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    <import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" />
    <import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
    <import namespace="http://xbrl.sec.gov/dei/2014-01-31" schemaLocation="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd" />
    <import namespace="http://fasb.org/us-gaap/2016-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd" />
    <import namespace="http://fasb.org/us-types/2016-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2016/elts/us-types-2016-01-31.xsd" />
    <import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" />
    <import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" />
    <import namespace="http://xbrl.sec.gov/country/2016-01-31" schemaLocation="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd" />
    <import namespace="http://xbrl.sec.gov/currency/2016-01-31" schemaLocation="http://xbrl.sec.gov/currency/2016/currency-2016-01-31.xsd" />
    <import namespace="http://xbrl.sec.gov/exch/2016-01-31" schemaLocation="http://xbrl.sec.gov/exch/2016/exch-2016-01-31.xsd" />
    <import namespace="http://xbrl.sec.gov/invest/2013-01-31" schemaLocation="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd" />
    <import namespace="http://xbrl.sec.gov/naics/2011-01-31" schemaLocation="http://xbrl.sec.gov/naics/2011/naics-2011-01-31.xsd" />
    <import namespace="http://xbrl.sec.gov/sic/2011-01-31" schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd" />
    <import namespace="http://xbrl.sec.gov/stpr/2011-01-31" schemaLocation="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd" />
    <element id="tgtx_ContingentlyIssuableShares" name="ContingentlyIssuableShares" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_NonCashStockExpense" name="NonCashStockExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_NonCashCompensationResearchAndDevelopmentExpenses" name="NonCashCompensationResearchAndDevelopmentExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_NonCashCompensationGeneralAndAdministrativeExpenses" name="NonCashCompensationGeneralAndAdministrativeExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockIssuedDuringPeriodValueExerciseOfWarrants" name="StockIssuedDuringPeriodValueExerciseOfWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockIssuedDuringPeriodSharesExerciseOfWarrants" name="StockIssuedDuringPeriodSharesExerciseOfWarrants" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_IssuanceOfCommonStockInConnectionWithExerciseOfOptions" name="IssuanceOfCommonStockInConnectionWithExerciseOfOptions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_IssuanceOfCommonStockInConnectionWithExerciseOfOptionsInShares" name="IssuanceOfCommonStockInConnectionWithExerciseOfOptionsInShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockIssuedDuringPeriodValueMarketPublicOffering" name="StockIssuedDuringPeriodValueMarketPublicOffering" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockIssuedDuringPeriodSharesMarketPublicOffering" name="StockIssuedDuringPeriodSharesMarketPublicOffering" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockIssuedDuringPeriodValueExerciseOfWarrantsCashLess" name="StockIssuedDuringPeriodValueExerciseOfWarrantsCashLess" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockIssuedDuringPeriodSharesExerciseOfWarrantsCashLess" name="StockIssuedDuringPeriodSharesExerciseOfWarrantsCashLess" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_IssuanceOfCommonStockInConnectionWithConversionOfNotesPayable" name="IssuanceOfCommonStockInConnectionWithConversionOfNotesPayable" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockIssuedDuringPeriodValuesIssuedForCash" name="StockIssuedDuringPeriodValuesIssuedForCash" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockIssuedDuringPeriodShareIssuedForCash" name="StockIssuedDuringPeriodShareIssuedForCash" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_SharesIssuedInConnectionWithInLicensingAgreement" name="SharesIssuedInConnectionWithInLicensingAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ChangeInFairValueOfNotesPayable" name="ChangeInFairValueOfNotesPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_PaymentsToAcquireHeldToMaturitySecuritiesShortTerm" name="PaymentsToAcquireHeldToMaturitySecuritiesShortTerm" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ProceedsFromMaturities" name="ProceedsFromMaturities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_NetProceedsFromSharesNewIssuesOverallotments" name="NetProceedsFromSharesNewIssuesOverallotments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ReclassificationOfDeferredFinancingCosts" name="ReclassificationOfDeferredFinancingCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_LicenseAgreementDisclosureTextBlock" name="LicenseAgreementDisclosureTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_BusinessDescriptionPolicyTextBlock" name="BusinessDescriptionPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_LiquidityDisclosure1PolicyTextBlock" name="LiquidityDisclosure1PolicyTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ImpairmentOfTangibleAndIntangibleAssetIncludingGoodwillPolicyTextBlock" name="ImpairmentOfTangibleAndIntangibleAssetIncludingGoodwillPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ScheduleOfWarrantsActivityTableTextBlock" name="ScheduleOfWarrantsActivityTableTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ScheduleOfShareBasedCompensationExpenseTableTextBlock" name="ScheduleOfShareBasedCompensationExpenseTableTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_LeaseholdInterest" name="LeaseholdInterest" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_IncreaseDecreaseInLeaseholdInterest" name="IncreaseDecreaseInLeaseholdInterest" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_AdjustmentToContingentlyIssuableShares" name="AdjustmentToContingentlyIssuableShares" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInterestAccruedIncludedInEarnings" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInterestAccruedIncludedInEarnings" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_WarrantOrRightExpired" name="WarrantOrRightExpired" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_WarrantOrRightExercised" name="WarrantOrRightExercised" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_WarrantOrRightIssued" name="WarrantOrRightIssued" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_WarrantOrRightOutstandingWeightedAverageExercisePrice" name="WarrantOrRightOutstandingWeightedAverageExercisePrice" nillable="true" xbrli:periodType="instant" type="num:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_WarrantOrRightExpiredWeightedAverageExercisePrice" name="WarrantOrRightExpiredWeightedAverageExercisePrice" nillable="true" xbrli:periodType="duration" type="num:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_WarrantOrRightExercisedWeightedAverageExercisePrice" name="WarrantOrRightExercisedWeightedAverageExercisePrice" nillable="true" xbrli:periodType="duration" type="num:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_WarrantOrRightIssuedWeightedAverageExercisePrice" name="WarrantOrRightIssuedWeightedAverageExercisePrice" nillable="true" xbrli:periodType="duration" type="num:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_CumulativeLiabilityOfNote" name="CumulativeLiabilityOfNote" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_AverageAnnualRentalPayments" name="AverageAnnualRentalPayments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_PrepaidResearchAndDevelopment" name="PrepaidResearchAndDevelopment" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_PeriodAnticipatedSufficientToFundOperatingCashFlow" name="PeriodAnticipatedSufficientToFundOperatingCashFlow" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_PrepaidManufacturing" name="PrepaidManufacturing" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_WarrantOrRightAggregateIntrinsicValue" name="WarrantOrRightAggregateIntrinsicValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_PurchasePrice" name="PurchasePrice" nillable="true" xbrli:periodType="instant" type="num:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_PercentageOfCashProceedsFromOperationToRepayInterestOnConvertibleDebt" name="PercentageOfCashProceedsFromOperationToRepayInterestOnConvertibleDebt" nillable="true" xbrli:periodType="duration" type="num:percentItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ResearchAndDevelopmentCarryforward" name="ResearchAndDevelopmentCarryforward" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_AdditionalAmountReceivableOnAchievementOfPreSpecifiedMilestones" name="AdditionalAmountReceivableOnAchievementOfPreSpecifiedMilestones" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_RoyaltyPaymentEffectivePercentage" name="RoyaltyPaymentEffectivePercentage" nillable="true" xbrli:periodType="instant" type="num:percentItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_MaximumSalesForRoyaltyExpense" name="MaximumSalesForRoyaltyExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_PercentageOfCashProceedsFromOperationToRepayConvertibleDebt" name="PercentageOfCashProceedsFromOperationToRepayConvertibleDebt" nillable="true" xbrli:periodType="duration" type="num:percentItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_CommonStockValueReservedForFutureIssuance" name="CommonStockValueReservedForFutureIssuance" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_UpfrontFeeReceivedFromSubLicense" name="UpfrontFeeReceivedFromSubLicense" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_MaximumPotentialPaymentsPayable" name="MaximumPotentialPaymentsPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_NonCashResearchAndDevelopmentExpense" name="NonCashResearchAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_OptionFeePaid" name="OptionFeePaid" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockIssuedDuringPeriodValue" name="StockIssuedDuringPeriodValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ManhattanAndAristonPharmaceuticalsMergerMember" name="ManhattanAndAristonPharmaceuticalsMergerMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_AtmMember" name="AtmMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_IncentivePlanMember" name="IncentivePlanMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_CorporateMilestoneMember" name="CorporateMilestoneMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_AristonMember" name="AristonMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_CollaborationAgreementMember" name="CollaborationAgreementMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_LfbGroupMember" name="LfbGroupMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_LfbLicenseAgreementMember" name="LfbLicenseAgreementMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_OpusMember" name="OpusMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_DeskAgreementMember" name="DeskAgreementMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_AoiCommunicationsLpMember" name="AoiCommunicationsLpMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ContingentlyIssuableShareMember" name="ContingentlyIssuableShareMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_SeriesJuniorParticipatingPreferredStockMember" name="SeriesJuniorParticipatingPreferredStockMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ConvertibleNotesMember" name="ConvertibleNotesMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_UsFederalIncomeTaxMember" name="UsFederalIncomeTaxMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_TgOneOneZeroOneMember" name="TgOneOneZeroOneMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_RhizenMember" name="RhizenMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_LigandMember" name="LigandMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_OpusPointPartnersLlcMember" name="OpusPointPartnersLlcMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ContractualObligationsMember" name="ContractualObligationsMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_NonEmployeeRestrictedStockMember" name="NonEmployeeRestrictedStockMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_WarrantsMember" name="WarrantsMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_SharesUponNoteConversionMember" name="SharesUponNoteConversionMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_OptionsMember" name="OptionsMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_JBETAgreementMember" name="JBETAgreementMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_SharedServicesAgreementMember" name="SharedServicesAgreementMember" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_DocumentAndEntityInformationAbstract" name="DocumentAndEntityInformationAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ImpairmentOfInProcessResearchAndDevelopment" name="ImpairmentOfInProcessResearchAndDevelopment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ChangeInFairValueOfNonCurrentNotePayable" name="ChangeInFairValueOfNonCurrentNotePayable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_CompensationAxis" name="CompensationAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="tgtx_CompensationDomain" name="CompensationDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_TreasuryStockValueDuringPeirod" name="TreasuryStockValueDuringPeirod" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_TreasuryStockSharesDuringPeirod" name="TreasuryStockSharesDuringPeirod" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_LicenseAgreementAbstract" name="LicenseAgreementAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_LitigationAbstract" name="LitigationAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_OrganizationAndSummaryOfSignificantAccountingPoliciesTablesAbstract" name="OrganizationAndSummaryOfSignificantAccountingPoliciesTablesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_OrganizationAndSummaryOfSignificantAccountingPoliciesDetailsAbstract" name="OrganizationAndSummaryOfSignificantAccountingPoliciesDetailsAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_SignificantAccountingPoliciesTable" name="SignificantAccountingPoliciesTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
    <element id="tgtx_SignificantAccountingPoliciesLineItems" name="SignificantAccountingPoliciesLineItems" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_VestingPeriodAxis" name="VestingPeriodAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="tgtx_VestingPeriodDomain" name="VestingPeriodDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_MarketCapitalizationTargetAxis" name="MarketCapitalizationTargetAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="tgtx_MarketCapitalizationTargetDomain" name="MarketCapitalizationTargetDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ImmaterialErrorAxis" name="ImmaterialErrorAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="tgtx_ImmaterialErrorDomain" name="ImmaterialErrorDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_InvestmentSecuritiesDetailsAbstract" name="InvestmentSecuritiesDetailsAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ScheduleOfFairValueSeparateAccountsByMajorCategoryOfInvestmentAxis" name="ScheduleOfFairValueSeparateAccountsByMajorCategoryOfInvestmentAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="tgtx_ScheduleOfFairValueSeparateAccountsByMajorCategoryOfInvestmentDomain" name="ScheduleOfFairValueSeparateAccountsByMajorCategoryOfInvestmentDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_FairValueMeasurementTable" name="FairValueMeasurementTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
    <element id="tgtx_FairValueMeasurementLineItems" name="FairValueMeasurementLineItems" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_TypeOfTransactionAxis" name="TypeOfTransactionAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="tgtx_TypeOfTransactionDomain" name="TypeOfTransactionDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_OtherOperatingCostAndExpenseAxis" name="OtherOperatingCostAndExpenseAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="tgtx_OtherOperatingCostAndExpenseDomain" name="OtherOperatingCostAndExpenseDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_EquityIncentivePlansStockOptionActivityTable" name="EquityIncentivePlansStockOptionActivityTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
    <element id="tgtx_EquityIncentivePlansStockOptionActivityLineItems" name="EquityIncentivePlansStockOptionActivityLineItems" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_EquityIncentivePlansRestrictedStockActivityTable" name="EquityIncentivePlansRestrictedStockActivityTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
    <element id="tgtx_EquityIncentivePlansRestrictedStockActivityLineItems" name="EquityIncentivePlansRestrictedStockActivityLineItems" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockBasedCompensationTable" name="StockBasedCompensationTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
    <element id="tgtx_AgreementTypeAxis" name="AgreementTypeAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="tgtx_AgreementTypeDomain" name="AgreementTypeDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockIssuedDuringPeriodSharesNewIssuesShelfRegistrationStatement" name="StockIssuedDuringPeriodSharesNewIssuesShelfRegistrationStatement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockIssuedDuringPeriodSharesNewIssuesOverAllotments" name="StockIssuedDuringPeriodSharesNewIssuesOverAllotments" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_UnderwritingDiscountsAndOfferingExpenses" name="UnderwritingDiscountsAndOfferingExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockIssuedDuringPeriodSharesIssuedForCash1" name="StockIssuedDuringPeriodSharesIssuedForCash1" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockIssuedDuringPeriodValueIssuedForCash1" name="StockIssuedDuringPeriodValueIssuedForCash1" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_StockholderRightsPlanDescription" name="StockholderRightsPlanDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_TotalAuthorizedShareCapital" name="TotalAuthorizedShareCapital" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_DecreaseAuthorizedShareCapital" name="DecreaseAuthorizedShareCapital" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_CommissionPercentage" name="CommissionPercentage" nillable="true" xbrli:periodType="instant" type="num:percentItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_NotesPayableTable" name="NotesPayableTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
    <element id="tgtx_NotesPayableLineItems" name="NotesPayableLineItems" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_AmendmentAxis" name="AmendmentAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="tgtx_AmendmentDomain" name="AmendmentDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ScheduleOfDeferredTaxAssetsAndLiabilitiesAbstract" name="ScheduleOfDeferredTaxAssetsAndLiabilitiesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_DeferredTaxAssetsAndLiabilitiesTable" name="DeferredTaxAssetsAndLiabilitiesTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
    <element id="tgtx_DeferredTaxAssetsAndLiabilitiesLineItems" name="DeferredTaxAssetsAndLiabilitiesLineItems" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_OperatingLossCarryForwardsExpirationPeriod" name="OperatingLossCarryForwardsExpirationPeriod" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_LicenseAgreementTable" name="LicenseAgreementTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
    <element id="tgtx_LicenseAgreementLineItems" name="LicenseAgreementLineItems" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_SaleBasedMileStonePayment" name="SaleBasedMileStonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_UpfrontPaymentAmount" name="UpfrontPaymentAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_PlacementAgencyAgreementAxis" name="PlacementAgencyAgreementAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="tgtx_PlacementAgencyAgreementDomain" name="PlacementAgencyAgreementDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_NumberOfCommonStockSharesGrantedInConnectionWithLicenseAgreementByIssueOfWarrants" name="NumberOfCommonStockSharesGrantedInConnectionWithLicenseAgreementByIssueOfWarrants" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_CommonStockPurchasePricePerShare" name="CommonStockPurchasePricePerShare" nillable="true" xbrli:periodType="instant" type="num:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_RoyaltyRevenueDiscription" name="RoyaltyRevenueDiscription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_PercentageOfOccupancy" name="PercentageOfOccupancy" nillable="true" xbrli:periodType="instant" type="num:percentItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_MinimumValueOfSharesToBePurchased" name="MinimumValueOfSharesToBePurchased" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_NumberOfCommonStockSharesGrantedInConnectionWithLicenseAgreementByExcerciseOfWarrants" name="NumberOfCommonStockSharesGrantedInConnectionWithLicenseAgreementByExcerciseOfWarrants" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_CommonStockExcerciseOfWarrantsPurchasePricePerShare" name="CommonStockExcerciseOfWarrantsPurchasePricePerShare" nillable="true" xbrli:periodType="instant" type="num:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_ContractualObligationsAxis" name="ContractualObligationsAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
    <element id="tgtx_ContractualObligationsDomain" name="ContractualObligationsDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_LeasePaymentTerm" name="LeasePaymentTerm" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_EquityIncentivePlansWarrantActivityLineItems" name="EquityIncentivePlansWarrantActivityLineItems" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_FairValueMeasurementChangesInLevel3InstrumentsLineItems" name="FairValueMeasurementChangesInLevel3InstrumentsLineItems" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="tgtx_FairValueMeasurementChangesInLevel3InstrumentsTable" name="FairValueMeasurementChangesInLevel3InstrumentsTable" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" />
</schema>
