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        <link:definition>000048 - Disclosure - LEASES (Details Narrative)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tgtherapeuticsinc.com/role/LicenseAgreementsDetailsNarrative" id="LicenseAgreementsDetailsNarrative">
        <link:definition>000049 - Disclosure - LICENSE AGREEMENTS (Details Narrative)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tgtherapeuticsinc.com/role/RelatedPartyTransactionsDetailsNarrative" id="RelatedPartyTransactionsDetailsNarrative">
        <link:definition>000050 - Disclosure - RELATED PARTY TRANSACTIONS (Details Narrative)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:element id="tgtx_StockOptionsMember" name="StockOptionsMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_ConvertibleNotesMember" name="ConvertibleNotesMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_PlacementAgencyAgreementAxis" name="PlacementAgencyAgreementAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element id="tgtx_PlacementAgencyAgreementDomain" name="PlacementAgencyAgreementDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_OfficeAgreementMember" name="OfficeAgreementMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_TgOneOneZeroOneMember" name="TgOneOneZeroOneMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_AgreementTypeAxis" name="AgreementTypeAxis" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element id="tgtx_AgreementTypeDomain" name="AgreementTypeDomain" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_SharedServicesAgreementMember" name="SharedServicesAgreementMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_CollaborationAgreementMember" name="CollaborationAgreementMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_TgOneSevenZeroOneMember" name="TgOneSevenZeroOneMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_TgOneEightZeroOneMember" name="TgOneEightZeroOneMember" abstract="true" nillable="true" xbrli:periodType="duration" type="nonnum:domainItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_LicenseAgreementAbstract" name="LicenseAgreementAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_AverageAnnualRentalPayments" name="AverageAnnualRentalPayments" nillable="true" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element id="tgtx_Licenseagreementdisclosuretextblock" name="Licenseagreementdisclosuretextblock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_NonCashStockExpenseAssociatedWithInLicensingAgreements" name="NonCashStockExpenseAssociatedWithInLicensingAgreements" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element id="tgtx_PrepaidResearchAndDevelopment" name="PrepaidResearchAndDevelopment" nillable="true" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element id="tgtx_LeaseHoldInterest" name="LeaseHoldInterest" nillable="true" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element id="tgtx_Warrantsweightedaverageexercisepriceissued" name="Warrantsweightedaverageexercisepriceissued" nillable="true" xbrli:periodType="duration" type="num:perShareItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_Warrantsweightedaverageexercisepriceoutstanding" name="Warrantsweightedaverageexercisepriceoutstanding" nillable="true" xbrli:periodType="duration" type="num:perShareItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_NoncashLicensingExpense" name="NoncashLicensingExpense" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element id="tgtx_NonCashCompensationResearchAndDevelopment" name="NonCashCompensationResearchAndDevelopment" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element id="tgtx_NonCashCompensationGeneralAndAdministrativeExpenses" name="NonCashCompensationGeneralAndAdministrativeExpenses" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element id="tgtx_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInterestAccruedIncludedInEarnings" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityInterestAccruedIncludedInEarnings" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="tgtx_ChangeInFairValueofNotesPayable" name="ChangeInFairValueofNotesPayable" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="tgtx_CumulativeLiabilityOfNote" name="CumulativeLiabilityOfNote" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="tgtx_IncreaseDecreaseInDeferredrent" name="IncreaseDecreaseInDeferredrent" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element id="tgtx_EndOfTermFee" name="EndOfTermFee" nillable="true" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="tgtx_LongTermDebtGross" name="LongTermDebtGross" nillable="true" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="tgtx_ClassOfWarrantOrRightFairValue" name="ClassOfWarrantOrRightFairValue" nillable="true" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="tgtx_PaymentsToAcquireHeldToMaturitySecuritiesShortterm" name="PaymentsToAcquireHeldToMaturitySecuritiesShortterm" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="tgtx_ProceedsFromMaturities" name="ProceedsFromMaturities" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element id="tgtx_NetProceedsFromSharesNewIssuesOverallotments" name="NetProceedsFromSharesNewIssuesOverallotments" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element id="tgtx_OperatingLeaseLiabilityImputedInterest" name="OperatingLeaseLiabilityImputedInterest" nillable="true" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element id="tgtx_AccruedFinancingCosts" name="AccruedFinancingCosts" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element id="tgtx_PercentageOfOccupancy" name="PercentageOfOccupancy" nillable="true" xbrli:periodType="instant" type="num:percentItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_WarrantsIssuedWithDebtFinancing" name="WarrantsIssuedWithDebtFinancing" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="tgtx_OperatingLeaseInitialCommitmentPeriod" name="OperatingLeaseInitialCommitmentPeriod" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_UpfrontFeeReceivedFromSubLicense" name="UpfrontFeeReceivedFromSubLicense" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="tgtx_AgreementCostsCurrentLiabilities" name="AgreementCostsCurrentLiabilities" nillable="true" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="tgtx_ScheduleOfLongTermDebtKeyAssumptionsTableTextBlock" name="ScheduleOfLongTermDebtKeyAssumptionsTableTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_ScheduleOfLongTermDebtTextBlock" name="ScheduleOfLongTermDebtTextBlock" nillable="true" xbrli:periodType="duration" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTermOne" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTermOne" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_IssuanceOfCommonStockInAtMarketOfferingNetOfOfferingCostsShares" name="IssuanceOfCommonStockInAtMarketOfferingNetOfOfferingCostsShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_SharesIssuedInConnectionWithInLicensingAgreements" name="SharesIssuedInConnectionWithInLicensingAgreements" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
  <xsd:element id="tgtx_IssuanceOfCommonStockInAtMarketOfferingNetOfOfferingCosts" name="IssuanceOfCommonStockInAtMarketOfferingNetOfOfferingCosts" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="tgtx_SharesIssuedInConnectionWithInLicensingAgreementsValue" name="SharesIssuedInConnectionWithInLicensingAgreementsValue" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="tgtx_AgreementCostsNoncurrentLiabilities" name="AgreementCostsNoncurrentLiabilities" nillable="true" xbrli:periodType="instant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="tgtx_FirstMilestonePaidInLicensingAgreements" name="FirstMilestonePaidInLicensingAgreements" nillable="true" xbrli:periodType="duration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:balance="credit" />
</xsd:schema>
