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<loc xlink:type="locator" xlink:href="tgtx-20130331.xsd#tgtx_IssuancePeriodAxis" xlink:label="loc_tgtx_IssuancePeriodAxis_37"/>
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<loc xlink:type="locator" xlink:href="tgtx-20130331.xsd#tgtx_TwoThousandElevenIssuanceMember" xlink:label="loc_tgtx_TwoThousandElevenIssuanceMember_39"/>
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<loc xlink:type="locator" xlink:href="tgtx-20130331.xsd#tgtx_TwoThousandTwelveIssuanceMember" xlink:label="loc_tgtx_TwoThousandTwelveIssuanceMember_40"/>
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<loc xlink:type="locator" xlink:href="tgtx-20130331.xsd#tgtx_ConvertiblePreferredStockShareConvertedIntoCommonStock" xlink:label="loc_tgtx_ConvertiblePreferredStockShareConvertedIntoCommonStock_44"/>
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<loc xlink:type="locator" xlink:href="tgtx-20130331.xsd#tgtx_StockIssuedDuringPeriodShareSnewIssuesIssuePrice" xlink:label="loc_tgtx_StockIssuedDuringPeriodShareSnewIssuesIssuePrice_49"/>
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<loc xlink:type="locator" xlink:href="tgtx-20130331.xsd#tgtx_FairValuePerShareIssued" xlink:label="loc_tgtx_FairValuePerShareIssued_50"/>
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<loc xlink:type="locator" xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_56"/>
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<loc xlink:type="locator" xlink:href="tgtx-20130331.xsd#tgtx_AgentCashCommissionPercentageOnProceedsFromSharesIssuance" xlink:label="loc_tgtx_AgentCashCommissionPercentageOnProceedsFromSharesIssuance_57"/>
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<loc xlink:type="locator" xlink:href="tgtx-20130331.xsd#tgtx_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostYetToBeRecognized" xlink:label="loc_tgtx_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostYetToBeRecognized_58"/>
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<loc xlink:type="locator" xlink:href="tgtx-20130331.xsd#tgtx_PreferredStockConvertedIntoCommonStockPriorToConversion" xlink:label="loc_tgtx_PreferredStockConvertedIntoCommonStockPriorToConversion_76"/>
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<loc xlink:type="locator" xlink:href="tgtx-20130331.xsd#tgtx_WarrantTerm" xlink:label="loc_tgtx_WarrantTerm_77"/>
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<loc xlink:type="locator" xlink:href="tgtx-20130331.xsd#tgtx_AgentWarrantPercentageOnIssuanceOfShares" xlink:label="loc_tgtx_AgentWarrantPercentageOnIssuanceOfShares_78"/>
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<loc xlink:type="locator" xlink:href="tgtx-20130331.xsd#tgtx_AgentNonAccountableExpensePercentageOnGrossProceedsFromShareIssuance" xlink:label="loc_tgtx_AgentNonAccountableExpensePercentageOnGrossProceedsFromShareIssuance_79"/>
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