Delaware
(State
or other jurisdiction of
incorporation
or organization)
|
36-3898269
(I.R.S.
Employer Identification No.)
|
Page
|
||
PART
I
|
FINANCIAL
INFORMATION
|
|
Item
1.
|
Unaudited
Condensed Consolidated Balance Sheets
|
5
|
Unaudited
Condensed Consolidated Statements of Operations
|
6
|
|
Unaudited
Condensed Consolidated Statement of Stockholders’ Equity
(Deficiency)
|
7
|
|
Unaudited
Condensed Consolidated Statements of Cash Flows
|
9
|
|
|
Notes
to Unaudited Condensed Consolidated Financial Statements
|
10
|
Item
2.
|
Management’s
Discussion and Analysis of Financial Condition and Results of
Operations
|
22
|
Item
3.
|
Quantitative
and Qualitative Disclosure About Market Risk
|
36
|
Item
4.
|
Controls
and Procedures
|
36
|
PART
II
|
OTHER
INFORMATION
|
|
Item
1.
|
Legal
Proceedings
|
37
|
Item
1A.
|
Risk
Factors
|
37
|
Item
6.
|
Exhibits
|
37
|
Signatures
|
38
|
· |
the
development of our drug candidates;
|
· |
the
regulatory approval of our drug
candidates;
|
· |
our
use of clinical research centers and other
contractors;
|
· |
our
ability to find collaborative partners for research, development
and
commercialization of potential
products;
|
· |
acceptance
of our products by doctors, patients or
payers;
|
· |
our
ability to market any of our
products;
|
· |
our
history of operating losses;
|
· |
our
ability to compete against other companies and research
institutions;
|
· |
our
ability to secure adequate protection for our intellectual
property;
|
· |
our
ability to attract and retain key
personnel;
|
· |
availability
of reimbursement for our product
candidates;
|
· |
the
effect of potential strategic transactions on our
business;
|
· |
our
ability to obtain adequate financing;
and
|
· |
the
volatility of our stock price.
|
|
March
31,
2008
|
December
31,
2007
|
|||||
|
(Unaudited)
|
(See
Note 1)
|
|||||
Assets
|
|||||||
Current
assets:
|
|||||||
Cash
and cash equivalents
|
$
|
1,133,124
|
$
|
649,686
|
|||
Prepaid
expenses
|
233,545
|
215,852
|
|||||
Total
current assets
|
1,366,669
|
865,538
|
|||||
|
|||||||
Investment
in Hedrin JV
|
230,127
|
—
|
|||||
Property
and equipment, net
|
36,621
|
44,533
|
|||||
Other
assets
|
84,126
|
70,506
|
|||||
Total
assets
|
$
|
1,717,543
|
$
|
980,577
|
|||
|
|||||||
Liabilities
and Stockholders’ Deficiency
|
|||||||
|
|||||||
Current
liabilities:
|
|||||||
Accounts
payable
|
$
|
986,223
|
$
|
1,279,485
|
|||
Accrued
expenses
|
800,215
|
592,177
|
|||||
Total
current liabilities
|
1,786,438
|
1,871,662
|
|||||
Exchange
obligation
|
2,058,683
|
—
|
|||||
Total
liabilities
|
3,845,121
|
1,871,662
|
|||||
|
|||||||
Commitments
and contingencies
|
|||||||
|
|||||||
Stockholders’
deficiency:
|
|||||||
Preferred
stock, $.001 par value. Authorized 1,500,000 shares; no shares
issued
|
|||||||
and
outstanding at March 31, 2008 and December 31, 2007
|
|||||||
Common
stock, $.001 par value. Authorized 150,000,000 shares; 70,624,232
|
|||||||
shares
issued and outstanding at March 31, 2008 and December 31,
2007
|
70,624
|
70,624
|
|||||
Additional
paid-in capital
|
54,380,215
|
54,037,361
|
|||||
Deficit
accumulated during the development stage
|
(56,578,417
|
)
|
(54,999,070
|
)
|
|||
|
|||||||
Total
stockholders’ deficiency
|
(2,127,578
|
)
|
(891,085
|
)
|
|||
|
|||||||
Total
liabilities and stockholders' deficiency
|
$
|
1,717,543
|
$
|
980,577
|
|
Three months ended March 31,
|
Cumulative
period from
August 6, 2001
(inception) to
March 31,
|
||||||||
|
2008
|
2007
|
2008
|
|||||||
Costs
and expenses:
|
||||||||||
Research
and development
|
$
|
800,071
|
$
|
1,679,448
|
$
|
27,289,113
|
||||
General
and administrative
|
814,060
|
914,724
|
14,666,424
|
|||||||
In-process
research and development charge
|
—
|
—
|
11,887,807
|
|||||||
Impairment
of intangible assets
|
—
|
—
|
1,248,230
|
|||||||
Loss
on disposition of intangible assets
|
—
|
—
|
1,213,878
|
|||||||
Total
operating expenses
|
1,614,131
|
2,594,172
|
56,305,452
|
|||||||
|
||||||||||
Operating
loss
|
(1,614,131
|
)
|
(2,594,172
|
)
|
(56,305,452
|
)
|
||||
|
||||||||||
Other
(income) expense:
|
||||||||||
Equity
in loss of Hedrin JV
|
19,873
|
—
|
19,873
|
|||||||
Interest
and other income
|
(54,657
|
)
|
(30,390
|
)
|
(876,554
|
)
|
||||
Interest
expense
|
—
|
475
|
26,034
|
|||||||
Realized
gain on sale of marketable equity securities
|
—
|
—
|
(76,032
|
)
|
||||||
Total
other income
|
(34,784
|
)
|
(29,915
|
)
|
(906,679
|
)
|
||||
|
||||||||||
Net
loss
|
(1,579,347
|
)
|
(2,564,257
|
)
|
(55,398,773
|
)
|
||||
|
||||||||||
Preferred
stock dividends (including imputed amounts)
|
—
|
—
|
(1,179,644
|
)
|
||||||
|
||||||||||
Net
loss applicable to common shares
|
$
|
(1,579,347
|
)
|
$
|
(2,564,257
|
)
|
$
|
(56,578,417
|
)
|
|
|
||||||||||
Net
loss per common share:
|
||||||||||
Basic
and diluted
|
$
|
(0.02
|
)
|
$
|
(0.04
|
)
|
||||
|
||||||||||
Weighted
average shares of common stock outstanding:
|
||||||||||
Basic
and diluted
|
70,624,232
|
60,120,038
|
Series A
convertible preferred stock
|
Series A
convertible preferred stock
|
Common
stock
|
Common
stock
|
Additional
paid-in
capital
|
Subscription
receivable
|
Deficit
accumulated during development stage
|
Dividends
payable in Series A preferred
stock
|
Accumulated
other comprehensive income (loss)
|
Unearned
consulting services
|
Total
stockholders’ equity (deficiency)
|
||||||||||||||||||||||
Shares
|
Amount
|
Shares
|
Amount
|
Amount
|
Amount
|
Amount
|
Amount
|
Amount
|
Amount
|
Amount
|
||||||||||||||||||||||
Stock
issued at $0.0004 per share for subscription receivable
|
|
—
|
$
|
—
|
|
10,167,741
|
$
|
10,168
|
$
|
(6,168
|
)
|
$
|
(4,000
|
)
|
$
|
—
|
|
$
|
—
|
|
$
|
—
|
|
$
|
—
|
|
$
|
—
|
|
|||
Net
loss
|
|
—
|
|
—
|
|
—
|
|
—
|
|
—
|
|
|
—
|
|
|
(56,796
|
)
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(56,796
|
)
|
|||
Balance
at December 31, 2001
|
|
—
|
|
—
|
|
10,167,741
|
|
10,168
|
|
(6,168
|
)
|
|
(4,000
|
)
|
|
(56,796
|
)
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(56,796
|
)
|
|||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
Proceeds
from subscription receivable
|
|
—
|
|
—
|
|
—
|
|
—
|
|
—
|
|
|
4,000
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
4,000
|
|
|||
Stock
issued at $0.0004 per share for license rights
|
|
—
|
|
—
|
|
2,541,935
|
|
2,542
|
|
(1,542
|
)
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
1,000
|
|
|||
Stock
options issued for consulting services
|
|
—
|
|
—
|
|
—
|
|
—
|
|
60,589
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(60,589
|
)
|
|
—
|
|
|||
Amortization
of unearned consulting services
|
|
—
|
|
—
|
|
—
|
|
—
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
22,721
|
|
|
22,721
|
|
|||
Common
stock issued at $0.63 per share, net of expenses
|
|
—
|
|
—
|
|
3,043,332
|
|
3,043
|
|
1,701,275
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
1,704,318
|
|
|||
Net
loss
|
|
—
|
|
—
|
|
—
|
|
—
|
|
|
|
|
—
|
|
|
(1,037,320
|
)
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(1,037,320
|
)
|
|||
Balance
at December 31, 2002
|
|
—
|
|
—
|
|
15,753,008
|
|
15,753
|
|
1,754,154
|
|
|
—
|
|
|
(1,094,116
|
)
|
|
—
|
|
|
—
|
|
|
(37,868
|
)
|
|
637,923
|
|
|||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
Common
stock issued at $0.63 per share, net of expenses
|
|
—
|
|
—
|
|
1,321,806
|
|
1,322
|
|
742,369
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
743,691
|
|
|||
Effect
of reverse acquisition
|
|
—
|
|
—
|
|
6,287,582
|
|
6,287
|
|
2,329,954
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
2,336,241
|
|
|||
Amortization
of unearned consulting costs
|
|
—
|
|
—
|
|
—
|
|
—
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
37,868
|
|
|
37,868
|
|
|||
Unrealized
loss on short-term investments
|
|
—
|
|
—
|
|
—
|
|
—
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(7,760
|
)
|
|
—
|
|
|
(7,760
|
)
|
|||
Payment
for fractional shares for stock combination
|
|
—
|
|
—
|
|
—
|
|
—
|
|
(300
|
)
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(300
|
)
|
|||
Preferred
stock issued at $10 per share, net of expenses
|
|
1,000,000
|
|
1,000
|
|
—
|
|
—
|
|
9,045,176
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
9,046,176
|
|
|||
Imputed
preferred stock dividend
|
|
|
|
|
|
|
|
|
|
418,182
|
|
|
—
|
|
|
(418,182
|
)
|
|
—
|
|
|
|
|
|
|
|
|
—
|
|
|||
Net
loss
|
|
—
|
|
—
|
|
—
|
|
—
|
|
—
|
|
|
—
|
|
|
(5,960,907
|
)
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(5,960,907
|
)
|
|||
Balance
at December 31, 2003
|
|
1,000,000
|
|
1,000
|
|
23,362,396
|
|
23,362
|
|
14,289,535
|
|
|
—
|
|
|
(7,473,205
|
)
|
|
—
|
|
|
(7,760
|
)
|
|
—
|
|
|
6,832,932
|
|
|||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
Exercise
of stock options
|
|
—
|
|
—
|
|
27,600
|
|
27
|
|
30,073
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
30,100
|
|
|||
Common
stock issued at $1.10, net of expenses
|
|
—
|
|
—
|
|
3,368,952
|
|
3,369
|
|
3,358,349
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
3,361,718
|
|
|||
Preferred
stock dividend accrued
|
|
—
|
|
—
|
|
—
|
|
—
|
|
—
|
|
|
—
|
|
|
(585,799
|
)
|
|
585,799
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|||
Preferred
stock dividends paid by issuance of shares
|
|
24,901
|
|
25
|
|
—
|
|
—
|
|
281,073
|
|
|
—
|
|
|
—
|
|
|
(282,388
|
)
|
|
—
|
|
|
—
|
|
|
(1,290
|
)
|
|||
Conversion
of preferred stock to common stock at $1.10 per share
|
|
(170,528
|
) |
|
(171
|
)
|
1,550,239
|
|
1,551
|
|
(1,380
|
)
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
||
Warrants
issued for consulting services
|
|
—
|
|
—
|
|
—
|
|
—
|
|
125,558
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(120,968
|
)
|
|
4,590
|
|
|||
Amortization
of unearned consulting costs
|
|
—
|
|
—
|
|
—
|
|
—
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
100,800
|
|
|
100,800
|
|
|||
Unrealized
gain on short-term investments and reversal of unrealized loss on
short-term investments
|
|
—
|
|
—
|
|
—
|
|
—
|
|
—
|
|
|
—
|
|
|
—
|
|
|
—
|
|
|
20,997
|
|
|
—
|
|
|
20,997
|
|
|||
Net
loss
|
|
—
|
|
—
|
|
—
|
|
—
|
|
—
|
|
|
—
|
|
|
(5,896,031
|
)
|
|
—
|
|
|
—
|
|
|
—
|
|
|
(5,896,031
|
)
|
|||
Balance
at December 31, 2004
|
|
854,373
|
|
854
|
|
28,309,187
|
|
28,309
|
|
18,083,208
|
|
|
—
|
|
|
(13,955,035
|
)
|
|
303,411
|
|
|
13,237
|
|
|
(20,168
|
)
|
|
4,453,816
|
|
Series A
convertible preferred stock
|
Series A
convertible preferred stock
|
Common
stock
|
Common
stock
|
Additional
paid-in capital
|
Subscription
receivable
|
Deficit
accumulated during development stage
|
Dividends
payable in Series A preferred
stock
|
Accumulated
other comprehensive income (loss)
|
Unearned
consulting services
|
Total
stockholders’ equity (deficiency)
|
||||||||||||||||||||||||
Shares
|
Amount
|
Shares
|
Amount
|
Amount
|
Amount
|
Amount
|
Amount
|
Amount
|
Amount
|
Amount
|
||||||||||||||||||||||||
Common
stock issued at $1.11 and $1.15, net of expenses
|
—
|
—
|
11,917,680
|
11,918
|
12,238,291
|
—
|
—
|
—
|
—
|
—
|
12,250,209
|
|||||||||||||||||||||||
Common
stock issued to vendor at $1.11 per share in satisfaction of accounts
payable
|
—
|
—
|
675,675
|
676
|
749,324
|
—
|
—
|
—
|
—
|
—
|
750,000
|
|||||||||||||||||||||||
Exercise
of stock options
|
—
|
—
|
32,400
|
33
|
32,367
|
—
|
—
|
—
|
—
|
—
|
32,400
|
|||||||||||||||||||||||
Exercise
of warrants
|
—
|
—
|
279,845
|
279
|
68,212
|
—
|
—
|
—
|
—
|
—
|
68,491
|
|||||||||||||||||||||||
Preferred
stock dividend accrued
|
—
|
—
|
—
|
—
|
—
|
—
|
(175,663
|
)
|
175,663
|
—
|
—
|
—
|
||||||||||||||||||||||
Preferred
stock dividends paid by issuance of shares
|
41,781
|
42
|
—
|
—
|
477,736
|
—
|
—
|
(479,074
|
)
|
—
|
—
|
(1,296
|
)
|
|||||||||||||||||||||
Conversion
of preferred stock to common stock at $1.10 per share
|
(896,154
|
)
|
(896
|
)
|
8,146,858
|
8,147
|
(7,251
|
)
|
—
|
—
|
—
|
—
|
—
|
—
|
||||||||||||||||||||
Share-based
compensation
|
—
|
—
|
—
|
—
|
66,971
|
—
|
—
|
—
|
—
|
20,168
|
87,139
|
|||||||||||||||||||||||
Reversal
of unrealized gain on short-term investments
|
—
|
—
|
—
|
—
|
—
|
—
|
—
|
—
|
(12,250
|
)
|
—
|
(12,250
|
)
|
|||||||||||||||||||||
Stock
issued in connection with acquisition of Tarpan Therapeutics,
Inc.
|
—
|
—
|
10,731,052
|
10,731
|
11,042,253
|
—
|
—
|
—
|
—
|
—
|
11,052,984
|
|||||||||||||||||||||||
Net
loss
|
—
|
—
|
—
|
—
|
—
|
—
|
(19,140,997
|
)
|
—
|
—
|
—
|
(19,140,997
|
)
|
|||||||||||||||||||||
Balance
at December 31, 2005
|
—
|
—
|
60,092,697
|
60,093
|
42,751,111
|
—
|
(33,271,695
|
)
|
—
|
987
|
—
|
9,540,496
|
||||||||||||||||||||||
|
|
|
|
|
|
|||||||||||||||||||||||||||||
Cashless
exercise of warrants
|
—
|
—
|
27,341
|
27
|
(27
|
)
|
—
|
—
|
—
|
—
|
—
|
—
|
||||||||||||||||||||||
Share-based
compensation
|
—
|
—
|
—
|
—
|
1,675,499
|
—
|
—
|
—
|
—
|
—
|
1,675,499
|
|||||||||||||||||||||||
Unrealized
loss on short-term investments
|
—
|
—
|
—
|
—
|
—
|
—
|
—
|
—
|
(987
|
)
|
—
|
(987
|
)
|
|||||||||||||||||||||
Costs
associated with private placement
|
—
|
—
|
—
|
—
|
(15,257
|
)
|
—
|
—
|
—
|
—
|
—
|
(15,257
|
)
|
|||||||||||||||||||||
Net
loss
|
—
|
—
|
—
|
—
|
—
|
—
|
(9,695,123
|
)
|
—
|
—
|
—
|
(9,695,123
|
)
|
|||||||||||||||||||||
Balance
at December 31, 2006
|
—
|
—
|
60,120,038
|
60,120
|
$
|
44,411,326
|
—
|
(42,966,818
|
)
|
—
|
—
|
—
|
1,504,628
|
|||||||||||||||||||||
Common
stock issued at $0.84 and $0.90 per shares, net of
expenses
|
—
|
—
|
10,185,502
|
10,186
|
7,841,999
|
—
|
—
|
—
|
—
|
—
|
7,852,185
|
|||||||||||||||||||||||
Common
stock issued to directors at $0.72 per share in satisfaction of accounts
payable
|
—
|
—
|
27,776
|
28
|
19,972
|
—
|
—
|
—
|
—
|
—
|
20,000
|
|||||||||||||||||||||||
Common
stock issued to in connection with in-licensing agreement at $0.90
per
share
|
—
|
—
|
125,000
|
125
|
112,375
|
—
|
—
|
—
|
—
|
—
|
112,500
|
|||||||||||||||||||||||
Common
stock issued to in connection with in-licensing agreement at $0.80
per
share
|
—
|
—
|
150,000
|
150
|
119,850
|
—
|
—
|
—
|
—
|
—
|
120,000
|
|||||||||||||||||||||||
Exercise
of warrants
|
—
|
—
|
10,327
|
15
|
7,219
|
—
|
—
|
—
|
—
|
—
|
7,234
|
|||||||||||||||||||||||
Cashless
exercise of warrants
|
—
|
—
|
5,589
|
—
|
(6
|
)
|
—
|
—
|
—
|
—
|
—
|
(6
|
)
|
|||||||||||||||||||||
Share-based
compensation
|
—
|
—
|
—
|
—
|
1,440,956
|
—
|
—
|
—
|
—
|
—
|
1,440,956
|
|||||||||||||||||||||||
Warrants
issued for consulting
|
83,670
|
83,670
|
||||||||||||||||||||||||||||||||
Net
loss
|
—
|
—
|
—
|
—
|
—
|
—
|
(12,032,252
|
)
|
—
|
—
|
—
|
(12,032,252
|
)
|
|||||||||||||||||||||
Balance
at December 31, 2007
|
—
|
—
|
70,624,232
|
70,624
|
54,037,361
|
—
|
(54,999,070
|
)
|
—
|
—
|
—
|
(891,085
|
)
|
|||||||||||||||||||||
Share-based
compensation
|
—
|
—
|
—
|
—
|
192,854
|
—
|
—
|
—
|
—
|
—
|
192,854
|
|||||||||||||||||||||||
Sale
of warrant
|
—
|
—
|
—
|
—
|
150,000
|
—
|
—
|
—
|
—
|
—
|
150,000
|
|||||||||||||||||||||||
Net
loss
|
—
|
—
|
—
|
—
|
—
|
—
|
(1,579,347
|
)
|
—
|
—
|
—
|
(1,579,347
|
)
|
|||||||||||||||||||||
Balance
at March 31, 2008
|
—
|
—
|
70,624,232
|
$
|
70,624
|
$
|
54,380,215
|
$
|
—
|
$
|
(56,578,417
|
)
|
$
|
—
|
$
|
—
|
$
|
—
|
$
|
(2,127,578
|
)
|
Three months ended March 31,
|
Cumulative
period from
August 6, 2001
(inception) to
March 31,
|
|||||||||
2008
|
2007
|
2008
|
||||||||
Cash
flows from operating activities:
|
||||||||||
Net
loss
|
$
|
(1,579,347
|
)
|
$
|
(2,564,257
|
)
|
$
|
(55,398,773
|
)
|
|
Adjustments
to reconcile net loss to net cash used in operating
activities:
|
||||||||||
Equity
in loss of Hedrin JV
|
19,873
|
—
|
19,873
|
|||||||
Share-based
compensation
|
192,854
|
335,210
|
3,557,837
|
|||||||
Shares
issued in connection with in-licensing agreement
|
—
|
—
|
232,500
|
|||||||
Warrants
issued to consultant
|
—
|
—
|
83,670
|
|||||||
Amortization
of intangible assets
|
—
|
—
|
145,162
|
|||||||
Gain
on sale of marketable equity securities
|
—
|
(76,032
|
)
|
|||||||
Depreciation
|
7,912
|
15,878
|
203,737
|
|||||||
Non
cash portion of in-process research and development charge
|
—
|
—
|
11,721,623
|
|||||||
Loss
on impairment and disposition of intangible assets
|
—
|
—
|
2,462,108
|
|||||||
Other
|
—
|
—
|
5,590
|
|||||||
Changes
in operating assets and liabilities, net of acquisitions:
|
||||||||||
(Increase)/decrease
in prepaid expenses
|
(17,693
|
)
|
12,494
|
(175,300
|
)
|
|||||
Increase
in other assets
|
—
|
(250,000
|
)
|
(70,506
|
)
|
|||||
Increase
/(decrease) in accounts payable
|
(293,262
|
)
|
150,367
|
1,406,436
|
||||||
Increase
in accrued expenses
|
208,038
|
119,218
|
259,894
|
|||||||
Net
cash used in operating activities
|
(1,461,625
|
)
|
(2,181,090
|
)
|
(35,622,181
|
)
|
||||
Cash
flows from investing activities:
|
||||||||||
Purchase
of property and equipment
|
—
|
(6,267
|
)
|
(230,635
|
)
|
|||||
Cash
paid in connection with acquisitions
|
—
|
—
|
(26,031
|
)
|
||||||
Net
cash provided from the purchase and sale of short-term investments,
net
|
—
|
—
|
435,938
|
|||||||
Proceeds
from the sale of license
|
—
|
—
|
200,001
|
|||||||
Investment
in Hedrin JV’s general partner
|
(13,620
|
)
|
—
|
(13,620
|
)
|
|||||
Net
cash (used in) provided by investing activities
|
(13,620
|
)
|
(6,267
|
)
|
365,653
|
|||||
Cash
flows from financing activities:
|
||||||||||
Repayments
of notes payable to stockholders
|
—
|
—
|
(884,902
|
)
|
||||||
Proceeds
related to sale of common stock, net
|
—
|
7,848,031
|
25,896,262
|
|||||||
Proceeds
from sale of preferred stock, net
|
—
|
—
|
9,046,176
|
|||||||
Proceeds
from exercise of warrants and stock options
|
—
|
—
|
138,219
|
|||||||
Proceeds
from Hedrin JV Agreement, net
|
1,958,683
|
—
|
1,958,683
|
|||||||
Other,
net
|
—
|
—
|
235,214
|
|||||||
Net
cash provided by financing activities
|
1,958,683
|
7,848,031
|
36,389,652
|
|||||||
Net
increase in cash and cash equivalents
|
483,438
|
5,660,674
|
1,133,124
|
|||||||
Cash
and cash equivalents at beginning of period
|
649,686
|
3,029,118
|
—
|
|||||||
Cash
and cash equivalents at end of period
|
$
|
1,133,124
|
$
|
8,689,792
|
$
|
1,133,124
|
||||
|
||||||||||
Supplemental
disclosure of cash flow information:
|
||||||||||
Interest
paid
|
$
|
—
|
$
|
475
|
$
|
26,033
|
||||
Supplemental
disclosure of noncash investing and financing activities:
|
||||||||||
Common
stock issued in satisfaction of accounts payable
|
$
|
—
|
$
|
—
|
$
|
770,000
|
||||
Imputed
preferred stock dividend
|
—
|
—
|
418,182
|
|||||||
Preferred
stock dividends accrued
|
—
|
—
|
761,462
|
|||||||
Preferred
stock dividends paid by issuance of shares
|
—
|
—
|
759,134
|
|||||||
Conversion
of preferred stock to common stock
|
—
|
—
|
1,067
|
|||||||
Issuance
of common stock for acquisitions
|
—
|
—
|
13,389,226
|
|||||||
Issuance
of common stock in connection with in-licensing agreement
|
—
|
—
|
232,500
|
|||||||
Marketable
equity securities received in connection with sale of
license
|
—
|
—
|
359,907
|
|||||||
Warrants
issued to consultant
|
—
|
—
|
83,670
|
|||||||
Net
liabilities assumed over assets acquired in business
combination
|
—
|
—
|
(675,416
|
)
|
||||||
Investment
in Hedrin JV
|
250,000
|
—
|
250,000
|
|||||||
Cashless
exercise of warrants
|
—
|
27
|
33
|
Three months ended March 31,
|
|||||||
2008
|
2007
|
||||||
General
and administrative expense:
|
|||||||
Share-based
employee compensation costs
|
$
|
140,043
|
$
|
221,921
|
|||
Share-based
consultant and non-employee costs
|
—
|
10,550
|
|||||
Total
general and administrative expense
|
$
|
140,043
|
$
|
232,471
|
|||
Research
and development expense:
|
|||||||
Share-based
employee compensation costs
|
$
|
52,265
|
$
|
109,918
|
|||
Share-based
consultant and non-employee (credits) costs
|
546
|
(7,179
|
)
|
||||
Total
research and development expense
|
$
|
52,811
|
$
|
102,739
|
|||
Total
share-based costs
|
$
|
192,854
|
$
|
335,210
|
Three months ended March 31,
|
|||||||
2008
|
2007
|
||||||
Expected
Volatility
|
93
|
%
|
55
|
%
|
|||
Dividend
yield
|
—
|
—
|
|||||
Expected
term (in years)
|
6
|
6
|
|||||
Risk-free
interest rate
|
2.81
|
%
|
4.88
|
%
|
Shares
|
Weighted
Average
Exercise
Price
|
Weighted
Average
Remaining
Contractual
Term (years)
|
Aggregate
Intrinsic
Value
|
||||||||||
Outstanding
at December 31, 2007
|
8,033,808
|
$
|
1.25
|
||||||||||
Granted:
|
|||||||||||||
Officers
|
2,400,000
|
||||||||||||
Directors
|
375,000
|
||||||||||||
Employees
|
192,500
|
||||||||||||
Total
granted
|
2,967,500
|
0.17
|
|||||||||||
Exercised
|
-
|
||||||||||||
Cancelled
|
-
|
||||||||||||
Outstanding
at March 31, 2008
|
11,001,308
|
$
|
0.96
|
7.55
|
$
|
500
|
|||||||
Exercisable
at March 31, 2008
|
6,687,574
|
$
|
1.10
|
6.96
|
|||||||||
Weighted
average fair value of options granted during the three months ended
March
31, 2008
|
$
|
0.13
|
·
|
Topical
PTH (1-34) for the treatment of
psoriasis;
|
·
|
Altoderm,
a proprietary formulation of topical cromolyn sodium for the treatment
of
atopic dermatitis;
|
·
|
Hedrin,
a novel, non-insecticide treatment for head
lice;
|
·
|
and
Altolyn, a proprietary site specific tablet formulation of oral
cromolyn
sodium for the treatment of
mastocytosis.
|
Quarter ended March 31,
|
|||||||||||||
2008
|
2007
|
Increase
(decrease)
|
%
Increase
(decrease)
|
||||||||||
COSTS
AND EXPENSES
|
|||||||||||||
Research
and development
|
|||||||||||||
Share-based
compensation
|
$
|
53,000
|
$
|
103,000
|
($50,000
|
)
|
(48.5
|
)%
|
|||||
Other
research and development expense
|
$
|
747,000
|
$
|
1,576,000
|
($829,000
|
)
|
(52.6
|
)%
|
|||||
Total
research and development expense
|
$
|
800,000
|
$
|
1,679,000
|
($879,000
|
)
|
(52.4
|
)%
|
|||||
General
and administrative
|
|||||||||||||
Share-based
compensation
|
$
|
140,000
|
$
|
232,000
|
($92,000
|
)
|
(39.7
|
)%
|
|||||
Other
general and administrative expense
|
$
|
674,000
|
$
|
683,000
|
($9,000
|
)
|
(1.3
|
)%
|
|||||
Total
general and administrative expense
|
$
|
814,000
|
$
|
915,000
|
($101,000
|
)
|
(11.0
|
)%
|
|||||
Other
income
|
$
|
35,000
|
$
|
30,000
|
$
|
5,000
|
16.7
|
%
|
|||||
NET
LOSS
|
($1,579,000
|
)
|
($2,564,000
|
)
|
$
|
985,000
|
(38.4
|
)%
|
Exhibit
No.
|
Description
|
|
31.1
|
Certification
of Chief Executive Officer
|
|
31.2
|
Certification
of Chief Financial Officer
|
|
32.1
|
Certifications
of Chief Executive Officer and Chief Financial Officer pursuant
to Section
906 of the Sarbanes-Oxley Act of
2002.
|
MANHATTAN PHARMACEUTICALS, INC. | ||
Date:
September 3, 2008
|
By:
|
/s/
Douglas Abel
|
Douglas Abel | ||
President and Chief Executive Officer | ||
Date:
September 3, 2008
|
By:
|
/s/
Michael G. McGuinness
|
Michael G. McGuinness | ||
Chief Operating and Financial Officer |
Description
|
||
31.1
|
Certification
of Chief Executive Officer
|
|
Certification
of Chief Financial Officer
|
||
32.1
|
Certifications
of Chief Executive Officer and Chief Financial Officer pursuant
to Section
906 of the Sarbanes-Oxley Act of
2002.
|
Date:
September 3, 2008
|
/s/ Douglas Abel
|
Douglas
Abel
|
|
President
and Chief Executive Officer
|
Date:
September 3, 2008
|
/s/
Michael G. McGuinness
|
Michael
G. McGuinness
|
|
Chief
Operating and Financial Officer
|
/s/ Douglas Abel
|
|
Douglas
Abel
|
|
President
and Chief Executive Officer
|
|
Dated:
September 3, 2008
|
/s/
Michael G. McGuinness
|
Michael
G. McGuinness
|
|
Chief
Operating and Financial Officer
|