TG Therapeutics, Inc. Announces Poster Presentation for Ublituximab (TGTX-1101) at the 7th International Workshop on Waldenstrom's Macroglobulinemia
Anti-CD20 monoclonal antibodies have several potential mechanisms of action, including ADCC which involves recruitment of effector cells such as Natural Killer (NK) cells to deplete circulating B-lymphocytes. This study evaluated the ADCC recruitment of NK cells in the presence of ublituximab in comparison to rituximab. Data presented at the meeting demonstrated that ublituximab is more efficient than rituximab in inducing ADCC at low doses and more importantly, results suggest that ublituximab could be more efficient than rituximab both to induce NK cell degranulation and ADCC in the presence of autologous peripheral tumor cells.
"Anti-CD20 monoclonal antibody therapy is a critical treatment component in WM; however patients continue to relapse. This data highlights the excitement for ublituximab, a new optimized anti-CD20 monoclonal antibody in the treatment of WM," stated Professor Leblond.
Ublituximab is a novel, third generation chimeric monoclonal antibody targeting a unique epitope on the CD20 antigen found on B lymphocytes. Ublituximab has been bioengineered for enhanced biological activity with an increased ability to trigger an immune response, delivering superior ADCC effects to aid in B-cell depletion. Ublituximab has displayed high single agent activity in a Phase I/II clinical trial in patients with relapsed Chronic Lymphocytic Leukemia, and is being developed by
Ublituximab has been granted orphan status in
Some of the statements included in this press release, particularly those anticipating future clinical trials and business prospects for ublituximab may be forward-looking statements that involve a number of risks and uncertainties. For those statements, we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Among the factors that could cause our actual results to differ materially are the following: our ability to successfully and cost-effectively complete pre-clinical and clinical trials for ublituximab; the risk that the data (both safety and efficacy) from future clinical trials will not coincide with the data analyses from prior pre-clinical and clinical trials; and other risk factors identified from time to time in our reports filed with the
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Jenna BoscoDirector- Investor Relations TG Therapeutics, Inc.Telephone: 212.554.4484 Email: firstname.lastname@example.org
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