOLE VOTING POWER 113,764 SHARES |____|____________________________________________________________ BENEFICIALLY | | OWNED BY |6. | SHARED VOTING POWER 0 EACH |____|____________________________________________________________ REPORTING | | PERSON WITH |7. | SOLE DISPOSITIVE POWER 113,764 |____|____________________________________________________________ | | |8. | SHARED DISPOSITIVE POWER 0 ______________|____|____________________________________________________________ 9. | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 113,764 ___|____________________________________________________________________________ 10.| CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES | CERTAIN SHARES: [ ] ___|____________________________________________________________________________ 11.| PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) .41%(1) ___|____________________________________________________________________________ 12 | TYPE OF REPORTING PERSON IN ___|____________________________________________________________________________
SCHEDULE 13G ========================= ========================= CUSIP No. 563118207 Page 3 of 5 Pages ========================= ========================= Item 1(a). Name of Issuer: Manhattan Pharmaceuticals, Inc. Item 1(b). Address of Issuer's Principal Executive Offices: 810 Seventh Avenue, 4th Floor New York, New York 10019 Item 2(a). Name of Person Filing: J. Jay Lobell Item 2(b). Address of Principal Business Office or, if None, Residence: 365 West End Avenue New York, New York 10024 Item 2(c). Citizenship: United States Item 2(d). Title of Class of Securities: Common Stock Item 2(e). CUSIP Number: 563118207 Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a: Not Applicable (a) [ ] Broker or dealer registered under Section 15 of the Exchange Act; (b) [ ] Bank as defined in Section 3(a)(6) of the Exchange Act; (c) [ ] Insurance Company as defined in Section 3(a)(19) of the Exchange Act; (d) [ ] Investment Company registered under Section 8 of the Investment Company Exchange Act; (e) [ ] Investment Adviser in accordance with Rule 13d-1(b)(1)(ii)(E);
SCHEDULE 13G ========================= ========================= CUSIP No. 563118207 Page 4 of 5 Pages ========================= ========================= (f) [ ] Employee Benefit Plan or Endowment Fund in accordance with Rule 13d-1(b)(1)(ii)(F); (g) [ ] Parent Holding Company or Control Person in accordance with Rule 13d-1(b)(1)(ii)(G); (h) [ ] Saving Association as defined in Section 3(b) of The Federal Deposit Insurance Act; (i) [ ] Church Plan that is excluded from the definition of an Investment Company under Section 3(c)(14) of the Investment Company Act; (j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J). Item 4. Ownership. (a) Amount beneficially owned: 113,764 (b) Percent of Class: .41%(1) (c) Number of shares as to which such person has: (i) Sole power to vote or direct the vote: 113,764 (ii) Shared power to vote or to direct the vote: 0 (iii) Sole power to dispose or direct the disposition of: 113,764 (iv) Shared power to dispose or to direct the disposition of: 0 Item 5. Ownership of Five Percent or Less of a Class. If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: [X] Effective as of December 15, 2004, Mr. Lobell resigned as (i) trustee of the Rosenwald 2000 Family Trusts, (ii) adviser of the Lindsay A. Rosenwald 2000 (Delaware) Irrevocable Indenture of Trust, (iii) adviser of the Lindsay A. Rosenwald Alaska Irrevocable Indenture of Trust, and (iv) adviser of the Lindsay A. Rosenwald Rhode Island Irrevocable Indenture of Trust. As a result, Mr. Lobell is no longer the beneficial owner of 5% or more of the shares of the issuer's stock.
SCHEDULE 13G ========================= ========================= CUSIP No. 563118207 Page 5 of 5 Pages ========================= ========================= Item 6. Ownership of More than Five Percent on Behalf of Another Person. Not Applicable Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company. Not Applicable Item 8. Identification and Classification of Members of the Group. Not Applicable Item 9. Notice of Dissolution of Group. Not Applicable Item 10. Certification. By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. December 16, 2004 ----------------------- (Date) J. Jay Lobell ----------------------- (Signature) J. Jay Lobell ----------------------- (Name/Title) (1) Based on 27,540,495 shares reported outstanding at November 12, 2004.