As filed with the Securities and Exchange Commission on March 24, 1998
                                                          Registration No. 333-
- -------------------------------------------------------------------------------

                         SECURITIES AND EXCHANGE COMMISSION
                               Washington, D.C. 20549

                                      FORM S-8
                               REGISTRATION STATEMENT
                                       UNDER
                             THE SECURITIES ACT OF 1933
            
                                 -----------------

                           ATLANTIC PHARMACEUTICALS, INC.
               (Exact name of registrant as specified in its charter)

               DELAWARE                                   36-389269
     (State or other jurisdiction             (IRS Employer Identification No.)
     of incorporation or organization)

                         1017 MAIN CAMPUS DRIVE, SUITE 3900
                           RALEIGH, NORTH CAROLINA  27606
                (Address of principal executive offices) (Zip Code)
                                                      
                                 -----------------

                               1995 STOCK OPTION PLAN
                              (Full title of the Plan)
                                                     
                                 -----------------

                                  JON D. LINDJORD
                        PRESIDENT & CHIEF EXECUTIVE OFFICER
         1017 MAIN CAMPUS DRIVE, SUITE 3900, RALEIGH, NORTH CAROLINA 27606
            (Name and address, including zip code of agent for service)
                                   (919) 513-7020
           (Telephone number, including area code, of agent for service)
                                                      
                                 -----------------

                          CALCULATION OF REGISTRATION FEE

- ---------------------------------------------------------------------------------------------------- Proposed Proposed Title of Maximum Maximum Securities Amount Offering Aggregate Amount of to be to be Price Offering Registration Registered Registered(1) per Share(2) Price(2) Fee ------------- --------------- ------------- ------------ -------------------- Common Stock, $0.001 par value 59,783 shares $6.00 $358,698.00 $105.82 - ----------------------------------------------------------------------------------------------------
(1) This Registration Statement shall also cover any additional shares of Common Stock which become issuable under the Atlantic Pharmaceuticals, Inc. 1995 Stock Option Plan, by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the Registrant's receipt of consideration which results in an increase in the number of the outstanding shares of Registrant's Common Stock. (2) Calculated solely for purposes of this offering under Rule 457(h) of the Securities Act of 1933, as amended (the "1933 Act"), on the basis of the average of the high and low selling prices per share of Registrant's Common Stock on March 19, 1998 as reported on the Nasdaq Small Cap Market. PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT Item 3. INCORPORATION OF DOCUMENTS BY REFERENCE Atlantic Pharmaceuticals, Inc. (the "Registrant") hereby incorporates by reference into this Registration Statement the following documents previously filed with the Securities and Exchange Commission ("SEC"): (a) The Registrant's Annual Report on Form 10-KSB for the fiscal year ended December 31, 1997, filed with the SEC on March 23, 1998; and (b) The Registrant's Registration Statement No. 000-27282 on Form 8-A filed with the SEC on November 28, 1995, pursuant to Section 12(b) of the Securities Exchange Act of 1934, as amended (the "1934 Act"), in which there is described the terms, rights and provisions applicable to the Registrant's outstanding Common Stock. All reports and definitive proxy or information statements filed pursuant to Section 13(a), 13(c), 14 or 15(d) of the 1934 Act after the date of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed document which also is deemed to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement. Item 4. DESCRIPTION OF SECURITIES Not Applicable. Item 5. INTERESTS OF NAMED EXPERTS AND COUNSEL Not Applicable. Item 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS Section 145 of the Delaware General Corporation Law ("Section 145") authorizes a court to award or a corporation's Board of Directors to grant indemnification to directors and officers in terms sufficiently broad to permit such indemnification under certain circumstances for liabilities (including reimbursement for expenses incurred) arising under the Securities Act of 1933, as amended (the "1933 Act"). Article Ten of the Registrant's Restated Certificate of Incorporation and Article Seven of the Registrant's Restated Bylaws provide for mandatory indemnification by the Registrant of all persons the Registrant may indemnify under Section 145 to the maximum extent permitted by the Delaware General Corporation Law. Article Nine of the Registrant's Restated Certificate of Incorporation provides that the personal liability of its directors to the Registrant is eliminated to the fullest extent permitted by the Delaware General Corporation Law. These provisions do not eliminate the director's fiduciary duty, and in appropriate circumstances equitable remedies such as injunctive or other forms of non-monetary relief will remain available under Delaware law. In addition, each director has entered into a separate indemnification agreement (effective June 1997) with the Registrant and will continue to be subject to liability for breach of the director's duty of loyalty to the Company for acts or omissions not in good faith or involving intentional misconduct, for knowing violations of law, for actions leading to improper personal benefit to the director, and for payment of dividends or approval of stock repurchases or redemptions that are unlawful under Delaware law. These provisions also do not affect a director's responsibilities under any other law, such as the federal securities laws or state or federal environmental laws. Item 7. EXEMPTION FROM REGISTRATION CLAIMED Not Applicable. Item 8. EXHIBITS
EXHIBIT NUMBER EXHIBIT 4 Instruments Defining Rights of Stockholders. Reference is made to Registrant's Registration No. 000-27282 on Form 8-A which is incorporated herein by reference pursuant to Item 3(b) of this Registration Statement. 5 Opinion and Consent of Brobeck, Phleger & Harrison LLP. 23.1 Consent of KPMG Peat Marwick LLP - Independent Accountants. 23.2 Consent of Brobeck, Phleger & Harrison LLP is contained in Exhibit 5. 24 Power of Attorney. Reference is made to page II-4 of this Registration Statement. 99.1 1995 Stock Option Plan (as amended and restated June 9, 1996). 99.2* Form of Notice of Grant of Stock Option. 99.3* Form of Stock Option Agreement. 99.4* Form of Addendum to Stock Option Agreement (Special Tax Elections). 99.5* Form of Addendum to Stock Option Agreement (Involuntary Termination Following Change in Control). 99.6* Form of Addendum to Stock Option Agreement (Limited Stock Appreciation Rights). 99.7* Form of Notice of Grant of Automatic Stock Option (Initial Grant). 99.8* Form of Notice of Grant of Automatic Stock Option (Annual Grant). 99.9* Form of Automatic Stock Option Agreement.
* Exhibits 99.2 through 99.9 are incorporated herein by reference to Exhibits 99.2 through 99.9, respectively, to Registrants's Registration Statement No. 333-15807 on Form S-8, filed with the SEC on November 8, 1996. Item 9. UNDERTAKINGS A. The undersigned Registrant hereby undertakes: (1) to file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement (i) to include any prospectus required by Section 10(a)(3) of the 1933 Act, (ii) to reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement and (iii) to include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement or any material change to such information in this Registration Statement; PROVIDED, however, that clauses (1)(i) and (1)(ii) shall not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in periodic reports filed by the Registrant pursuant to Section 13 or Section 15(d) of the 1934 Act that are incorporated by reference into this Registration Statement; (2) that for the purpose of determining any liability under the 1933 Act each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof and (3) to remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the Registrant's 1995 Stock Option Plan. B. The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the 1933 Act, each filing of the Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the 1934 Act that is incorporated by reference into this Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. II-2 C. Insofar as indemnification for liabilities arising under the 1933 Act may be permitted to directors, officers or controlling persons of the Registrant pursuant to the indemnification provisions summarized in Item 6 or otherwise, the Registrant has been advised that, in the opinion of the SEC, such indemnification is against public policy as expressed in the 1933 Act, and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the 1933 Act and will be governed by the final adjudication of such issue. II-3 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8, and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Raleigh, State of North Carolina, on this 19th day of March, 1998. ATLANTIC PHARMACEUTICALS, INC. By: /s/ Jon D. Lindjord ---------------------------------------------- Jon D. Lindjord Chief Executive Officer, President and Director POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS: That the undersigned officers and directors of Atlantic Pharmaceuticals, Inc., a Delaware corporation, do hereby constitute and appoint Jon D. Lindjord the lawful attorney-in-fact and agent with full power and authority to do any and all acts and things and to execute any and all instruments which said attorney and agent determines may be necessary or advisable or required to enable said corporation to comply with the Securities Act of 1933, as amended, and any rules or regulations or requirements of the Securities and Exchange Commission in connection with this Registration Statement. Without limiting the generality of the foregoing power and authority, the powers granted include the power and authority to sign the names of the undersigned officers and directors in the capacities indicated below to this Registration Statement, to any and all amendments, both pre-effective and post-effective, and supplements to this Registration Statement, and to any and all instruments or documents filed as part of or in conjunction with this Registration Statement or amendments or supplements thereof, and each of the undersigned hereby ratifies and confirms that said attorney and agent, shall do or cause to be done by virtue hereof. This Power of Attorney may be signed in several counterparts. IN WITNESS WHEREOF, each of the undersigned has executed this Power of Attorney as of the date indicated. Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed below by the following persons in the capacities and on the dates indicated.
Signature Title Date - ---------- ------ ---- /s/ Jon D. Lindjord Chief Executive Officer, President March 19, 1998 - ----------------------------- and Director Jon D. Lindjord /s/ Shimshon Mizrachi Chief Financial Officer March 19, 1998 - ----------------------------- (Principal Financial and Shimshon Mizrachi Accounting Officer)
Signature Title Date - ---------- ------ ---- /s/ Robert Fildes Director March 19, 1998 - ----------------------------- Robert Fildes /s/ Yuichi Iwaki Director March 19, 1998 - ----------------------------- Yuichi Iwaki, M.D., Ph.D. /s/ Steve H. Kanzer Director March 19, 1998 - ----------------------------- Steve H. Kanzer /s/ John K. A. Prendergast - ----------------------------- Director March 19, 1998 John K. A. Prendergast, Ph.D. /s/ Paul D. Rubin - ----------------------------- Director March 19, 1998 Paul D. Rubin, M.D.
II-5 EXHIBIT INDEX
Exhibit Number Exhibit -------- -------- 4 Instruments Defining Rights of Stockholders. Reference is made to Registrant's Registration No. 000-27282 on Form 8-A which is incorporated herein by reference pursuant to Item 3(b) of this Registration Statement. 5 Opinion and Consent of Brobeck, Phleger & Harrison LLP. 23.1 Consent of KPMG Peat Marwick LLP - Independent Accountants. 23.2 Consent of Brobeck, Phleger & Harrison LLP is contained in Exhibit 5. 24 Power of Attorney. Reference is made to page II-4 of this Registration Statement. 99.1 1995 Stock Option Plan (as amended and restated June 9, 1996). 99.2* Form of Notice of Grant of Stock Option. 99.3* Form of Stock Option Agreement. 99.4* Form of Addendum to Stock Option Agreement (Special Tax Elections). 99.5* Form of Addendum to Stock Option Agreement (Involuntary Termination Following Change in Control). 99.6* Form of Addendum to Stock Option Agreement (Limited Stock Appreciation Rights). 99.7* Form of Notice of Grant of Automatic Stock Option (Initial Grant). 99.8* Form of Notice of Grant of Automatic Stock Option (Annual Grant). 99.9* Form of Automatic Stock Option Agreement.
* Exhibits 99.2 through 99.9 are incorporated herein by reference to Exhibits 99.2 through 99.9, respectively, to Registrants's Registration Statement No. 333-15807 on Form S-8, filed with the SEC on November 8, 1996.


                                     EXHIBIT 5

               Opinion and Consent of Brobeck, Phleger & Harrison LLP





                                     March 20, 1998


Atlantic Pharmaceuticals, Inc.
1017 Main Campus Drive, Suite 3900
Raleigh, NC  27606



          Re: Registration Statement for 
              Offering of 59,783 Shares of Common Stock 


Ladies and Gentlemen:

                   We refer to your registration on Form S-8 (the "Registration 
Statement") under the Securities Act of 1933, as amended, of 59,783 shares of 
the Common Stock of Atlantic Pharmaceuticals, Inc. (the "Company") available 
for issuance under the Company's 1995 Stock Option Plan (the "Plan"). We 
advise you that, in our opinion, when such shares have been issued and sold 
pursuant to the applicable provisions of the Plan and in accordance with the 
Registration Statement, such shares will be validly issued, fully paid and 
non-assessable shares of the Company's Common Stock.

                   We hereby consent to the filing of this opinion as an exhibit
to the Registration Statement.

                                  Very truly yours,


                                  /s/ Brobeck, Phleger & Harrison LLP

                                  BROBECK, PHLEGER & HARRISON LLP





                                 Exhibit 23.1

              CONSENT OF INDEPENDENT CERTIFIED PUBLIC ACCOUNTANTS



The Board of Directors and Stockholders
Atlantic Pharmaceuticals, Inc.



We consent to incorporation by reference in this Registration Statement on 
Form S-8 of Atlantic Pharmaceuticals, Inc. (a development stage company), for 
the 1995 Stock Option Plan, of our reported dated February 25, 1998, relating 
to the consolidated balance sheets of Atlantic Pharmaceuticals, Inc. and 
subsidiaries as of December 31, 1997 and 1996, and the related consolidated 
statements of operations, stockholders' equity (deficit), and cash flows for 
each of the years in three-year period ended December 31, 1997 and for the 
period from July 13, 1993 (inception) to December 31, 1997, which report 
appears in the December 31, 1997 annual report on Form 10-KSB of Atlantic 
Pharmaceuticals, Inc.



                                       /s/ KPMG Peat Marwick LLP
                                       --------------------------------------
                                       KPMG Peat Marwick LLP


Raleigh, North Carolina
March 19, 1998






                                    Exhibit 99.1

                           ATLANTIC PHARMACEUTICALS, INC.
                               1995 STOCK OPTION PLAN
                        as amended and restated June 9, 1996


                                    ARTICLE ONE

                                 GENERAL PROVISIONS


   I.     PURPOSE OF THE PLAN

          This 1995 Stock Option Plan is intended to promote the interests of
Atlantic Pharmaceuticals, Inc., a Delaware corporation, by providing eligible
persons with the opportunity to acquire a proprietary interest, or otherwise
increase their proprietary interest, in the Corporation as an incentive for them
to remain in the service of the Corporation.

          Capitalized terms shall have the meanings assigned to such terms in
the attached Appendix.

   II.    STRUCTURE OF THE PLAN

          A.    The Plan shall be divided into two separate equity programs:

                 (i)    the Discretionary Option Grant Program under which 
    eligible persons may, at the discretion of the Plan Administrator, be 
    granted options to purchase shares of Common Stock, and 

                (ii)    the Automatic Option Grant Program under which Eligible
    Directors shall automatically receive option grants at periodic intervals to
    purchase shares of Common Stock. 

          B.    The provisions of Articles One and Four shall apply to all 
equity programs under the Plan and shall accordingly govern the interests of all
persons under the Plan.

   III.   ADMINISTRATION OF THE PLAN

          A.    The Primary Committee shall have sole and exclusive authority to
administer the Discretionary Option Grant Program with respect to Section 16
Insiders.  No non-employee Board member shall be eligible to serve on the
Primary Committee if such individual has, during the twelve (12)-month period
immediately preceding the date of his or her appointment to the Committee or (if
shorter) the period commencing with the Section 12(g) Registration Date and
ending with the date of his or her appointment to the Primary Committee,




received an option grant or direct stock issuance under the Plan or any other
stock option, stock appreciation, stock bonus or other stock plan of the
Corporation (or any Parent or Subsidiary), other than pursuant to the Automatic
Option Grant Program.

          B.    Administration of the Discretionary Option Grant Program with
respect to all other persons eligible to participate in that program may, at the
Board's discretion, be vested in the Primary Committee or a Secondary Committee,
or the Board may retain the power to administer those programs with respect to
all such persons.  The members of the Secondary Committee may be Board members
who are Employees eligible to receive discretionary option grants or direct
stock issuances under the Plan or any other stock option, stock appreciation,
stock bonus or other stock plan of the Corporation (or any Parent or
Subsidiary).

          C.    Members of the Primary Committee or any Secondary Committee 
shall serve for such period of time as the Board may determine and may be 
removed by the Board at any time.  The Board may also at any time terminate 
the functions of any Secondary Committee and reassume all powers and 
authority previously delegated to such committee.

          D.    Each Plan Administrator shall, within the scope of its 
administrative functions under the Plan, have full power and authority to 
establish such rules and regulations as it may deem appropriate for proper 
administration of the Discretionary Option Grant Program and to make such 
determinations under, and issue such interpretations of, the provisions of 
such program and any outstanding options thereunder as it may deem necessary 
or advisable.  Decisions of the Plan Administrator within the scope of its 
administrative functions under the Plan shall be final and binding on all 
parties who have an interest in the Discretionary Option Grant Program under 
its jurisdiction or any option thereunder.

          E.    Service on the Primary Committee or the Secondary Committee 
shall constitute service as a Board member, and members of each such 
committee shall accordingly be entitled to full indemnification and 
reimbursement as Board members for their service on such committee.  No 
member of the Primary Committee or the Secondary Committee shall be liable 
for any act or omission made in good faith with respect to the Plan or any 
option grants under the Plan.

          F.    Administration of the Automatic Option Grant Program shall be 
self-executing in accordance with the terms of that program, and no Plan 
Administrator shall exercise any discretionary functions with respect to 
option grants made thereunder.

   IV.    ELIGIBILITY

          A.    The persons eligible to participate in the Discretionary Option
Grant Program are as follows:

                 (i)    Employees, 

                                       2.



                (ii)    non-employee members of the Board (other than those 
    serving as members of the Primary Committee) or the board of directors of 
    any Parent or Subsidiary, and



                (iii)   consultants and other independent advisors who provide
    services to the Corporation (or any Parent or Subsidiary).

          B.    Each Plan Administrator shall, within the scope of its
administrative jurisdiction under the Plan, have full authority (subject to the
provisions of the Plan) to determine, with respect to the option grants under
the Discretionary Option Grant Program, which eligible persons are to receive
option grants, the time or times when such option grants are to be made, the
number of shares to be covered by each such grant, the status of the granted
option as either an Incentive Option or a Non-Statutory Option, the time or
times at which each option is to become exercisable and the vesting schedule (if
any) applicable to the option shares and the maximum term for which the option
is to remain outstanding. 

          C.    The individuals eligible to participate in the Automatic 
Option Grant Program shall be (i) those individuals who first become 
non-employee Board members after the Automatic Option Grant Program Effective 
Date, whether through appointment by the Board or election by the 
Corporation's stockholders, and (ii) those individuals who continue to serve 
as non-employee Board members after one or more Annual Stockholders Meetings 
held after the Automatic Option Grant Program Effective Date, including those 
individuals serving as non-employee Board members on the Automatic Option 
Grant Program Effective Date.  A non-employee Board member who has previously 
been in the employ of the Corporation (or any Parent or Subsidiary) shall not 
be eligible to receive an initial option grant under the Automatic Option 
Grant Program at the time he or she first becomes a non-employee Board 
member, but such individual shall be eligible to receive periodic option 
grants under the Automatic Option Grant Program upon his or her continued 
service as a non-employee Board member following one or more Annual 
Stockholders Meetings.  However, in no event shall a non-employee Board 
member be eligible to receive option grants under the Automatic Option Grant 
Program if such individual is a 5% Stockholder or is a representative of, or 
affiliated with, a 5% Stockholder.

   V.     STOCK SUBJECT TO THE PLAN

          A.    The stock issuable under the Plan shall be shares of authorized
but unissued or reacquired Common Stock, including shares repurchased by the
Corporation on the open market.  The maximum number of shares of Common Stock 
which may be issued over the term of the Plan shall initially not exceed 
950,000 shares.

          B.    The number of shares of Common Stock available for issuance 
under the Plan shall automatically increase on the first trading day of each 
calendar year during the term of the Plan, beginning with the 1997 calendar 
year, by an amount equal to one percent (1%) of the shares of Common Stock 
outstanding on December 31 of the immediately preceding calendar 

                                      3.



year.  No Incentive Options may be granted on the basis of the additional 
shares of Common Stock resulting from such annual increases.

          C.    No one person participating in the Plan may receive options 
and separately exercisable stock appreciation rights for more than 100,000 
shares of Common Stock in the aggregate per calendar year, beginning with the 
1995 calendar year; provided, however, that for the calendar year in which 
such person first commences Service, the limit shall be increased to 200,000 
shares. 

          D.    Shares of Common Stock subject to outstanding options shall 
be available for subsequent issuance under the Plan to the extent (i) the 
options expire or terminate for any reason prior to exercise in full or (ii) 
the options are cancelled in accordance with the cancellation-regrant 
provisions of Article Two.  All shares issued under the Plan, whether or not 
those shares are subsequently repurchased by the Corporation pursuant to its 
repurchase rights under the Plan, shall reduce on a share-for-share basis the 
number of shares of Common Stock available for subsequent issuance under the 
Plan.  In addition, should the exercise price of an option under the Plan be 
paid with shares of Common Stock or should shares of Common Stock otherwise 
issuable under the Plan be withheld by the Corporation in satisfaction of the 
withholding taxes incurred in connection with the exercise of an option under 
the Plan, then the number of shares of Common Stock available for issuance 
under the Plan shall be reduced by the gross number of shares for which the 
option is exercised, and not by the net number of shares of Common Stock 
issued to the holder of such option. 

          E.    Should any change be made to the Common Stock by reason of 
any stock split, stock dividend, recapitalization, combination of shares, 
exchange of shares or other change affecting the outstanding Common Stock as 
a class without the Corporation's receipt of consideration, appropriate 
adjustments shall be made to (i) the maximum number and/or class of 
securities issuable under the Plan, (ii) the maximum number and/or class of 
securities for which the share reserve is to increase automatically each 
year, (iii) the number and/or class of securities for which any one person 
may be granted options and separately exercisable stock appreciation rights 
per calendar year, (iv) the number and/or class of securities for which 
automatic option grants are to be made subsequently per Eligible Director 
under the Automatic Option Grant Program and (v) the number and/or class of 
securities and the exercise price per share in effect under each outstanding 
option in order to prevent the dilution or enlargement of benefits 
thereunder.  The adjustments determined by the Plan Administrator shall be 
final, binding and conclusive, absent manifest error.

                                   4.



                                  ARTICLE TWO

                       DISCRETIONARY OPTION GRANT PROGRAM


   I.     OPTION TERMS
          
          Each option shall be evidenced by one or more documents in the form
approved by the Plan Administrator; PROVIDED, however, that each such document
shall comply with the terms specified below.  Each document evidencing an
Incentive Option shall, in addition, be subject to the provisions of the Plan
applicable to such options.

          A.    EXERCISE PRICE.

                1.    The exercise price per share shall be fixed by the Plan 
Administrator and may be less than, equal to or greater than the Fair Market 
Value per share of  Common Stock on the option grant date. 

                2.    The exercise price shall become immediately due upon 
exercise of the option and shall, subject to the provisions of Section I of 
Article Four and the documents evidencing the option, be payable in cash or 
check made payable to the Corporation.  After the Section 12(g) Registration 
Date, the exercise price may also be paid as follows:

                  (i)   in shares of Common Stock held for the requisite 
      period necessary to avoid a charge to the Corporation's earnings for 
      financial reporting purposes and valued at Fair Market Value on the 
      Exercise Date, or

                 (ii)   to the extent the option is exercised for vested 
      shares, through a special sale and remittance procedure pursuant to 
      which the Optionee shall concurrently provide irrevocable written 
      instructions to (a) a Corporation-designated brokerage firm to effect 
      the immediate sale of the purchased shares and remit to the 
      Corporation, out of the sale proceeds available on the settlement date, 
      sufficient funds to cover the aggregate exercise price payable for the 
      purchased shares plus all applicable Federal, state and local income 
      and employment taxes required to be withheld by the Corporation by 
      reason of such exercise and (b) the Corporation to deliver the 
      certificates for the purchased shares directly to such brokerage firm 
      in order to complete the sale.

          Except to the extent such sale and remittance procedure is utilized,
payment of the exercise price for the purchased shares must be made on the
Exercise Date.

          B.    EXERCISE AND TERM OF OPTIONS.  Each option shall be exercisable
at such time or times, during such period and for such number of shares as shall
be determined by the 

                                       5.



Plan Administrator and set forth in the documents evidencing the option.  
However, no option shall have a term in excess of ten (10) years measured from 
the option grant date.  
          C.    EFFECT OF TERMINATION OF SERVICE.

                1.    The following provisions shall govern the exercise of any
options held by the Optionee at the time of cessation of Service or death:

                  (i)   Any option outstanding at the time of the Optionee's 
      cessation of Service for any reason shall remain exercisable for such 
      period of time thereafter as shall be determined by the Plan 
      Administrator and set forth in the documents evidencing the option, but 
      no such option shall be exercisable after the expiration of the option 
      term.

                 (ii)   Any option exercisable in whole or in part by the 
      Optionee at the time of death may be exercised subsequently by the 
      personal representative of the Optionee's estate or by the person or 
      persons to whom the option is transferred pursuant to the Optionee's 
      will or in accordance with the laws of descent and distribution.  

                (iii)   During the applicable post-Service exercise period, 
      the option may not be exercised in the aggregate for more than the 
      number of vested shares for which the option is exercisable on the date 
      of the Optionee's cessation of Service.  Upon the expiration of the 
      applicable exercise period or (if earlier) upon the expiration of the 
      option term, the option shall terminate and cease to be outstanding for 
      any vested shares for which the option has not been exercised.  
      However, the option shall, immediately upon the Optionee's cessation of 
      Service, terminate and cease to be outstanding to the extent the option 
      is not otherwise at that time exercisable for vested shares. 

                 (iv)   Should the Optionee's Service be terminated for 
      Misconduct, then all outstanding options held by the Optionee shall 
      terminate immediately and cease to be outstanding.

                  (v)   In the event of an Involuntary Termination following 
      a Corporate Transaction,the provisions of Section III of this Article 
      Two shall govern the period for which the outstanding options are to 
      remain exercisable following the Optionee's cessation of Service and 
      shall supersede any provisions to the contrary in this section.

                2.    The Plan Administrator shall have the discretion,
exercisable either at the time an option is granted or at any time while the
option remains outstanding, to:

                  (i)   extend the period of time for which the option is to 
      remain exercisable following the Optionee's cessation of Service from 
      the period otherwise in effect for that option to such greater period 
      of time as the Plan 

                                       6.



      Administrator shall deem appropriate, but in no event beyond the 
      expiration of the option term, and/or

                 (ii)   permit the option to be exercised, during the 
      applicable post-Service exercise period, not only with respect to the 
      number of vested shares of Common Stock for which such option is 
      exercisable at the time of the Optionee's cessation of Service but also 
      with respect to one or more additional installments in which the 
      Optionee would have vested under the option had the Optionee continued 
      in Service.

          D.    STOCKHOLDER RIGHTS.  The holder of an option shall have no
stockholder rights with respect to the shares subject to the option until such
person shall have exercised the option, paid the exercise price and become a
holder of record of the purchased shares.

          E.    REPURCHASE RIGHTS.  The Plan Administrator shall have the 
discretion to grant options which are exercisable for unvested shares of 
Common Stock.  Should the Optionee cease Service while holding such unvested 
shares, the Corporation shall have the right to repurchase, at the exercise 
price paid per share, any or all of those unvested shares.  The terms upon 
which such repurchase right shall be exercisable (including the period and 
procedure for exercise and the appropriate vesting schedule for the purchased 
shares) shall be established by the Plan Administrator and set forth in the 
document evidencing such repurchase right.  

          F.    FIRST REFUSAL RIGHTS.  Until the Section 12(g) Registration 
Date, the Corporation shall have the right of first refusal with respect to 
any proposed sale or other disposition by the Optionee (or any successor in 
interest by reason of purchase, gift or other transfer) of any shares of 
Common Stock issued under the Plan.  Such right of first refusal shall be 
exercisable in accordance with the terms and conditions established by the 
Plan Administrator and set forth in the agreement evidencing such right.

          G.    LIMITED TRANSFERABILITY OF OPTIONS.  During the lifetime of 
the Optionee, the option shall be exercisable only by the Optionee and shall 
not be assignable or transferable other than by will or by the laws of 
descent and distribution following the Optionee's death.  However, a 
Non-Statutory Option may be assigned in whole or in part during the 
Optionee's lifetime in accordance with the terms of a Qualified Domestic 
Relations Order.  The assigned portion may only be exercised by the person or 
persons who acquire a proprietary interest in the option pursuant to such 
Qualified Domestic Relations Order.  The terms applicable to the assigned 
portion shall be the same as those in effect for the option immediately prior 
to such assignment and shall be set forth in such documents issued to the 
assignee as the Plan Administrator may deem appropriate.

                                       7.



   II.    INCENTIVE OPTIONS

          The terms specified below shall be applicable to all Incentive 
Options.  Except as modified by the provisions of this Section II, all the 
provisions of Articles One, Two and Five shall be applicable to Incentive 
Options. Options which are specifically designated as Non-Statutory Options 
when issued under the Plan shall NOT be subject to the terms of this 
Section II.

          A.    ELIGIBILITY.  Incentive Options may only be granted to 
Employees. 

          B.    EXERCISE PRICE.  The exercise price per share shall not be 
less than one hundred percent (100%) of the Fair Market Value per share of 
Common Stock on the option grant date.

          C.    DOLLAR LIMITATION.  The aggregate Fair Market Value of the 
shares of Common Stock (determined as of the respective date or dates of 
grant) for which one or more options granted to any Employee under the Plan 
(or any other option plan of the Corporation or any Parent or Subsidiary) may 
for the first time become exercisable as Incentive Options during any one (1) 
calendar year shall not exceed the sum of One Hundred Thousand Dollars 
($100,000).  To the extent the Employee holds two (2) or more such options 
which become exercisable for the first time in the same calendar year, the 
foregoing limitation on the exercisability of such options as Incentive 
Options shall be applied on the basis of the order in which such options are 
granted.

          D.    10% STOCKHOLDER.  If any Employee to whom an Incentive Option 
is granted is a 10% Stockholder, then the exercise price per share shall not 
be less than one hundred ten percent (110%) of the Fair Market Value per 
share of Common Stock on the option grant date, and the option term shall not 
exceed five (5) years measured from the option grant date.

   III.   CORPORATE TRANSACTION/CHANGE IN CONTROL

          A.    In the event of any Corporate Transaction, each outstanding
option shall automatically accelerate so that each such option shall,
immediately prior to the effective date of the Corporate Transaction, become
fully exercisable for all of the shares of Common Stock at the time subject to
such option and may be exercised for any or all of those shares as fully-vested
shares of Common Stock.  However, an outstanding option shall NOT so accelerate
if and to the extent:  (i) such option is, in connection with the Corporate
Transaction, either to be assumed by the successor corporation (or parent
thereof) or to be replaced with a comparable option to purchase shares of the
capital stock of the successor corporation (or parent thereof), (ii) such option
is to be replaced with a cash incentive program of the successor corporation
which preserves the spread existing on the unvested option shares at the time of
the Corporate Transaction and provides for subsequent payout in accordance with
the same vesting schedule applicable to such option or (iii) the acceleration of
such option is subject to other limitations imposed by the Plan Administrator at
the time of the option grant.  The determination of option 

                                       8.



comparability under clause (i) above shall be made by the Plan Administrator, 
and its determination shall be final, binding and conclusive, absent manifest 
error.

          B.    All outstanding repurchase rights shall also terminate 
automatically, and the shares of Common Stock subject to those terminated 
rights shall immediately vest in full, in the event of any Corporate 
Transaction, except to the extent: (i) those repurchase rights are to be 
assigned to the successor corporation (or parent thereof) in connection with 
such Corporate Transaction or (ii) such accelerated vesting is precluded by 
other limitations imposed by the Plan Administrator at the time the 
repurchase right is issued.  

          C.    Immediately following the consummation of the Corporate 
Transaction, all outstanding options shall terminate and cease to be 
outstanding, except to the extent assumed by the successor corporation (or 
parent thereof).

          D.    Each option which is assumed in connection with a Corporate 
Transaction shall be appropriately adjusted, immediately after such Corporate 
Transaction, to apply to the number and class of securities which would have 
been issuable to the Optionee in consummation of such Corporate Transaction 
had the option been exercised immediately prior to such Corporate 
Transaction. Appropriate adjustments shall also be made to (i) the number and 
class of securities available for issuance under the Plan  following the 
consummation of such Corporate Transaction, (ii) the exercise price payable 
per share under each outstanding option, PROVIDED the aggregate exercise 
price payable for such securities shall remain the same and (iii) the maximum 
number of securities and/or class of securities for which any one person may 
be granted options and separately exercisable stock appreciation rights under 
the Plan per calendar year.  

          E.    Any options which are assumed or replaced in the Corporate 
Transaction and do not otherwise accelerate at that time, shall automatically 
accelerate (and any of the Corporation's outstanding repurchase rights which 
do not otherwise terminate at the time of the Corporate Transaction shall 
automatically terminate and the shares of Common Stock subject to those 
terminated rights shall immediately vest in full) in the event the Optionee's 
Service should subsequently terminate by reason of an Involuntary Termination 
within eighteen (18) months following the effective date of such Corporate 
Transaction.  Any options so accelerated shall remain exercisable for 
fully-vested shares until the EARLIER of (i) the expiration of the option 
term or (ii) the expiration of the one (1)-year period measured from the 
effective date of the Involuntary Termination.

          F.    The Plan Administrator shall have the discretion to grant 
options with terms different from those described in this Section III in 
connection with a Corporate Transaction.

          G.    The Plan Administrator shall have the discretion, exercisable 
either at the time the option is granted or at any time while the option 
remains outstanding, to (i)  provide for the automatic acceleration of one or 
more outstanding options (and the automatic termination of one or more 
outstanding repurchase rights with the immediate vesting of the shares of 
Common Stock subject to those rights) upon the occurrence of a Change in 
Control or (ii) condition any 

                                       9.



such option acceleration (and the termination of any outstanding repurchase 
rights) upon the subsequent Involuntary Termination of the Optionee's Service 
within a specified period following the effective date of such Change in 
Control.  Any options accelerated in connection with a Change in Control 
shall remain fully exercisable until the expiration or sooner termination of 
the option term.

          H.    The portion of any Incentive Option accelerated in connection 
with a Corporate Transaction or Change in Control shall remain exercisable as 
an Incentive Option only to the extent the applicable One Hundred Thousand 
Dollar ($100,000) limitation is not exceeded.  To the extent such dollar 
limitation is exceeded, the accelerated portion of such option shall be 
exercisable as a Non-Statutory Option under the Federal tax laws.

          I.    The grant of options under the Discretionary Option Grant 
Program shall in no way affect the right of the Corporation to adjust, 
reclassify, reorganize or otherwise change its capital or business structure 
or to merge, consolidate, dissolve, liquidate or sell or transfer all or any 
part of its business or assets.

   IV.    CANCELLATION AND REGRANT OF OPTIONS

          The Plan Administrator shall have the authority to effect, at any 
time and from time to time, with the consent of the affected option holders, 
the cancellation of any or all outstanding options under the Discretionary 
Option Grant Program and to grant in substitution new options covering the 
same or different number of shares of Common Stock but with an exercise price 
per share based on the Fair Market Value per share of Common Stock on the new 
option grant date. 

    V.    STOCK APPRECIATION RIGHTS

          A.    The Plan Administrator shall have full power and authority to 
grant to selected Optionees tandem stock appreciation rights and/or limited 
stock appreciation rights.

          B.    The following terms shall govern the grant and exercise of 
tandem stock appreciation rights:

                  (i)   One or more Optionees may be granted the right, 
      exercisable upon such terms as the Plan Administrator may establish, to 
      elect between the exercise of the underlying option for shares of 
      Common Stock and the surrender of that option in exchange for a 
      distribution from the Corporation in an amount equal to the excess of 
      (a) the Fair Market Value (on the option surrender date) of the number 
      of shares in which the Optionee is at the time vested under the 
      surrendered option (or surrendered portion thereof) over (b) the 
      aggregate exercise price payable for such shares.

                                       10.


                 (ii)   No such option surrender shall be effective unless it 
      is approved by the Plan Administrator.  If the surrender is so 
      approved, then the distribution to which the Optionee shall  be 
      entitled may be made in shares of Common Stock valued at Fair Market 
      Value on the option surrender date, in cash, or partly in shares and 
      partly in cash, as the Plan Administrator shall in its sole discretion 
      deem appropriate.

                (iii)   If the surrender of an option is rejected by the Plan 
      Administrator, then the Optionee shall retain whatever rights the 
      Optionee had under the surrendered option (or surrendered portion 
      thereof) on the option surrender date and may exercise such rights at 
      any time prior to the LATER of (a) five (5) business days after the 
      receipt of the rejection notice or (b) the last day on which the option 
      is otherwise exercisable in accordance with the terms of the documents 
      evidencing such option, but in no event may such rights be exercised 
      more than ten (10) years after the  option grant date.

          C.    The following terms shall govern the grant and exercise of 
limited stock appreciation rights:

                  (i)   One or more Section 16 Insiders may be granted 
      limited stock appreciation rights with respect to their outstanding 
      options.

                  (ii)   Upon the occurrence of a Hostile Take-Over, each such 
      individual holding one or more options with such a limited stock 
      appreciation right in effect for at least six (6) months shall have the 
      unconditional right (exercisable for a thirty (30)-day period following 
      such Hostile Take-Over) to surrender each such option to the 
      Corporation, to the extent the option is at the time exercisable for 
      vested shares of Common Stock. In return for the surrendered option, 
      the Optionee shall receive a cash distribution from the Corporation in 
      an amount equal to the excess of (a) the Take-Over Price of the shares 
      of Common Stock which are at the time vested under each surrendered 
      option (or surrendered portion thereof) over (b) the aggregate exercise 
      price payable for such shares.  
                                      
      Such cash distribution shall be paid within five (5) days following 
      the option surrender date.

                (iii)   Neither the approval of the Plan Administrator nor 
      the consent of the Board shall be required in connection with such 
      option surrender and cash distribution.

                 (iv)   The balance of the option (if any) shall continue in 
      full force and effect in accordance with the documents evidencing such 
      option.

                                       11.



                                    ARTICLE THREE 

                           AUTOMATIC OPTION GRANT PROGRAM


   I.     OPTION TERMS 

          A.    GRANT DATES.  Option grants shall be made on the dates 
specified below:

                1.   Each Eligible Director who is first elected or appointed 
as a non-employee Board member after the Automatic Option Grant Program 
Effective Date shall automatically be granted, on the date of such initial 
election or appointment (as the case may be), a Non-Statutory Option to 
purchase 10,000 shares of Common Stock.

                2.   On the date of each Annual Stockholders Meeting held 
after the Automatic Option Grant Program Effective Date, each individual who 
is to continue to serve as an Eligible Director after such meeting, shall 
automatically be granted, whether or not such individual is standing for 
re-election as a Board member at that Annual Meeting, a Non-Statutory Option 
to purchase an additional 2,000 shares of Common Stock, provided such 
individual has served as a non-employee Board member for at least six (6) 
months.  There shall be no limit on the number of such 2,000-share option 
grants any one Eligible Director may receive over his or her period of Board 
service.

          B.    EXERCISE PRICE. 

                1.   The exercise price per share shall be equal to one 
hundred percent (100%) of the Fair Market Value per share of Common Stock on 
the option grant date.

                2.   The exercise price shall be payable in one or more of 
the alternative forms authorized under the Discretionary Option Grant 
Program. Except to the extent the sale and remittance procedure specified 
thereunder is utilized, payment of the exercise price for the purchased 
shares must be made on the Exercise Date.

          C.    OPTION TERM.  Each option shall have a term of ten (10) years 
measured from the option grant date.

          D.    EXERCISE AND VESTING OF OPTIONS.  Each option shall be 
immediately exercisable for any or all of the option shares.  However, any 
shares purchased under the option shall be subject to repurchase by the 
Corporation, at the exercise price paid per share, upon the Optionee's 
cessation of Board service prior to vesting in those shares.  Each initial 
grant shall vest, and the Corporation's repurchase right shall lapse, in a 
series of three (3) successive and equal annual installments over the 
Optionee's period of continued service as a Board member, with the first such 
installment to vest upon the Optionee's completion of one (1) year of Board 

                                       12.



service measured from the option grant date.  Each annual grant shall vest, 
and the Corporation's repurchase right shall lapse, upon the  Optionee's 
completion of one (1) year of Board service measured from the option grant 
date. 

          E.    EFFECT OF TERMINATION OF BOARD SERVICE.  The following 
provisions shall govern the exercise of any options held by the Optionee at 
the time the Optionee ceases to serve as a Board member:

                  (i)   The Optionee (or, in the event of Optionee's death, 
      the personal representative of the Optionee's estate or the person or 
      persons to whom the option is transferred pursuant to the Optionee's 
      will or in accordance with the laws of descent and distribution) shall 
      have a twelve (12)-month period following the date of such cessation of 
      Board service in which to exercise each such option.  

                 (ii)   During the twelve (12)-month exercise period, the 
      option may not be exercised in the aggregate for more than the number 
      of vested shares of Common Stock for which the option is exercisable at 
      the time of the Optionee's cessation of Board service.  

                (iii)   Should the Optionee cease to serve as a Board member 
      by reason of death or Permanent Disability, then all shares at the time 
      subject to the option shall immediately vest so that such option may, 
      during the twelve (12)-month exercise period following such cessation 
      of Board service, be exercised for all or any portion of those shares 
      as fully-vested shares of Common Stock.

                 (iv)   In no event shall the option remain exercisable after 
      the expiration of the option term.  Upon the expiration of the twelve 
      (12)-month exercise period or (if earlier) upon the expiration of the 
      option term, the option shall terminate and cease to be outstanding for 
      any vested shares for which the option has not been exercised.  
      However, the option shall, immediately upon the Optionee's cessation of 
      Board service for any reason other than death or Permanent Disability, 
      terminate and cease to be outstanding to the extent the option is not 
      otherwise at that time exercisable for vested shares. 

  II.     CORPORATE TRANSACTION/CHANGE IN CONTROL/HOSTILE TAKE-OVER

          A.    In the event of any Corporate Transaction, the shares of 
Common Stock at the time subject to each outstanding option but not otherwise 
vested shall automatically vest in full so that each such option shall, 
immediately prior to the effective date of the Corporate Transaction, become 
fully exercisable for all of the shares of Common Stock at the time subject 
to such option and may be exercised for all or any portion of those shares as 
fully-vested shares of Common Stock.  Immediately following the consummation 
of the Corporate Transaction, each 

                                       13.




automatic option grant shall terminate and cease to be outstanding, except to 
the extent assumed by the successor corporation (or parent thereof).

          B.    In connection with any Change in Control, the shares of 
Common Stock at the time subject to each outstanding option but not otherwise 
vested shall automatically vest in full so that each such option shall, 
immediately prior to the effective date of the Change in Control, become 
fully exercisable for all of the shares of Common Stock at the time subject 
to such option and may be exercised for all or any portion of such shares as 
fully-vested shares of Common Stock.  Each such option shall remain 
exercisable for such fully-vested option shares until the expiration or 
sooner termination of the option term or the surrender of the option in 
connection with a Hostile Take-Over.

          C.    Upon the occurrence of a Hostile Take-Over, the Optionee 
shall have a thirty (30)-day period in which to surrender to the Corporation 
each automatic option held by him or her for a period of at least six (6) 
months. The Optionee shall in return be entitled to a cash distribution from 
the Corporation in an amount equal to the excess of (i) the Take-Over Price 
of the shares of Common Stock at the time subject to the surrendered option 
(whether or not the Optionee is otherwise at the time vested in those shares) 
over (ii) the aggregate exercise price payable for such shares.  Such cash 
distribution shall be paid within five (5) days following the surrender of 
the option to the Corporation.  No approval or consent of the Board or any 
Plan Administrator shall be required in connection with such option surrender 
and cash distribution.  

          D.    Each option which is assumed in connection with a Corporate 
Transaction shall be appropriately adjusted, immediately after such Corporate 
Transaction, to apply to the number and class of securities which would have 
been issuable to the Optionee in consummation of such Corporate Transaction 
had the option been exercised immediately prior to such Corporate 
Transaction. Appropriate adjustments shall also be made to the exercise price 
payable per share under each outstanding option, provided the aggregate 
exercise price payable for such securities shall remain the same.

          E.    The grant of options under the Automatic Option Grant Program 
shall in no way affect the right of the Corporation to adjust, reclassify, 
reorganize or otherwise change its capital or business structure or to merge, 
consolidate, dissolve, liquidate or sell or transfer all or any part of its 
business or assets.
 
 III.     AMENDMENT OF THE AUTOMATIC OPTION GRANT PROGRAM

          The provisions of this Automatic Option Grant Program, together 
with the option grants outstanding thereunder, may not be amended at 
intervals more frequently than once every six (6) months, other than to the 
extent necessary to comply with applicable Federal income tax laws and 
regulations.

  IV.     REMAINING TERMS  

                                      14.



          The remaining terms of each option granted under the Automatic Option
Grant Program shall be the same as the terms in effect for option grants made
under the Discretionary Option Grant Program. 


                                      15.



                                    ARTICLE FOUR

                                   MISCELLANEOUS


   I.     FINANCING

          A.    The Plan Administrator may permit any Optionee to pay the 
option exercise price under the Discretionary Option Grant Program by 
delivering a promissory note payable in one or more installments.  The terms 
of any such promissory note (including the interest rate and the terms of 
repayment) shall be established by the Plan Administrator in its sole 
discretion.  Promissory notes may be authorized with or without security or 
collateral.  In all events, the maximum credit available to the Optionee may 
not exceed the sum of (i) the aggregate option exercise price payable for the 
purchased shares plus (ii) any Federal, state and local income and employment 
tax liability incurred by the Optionee in connection with the option 
exercise. 

          B.    The Plan Administrator may, in its discretion, determine that 
one or more such promissory notes shall be subject to forgiveness by the 
Corporation in whole or in part upon such terms as the Plan Administrator may 
deem appropriate.

  II.     TAX WITHHOLDING

          A.    The Corporation's obligation to deliver shares of Common 
Stock upon the exercise of options or stock appreciation rights under the 
Plan shall be subject to the satisfaction of all applicable Federal, state 
and local income and employment tax withholding requirements.

          B.    The Plan Administrator may, in its discretion, provide any or 
all holders of Non-Statutory Options under the Plan (other than the options 
granted under the Automatic Option Grant Program) with the right to use 
shares of Common Stock in satisfaction of all or part of the Taxes incurred 
by such holders in connection with the exercise of their options.  Such right 
may be provided to any such holder in either or both of the following formats:

                  (i)   STOCK WITHHOLDING:  The election to have the 
      Corporation withhold, from the shares of Common Stock otherwise 
      issuable upon the exercise of such Non-Statutory Option, a portion of 
      those shares with an aggregate Fair Market Value equal to the 
      percentage of the Taxes (not to exceed one hundred percent (100%)) 
      designated by the holder.

                 (ii)   STOCK DELIVERY:  The election to deliver to the 
      Corporation, at the time the Non-Statutory Option is exercised, one or 
      more shares of Common Stock previously acquired by such holder (other 
      than in connection with the option exercise triggering the Taxes) with 
      an aggregate Fair Market Value 

                                      16.



      equal to the percentage of the Taxes (not to exceed one hundred percent 
      (100%)) designated by the holder.

 III.     EFFECTIVE DATE AND TERM OF THE PLAN

          A.    The Discretionary Option Grant Program shall became effective 
on the Plan Effective Date and options may be granted under the Discretionary 
Option Grant Program at any time after the Plan Effective Date.  The 
Automatic Option Grant Program became effective on the Automatic Option Grant 
Program Effective Date and option grants under the Automatic Option Grant 
Program may be made to the Eligible Directors after such date.  However, no 
options granted under the Plan may be exercised until the Plan is approved by 
the Corporation's stockholders.  If such stockholder approval is not obtained 
within twelve (12) months after the Plan Effective Date, then all options 
previously granted under this Plan shall terminate and cease to be 
outstanding, and no further options shall be granted and no shares shall be 
issued under the Plan. 

          B.    The Plan was amended on June 9, 1995 to (i) increase the 
total number of shares of Common Stock available for issuance from 650,000 
shares to 950,000 shares and (ii) to increase the number of shares of Common 
Stock subject to the options granted under the Automatic Option Grant Program 
upon the initial election or appointment of an Eligible Director from 5,000 
shares to 10,000 and to increase the number of shares of Common Stock subject 
to the annual option grants thereunder to be made on the date of each Annual 
Stockholders Meeting to continuing non-employee Board members from 1,000 to 
2,000 shares.  

          C.    The Plan shall terminate upon the EARLIEST of (i) June 30, 
2005, (ii) the date on which all shares available for issuance under the Plan 
shall have been issued pursuant to the exercise of the options under the Plan 
or (iii) the termination of all outstanding options in connection with a 
Corporate Transaction.  Upon such Plan termination, all outstanding options 
shall continue to have force and effect in accordance with the provisions of 
the documents evidencing such options.  

  IV.     AMENDMENT OF THE PLAN 

          A.    The Board shall have complete and exclusive power and 
authority amend or modify the Plan in any or all respects.  However, (i) no 
such amendment or modification shall adversely affect any rights and 
obligations with respect to options or stock appreciation rights at the time 
outstanding under the Plan unless the Optionee consents to such amendment or 
modification, and (ii) any amendment made to the Automatic Option Grant 
Program (or any options outstanding thereunder) shall be in compliance with 
the limitations of that program.  In addition, the Board shall not, without 
the approval of the Corporation's stockholders, (i) materially increase the 
maximum number of shares issuable under the Plan, the number of shares for 
which options may be granted under the Automatic Option Grant Program or the 
maximum number of shares for which any one person may be granted options or 
separately exercisable stock appreciation rights in the aggregate per 
calendar year, except for permissible adjustments 

                                       17.



in the event of certain changes in the Corporation's capitalization, (ii) 
materially modify the eligibility requirements for Plan participation or 
(iii) materially increase the benefits accruing to Plan participants.

          B.    Options to purchase shares of Common Stock may be granted 
under the Discretionary Option Grant Program that are in excess of the number 
of shares then available for issuance under the Plan, provided any excess 
shares actually issued under those programs are held in escrow until there is 
obtained stockholder approval of an amendment sufficiently increasing the 
number of shares of Common Stock available for issuance under the Plan.  If 
such stockholder approval is not obtained within twelve (12) months after the 
date the first such excess grants are made, then (i) any unexercised options 
granted on the basis of such excess shares shall terminate and cease to be 
outstanding and (ii) the Corporation shall promptly refund to the Optionees 
the exercise price paid for any excess shares issued under the Plan and held 
in escrow, together with interest (at the applicable Short Term Federal Rate) 
for the period the shares were held in escrow, and such shares shall 
thereupon be automatically cancelled and cease to be outstanding.

   V.     USE OF PROCEEDS

          Any cash proceeds received by the Corporation from the sale of 
shares of Common Stock under the Plan shall be used for general corporate 
purposes.

  VI.     REGULATORY APPROVALS

          A.    The implementation of the Plan, the granting of any option or 
stock appreciation right under the Plan and the issuance of any shares of 
Common Stock upon the exercise of any option or stock appreciation right 
shall be subject to the Corporation's procurement of all approvals and 
permits required by regulatory authorities having jurisdiction over the Plan, 
the options and stock appreciation rights granted under it and the shares of 
Common Stock issued pursuant to it.

          B.    No shares of Common Stock or other assets shall be issued or 
delivered under the Plan unless and until there shall have been compliance 
with all applicable requirements of Federal and state securities laws and all 
applicable listing requirements of any stock exchange (or the Nasdaq National 
Market, if applicable) on which Common Stock is then listed for trading. 

 VII.     NO EMPLOYMENT/SERVICE RIGHTS

          Nothing in the Plan shall confer upon the Optionee any right to 
continue in Service     for any period of specific duration or interfere with 
or otherwise restrict in any way the rights of the Corporation (or any Parent 
or Subsidiary employing or retaining such person) or of the Optionee, which 
rights are hereby expressly reserved by each, to terminate such person's 
Service at any time for any reason, with or without cause.

                                       18.



                               APPENDIX

          The following definitions shall be in effect under the Plan:

          A.    AUTOMATIC OPTION GRANT PROGRAM shall mean the automatic 
option grant program in effect under the Plan.

          B.    AUTOMATIC OPTION GRANT PROGRAM EFFECTIVE DATE shall mean the 
date on which the Underwriting Agreement is executed and the initial public 
offering price of the Common Stock is established.

          C.    BOARD shall mean the Corporation's Board of Directors.

          D.    CHANGE IN CONTROL shall mean a change in ownership or control 
of the Corporation effected through either of the following transactions:

                  (i)   the acquisition, directly or indirectly, by any 
      person or related group of persons (other than the Corporation or a 
      person that directly or indirectly controls, is controlled by, or is 
      under common control with, the Corporation), of beneficial ownership 
      (within the meaning of Rule 13d-3 of the 1934 Act) of securities 
      possessing more than fifty percent (50%) of the total combined voting 
      power of the Corporation's outstanding securities pursuant to a tender 
      or exchange offer made directly to the Corporation's stockholders which 
      the Board does not recommend such stockholders to accept, or

                  (i)   a change in the composition of the Board over a 
      period of thirty-six (36) consecutive months or less such that a 
      majority of the Board members ceases, by reason of one or more 
      contested elections for Board membership, to be comprised of 
      individuals who either (A) have been Board members continuously since 
      the beginning of such period or (B) have been elected or nominated for 
      election as Board members during such period by at least a majority of 
      the Board members described in clause (A) who were still in office at 
      the time the Board approved such election or nomination.

          E.    CODE shall mean the Internal Revenue Code of 1986, as amended.

          F.    COMMON STOCK shall mean the Corporation's common stock.

          G.    CORPORATE TRANSACTION shall mean either of the following 
stockholder-approved transactions to which the Corporation is a party:

                  (i)   a merger or consolidation in which securities 
      possessing more than fifty percent (50%) of the total combined voting 
      power of the 

                                       A-1.



      Corporation's outstanding securities are transferred to a person or 
      persons different from the persons holding those securities immediately 
      prior to such transaction; or 

                 (ii)   the sale, transfer or other disposition of all or 
      substantially all of the Corporation's assets in complete liquidation 
      or dissolution of the Corporation.

          H.    CORPORATION shall mean Atlantic Pharmaceuticals, Inc., a 
Delaware corporation, and any corporate successor to all or substantially all 
of the assets or voting stock of Atlantic Pharmaceuticals, Inc. which shall 
by appropriate action adopt the Plan.

          I.    DISCRETIONARY OPTION GRANT PROGRAM shall mean the 
discretionary option grant program in effect under the Plan.

          J.    DOMESTIC RELATIONS ORDER shall mean any judgment, decree or 
order (including approval of a property settlement agreement) which provides 
or otherwise conveys, pursuant to applicable State domestic relations laws 
(including community property laws), marital property rights to any spouse or 
former spouse of the Optionee.

          K.    ELIGIBLE DIRECTOR shall mean a non-employee Board member 
eligible to participate in the Automatic Option Grant Program in accordance 
with the eligibility provisions of Article One.

          L.    EMPLOYEE shall mean an individual who is in the employ of the 
Corporation (or any Parent or Subsidiary), subject to the control and 
direction of the employer entity as to both the work to be performed and the 
manner and method of performance.

          M.    EXERCISE DATE shall mean the date on which the Corporation 
shall have received written notice of the option exercise.

          N.    FAIR MARKET VALUE per share of Common Stock on any relevant 
date shall be determined in accordance with the following provisions:

                  (i)   If the Common Stock is at the time traded on the 
      Nasdaq National Market, then the Fair Market Value shall be the closing 
      selling price per share of Common Stock on the date in question, as 
      such price is reported by the National Association of Securities 
      Dealers on the Nasdaq National Market or any successor system.  If 
      there is no closing selling price for the Common Stock on the date in 
      question, then the Fair Market Value shall be the closing selling price 
      on the last preceding date for which such quotation exists.

                 (ii)   If the Common Stock is at the time traded on the 
      Nasdaq SmallCap Market or the over-the-counter market, then the Fair 
      Market Value shall 

                                       A-2.



      be the average of the highest bid and lowest asked prices per share of 
      Common Stock on the date in question on the Nasdaq SmallCap Market or 
      the over-the-counter market, as such prices are reported by the 
      National Association of Securities Dealers through its Nasdaq system or 
      any successor system.  If there are no reported bid and asked prices 
      for the Common Stock on the date in question, then the Fair Market 
      Value shall be the average of the highest bid and lowest asked prices 
      on the last preceding date for which such quotations exist.

                (iii)   If the Common Stock is at the time listed on any 
      Stock Exchange, then the Fair Market Value shall be the closing selling 
      price per share of Common Stock on the date in question on the Stock 
      Exchange determined by the Plan Administrator to be the primary market 
      for the Common Stock, as such price is officially quoted in the 
      composite tape of transactions on such exchange.  If there is no 
      closing selling price for the Common Stock on the date in question, 
      then the Fair Market Value shall be the closing selling price  on the 
      last preceding date for which such quotation exists.

                 (iv)   For purposes of any option grants made on the date 
      the Underwriting Agreement is executed and the initial public offering 
      price of the Common Stock is established, the Fair Market Value shall 
      be deemed to be equal to the established initial offering price per 
      share.  For purposes of option grants made prior to such date, the Fair 
      Market Value shall be determined by the Plan Administrator after taking 
      into account such factors as the Plan Administrator shall deem 
      appropriate.

          O.    5% STOCKHOLDER shall mean the owner of stock (as determined 
under Code Section 424(d)) possessing more than five percent (5%) of the 
total combined voting power of all classes of stock of the Corporation (or 
any Parent or Subsidiary).

          P.    HOSTILE TAKE-OVER shall mean a change in ownership of the 
Corporation effected through the following transaction:

                  (i)   the acquisition, directly or indirectly, by any 
      person or related group of persons (other than the Corporation or a 
      person that directly or indirectly controls, is controlled by, or is 
      under common control with, the Corporation) of beneficial ownership 
      (within the meaning of Rule 13d-3 of the 1934 Act) of securities 
      possessing more than fifty percent (50%) of the total combined voting 
      power of the Corporation's outstanding securities  pursuant to a tender 
      or exchange offer made directly to the Corporation's stockholders which 
      the Board does not recommend such stockholders to accept, AND

                 (ii)   more than fifty percent (50%) of the securities so 
      acquired are accepted from persons other than Section 16 Insiders.

                                       A-3.



          Q.    INCENTIVE OPTION shall mean an option which satisfies the 
requirements of Code Section 422.

          R.    INVOLUNTARY TERMINATION shall mean the termination of the 
Service of any individual which occurs by reason of: 

                (i)  such individual's involuntary dismissal or discharge by 
          the Corporation for reasons other than Misconduct, or 

                (ii) such individual's voluntary resignation following (A) a 
          change in his or her position with the Corporation which materially 
          reduces his or her level of responsibility, (B) a reduction in his 
          or her level of compensation (including base salary, fringe 
          benefits and participation in corporate-performance based bonus or 
          incentive programs) by more than fifteen percent (15%) or (C) a 
          relocation of such individual's place of employment by more than 
          fifty (50) miles, provided and only if such change, reduction or 
          relocation is effected by the Corporation without the individual's 
          consent.

          S.    MISCONDUCT shall mean the commission of any act of fraud, 
embezzlement or dishonesty by the Optionee, any unauthorized use or 
disclosure by such person of confidential information or trade secrets of the 
Corporation (or any Parent or Subsidiary), or any other intentional 
misconduct by such person adversely affecting the business or affairs of the 
Corporation (or any Parent or Subsidiary) in a material manner.  The 
foregoing definition shall not be deemed to be inclusive of all the acts or 
omissions which the Corporation (or any Parent or Subsidiary) may consider as 
grounds for the dismissal or discharge of any Optionee or other person in the 
Service of the Corporation (or any Parent or Subsidiary). 

          T.    1934 ACT shall mean the Securities Exchange Act of 1934, as 
amended.

          U.    NON-STATUTORY OPTION shall mean an option not intended to 
satisfy  the requirements of Code Section 422.

          V.    OPTIONEE shall mean any person to whom an option is granted 
under the Discretionary Option Grant or Automatic Option Grant Program.

          W.    PARENT shall mean any corporation (other than the 
Corporation) in an unbroken chain of corporations ending with the 
Corporation, provided each corporation in the unbroken chain (other than the 
Corporation) owns, at the time of the determination, stock possessing fifty 
percent (50%) or more of the total combined voting power of all classes of 
stock in one of the other corporations in such chain.  For purposes of the 
grant of Non-Statutory Options and stock appreciation rights under the 
Discretionary Option Grant Program, the term Parent shall also include any 
corporation, partnership, joint venture or other business entity which, 
directly or indirectly, controls the management and policies of the 
Corporation, whether through the ownership of voting securities, by contract 
or otherwise.

                                       A-4.



          X.    PERMANENT DISABILITY OR PERMANENTLY DISABLED shall mean the 
inability of the Optionee to engage in any substantial gainful activity by 
reason of any medically determinable physical or mental impairment expected 
to result in death or to be of continuous duration of twelve (12) months or 
more.  However, solely for the purposes of the Automatic Option Grant 
Program, Permanent Disability or Permanently Disabled shall mean the 
inability of the non-employee Board member to perform his or her usual duties 
as a Board member by reason of any medically determinable physical or mental 
impairment expected to result in death or to be of continuous duration of 
twelve (12) months or more.

          Y.    PLAN shall mean the Corporation's 1995 Stock Option Plan, as 
set forth in this document.

          Z.    PLAN ADMINISTRATOR shall mean the particular entity, whether 
the Board, the Primary Committee or the Secondary Committee, which is 
authorized to administer the Discretionary Option Grant Program with respect 
to one or more classes of eligible persons, to the extent such entity is 
carrying out its administrative functions under those programs with respect 
to the persons under its jurisdiction.

         AA.    PLAN EFFECTIVE DATE shall mean the date on which the Plan is 
adopted by the Board.  

         AB.    PRIMARY COMMITTEE shall mean the committee of two (2) or more 
non-employee Board members appointed by the Board to administer the 
Discretionary Option Grant Program with respect to Section 16 Insiders.

         AC.    QUALIFIED DOMESTIC RELATIONS ORDER shall mean a Domestic 
Relations Order which substantially complies with the requirements of Code 
Section 414(p). The Plan Administrator shall have the sole discretion to 
determine whether a Domestic Relations Order is a Qualified Domestic 
Relations Order.

         AD.    SECONDARY COMMITTEE shall mean a committee of two (2) or more 
Board members appointed by the Board to administer the Discretionary Option 
Grant Program with respect to eligible persons other than Section 16 
Insiders. 

         AE.    SECTION 16 INSIDER shall mean an officer or director of the 
Corporation subject to the short-swing profit liabilities of Section 16 of 
the 1934 Act.

         AE.    SECTION 12(g) REGISTRATION DATE shall mean the first date on 
which the Common Stock is registered under Section 12(g) of the 1934 Act. 

         AG.    SERVICE shall mean the provision of services to the 
Corporation (or any Parent or Subsidiary) by a person in the capacity of an 
Employee, a non-employee member of the board of directors or a consultant or 
independent advisor, except to the extent otherwise specifically provided in 
the documents evidencing the option grant.

                                       A-5.



         AH.    STOCK EXCHANGE shall mean either the American Stock Exchange 
or the New York Stock Exchange.

         AI.    SUBSIDIARY shall mean any corporation (other than the 
Corporation) in an unbroken chain of corporations beginning with the 
Corporation, provided each corporation (other than the last corporation) in 
the unbroken chain owns, at the time of the determination, stock possessing 
fifty percent (50%) or more of the total combined voting power of all classes 
of stock in one of the other corporations in such chain.  For purposes of the 
grant of Non-Statutory Options and stock appreciation rights under the 
Discretionary Option Grant Program, the term Subsidiary shall also include 
any corporation, partnership, joint venture or other business entity in which 
the Corporation, directly or indirectly, controls the management and 
policies, whether through the ownership of voting securities, by contract or 
otherwise.

         AJ.    TAKE-OVER PRICE shall mean the GREATER of (i) the Fair Market 
Value per share of Common Stock on the date the option is surrendered to the 
Corporation in connection with a Hostile Take-Over or (ii) the highest 
reported price per share of Common Stock paid by the tender offeror in 
effecting such Hostile Take-Over.  However, if the surrendered option is an 
Incentive Option, the Take-Over Price shall not exceed the clause (i) price 
per share.

         AK.    TAXES shall mean the Federal, state and local income and 
employment tax liabilities incurred by the holder of Non-Statutory Options or 
unvested shares of Common Stock in connection with the exercise of those 
options or the vesting of those shares.

         AL.    10% STOCKHOLDER shall mean the owner of stock (as determined 
under Code Section 424(d)) possessing more than ten percent (10%) of the 
total combined voting power of all classes of stock of the Corporation (or 
any Parent or Subsidiary).

         AM.    UNDERWRITING AGREEMENT shall mean the agreement between the 
Corporation and the underwriter or underwriters managing the initial public 
offering of the Common Stock.

                               A-6.