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  <xsd:element id="tgtx_ScheduleOfBalanceSheetClassificationOfOperatingLeaseTableTextBlock" name="ScheduleOfBalanceSheetClassificationOfOperatingLeaseTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_StockbasedCompensationExpenseCapitalizedIntoInventoryMember" name="StockbasedCompensationExpenseCapitalizedIntoInventoryMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_SublicenseAgreementWithIldongPharmaceuticalCoMember" name="SublicenseAgreementWithIldongPharmaceuticalCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_TermAfterFirstCommercialSale" name="TermAfterFirstCommercialSale" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_TermLoanAdvancesMember" name="TermLoanAdvancesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_TermLoanMember" name="TermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_The2012IncentivePlanMember" name="The2012IncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_The2022AtmMember" name="The2022AtmMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_The2022IncentivePlanMember" name="The2022IncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_TheFirstAmendmentTermLoanMember" name="TheFirstAmendmentTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_TheFirstAmendmentWarrantMember" name="TheFirstAmendmentWarrantMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_TheNewJerseyLeaseMember" name="TheNewJerseyLeaseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_TheNorthCarolinaLeaseMember" name="TheNorthCarolinaLeaseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_Tranche3AAdvanceMember" name="Tranche3AAdvanceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_Tranche3bAdvanceAndTranche3cAdvanceMember" name="Tranche3bAdvanceAndTranche3cAdvanceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_Tranche3bAdvanceMember" name="Tranche3bAdvanceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_Tranche3cAdvanceMember" name="Tranche3cAdvanceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_Tranche4AdvanceMember" name="Tranche4AdvanceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_Tranche5AdvanceMember" name="Tranche5AdvanceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_UnvestedRestrictedStockMember" name="UnvestedRestrictedStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_UpfrontFeeReceivedFromSubLicense" name="UpfrontFeeReceivedFromSubLicense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="tgtx_WarrantCoveragePercentage" name="WarrantCoveragePercentage" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_WarrantsToPurchaseCommonStockAmendedLoanAgreementMember" name="WarrantsToPurchaseCommonStockAmendedLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_WarrantsToPurchaseCommonStockFirstAmendmentLoanAgreementMember" name="WarrantsToPurchaseCommonStockFirstAmendmentLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_WarrantsToPurchaseCommonStockFirstAmendmentMember" name="WarrantsToPurchaseCommonStockFirstAmendmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_WarrantsToPurchaseCommonStockLoanAgreementMember" name="WarrantsToPurchaseCommonStockLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-schedule-of-earnings-per-share-details" name="statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-schedule-of-earnings-per-share-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-schedule-of-potentially-dilutive-securities-details" name="statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-schedule-of-potentially-dilutive-securities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-tables" name="statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-2-revenue-disaggregation-of-revenue-details" name="statement-statement-note-2-revenue-disaggregation-of-revenue-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-2-revenue-tables" name="statement-statement-note-2-revenue-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-3-investment-securities-schedule-of-investment-securities-details" name="statement-statement-note-3-investment-securities-schedule-of-investment-securities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-3-investment-securities-schedule-of-investment-securities-details-parentheticals" name="statement-statement-note-3-investment-securities-schedule-of-investment-securities-details-parentheticals" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-3-investment-securities-tables" name="statement-statement-note-3-investment-securities-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-4-inventory-schedule-of-inventory-details" name="statement-statement-note-4-inventory-schedule-of-inventory-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-4-inventory-tables" name="statement-statement-note-4-inventory-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-5-fair-value-measurements-schedule-of-fair-value-measurements-details" name="statement-statement-note-5-fair-value-measurements-schedule-of-fair-value-measurements-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-5-fair-value-measurements-tables" name="statement-statement-note-5-fair-value-measurements-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-6-stockholders-equity-schedule-of-compensation-cost-related-to-unvested-awards-details" name="statement-statement-note-6-stockholders-equity-schedule-of-compensation-cost-related-to-unvested-awards-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-6-stockholders-equity-summary-of-activity-for-stock-options-and-restricted-stock-details" name="statement-statement-note-6-stockholders-equity-summary-of-activity-for-stock-options-and-restricted-stock-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-6-stockholders-equity-tables" name="statement-statement-note-6-stockholders-equity-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-7-loan-payable-schedule-of-key-assumptions-details" name="statement-statement-note-7-loan-payable-schedule-of-key-assumptions-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-7-loan-payable-schedule-of-loan-payble-details" name="statement-statement-note-7-loan-payable-schedule-of-loan-payble-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-7-loan-payable-tables" name="statement-statement-note-7-loan-payable-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-8-leases-schedule-of-classification-of-lease-liabilities-details" name="statement-statement-note-8-leases-schedule-of-classification-of-lease-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-8-leases-schedule-of-lease-cost-details" name="statement-statement-note-8-leases-schedule-of-lease-cost-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-8-leases-schedule-of-lease-liability-maturity-details" name="statement-statement-note-8-leases-schedule-of-lease-liability-maturity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-8-leases-tables" name="statement-statement-note-8-leases-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
