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Manhattan Pharmaceuticals to Webcast Annual Shareholder Meeting

Dec 14, 2006

NEW YORK, NY DEC 14, 2006 - Manhattan Pharmaceuticals, Inc. (AMEX: MHA) today announced it will host a live webcast of its annual shareholder meeting scheduled for Friday, December 15, 2006 at 10:00am EST. In addition to voting on the items in the Proxy Statement the meeting will also include a presentation by Douglas Abel, president and chief executive officer.

The meeting is being held at The American Stock Exchange, 86 Trinity Place in New York City.

To access the live audio webcast of this meeting please go to http://manhattanpharma.com approximately 15 minutes prior to the presentation in order to register and download any necessary software.

About Manhattan Pharmaceuticals, Inc.
Manhattan Pharmaceuticals, Inc., a development-stage pharmaceutical company, acquires and develops proprietary prescription drugs for large, underserved patient populations. In view of the worldwide obesity epidemic, the company is developing OE, an orally administered novel therapeutic for the treatment of obesity. To meet the needs of other major, underserved medical markets while lowering development risks, Manhattan Pharmaceuticals is also developing PTH (1-34), a peptide believed to be a regulator of epidermal cell growth, for psoriasis, and Propofol Lingual Spray, a convenient, proprietary lingual spray formulation of propofol, the world's best-selling general anesthetic, as a sedative-hypnotic for use during diagnostic and therapeutic procedures. (http://www.manhattanpharma.com)