Filed Pursuant to Rule 424(b)(3) and (c)
                                                          File Number 333-35079

                    PROSPECTUS SUPPLEMENT DATED AUGUST 31, 1998
                                         to
                         Prospectus Dated November 12, 1997
                                          
                           ATLANTIC PHARMACEUTICALS, INC.
                                          
             1,500,000 PREVIOUSLY REGISTERED REDEEMABLE WARRANTS, EACH 
       EXERCISABLE FOR ONE SHARE OF COMMON STOCK, OFFERED BY CERTAIN SELLING
                                  SECURITYHOLDERS
                                          
               3,702,750 PREVIOUSLY REGISTERED SHARES OF COMMON STOCK
                                          
                         3,805,654 SHARES OF COMMON STOCK, 
                     OFFERED BY CERTAIN SELLING SECURITYHOLDERS

          THIS PROSPECTUS SUPPLEMENT SUPPLEMENTS THE PROSPECTUS DATED 
NOVEMBER 12, 1997 (THE "PROSPECTUS") OF ATLANTIC PHARMACEUTICALS, INC., A 
DELAWARE CORPORATION (THE "COMPANY"), RELATING TO THE PUBLIC OFFERING, WHICH 
IS NOT BEING UNDERWRITTEN, OF (a) 1,500,000 PREVIOUSLY REGISTERED REDEEMABLE 
WARRANTS (THE "WARRANTS"), EACH OF WHICH IS EXERCISABLE FOR ONE PREVIOUSLY 
REGISTERED SHARE OF COMMON STOCK, PAR VALUE $0.001 PER SHARE (THE "COMMON 
STOCK"), OF THE COMPANY, (b) AN AGGREGATE OF 3,702,750 PREVIOUSLY REGISTERED 
SHARES OF COMMON STOCK (COLLECTIVELY, THE "UNIT OFFERING SHARES") AND (c) AN 
AGGREGATE OF 2,530,637 SHARES OF COMMON STOCK (COLLECTIVELY, THE "NEW 
SHARES"), CONSISTING OF (i) 2,202,216 SHARES ISSUABLE UPON CONVERSION OF 
1,237,200 SHARES OF THE COMPANY'S SERIES A CONVERTIBLE PREFERRED STOCK, PAR 
VALUE $0.001 PER SHARE (THE "SERIES A PREFERRED"), RECEIVED BY CERTAIN 
SELLING SECURITYHOLDERS IN PRIVATE PLACEMENT TRANSACTIONS OF THE COMPANY, 
(ii) 220,221 SHARES ISSUABLE UPON CONVERSION OF 123,720 SHARES OF SERIES A 
PREFERRED UNDERLYING WARRANTS TO PURCHASE SUCH SHARES OF SERIES A PREFERRED, 
(iii) 103,200 SHARES ISSUED IN CONNECTION WITH THE COMPANY'S ACQUISITION OF 
THE MINORITY INTEREST IN CHANNEL THERAPEUTICS, INC. AND (iv) 5,000 SHARES 
TRANSFERRED TO CERTAIN SELLING SECURITYHOLDERS BY A CERTAIN OTHER STOCKHOLDER 
IN CONNECTION WITH A SETTLEMENT AGREEMENT.  THE NEW SHARES, THE WARRANTS AND 
THE UNIT OFFERING SHARES ARE COLLECTIVELY REFERRED TO AS THE "SECURITIES."  
THIS PROSPECTUS SUPPLEMENT SHOULD BE READ IN CONJUNCTION WITH THE PROSPECTUS, 
AND THIS PROSPECTUS SUPPLEMENT IS QUALIFIED BY REFERENCE TO THE PROSPECTUS 
EXCEPT TO THE EXTENT THAT THE INFORMATION HEREIN CONTAINED SUPERSEDES THE 
INFORMATION CONTAINED IN THE PROSPECTUS.  CAPITALIZED TERMS USED IN THIS 
PROSPECTUS SUMMARY AND NOT OTHERWISE DEFINED HEREIN HAVE THE MEANINGS 
SPECIFIED IN THE PROSPECTUS.

                               SELLING SECURITYHOLDERS

          The following table sets forth, as  of August 27, 1998, the number 
of shares of Common Stock beneficially owned by stockholders of the Company 
identified in the Prospectus as Selling Securityholders.  However, any or all 
of the shares of Common Stock listed below may be offered for sale pursuant 
to this Prospectus by the Selling Securityholders from time to time.  
Accordingly, no estimate can be given as to the amounts of shares of Common 
Stock that will be held by the Selling Securityholders upon consummation of 
any such sales.  In addition, the Selling Securityholders identified below 
may have sold, transferred or otherwise disposed of all or a portion of their 
shares of Common Stock since the date on which the information regarding 
their shares of Common Stock was provided, in transactions exempt from the 
registration requirements of the Act.  The table of Selling Securityholders 
on page 18 of the Prospectus is hereby deleted in its entirety and 
supplemented with the following table: 

COMMON STOCK ------------ NUMBER NUMBER BENEFICIALLY OFFERED NAME AND POSITION OF SELLING SECURITYHOLDER OWNED HEREBY - ------------------------------------------- ----- ------ Joseph Stevens & Company, L.P. (2) 330,000 330,000 Ronald J. DiCamillo 3,000 3,000 John Elges 1,000 1,000 Lindsay A. Rosenwald, M.D. (3) 1,133,458 788,951 H. Lawrence Shaw, M.D. (4) 23,682 23,557 Sumner Burstein, Ph.D. 11,250 11,250 William A. Ryan, Jr. 48 48 Carl Spana, Ph.D. 3,777 3,777 Paul Weisz, Ph.D. 7,500 7,500 Eliot Barnathan, M.D. 7,500 7,500 Alexander W. Clowes, M.D. 750 750 Dwight Robinson, M.D. 750 750 Paul Rys, Ph.D. 750 750 David DeWitt, Ph.D. 750 750 --------------------------------- TOTAL 1,524,215 1,179,583 - --------------------------
(2) Represents shares of Common Stock underlying the Underwriter's Warrants and the Underwriter's Redeemable Warrants, which are fully exercisable as of the date hereof. Joseph Stevens & Company, L.P. acted as the underwriter of the Unit Offering and is a greater than five percent stockholder of the Company. (3) Includes 788,951 shares of Common Stock underlying a fully-exercisable option granted to Dr. Rosenwald. Dr. Rosenwald, a principal stockholder of the Company, is the President and sole stockholder of the Placement Agent and of VentureTek, L.P., a principal stockholder of the Company. (4) Includes 23,557 shares of Common Stock underlying a fully-exercisable option granted to Dr. Shaw. The preceding table has been prepared based upon information furnished to the Company by Continental Stock Transfer & Trust Company. From time to time, additional information concerning ownership of the shares of Common Stock may rest with certain holders thereof not named in the preceding table, with whom the Company believes it has no affiliation. The following table sets forth the number of shares of Common Stock issuable upon conversion of shares of Series A Preferred beneficially owned by stockholders of the Company identified in the Prospectus as Selling Securityholders, based upon the conversion rate as of the effective date of the Prospectus. At such time and until August 6, 1998, each share of Series A Preferred was convertible into 2.12 shares of Common Stock. The Company has undertaken to register the resale of additional shares of Common Stock issuable upon conversion of the Series A Preferred resulting from the adjustment, effective August 7, 1998, in the conversion rate. See "Description of Securities--Series A Preferred Stock--Conversion." Any or all of the shares of Common Stock listed below may be offered for sale pursuant to this Prospectus by the Selling Securityholders from time to time. Accordingly, no estimate can be given as to the amounts of shares of Common Stock that will be held by the Selling Securityholders upon consummation of any such sales. In addition, the Selling Securityholders identified below may have sold, transferred or otherwise disposed of all or a portion of their shares of Series A Preferred since the date on which the information regarding their Series A Preferred was provided, in transactions exempt from the registration requirements of the Act. The table of Selling Securityholders on pages 18 to 22 of the Prospectus is hereby deleted in its entirety and supplemented with the following table:
COMMON STOCK (5) ------------ NUMBER NUMBER BENEFICIALLY OFFERED NAME AND POSITION OF SELLING SECURITYHOLDER OWNED HEREBY - ------------------------------------------- ----- ------ Mark Abel 5,300 5,300 Ross D. Ain 2,120 2,120 Sal and Lorraine Albanese 5,359 5,359 Leslie and Maria Anderson 10,600 10,600 Andrade Enterprises, LLC 21,200 21,200 Mario Aristizabal 5,397 5,397 Harriet E. Arneson 5,300 5,300 Austray Limited 42,400 42,400 Martin G. Ballweg 10,600 10,600 Bryan C. and Leah D. Barker 5,300 5,300 Ronald Baruch 742 742 Sam & Katie Benrubi 5,300 5,300 Larry Bernstein 2,120 2,120 Blumen Partners 1,329 1,329 Lewis S. Broad 10,600 10,600 Betty Joan Burr 2,650 2,650 Henry Burr 2,650 2,650 John Burr 2,650 2,650 Cambrian Investments Limited Partnership 5,300 5,300 Robert A. Cameron 10,600 10,600 Francis P. Cappione 1,329 1,329 Thomas L. Cassidy 2,650 2,650 Jacob T. Chachkes and Bette Chachkes, Trustees for Jacob T. Chachkes, M.D., P.C., MPPP, Dated 11-1-85 5,300 5,300 Richard L. Childs 2,650 2,650 Moun-Shung Chi & Sue-Jame Chi, Co-Trustees, Chi Living Trust 42,400 42,400 Claughton Company Inc. 5,300 5,300 CNCA SCT BRUNOY/acct BGP 53,000 53,000 Irwin J. Cohen, M.D. 5,300 5,300 Max Cohen 2,650 2,650 Concordia Partners L.P. 26,500 26,500 Robert J. Conrads 3,983 3,983 Bradley Cooper 10,600 10,600 Archibald Cox, Jr. 27,398 27,398 Thomas H. Cruikshank 10,600 10,600 Alfred C. D'Alessandro 5,300 5,300 Michael and Mary Darling JTWROS 5,300 5,300 Andrew Davilman & Nancy Davilman, JTWROS 5,300 5,300 Tommy Lee Davis 21,200 21,200 Delaware Charter FBO R. Craig Fetz 42,400 42,400 Chris P. Dialynas, as Trustee of the Chris and Sheri Dialynas Living Trust, Dated January 30, 1997 10,600 10,600 Dorothy Dulman 10,600 10,600 David Dworetzky 5,300 5,300 Edward Dworetzky 21,200 21,200 Robert & Evelyn Elliott Trust 5,300 5,300 Richard C. & Mary Ann Fick Community Property 5,300 5,300 Denis Fortin 5,300 5,300 Lloyd A. Fox 10,600 10,600 Brian D. Frenzel 5,300 5,300 Benjamin & Sharyn Friedman 5,300 5,300 Merrit Brad Friedman 5,300 5,300 Craig S. Frolich 2,650 2,650 Gerald Frolich & Gloria A. Frolich JT Ten. 5,300 5,300 Robert J. Gall 5,300 5,300 A. Mark Gambee, M.D. and Karen D. Todd, M.D. J.T.-W.R.O.S. 5,300 5,300 Ofelia Anton Gomez 1,700 1,700 Michael J. Gordon 663 663 Robert P. Gordon 1,325 1,325 Philip Granowitz 5,300 5,300 Bernard Gross 1,066 1,066 Grossman Family Trust 5,300 5,300 Leonard Grunstein 2,323 2,323 Allison Gushe Molkenthin 10,282 10,282 Alan and Paula Halperin 5,300 5,300 Fridolf Hanson 4,240 4,240 Harrigan Family Trust 5,300 5,300 Thomas Scott Haydon & Thomas Welch Haydon 5,300 5,300 Austin E. Hills 5,300 5,300 HM Singer & Co Employee Pension Trust, Howard M. Singer TTEE U/A/D/ 1/1/95 5,300 5,300 Harry Huang and Adrienne Masters, Tenants by the Entirety 8,480 8,480 Hull Overseas, Ltd. 10,600 10,600 Gerald Johnston 10,600 10,600 Charles Jurgensmeyer 10,600 10,600 Joe Jurgensmeyer 10,600 10,600 Robert Jurgensmeyer 10,600 10,600 Virgil Jurgensmeyer 10,600 10,600 Patrick M. Kane 5,598 5,598 Amram Kass P.C. Defined Benefit Pension Plan 2,650 2,650 Ery W. & Helga L. Kehaya, JTWROS 21,200 21,200 Kenbar Group, LP 31,800 31,800 Donald R. Kendall, Jr. 10,600 10,600 John R. Kennedy 1,325 1,325 Shirley F. Kerbel 5,300 5,300 Keys Foundation 53,000 53,000 Robert Knox 5,300 5,300 Gwen S. Korovin, M.D. 5,300 5,300 Larkstone Inc. 21,200 21,200 Joseph Larosa 5,300 5,300 Laser Trading Ltd. 2,139 2,139 Stephen H. Lebovitz 10,600 10,600 Theodore Levine 5,300 5,300 Hyman Lezell Revocable Trust 21,200 21,200 L.G. Foley Inc. Profit Sharing Plan 10,600 10,600 Donna Lipman and Lawrence Lipman, Tenants in Common 5,300 5,300 Alfredo Livas 3,180 3,180 M&S Andrade Rev. Tr. For Comm. & Sep. Property UA Dtd 10/19/78, as amended 5,300 5,300 Jon S. Marks 5,300 5,300 William M. Marks 5,300 5,300 Masada I Limited Ptnrs 1,859 1,859 Kevin T. McManus, MD 1,329 1,329 Lindsay A. McManus 5,300 5,300 Mega International Corporation 5,300 5,300 William H. Metzger MD Inc. Retirement Trust 5,300 5,300 Maurice Meyer III 5,300 5,300 Michael C. Miles 5,300 5,300 Mike & Terry Miller 5,300 5,300 Moonlight International Ltd 25,440 25,440 W. Kym Murphy 5,300 5,300 Arthur J. Nagle 5,300 5,300 Mechie Nebenzahl 2,120 2,120 John S. Osterweis, Trustee For The Osterweis Revocable Trust U/A Dated 09/13/93 2,650 2,650 Palmetto Partners, Ltd. 10,648 10,648 Alan Paulenoff 5,300 5,300 Gregory P. & Christine K. Pellizzon 5,300 5,300 Peter & Pamela Pellizzon 5,300 5,300 Nita E. Pepper and James G. Pepper, Co Trustees, Trust F/B/O Nita E. Pepper U/A Dtd 1/9/90 21,200 21,200 Dr. Tis Prager 7,950 7,950 Profutures Special Equities Fund, LP 10,600 10,600 Alois Putre Jr. 5,300 5,300 Raimundo J. Rodriguez P. and Anelies H. Huter de R. 5,300 5,300 Marion Roffer 10,600 10,600 Robert W. Rohrlich 5,300 5,300 Michael Rosenbaum 10,600 10,600 Jonathan Rothschild 5,300 5,300 RSA Trust (DTD) 3/7/95 (Ralph E. Adams Jr. and Shirlee Yvonne Adams, Trustees for RSA Trust) 5,300 5,300 Alan T. Rubin 15,900 15,900 David W. Ruttenberg 5,300 5,300 Sagres Group Ltd. 16,198 16,198 Gordon S. Salter 5,300 5,300 Kaya K. Sarier 2,650 2,650 Barry A. Saunders 5,300 5,300 Jan A. Saunders 5,300 5,300 Robert Schlotterbeck & Barbara J. Schlotterbeck, TTEES U/A Dtd 12/22/89 The Schlotterbeck Family Trust 5,300 5,300 Robert L. Schuessler 5,300 5,300 Carl F. Schwartz 7,950 7,950 Roberto Segovia 5,300 5,300 Uri R. Shabto M.D., P.C. 5,300 5,300 Gerald Shepps 5,300 5,300 Melvin Silon 5,300 5,300 Nathaniel Silon Revocable Living Trust Dtd 6/2/93 21,200 21,200 William & Elinor Silver 5,300 5,300 Ronald Simon 1,325 1,325 Harvey Slevin, TTEE U/A Dtd 4/25/90 Harvey Slevin Revoc. Liv. Trust 1,325 1,325 Hollis R. and Lucille B. Smith 5,300 5,300 Philip Solomon 5,300 5,300 Sovereign Partners L.P. 21,200 21,200 Robert L. Spint Trustee For Robert L. Spint Trust UAD 10/19/89 5,300 5,300 Stern Joint Venture, L.P. 15,900 15,900 Andrew Strassman 5,300 5,300 Joseph & Barbara Strassman 21,200 21,200 Richard Strassman 5,300 5,300 Robert Strassman 2,650 2,650 Burton M. Strauss, Jr. 5,300 5,300 Michael and Pamela Sulewski 2,650 2,650 Sidney Sutter 3,701 3,701 The 1992 Houston Partnership, L.P. 10,600 10,600 Tokenhouse Trading Company Limited 14,199 14,199 Alyce P. Twomey 2,650 2,650 Union D'Etudes et D'Investissements 106,000 106,000 Valori Associates, Inc. 2,650 2,650 Donald E. and Virginia V. Vinson Trust 5,300 5,300 J. Vitols 21,200 21,200 Mark & Sallie Lynn Walko 6,599 6,599 Saul Waring 5,300 5,300 Paul H. Warren 10,600 10,600 Robert J. Whetten 7,950 7,950 Allen Whipple 31,800 31,800 John R. Wiencek 1,619 1,619 B. R. Williamson Jr. 10,600 10,600 Robert B. Wolford IRA 5,300 5,300 Charles C. Young 3,975 3,975 Lindsay A. Rosenwald, M.D. (6)(7) 100,004 100,004 Scott A. Katzman (6)(8) 35,529 35,529 Michael S. Weiss (6)(9) 14,885 14,885 Wayne L. Rubin (6)(8) 14,885 14,885 Credit Agricole (6)(10) 10,593 10,593 A. Joseph Rudick, Jr., M.D. (6)(11) 10,540 10,540 Tim McInerney (6)(8) 9,484 9,484 Martin S. Kratchman (6)(8) 9,121 9,121 Richard Strassman (6)(8) 8,501 8,501 Karl Ruggeberg (6)(8) 8,102 8,102 David R. Walner (6)(8) 5,000 5,000 Bluestone Capital (6)(10) 4,370 4,370 Marc Florin (6)(8) 3,475 3,475 Joseph Edelman (6)(8) 3,276 3,276 Peter M. Kash (6)(8) 3,122 3,122 Joseph Fabiani, Jr. (6)(8) 2,648 2,648 Deborah Solomon (6)(8) 2,489 2,489 Lauren S. Fischer (6)(8) 1,135 1,135 John Knox (6)(8) 1,135 1,135 ------------------------------- TOTAL 1,827,279 1,827,279
- -------------------------- (5) Represents shares of Common Stock into which the shares of Series A Preferred owned by such Selling Securityholder are convertible. This Registration Statement shall also cover any additional shares of Common Stock which become issuable in connection with the shares registered for sale hereby by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration which results in an increase in the number of the Selling Securityholder's outstanding shares of Common Stock. (6) Represents shares of Common Stock issuable upon conversion of Series A Preferred issuable upon exercise of the Placement Warrants. This Registration Statement shall also cover any additional shares of Common Stock which become issuable in connection with the shares registered for sale hereby by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without the receipt of consideration which results in an increase in the number of the Selling Securityholder's outstanding shares of Common Stock. (7) Lindsay A. Rosenwald, M.D., a principal stockholder of the Company, is the President and sole stockholder of Paramount Capital, Inc. ("Paramount"). VentureTek, L.P., a principal stockholder of the Company, is a limited partnership, the limited partners of which include Dr. Rosenwald's wife, children, sisters of Dr. Rosenwald's wife, and their husbands and children. (8) Securityholder is agent of Paramount. (9) Michael S. Weiss, the Company's Secretary, is a Senior Managing Director of Paramount. (10) Securityholder acted as a Selected Dealer in the Private Placement. (11) Dr. Rudick, an associate of the Placement Agent and Paramount Capital Investments, LLC, is a director of each of Channel Therapeutics, Inc. and Optex Ophthalmologics, Inc., each a wholly owned subsidiary of the Company. The preceding table has been prepared based upon information furnished to the Company by Continental Stock Transfer & Trust Company. From time to time, additional information concerning ownership of the shares of Common Stock may rest with certain holders thereof not named in the preceding table, with whom the Company believes it has no affiliation. DESCRIPTION OF SECURITIES SERIES A PREFERRED STOCK CONVERSION. Pursuant to the Certificate of Designations of the Series A Preferred, on August 7, 1998, the conversion price of the Series A Preferred was adjusted from $4.72 per share to $3.06 per share. As a result, on such date the conversion rate of the Series A Preferred was adjusted such that each share of Series A Preferred converted after August 7, 1998 is convertible into 3.27 shares of Common Stock, whereas each share of Series A Preferred converted prior to August 7, 1998 was convertible into 2.12 shares of Common Stock. --------------------